LOCUS       NM_001099402            3524 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cyclin K (CCNK), mRNA.
ACCESSION   NM_001099402
VERSION     NM_001099402.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3524)
  AUTHORS   Dai,W., Wang,H., Zhan,Y., Li,N., Li,F., Wang,J., Yan,H., Zhang,Y.,
            Wang,J., Wu,L., Liu,H., Fan,Y., Tao,Y., Mo,X., Yang,J.J., Sun,K.,
            Chen,G. and Yu,Y.
  TITLE     CCNK Gene Deficiency Influences Neural Progenitor Cells Via Wnt5a
            Signaling in CCNK-Related Syndrome
  JOURNAL   Ann Neurol 94 (6), 1136-1154 (2023)
   PUBMED   37597256
  REMARK    GeneRIF: CCNK Gene Deficiency Influences Neural Progenitor Cells
            Via Wnt5a Signaling in CCNK-Related Syndrome.
REFERENCE   2  (bases 1 to 3524)
  AUTHORS   Sun,R., Wei,T., Ding,D., Zhang,J., Chen,S., He,H.H., Wang,L. and
            Huang,H.
  TITLE     CYCLIN K down-regulation induces androgen receptor gene intronic
            polyadenylation, variant expression and PARP inhibitor
            vulnerability in castration-resistant prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (39), e2205509119 (2022)
   PUBMED   36129942
  REMARK    GeneRIF: CYCLIN K down-regulation induces androgen receptor gene
            intronic polyadenylation, variant expression and PARP inhibitor
            vulnerability in castration-resistant prostate cancer.
REFERENCE   3  (bases 1 to 3524)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3524)
  AUTHORS   Chai,Q., Li,S., Collins,M.K., Li,R., Ahmad,I., Johnson,S.F.,
            Frabutt,D.A., Yang,Z., Shen,X., Sun,L., Hu,J., Hultquist,J.F.,
            Peterlin,B.M. and Zheng,Y.H.
  TITLE     HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize
            SERINC5 for optimal viral infectivity
  JOURNAL   Cell Rep 36 (6), 109514 (2021)
   PUBMED   34380030
  REMARK    GeneRIF: HIV-1 Nef interacts with the cyclin K/CDK13 complex to
            antagonize SERINC5 for optimal viral infectivity.
REFERENCE   5  (bases 1 to 3524)
  AUTHORS   Dieter,S.M., Siegl,C., Codo,P.L., Huerta,M.,
            Ostermann-Parucha,A.L., Schulz,E., Zowada,M.K., Martin,S.,
            Laaber,K., Nowrouzi,A., Blatter,M., Kreth,S., Westermann,F.,
            Benner,A., Uhrig,U., Putzker,K., Lewis,J., Haegebarth,A.,
            Mumberg,D., Holton,S.J., Weiske,J., Toepper,L.M., Scheib,U.,
            Siemeister,G., Ball,C.R., Kuster,B., Stoehr,G., Hahne,H.,
            Johannes,S., Lange,M., Herbst,F. and Glimm,H.
  TITLE     Degradation of CCNK/CDK12 is a druggable vulnerability of
            colorectal cancer
  JOURNAL   Cell Rep 36 (3), 109394 (2021)
   PUBMED   34289372
  REMARK    GeneRIF: Degradation of CCNK/CDK12 is a druggable vulnerability of
            colorectal cancer.
REFERENCE   6  (bases 1 to 3524)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 3524)
  AUTHORS   Lin,X., Taube,R., Fujinaga,K. and Peterlin,B.M.
  TITLE     P-TEFb containing cyclin K and Cdk9 can activate transcription via
            RNA
  JOURNAL   J Biol Chem 277 (19), 16873-16878 (2002)
   PUBMED   11884399
  REMARK    GeneRIF: P-TEFb containing cyclin K and Cdk9 can activate
            transcription via RNA.
REFERENCE   8  (bases 1 to 3524)
  AUTHORS   Mori,T., Anazawa,Y., Matsui,K., Fukuda,S., Nakamura,Y. and
            Arakawa,H.
  TITLE     Cyclin K as a direct transcriptional target of the p53 tumor
            suppressor
  JOURNAL   Neoplasia 4 (3), 268-274 (2002)
   PUBMED   11988847
  REMARK    GeneRIF: cyclin K may play a role in regulating the cell cycle or
            apoptosis
REFERENCE   9  (bases 1 to 3524)
  AUTHORS   Fu,T.J., Peng,J., Lee,G., Price,D.H. and Flores,O.
