LOCUS       NM_001039780            2613 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens cyclin I family member 2 (CCNI2), transcript variant
            2, mRNA.
ACCESSION   NM_001039780 XM_928152 XM_938520
VERSION     NM_001039780.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Lai,D.M., Bi,J.J., Chen,Y.H., Wu,Y.D., Huang,Q.W., Li,H.J.,
            Zhang,S., Fu,Z. and Tong,Y.X.
  TITLE     CCNI2 plays a promoting role in the progression of colorectal
            cancer
  JOURNAL   Cancer Med 10 (6), 1913-1924 (2021)
   PUBMED   33620152
  REMARK    GeneRIF: CCNI2 plays a promoting role in the progression of
            colorectal cancer.
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Liu,C., Zhai,X., Zhao,B., Wang,Y. and Xu,Z.
  TITLE     Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5)
            activator and is involved in cell cycle regulation
  JOURNAL   Sci Rep 7, 40979 (2017)
   PUBMED   28112194
  REMARK    GeneRIF: Here the authors show that cyclin I-like (CCNI2), a
            homolog of CCNI, interacts with CDK5 and activates the kinase
            activity of CDK5. Different from CCNI, which colocalizes with CDK5
            in the nuclei in transfected cells, CCNI2 mainly retains CDK5 in
            the cytoplasm as well as on the cell membrane.
            Erratum:[Sci Rep. 2017 Mar 15;7:44164. doi: 10.1038/srep44164..
            PMID: 28294125]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Taneera,J., Fadista,J., Ahlqvist,E., Zhang,M., Wierup,N.,
            Renstrom,E. and Groop,L.
  TITLE     Expression profiling of cell cycle genes in human pancreatic islets
            with and without type 2 diabetes
  JOURNAL   Mol Cell Endocrinol 375 (1-2), 35-42 (2013)
   PUBMED   23707792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004775.1, AK131553.1 and AW131382.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001039780.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (isoform 2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131553.1, BC136836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378731.6/ ENSP00000368005.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC004775.1         79135-79153         c
            20-1811             AK131553.1         2-1793
            1812-1812           AC004775.1         72977-72977         c
            1813-2374           AK131553.1         1795-2356
            2375-2613           AW131382.1         192-430
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2613
                     /gene="CCNI2"
                     /note="cyclin I family member 2"
                     /db_xref="GeneID:645121"
                     /db_xref="HGNC:HGNC:33869"
                     /db_xref="MIM:620419"
     exon            1..499
                     /gene="CCNI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1180
                     /gene="CCNI2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cyclin-I2"
                     /codon_start=1
                     /product="cyclin-I2 isoform 2"
                     /protein_id="NP_001034869.1"
                     /db_xref="CCDS:CCDS34236.1"
                     /db_xref="GeneID:645121"
                     /db_xref="HGNC:HGNC:33869"
                     /db_xref="MIM:620419"
                     /translation="MASGAQLPPQPSSSEVSAVQSPGGRPGAGLEETALGVPLPPSPG
                     EAPLPRSNRSRCPGTRQPGAASLHAASAAVPVRPRRGTAPAGKTADAVPAAAPEQAPR
                     PAPQSRKPRNLEGDLDERRLLCHLQLAQDREARLWRGGKPQDEICDAFEEVVLWLLRL
                     QNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEEFIPQVKD
                     FTKHYGSDYSPNELLRMELAILDRLHWDLYIGTPLDFLTIFHALVVLSWPHVLELLPQ
                     RNPSLHVASLTRQLQHCMAGHQLLQFKGSTLALVIITLELERLMPGWCAPISDLLKKA
                     QVGDMQYSCCKELVMQQLRSLQSSSCTDNFVSPAN"
     exon            500..628
                     /gene="CCNI2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..703
