LOCUS       NM_001134375            3959 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin J (CCNJ), transcript variant 1, mRNA.
ACCESSION   NM_001134375
VERSION     NM_001134375.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3959)
  AUTHORS   Shi,L., Xu,Z., Wu,G., Chen,X., Huang,Y., Wang,Y., Jiang,W. and
            Ke,B.
  TITLE     Up-regulation of miR-146a increases the sensitivity of non-small
            cell lung cancer to DDP by downregulating cyclin J
  JOURNAL   BMC Cancer 17 (1), 138 (2017)
   PUBMED   28202053
  REMARK    GeneRIF: High Cyclin J expression is associated with drug
            resistance in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3959)
  AUTHORS   Venturutti,L., Cordo Russo,R.I., Rivas,M.A., Mercogliano,M.F.,
            Izzo,F., Oakley,R.H., Pereyra,M.G., De Martino,M., Proietti,C.J.,
            Yankilevich,P., Roa,J.C., Guzman,P., Cortese,E., Allemand,D.H.,
            Huang,T.H., Charreau,E.H., Cidlowski,J.A., Schillaci,R. and
            Elizalde,P.V.
  TITLE     MiR-16 mediates trastuzumab and lapatinib response in
            ErbB-2-positive breast and gastric cancer via its novel targets
            CCNJ and FUBP1
  JOURNAL   Oncogene 35 (48), 6189-6202 (2016)
   PUBMED   27157613
  REMARK    GeneRIF: we identified cyclin J and far upstream element-binding
            protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16
            antiproliferative effects.
            Erratum:[Oncogene. 2023 Dec;42(50):3719. doi:
            10.1038/s41388-023-02870-9.. PMID: 37978227]
REFERENCE   3  (bases 1 to 3959)
  AUTHORS   Sun,X., Du,P., Yuan,W., Du,Z., Yu,M., Yu,X. and Hu,T.
  TITLE     Long non-coding RNA HOTAIR regulates cyclin J via inhibition of
            microRNA-205 expression in bladder cancer
  JOURNAL   Cell Death Dis 6 (10), e1907 (2015)
   PUBMED   26469956
  REMARK    GeneRIF: CCNJ is a target of miR205 mediated downregulation in
            bladder cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3959)
  AUTHORS   Takano,N., Hishida,M., Inokawa,Y., Hayashi,M., Kanda,M.,
            Nishikawa,Y., Iwata,N., Kobayashi,D., Tanaka,C., Yamada,S.,
            Nakayama,G., Fujii,T., Sugimoto,H., Koike,M., Fujiwara,M.,
            Kodera,Y. and Nomoto,S.
  TITLE     CCNJ detected by triple combination array analysis as a
            tumor-related gene of hepatocellular carcinoma
  JOURNAL   Int J Oncol 46 (5), 1963-1970 (2015)
   PUBMED   25672416
  REMARK    GeneRIF: In conclusion, our results indicated that CCNJ could be a
            novel prognostic marker of HCC, and this study indicated that
            triple combination array analysis was effective in detecting new
            tumor-related genes and their mechanisms.
REFERENCE   5  (bases 1 to 3959)
  AUTHORS   Feliciano,A., Castellvi,J., Artero-Castro,A., Leal,J.A.,
            Romagosa,C., Hernandez-Losa,J., Peg,V., Fabra,A., Vidal,F.,
            Kondoh,H., Ramon Y Cajal,S. and Lleonart,M.E.
