LOCUS       NM_001308173            5709 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens cyclin J like (CCNJL), transcript variant 2, mRNA.
ACCESSION   NM_001308173 XM_005265982
VERSION     NM_001308173.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5709)
  AUTHORS   Li,J., Zhou,L., Liu,Y., Yang,L., Jiang,D., Li,K., Xie,S., Wang,X.
            and Wang,S.
  TITLE     Comprehensive Analysis of Cyclin Family Gene Expression in Colon
            Cancer
  JOURNAL   Front Oncol 11, 674394 (2021)
   PUBMED   33996604
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5709)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5709)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5709)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK302823.1, BC013353.2, BF111450.1 and AC112191.2.
            
            On Feb 27, 2020 this sequence version replaced NM_001308173.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2079328.1,
                                           SRR14038197.1992783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257536.13/ ENSP00000257536.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1812              AK302823.1         37-1848
            1813-3128           BC013353.2         1029-2344
            3129-3140           BF111450.1         10-21               c
            3141-5709           AC112191.2         118249-120817
FEATURES             Location/Qualifiers
     source          1..5709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..5709
                     /gene="CCNJL"
                     /note="cyclin J like"
                     /db_xref="GeneID:79616"
                     /db_xref="HGNC:HGNC:25876"
     exon            1..201
                     /gene="CCNJL"
                     /inference="alignment:Splign:2.1.0"
     exon            202..316
                     /gene="CCNJL"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1414
                     /gene="CCNJL"
                     /note="isoform b is encoded by transcript variant 2;
                     cyclin-J-like protein"
                     /codon_start=1
                     /product="cyclin-J-like protein isoform b"
                     /protein_id="NP_001295102.1"
                     /db_xref="CCDS:CCDS78082.1"
                     /db_xref="GeneID:79616"
                     /db_xref="HGNC:HGNC:25876"
                     /translation="MMDEPWWEGRVASDVHCTLREKELKLPTFRAHSPLLKSRRFFVD
                     ILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKQLYTVAVSCLLLASKFEDREDH
                     VPKLEQINSTRILSSQNFTLTKKELLSTELLLLEAFSWNLCLPTPAHFLDYYLLASVS
                     QKDHHCHTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICL
                     QLSPYWTRDLQRISSYSLEHLSTCIEILLVVYDNVLKDAVAVKSQALAMVPGTPPTPT
                     QVLFQPPAYPALGQPATTLAQFQTPVQDLCLAYRDSLQAHRSGSLLSGSTGSSLHTPY
                     QPLQPLDMCPVPVPASLSMHMAIAAEPRHCLATTYGSSYFSGSHMFPTGCFDR"
     exon            317..530
                     /gene="CCNJL"
                     /inference="alignment:Splign:2.1.0"
     exon            531..833
                     /gene="CCNJL"
                     /inference="alignment:Splign:2.1.0"
     exon            834..993
                     /gene="CCNJL"
                     /inference="alignment:Splign:2.1.0"
     exon            994..5709
                     /gene="CCNJL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNJL"
                     /note="hexamer: AATAAA"
     polyA_site      3140
                     /gene="CCNJL"
                     /note="major polyA site"
     regulatory      5689..5694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNJL"