  TITLE     Cyclin K functions as a CDK9 regulatory subunit and participates in
            RNA polymerase II transcription
  JOURNAL   J Biol Chem 274 (49), 34527-34530 (1999)
   PUBMED   10574912
REFERENCE   10 (bases 1 to 3524)
  AUTHORS   Edwards,M.C., Wong,C. and Elledge,S.J.
  TITLE     Human cyclin K, a novel RNA polymerase II-associated cyclin
            possessing both carboxy-terminal domain kinase and Cdk-activating
            kinase activity
  JOURNAL   Mol Cell Biol 18 (7), 4291-4300 (1998)
   PUBMED   9632813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG503760.1, BQ432222.1,
            BX247958.1, BM505592.1 and AL110504.6.
            
            On May 17, 2019 this sequence version replaced NM_001099402.1.
            
            Summary: The protein encoded by this gene is a member of the
            transcription cyclin family. These cyclins may regulate
            transcription through their association with and activation of
            cyclin-dependent kinases (CDK) that phosphorylate the C-terminal
            domain (CTD) of the large subunit of RNA polymerase II. This gene
            product may play a dual role in regulating CDK and RNA polymerase
            II activities. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.809886.1,
                                           SRR7346977.1180546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389879.9/ ENSP00000374529.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-459               BG503760.1         9-467
            460-1146            BQ432222.1         43-729
            1147-2561           BX247958.1         190-1604
            2562-2599           BM505592.1         13-50               c
            2600-3524           AL110504.6         138395-139319       c
FEATURES             Location/Qualifiers
     source          1..3524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..3524
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /note="cyclin K"
                     /db_xref="GeneID:8812"
                     /db_xref="HGNC:HGNC:1596"
                     /db_xref="MIM:603544"
     exon            1..71
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            72..320
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1866
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /codon_start=1
                     /product="cyclin-K"
                     /protein_id="NP_001092872.1"
                     /db_xref="CCDS:CCDS45160.1"
                     /db_xref="GeneID:8812"
                     /db_xref="HGNC:HGNC:1596"
                     /db_xref="MIM:603544"
                     /translation="MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPA
                     TEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFL
                     AGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHP
                     YQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLC
                     KFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQP
                     PSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVK
                     RAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVD
                     ATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSM
                     MKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPP
                     PPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPG
                     MPPVGGLGRAAWMR"
     exon            321..402
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            403..534
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            535..640
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            641..698
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            699..868
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1134
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1168
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1240
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..3524
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /note="hexamer: AATAAA"
     polyA_site      2599
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /note="major polyA site"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
                     /note="hexamer: ACTAAA"
     polyA_site      3227
                     /gene="CCNK"
                     /gene_synonym="CPR4; IDDHDF"
ORIGIN      