  TITLE     miR-125b acts as a tumor suppressor in breast tumorigenesis via its
            novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9
  JOURNAL   PLoS One 8 (10), e76247 (2013)
   PUBMED   24098452
  REMARK    GeneRIF: miR-125b acts as a tumor suppressor in breast
            tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ,
            and MEGF9.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3959)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC043175.1, BM789816.1, AK001757.1 and AK025932.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001134375.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297264.1, SRR1660807.191750.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000465148.3/ ENSP00000435373.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               BC043175.1         192-460
            270-936             BM789816.1         1-667
            937-1351            BC043175.1         1095-1509
            1352-1352           AK001757.1         760-760
            1353-3444           BC043175.1         1511-3602
            3445-3445           AK001757.1         2851-2851
            3446-3731           BC043175.1         3604-3889
            3732-3947           AK001757.1         3138-3353
            3948-3959           AK025932.1         1928-1939
FEATURES             Location/Qualifiers
     source          1..3959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..3959
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /note="cyclin J"
                     /db_xref="GeneID:54619"
                     /db_xref="HGNC:HGNC:23434"
                     /db_xref="MIM:620395"
     exon            1..137
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..247
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1330
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cyclin-J isoform 1"
                     /protein_id="NP_001127847.1"
                     /db_xref="CCDS:CCDS44462.1"
                     /db_xref="GeneID:54619"
                     /db_xref="HGNC:HGNC:23434"
                     /db_xref="MIM:620395"
                     /translation="MELEGQWWRGQLAADIHQALRYKELKLPSYKGQSPQLSLRRYFA
                     DLIAIVSNRFTLCPSARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEDS
                     VPKLEQLNSLGCMTNMNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVH
                     ETDLHDGWPMICLEKTKLYMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASSRIILR
                     LSPTWPTRLHRLTAYSWDFLVQCIERLLIAHDNDVKEANKQRGQAGPQSAQLSVFQTA
                     SQPSRPVHFQQPQYLHQTHQTSLQYRHPTSEQPSCQQIVSTTHTSSYTLQTCPAGFQT
                     SVQGLGHMQTGVGMSLAIPVEVKPCLSVSYNRSYQINEHYPCITPCFER"
     exon            248..458
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..758
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..918
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..3959
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3808..3813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /note="hexamer: AATAAA"
     polyA_site      3843
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /note="major polyA site"
     regulatory      3937..3942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
                     /note="hexamer: AATAAA"
     polyA_site      3959
                     /gene="CCNJ"
                     /gene_synonym="bA690P14.1"
ORIGIN      
        1 aacaatgggc ggcgcgagcg tccaggcgct gggctctagc tgaggccggc gcttagcggc
       61 ccactgtccg cagcatgagc ggggccggcg tccgccgcac gacggcgggg ctggggctgt
      121 gagggccgcg gttccggact cgagttgccg cgtcgggctg ggcgcgccgc cgggtcccat
      181 ggagctggag gggcagtggt ggcgaggaca gctggccgcc gatattcacc aagcgcttcg
      241 ctacaaggag ctgaagttgc cctcctataa aggccagtcc cctcagttaa gtctcagacg
      301 gtattttgct gacttgattg ccattgtgag caatcgcttc acactctgcc cttctgcccg
      361 ccatcttgct gtctatttac tggacctgtt tatggaccgc tatgacatct ctatccagca
      421 gctgcattta gttgcgcttt cctgcctgct tctagcaagt aaatttgaag aaaaagaaga
      481 cagtgtgcct aagctggagc agctcaacag cctgggttgt atgactaata tgaatctagt
      541 attaacaaaa caaaatttgc tacatatgga actattatta ttagaaacct ttcagtggaa