                     /note="hexamer: ATTAAA"
     polyA_site      5709
                     /gene="CCNJL"
ORIGIN      
        1 gggagcctgc gagccgcggc gggacccgag cgcacgcagg ggcgcggcga cggcgggggc
       61 tagtcgggct gcggaggcgg ccgtcgggag tgcggagcgc ctcggacgag ggtccaaccg
      121 ccggcaggca ccagagggca cggctggctc ggcactggga ggggcccggc gctcgcagcc
      181 ccccacgccc agagaggatg cggtgcgccc tgagagccgg gtagcctcgg atagcggcgc
      241 tgcgtacgcg atgatggatg agccgtggtg ggaagggcgc gtcgcctcgg acgtccactg
      301 caccctgcgc gagaaggaac tgaagctgcc caccttccga gcccactccc cactcctgaa
      361 gagccgccgg ttcttcgtgg acatcctgac cctgctgagc agccactgcc agctctgccc
      421 tgcagcccgg cacctggccg tctacctgct ggaccacttc atggatcgct acaacgtcac
      481 cacctccaag cagctctaca ccgtggccgt ctcctgcctc ctgcttgcaa gtaagttcga
      541 ggatcgggaa gaccacgtcc ccaagttgga gcaaataaac agcacgagga tcctgagcag
      601 ccagaacttc accctcacca agaaggagct gctgagcaca gagctgctgc tcctggaggc
      661 cttcagctgg aacctctgcc tgcccacgcc tgcccacttc ctggactact acctcttggc
      721 ctccgtcagc cagaaggacc accactgcca cacctggccc accacctgcc cccgcaagac
      781 caaagagtgc ctcaaggagt atgcccatta cttcctagag gtcaccctgc aagatcacat
      841 attctacaaa ttccagcctt ctgtggtcgc tgcggcctgt gttggggcct ccaggatttg
      901 cctgcagctt tctccctact ggaccagaga cctgcagagg atctcaagct attccctgga
      961 gcacctcagc acgtgtattg aaatcctgct ggtagtgtat gacaacgtcc tcaaggatgc
     1021 cgtagccgtc aagagccagg ccttggcaat ggtgcccggc acacccccca cccccactca
     1081 agtgctgttc cagccaccag cctacccggc cctcggccag ccagcgacca ccctggcaca
     1141 gttccagacc cccgtgcagg acctatgctt ggcctatcgg gactccttgc aggcccaccg
     1201 ttcagggagc ctgctctcgg ggagtacagg ctcatccctc cacaccccgt accaaccgct
     1261 gcagcccttg gatatgtgtc ccgtgcccgt ccctgcatcc cttagcatgc atatggccat
     1321 tgcagctgag cccaggcact gcctcgccac cacctatgga agcagctact tcagtgggag
     1381 ccacatgttc cccaccggct gctttgacag ataggccacc tccagacctc acgaggaagc
     1441 cttggagatg tgggcagagg aagaggacac tgaagaggag agctcagcca agtgaggcag
     1501 caggaggcca tccctgaaga gccttggaac gtggagggtc tgtgctcctt ttaaataaaa
     1561 ctgacccaga gcaaaacatt caataacata cctcacccga gagcattcct ctgagaaacg
     1621 tctgccacgt gtggctaggg tacaaaagga tggcttggtg gccgtccccc cacacagggg
     1681 cccagtgaat cgagaaagac ttgataagag gccaggagag tgggaactgg acacagacca
     1741 ctgatctcaa gcatgtccag tttttagcat taaagacttt tctattcttt gctgatggca
     1801 gctacaccgc tgaaaaagga ggggcagcct ggcgtgttct caggaccccc ggaggatccc
     1861 atattgggtg cttttctttc cctggctcta tgcagagggg cctgagttgg tgtgtatgcc
     1921 tgagtgtttg ccttgcgagg cacagtgggt ggctgtcttg cctttgtttt cgaacctaaa
     1981 accattttca gccttttaga tatgtcatgt gctgctgctt cccgaagtgg tcttgctttc
     2041 tgtttcgtaa gatgtcttgt ttacacactg tatcagggat ttggtgatac ttgaaaattc
     2101 ctttggagaa aaaaacaaat ttaattgcca cactgcctgt cccacatgag ggctgttaat
     2161 ttggaaccca agtttgaacc caacttgtga tggacccgca ggtaaccaca gagcttcctt
     2221 tttgaaggca tatggttgga gagaaccatt ttcccagctc tcggttccgg aagattccac
     2281 gtcttggagg ctgtgttcac cactagaact ttaataacta cccagggagg gagaagctcg
     2341 ttgaaaggaa gacaaagatt taaacagttc ccacctctct ccaccacata cttacagggc
     2401 atgagtttaa cccagtctag gctttgagtg tggctgatag cgaaggatag caatgtggaa
     2461 aatttgctta gtcccacctg tatttgggga gtgggatgta catgggcgtt tgataccacc
     2521 attgataggc aagcgactgg ttggatcaaa agccagtatt tagggatctg cagcgagagg
     2581 gccctcagga agactcttgt aaccatgtgc aatatgtttt tattctgact cgcagcttgt
     2641 gctcagcatg ttctttggtt tagtttgggg ttgggggaca cattgttcac ccagcagaac
     2701 tgggaggtgc aaaggaccgt ggaagcaatt tttgttttgt ttgaggaata cctgtcttgg
     2761 attccttagc cccttgccag tcctggagac tgtggcaggg gccgccagga aggcagctgt