        1 gacattccat atacaagatg gccgcagtcg gcaaggagag acgtcgctga ggggcttgcc
       61 tgaagcgagg ggattctaac attttcagag aaccttttgg aaagaacaag cctacttcaa
      121 taaatgaagg agaataaaga aaattcaagc ccttcagtaa cttcagcaaa cctggaccac
      181 acaaagccat gttggtactg ggataagaaa gacttggctc atacaccctc acaacttgaa
      241 ggacttgatc cagccaccga ggcccggtac cgccgagagg gcgctcggtt catctttgat
      301 gtgggcacac gtttggggct acactatgat accctggcaa ctggaataat ttattttcat
      361 cgcttctata tgtttcattc cttcaagcaa ttcccaagat atgtgacagg agcctgttgc
      421 ctctttctgg ctgggaaagt agaagaaaca ccaaaaaaat gtaaagatat catcaaaaca
      481 gctcgtagtt tattaaatga tgtacaattt ggccagtttg gagatgaccc aaaggaggaa
      541 gtaatggttc tggagagaat cttactgcag accatcaagt ttgatttaca ggtagaacat
      601 ccataccagt tcctactaaa atatgcaaag caactcaaag gtgataaaaa caaaattcaa
      661 aagttggttc aaatggcatg gacatttgta aatgacagtc tctgcaccac cttgtcactg
      721 cagtgggaac cagagatcat agcagtagca gtgatgtatc tcgcaggacg tttgtgcaaa
      781 tttgaaatac aagaatggac ctccaaaccc atgtatagga gatggtggga gcagtttgtt
      841 caagatgtcc cggtcgacgt tttggaagac atctgccacc aaatcctgga tctttactca
      901 caaggaaaac aacagatgcc tcatcacacc ccccatcagc tgcaacagcc cccatctctt
      961 cagcctacac cacaagtgcc gcaagtacag cagtcacagc cgtctcaaag ctccgaacca
     1021 tcccagcccc agcagaagga cccccagcaa ccagcccagc agcagcagcc agcccaacag
     1081 cccaagaaac cctctccgca gcccagttct ccccgacagg ttaagcgagc cgtggttgtt
     1141 tctcccaaag aagagaacaa agcagcagaa ccaccaccac ctaaaatccc caaaattgag
     1201 accactcatc caccgttgcc tccagcccac ccacctccag accggaagcc tcccctcgct
     1261 gctgccttag gtgaggctga gccgccgggc cctgtggatg ccactgacct ccccaaagtc
     1321 cagattcccc ctccggccca cccggcccct gtgcaccagc caccgccgct gccacaccgg
     1381 cccccgcccc cacccccctc cagctacatg accgggatgt ccaccaccag ctcctacatg
     1441 tctggagagg gctaccagag cctgcagtcc atgatgaaga ccgagggacc ctcctacggt
     1501 gccctgcccc ccgcctacgg cccacctgca cacctgccct accaccccca tgtctacccg
     1561 cccaacccgc ccccgccacc tgtgcctcct cccccagcct ccttcccccc acctgccatc
     1621 ccacccccta ctcctggcta ccccccaccc ccacccacct acaaccccaa cttcccaccc
     1681 ccacccccac gcctcccgcc tacccacgca gtcccccctc atcctcctcc agggttgggc
     1741 ctgccgccag ccagctaccc acctcctgcc gtcccccctg gaggacagcc tcctgtgccc
     1801 ccgcccattc ccccacccgg catgcctcca gttggggggc tggggcgggc agcctggatg
     1861 agataacgtg agcctttttt ccctctttgt ttttttaaca agattttcta atcgacttgc
     1921 agagtagttg aagtgggtaa gcagcagggt accttgtata atgcacgaca gttgcagtat
     1981 gggaagaatg gaccgggccc ctgggataaa atcagagtgg tcctcacacc tagaggacgg
     2041 ggacaaccag ctttcagagt agcctcatca gtgcccttgc agtctgactg tgtacacttg
     2101 gttcagctaa tgtctgagag tcctgcactg ggttacttta tactagtgag gacgttaacc
     2161 agccatattg gctcaataaa tagcttcggt aaggagttaa tttccttcta gaaatcagtg
     2221 cctatttttc ctggaaactc aattttaaat agtccaattc catctgaagc caagctgttg
     2281 tcattttcat tcggtgacat tctctcccat gacacccaga aggggcagaa gaaccacatt
     2341 tttcatttat agatgtttgc atcctttgta ttaaaattat tttgaagggg ttgcctcatt
     2401 ggatggcttt ttttttttcc tccagggaga aggggagaaa tgtacttgga aattaatgta
     2461 tgtttacatc tctttgcaaa ttcctgtaca tagagatata ttttttaagt gtgaatgtaa
     2521 caacatactg tgaattccat cttggttaca aatgagactc cttcagtcag ttatccaaat
     2581 aaaagcagtt ctgaaactat ccctttcttt gttatgggtg gaaggtgggg ctccaggcct
     2641 tcgcagtctg tggcttataa aatgtgcaga ggccctcctt ccagaccctg gggacgcggg
     2701 agaggcctgg ctgcagctca cagcagccac agccaacccc actgcctccc aaggcactct
     2761 gggtggatcc gcacagctgc ctgccaagcc agcctgcccc catcctgtgc ctgccttggt
     2821 ttcctttgga ggacctggtt gagttccaaa ccagtttgaa actttgaagc cttgctgcgt
     2881 agaacgcaca caggaacccg ggggcttgga tttgaaaccc tttccacttc tggcctgtga
     2941 tgagacagag gcagctggag gagcagcggc ctcactgtcc accttgaggg gccacggctc
     3001 tgtctgtgga aggggccccg actgagcccc catctgcggt gcttgagggg ccttggccct
     3061 gtctctgcct gctgaccctg ccacccacga cagaaacaag cactgagcac ccagccagga
     3121 ggctcacaaa gaggccttta tttatctagc tcaaagtaga cactatcaca atcttgtttg
     3181 ttactccttt tactaaaata gttcaaatca atgtttttac cacactatca aaaagttcta
     3241 tttcttcttg tctccccacg tcagagtggt tgaatagaag gtagaaacag gccgggagtc
     3301 cacgggctcc cagctctaaa cggcgccagg gcaggaaggg gtggctccag gtctcactgt
     3361 ggcaccttct acagaaaata gacgtagctg ccgggcccgg ggacagaaac cagacgttcc
     3421 agtccatctc caaaaagcag cacaaatact ttgccccaca gtatgaaaaa tatacacctc
     3481 taccgctctg cagtcatgca tttagtttta agaaaaaaaa aaaa
//