                     /gene="CCNI2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..844
                     /gene="CCNI2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1075
                     /gene="CCNI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..2613
                     /gene="CCNI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2354..2359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNI2"
                     /note="hexamer: ATTACA"
     polyA_site      2375
                     /gene="CCNI2"
                     /note="major polyA site"
ORIGIN      
        1 agtgttccgg gagctgggtt ataaaatgcc gggttaagcg gcaactcaga ctcaggatcc
       61 cgctcacgac atggcctcgg gcgctcagct cccgccgcag ccgtcgagct cagaggtcag
      121 cgccgtccag agcccaggcg ggcgtcccgg cgccggtctg gaggaaacag ccctgggcgt
      181 tcctctcccg ccgtctccgg gggaggcccc tctgccccga agcaaccgga gcaggtgccc
      241 tgggacccgc cagcccggag cggcctccct ccacgcggcg tccgcagcag tccccgtgcg
      301 gccccggcgc ggtacggcgc cagccgggaa aaccgcagac gcggtccccg ccgccgcccc
      361 agagcaagct ccgcggccgg ctccacagtc ccgcaagccg cgcaacctgg aaggcgacct
      421 ggacgagcgc cggctgctct gccacttgca gctggcccag gaccgcgagg cgcgcctgtg
      481 gcggggcggc aaaccccagg atgaaatctg cgacgccttc gaggaagtcg tgctgtggct
      541 cctgcggctt cagaacacct tttacttctc ccagtccact tttaacctgg ccctcaccat
      601 ctttggccgc ctcctgattt cagtgaaggt aaaagagaaa tacctgcatt gcgccacaat
      661 tacttccttg aggctcgctg caaaagttaa tgaagaagag gagtttattc cacaagtaaa
      721 agacttcaca aagcactatg gctctgacta ttccccgaat gagctgctga ggatggagct
      781 ggctattctg gacagactgc actgggacct ctatattggg acgccgctgg acttcttgac
      841 tatattccat gccctggtgg tcctgagctg gccccatgtg ttggagctgc tgcctcagag
      901 gaatccttcc ctccacgtcg catccctgac caggcagctg cagcactgta tggcgggcca
      961 ccagctgctg cagttcaagg gctccacact ggccttggtc atcatcacct tagagctgga
     1021 gaggctcatg cccggctggt gtgctcctat atctgatctg ctaaagaaag cacaggttgg
     1081 tgatatgcag tacagctgct gcaaggaact tgtaatgcag caactgagaa gtcttcagtc
     1141 atcctcctgc acagacaact ttgtgtcacc tgccaactag cccctctgcc tccaccccgg
     1201 ggctttcaga gcatagtgtg aaacctcctt gcttggacta ccatgagttc tttggcttgt
     1261 tatgaatcct gtaaaaaggg aaggtggctc tggaagagca actgagaaaa agttcccaac
     1321 tgagcccttg gaaaaaaaat aaaggggaga ggggaaaggc aggctgaggt cagtagaggt
     1381 cagggtggtc tgatagacta tgaccctgtc ttcccttttt ctcctctggg cctgaagcca
     1441 gggagtatga atgaatgttc aaatggcagc ttgttttacc ttccttctcc agcaagggtt
     1501 ggcattggcc cctgggagcg ctggaatatg aaaccaagag gcaggcctgg ctcagggctg
     1561 aagggctggg gctagctctg accagttctt gctgctctac ctgccagagc tggccaggtc
     1621 cttccaactt cccaggctta tcccaaacac atatgtggtg cttccagtcc caactaccct
     1681 gcctgccact cctcacatgg gacagtctct gcagatgcat ttacccaacc atggctatga
     1741 cttatgtctt ccctttacaa ggactggatt ataaagtatg ctttgtttaa tgtaacttga
     1801 gcaagcttta ggcatatctt tcctttgtta ctcttaagca aagtggtttc agttattagt
     1861 ttaactagag ggattttgtg ctaatgaatg ggtattatag gctaacacct gtgatgggag
     1921 gcacagctct gaatgctttc tgttgggatg agcaggttct gaggccaagc ctgctccaac
     1981 cacagtgctg ccaggaggag gagccggctg cctctctcat gctgtgctac cacagagcca
     2041 ttctctaagc aggggagtgc agctgacaaa gatgccagct ggggctgtgt aagttgtgtt
     2101 gggggcatga atgactgagc cacacattca gaggtggttt gtgaagtctt ccactgtgaa
     2161 ctatggtttt tttttttttt tttttttttt ggtgtgtttg tgtaaatgtg ctaagccatg
     2221 gggtgggagg ggaaagattt actaggtgca aagtggtcaa gggccagata tactataatt
     2281 gtctatatta tagagttagt atacatctgt attttttctt gacacacttt tgcttgttgg
     2341 tgctttcgtt aaaattacac tttaattgct tccgatcctg tatgagtctt attttgagct
     2401 accatgcatt tagccttgcg agagtcagat acatttggaa cactatctcc taggtcatat
     2461 caagaactct cctctagtcc agaacccatt ttacagatgg agatgctgag gccatgctgc
     2521 tcacagcttc cagtggtggc cgttgagtgc cctctgcctc cttccttcca gtgtaagtgg
     2581 gaccacagtg catgaggcag aaggacatcc tga
//