     2821 ctgctgctga gtcagatcgg aaggtggtga atctttccag agcagctgaa aatctcagca
     2881 tggagacagt aagaaaagag acggggtgtg gataagactc tgccaccgtg tcacactagc
     2941 ataggaggct gcacgttcat ttgttgttgt ttttttttcc tttgccaacc tccgttctat
     3001 ttatgtgcaa gcagtttgga ttcaagttct tgtatctgtc tgttctggga cctggggatt
     3061 gtgagggttc cctcacagcc agcacgaccc ccagaaagag gcgtcccaca ataaacacgt
     3121 cacctgctct tgatctctca cctcttgtcc taggcatccc ctcttgggcc ggcccctcct
     3181 tccctctctc aaatcagccc tggtgagcat ctccctatgg tagagggtgg aatattgggg
     3241 gcagcagcaa gacctcggga gctgagtcct gccctctgag taggagctgg gcctccctgg
     3301 gcacacagag gccagcggag gggtgtataa ggcttgacac cccagctcca tcaccgtctc
     3361 agggtttttc caaagaaacc agtaggatat atatggagag agatttattt taaggaattg
     3421 gctcatgtga ttgcagaggc tgtggtctaa aatttgtggg gcatgtcagc aggctggaaa
     3481 ttcaggtaag agctgatgtt gcagtagagt tcaaaatctg tagggcaggc ccacaggctg
     3541 gaaactcagg catgatttct gtgttagcag tcgtgaggca aaatttattc tccaggaaac
     3601 ctcaatcttt gctcttacga ccttttacca gttggatgag gcccacccac attatggagg
     3661 cttttcttaa agtcaactga ttgtaaatgt taatcacatc taaaaatacc ttgacagcaa
     3721 catctagact agtacctagc cacacaacag gcactgtagc ctagccaagc tgccacataa
     3781 acttaatgat cacaccactt accagctgtt ggaaggcagt tgacccaacc tctctctgag
     3841 cctccatctt gtcacctgtt aaaatgggag tgataacacc ttgcctcata gggttcttaa
     3901 gaggattaaa taacataatg tacatcaagg ccagtacctc caaaaaagga gataattatt
     3961 atatttcttc aagcataaga tcagcttttt gtaagatgca ctattatttt atgcactaat
     4021 aagacttttt agaaaactaa atcatgaggc agtttgcaag ataccattga ttatatgttg
     4081 cattctgatt tcagaagcgt tacatgtcaa aatatgtata tgtagaattg atgagatata
     4141 gcatcagctg ttatgaaaaa tgtcagattc gtactcctcc ttgaagggag tctcactcaa
     4201 gacttctgtc ttgccctcta cctacccagc ttccagcagg agaaccaccc cagagagccg
     4261 gtgtcactgt ggggctgaga catttgctaa gtgcagatgc ctttgattag acaattaggg
     4321 gaggaatggg aagatgagct cagggcctga ggctgcagcc cagacccagg agtgtgtttg
     4381 acaccgccaa gggcggggct gagggcagtg ctcaccaccc gctgtgtgca aggctaggtg
     4441 aggcaggaag ctctaagttt tggggattca gagacaaggc aagtcttggg ttgaccaaga
     4501 gcacccacct cactttggac aaatccctcc ctctttgggc ttccatttct ccatctgtta
     4561 ctatggagat ggtcaagttg gtggatggtt ctaagctctt ggggcggggg gagactgtgc
     4621 cacagaggct gtgacctctg tggccttcag ccagagggat ccacttgtat ttcttccacc
     4681 cttgggcact cccatgtaag attgtgttaa ttcccatgct ggaggacagc tatgaaagct
     4741 ttaaaaagca caaagatagt cttaaagttc ctcccagggc tggcatcagg ttaaattcag
     4801 aggttttcaa gcctgagcaa gctgcagaat gacctggagc cttctctagg aggggtgggg
     4861 acctggaatc tgcactttag ccagcttctt ggtcattcag gcatatgatt tctttgtttg
     4921 ttttttatat ttcagttgta tttttataac tccccagttt agtttgattt tttaaatttt
     4981 tattttattt atttatttat ttatttattt atttatttat ttattttttg aaacagggtc
     5041 tcactctgtg gcccaggcta gagtgcagtg gcacagtcac ggctcactgc agcttcaacc
     5101 ttctgggctc aagtgatcct cccacctcag cctcctgagt agctgggact acaggcacct
     5161 gtcaccatac ccagctaatt ttggtatttt ttgtagagat gaggtttcac catgttgtcc
     5221 aggctggtct cagactcctg agctcaagca atctgactgc ctcggcctcc caaagtgctg
     5281 agattacagg tataagccac tacgcctggt ccagcttgtt ttgaaaagta ttttctgacg
     5341 tctatatgaa tttaacagaa ttatctcaaa gtacacagaa attacctgta tttgccagta
     5401 aatatgagat gctgatgaaa gaatactcaa tataccaata tttaagcatg tcaacataat
     5461 agaacttttt ccacctttta aaattatttt tcccacctaa cccaatttat atttgacatt
     5521 tgggttacat gtgcatatag aaacagacct attccacaac tgaccataga taaactagca
     5581 tgcaagtgtc ctttctggat gtaattaagt ttcagaggca gcatggttca aatgggagca
     5641 aatgagctga cctcctcatg aaatacacta ggcaaaaaat caagaagtat taaagttgct
     5701 aaagactga
//