      601 cctctgcctt ccaacagccg cccatttcat tgagtattat ctctctgaag cagtacacga
      661 aacagatctt catgacggct ggccaatgat ttgcttggaa aagactaaac tctacatggc
      721 caaatatgca gattacttcc tggaagtatc tttgcaagat tatgcctttc taaattatgc
      781 accttcttta gtagctgctg catgtgtggc ttcttcgagg attatacttc gtctttctcc
      841 aacgtggcct acaagactac atcgtcttac tgcctactct tgggatttct tagtgcagtg
      901 tattgaacga ctgttgatcg ctcatgataa tgatgtgaaa gaagcaaaca aacagagagg
      961 gcaagcagga cctcagtcag cgcaactaag tgtattccag acagcctccc agccatcacg
     1021 gccagttcac tttcagcaac ctcagtatct ccatcagaca catcagacct cactgcagta
     1081 tcgccatcct acgtcagaac aaccaagctg tcagcagatt gtatcgacca cacacacctc
     1141 atcttacaca ctacagacat gtcctgctgg cttccaaact agtgttcagg gccttgggca
     1201 catgcagact ggtgttggga tgtcactggc aataccagta gaagttaagc cctgtctgag
     1261 tgtttcttac aaccggagtt atcagataaa tgaacattac ccttgtatta ctccatgttt
     1321 tgaaaggtga ttatttgtga agctgataac cgacccagac tgctttgtga catgaagcta
     1381 tgggtaagcg ttttgtaaac ttctgttcaa aaggaaaggg atctaaatga catcagaact
     1441 cttcaggtac cagcaccagg aagactgaat atccttttta atgcaccatg aatcctggga
     1501 gactaagcaa attaacagta tgtcaaattc tgttacaaca aatccctgta tgacaaaaat
     1561 gttcaagtcc tggctgatgg tccaaatatt tcaaaaatat tcagtacaac agaaaatttg
     1621 gacagacttc aatttgccat tttgagattt gacctgtggt agcatctggg cctaatgttg
     1681 gcttctaagt caaagactaa atgtttatct catctatgga cttgccaaac agtcttttat
     1741 gaaggaaagt tacagtatta atttttgaaa aggttttttt tattctgcaa ttttttattt
     1801 ttgttctaca catgaatttt tgactaagtt taaactcatg aattgttatg ctataccaat
     1861 ctgcagtaaa aaaaattttt ttagatgatt ctatataact tcgtctcaca aatagtgtag
     1921 gtatctgggt ttatatacta aaattaaggg tggagaagat cttatttttt aaatcatggt
     1981 cataattttt ctttttttcc ctaagtgatc aacatcaaat ttttagaatt aaaatacatt
     2041 taactcaggg aatttgtact acttggaaac acttaactgt aatgcaacat gccttgggaa
     2101 tgttatagtg tgaactacct ttataacata ggttaaaata cgcttgctag ggtgtgtttt
     2161 caaatgagaa cataatatag ctcagaatga agtggtagtt cctgtgattc ataatacata
     2221 tgtaggtttt gcatatctca gtgcaatcca tgatttatac tcagaatcga cattcttaaa
     2281 aagttatttc aagggatggc ataactgtaa gaggtcagtg ctagaataaa gtcctgtagg
     2341 tttattttgg aagggactgt ggccagggta gttctcaggt tgtgctagag cagcactttg
     2401 ttatgtggaa gacaggtttt ttaagcaacc tttgaatcca gctctagtca gtctaagcag
     2461 gcaaaggtaa ctgatgacta aatttcagta gctactttca ttggattgac cctacaactg
     2521 ccctgggaca tttcactgta ccagtattaa ctgcaaacag caataattgt cattacagca
     2581 agggcagttt gggggtaaag cattttggag gaataacctt aaaaagttaa aaagtcattg
     2641 taataactga taaactgtat acattgtgct cctttctgtg ggagaagaaa gatttggtgg
     2701 agggaagctt tctggtttaa aaattagtaa ggtgtgtctt tttgtttttt ttaagatagc
     2761 acttgaatag aagggaaaac tgcatggcag atacgtgact gccacaatat gcatcgaaga
     2821 caaacttact ataaagatgt tgtgggtatg cagcaggagt ctcagtaatc aagccaatgg
     2881 cctttgtcag gaagggaagg ggctcaacac agtgatggac tgatccagat ggctcccggg
     2941 gatgaatgtg ggtgggtagc ttctgtcagt atcaatgctt agagaaatat cctttcctta
     3001 aaaagaaaat aacttttata tttagagtac atagggcatg atgtggattt attagtctgg
     3061 tagataaaat gaaaaaccac tcaggtaaga acactcactc atggcagttt ttaagcatga
     3121 aaattgtttt ctgaaagtat catcactttt cctttttaaa gaaggctgct aattggattt
     3181 tggtagttct tacctcaaga aaacttgaat tatttggggg aaagtaggct caaaagagaa
     3241 tatatctttc acattcacat tcagaaccca gcaacctgga gtccaatttt cagtatttta
     3301 actacctcaa taatgctatg aatgtaagat attgggatag agatcccaac ttgaaacaac
     3361 agccagtgcc tgtggtaact taatgtcttg tcaaatactt ttattgattg gtttatatgc
     3421 cattcttgtt atagaagaat atgcctttta aaaaagctta ttaataacac tttcccaatt
     3481 tatattttaa aaagctaaag aacactggat taataatctt ttgggagggt agaataaaat
     3541 aattgattac tattgctgca tacccggggt gggatggggt ggttggagaa ccagaactat
     3601 ttttaaaaca ttaggtttca atataaatac aactcacaac tgctagcttt ggggggtggg
     3661 ggaacattgt gtgggttttg ttttgtttaa tttattgatt agtctttaaa gtaggctttt
     3721 tttttttttt ttgagaatac tggaccatca ttaaatgtgt actgtgaaga gattaatatg
     3781 tatgaagggc tttaccaaag tccactaaat aaacactact caagtacaga ctgcaaacca
     3841 aaatgtatct gtgttacgac attaattgca aatagcaagt atggtgctaa agtctacacc
     3901 aatggaatta gatgagtgct atgcacttaa ttttaaaata aaactagttt tcagtaaaa
//
