LOCUS       NM_006835               2759 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin I (CCNI), transcript variant 1, mRNA.
ACCESSION   NM_006835
VERSION     NM_006835.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Quandt,E., Masip,N., Hernandez-Ortega,S., Sanchez-Botet,A.,
            Gasa,L., Fernandez-Elorduy,A., Plutta,S., Martinez-Lainez,J.M.,
            Bru,S., Munoz-Torres,P.M., Floor,M., Villa-Freixa,J., Morris,M.C.,
            Vidal,A., Villanueva,A., Clotet,J. and Ribeiro,M.P.C.
  TITLE     CDK6 is activated by the atypical cyclin I to promote E2F-mediated
            gene expression and cancer cell proliferation
  JOURNAL   Mol Oncol 17 (7), 1228-1245 (2023)
   PUBMED   37081792
  REMARK    GeneRIF: CDK6 is activated by the atypical cyclin I to promote
            E2F-mediated gene expression and cancer cell proliferation.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Li,R., Liu,G.Z., Luo,S.Y., Chen,R. and Zhang,J.X.
  TITLE     Cyclin I promotes cisplatin resistance via Cdk5 activation in
            cervical cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 19 (23), 4533-4541 (2015)
   PUBMED   26698249
  REMARK    GeneRIF: A cyclin I-Cdk5 complex forms a critical antiapoptotic
            factor in the process of generating cisplatin resistance in
            cervical cancer.
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   So,J., Pasculescu,A., Dai,A.Y., Williton,K., James,A., Nguyen,V.,
            Creixell,P., Schoof,E.M., Sinclair,J., Barrios-Rodiles,M., Gu,J.,
            Krizus,A., Williams,R., Olhovsky,M., Dennis,J.W., Wrana,J.L.,
            Linding,R., Jorgensen,C., Pawson,T. and Colwill,K.
  TITLE     Integrative analysis of kinase networks in TRAIL-induced apoptosis
            provides a source of potential targets for combination therapy
  JOURNAL   Sci Signal 8 (371), rs3 (2015)
   PUBMED   25852190
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Nagano,T., Hashimoto,T., Nakashima,A., Hisanaga,S., Kikkawa,U. and
            Kamada,S.
  TITLE     Cyclin I is involved in the regulation of cell cycle progression
  JOURNAL   Cell Cycle 12 (16), 2617-2624 (2013)
   PUBMED   23907122
  REMARK    GeneRIF: Knockdown of Cyclin I induced cell cycle arrest at S/G2/M
            phases.
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Sun,Z.L., Zhu,Y., Wang,F.Q., Chen,R., Peng,T., Fan,Z.N., Xu,Z.K.
            and Miao,Y.
  TITLE     Serum proteomic-based analysis of pancreatic carcinoma for the
            identification of potential cancer biomarkers
  JOURNAL   Biochim Biophys Acta 1774 (6), 764-771 (2007)
   PUBMED   17507299
  REMARK    GeneRIF: The increased levels of cyclin I and GDI2 found to be
            associated with pancreatic carcinoma were further confirmed by
            Western blot analyses in an independent series of serum samples
            and/or pancreatic juice samples
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Zhu,X. and Naz,R.K.
  TITLE     Expression of a novel isoform of cyclin I in human testis
  JOURNAL   Biochem Biophys Res Commun 249 (1), 56-60 (1998)
   PUBMED   9705831
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Nakamura,T., Sanokawa,R., Sasaki,Y.F., Ayusawa,D., Oishi,M. and
            Mori,N.
  TITLE     Cyclin I: a new cyclin encoded by a gene isolated from human brain
  JOURNAL   Exp Cell Res 221 (2), 534-542 (1995)
   PUBMED   7493655
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104771.4 and AC111196.4.
            
            On Nov 26, 2018 this sequence version replaced NM_006835.2.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin shows the highest similarity with cyclin G. The transcript
            of this gene was found to be expressed constantly during cell cycle
            progression. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1, 2, and
            3 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.96117.1,
                                           SRR3476690.909623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237654.9/ ENSP00000237654.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               AC104771.4         19377-19894         c
            519-675             AC104771.4         10154-10310         c
            676-804             AC104771.4         2412-2540           c
            805-879             AC104771.4         154-228             c
            880-886             AC104771.4         1-7                 c
            887-1020            AC111196.4         33058-33191         c
            1021-1251           AC111196.4         32246-32476         c
            1252-2759           AC111196.4         24251-25758         c
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..2759
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /note="cyclin I"
                     /db_xref="GeneID:10983"
                     /db_xref="HGNC:HGNC:1595"
                     /db_xref="MIM:618783"
     exon            1..518
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     exon            519..675
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..1695
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /note="isoform a is encoded by transcript variant 1;
                     cyclin ITI"
                     /codon_start=1
                     /product="cyclin-I isoform a"
                     /protein_id="NP_006826.1"
                     /db_xref="CCDS:CCDS3580.1"
                     /db_xref="GeneID:10983"
                     /db_xref="HGNC:HGNC:1595"
                     /db_xref="MIM:618783"
                     /translation="MKFPGPLENQRLSFLLEKAITREAQMWKVNVRKMPSNQNVSPSQ
                     RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTV
                     EEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVS
                     TRPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFRGSMLALAMVSLEMEKLIPDW
                     LSLTIELLQKAQMDSSQLIHCRELVAHHLSTLQSSLPLNSVYVYRPLKHTLVTCDKGV
                     FRLHPSSVPGPDFSKDNSKPEVPVRGTAAFYHHLPAASGCKQTSTKRKVEEMEVDDFY
                     DGIKRLYNEDNVSENVGSVCGTDLSRQEGHASPCPPLQPVSVM"
     exon            676..804
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     exon            805..879
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1020
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1251
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..2759
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /note="hexamer: AATAAA"
     polyA_site      2759
                     /gene="CCNI"
                     /gene_synonym="CCNI1; CYC1; CYI"
                     /note="major polyA site"
ORIGIN      
        1 ctccctcccc agccttcccc gcgagcggac gcggcagcgc ctctgtctcg ctttttctta
       61 tttttccccc ctttcccctt tctttttttt tttttctttt cttttctccc ctccccccct
      121 ttcaccattt cccctcggag gcgctttccc cgggcagggg cagagccggt ctcacccccc
      181 gcctctcccc ggcccccgcc gccctatggc gagagggagc cccctcccaa cccgggctcg
      241 agcggcggcg gcctcaggcc gggggtcatc atggaactaa ttcgctgacc gacccagcgg
      301 ccgcagccgt gcgtcccgct cgagcgccag cgcccgcgcc cgcgcccccc gatccgcttc
      361 ccctttctcc ctcctcagtt ggccgagtcg tcccgcgcgc accgcctccg cgcgcctatg
      421 agaatgaggt ggtaacgggc ccccggatga ccccgcgtca ccactgtgag gcctacagct
      481 ctgccgggga ggaggaggag gaggaagagg aggagaaggt agctacagca agctgggtag
      541 caggcagatc caaaggatat catgaagttt ccagggcctt tggaaaacca gagattgtct
      601 ttcctgttgg aaaaggcaat cactagggaa gcacagatgt ggaaagtgaa tgtgcggaaa
      661 atgccttcaa atcagaatgt ttctccatcc cagagagatg aagtaattca atggctggcc
      721 aaactcaagt accaattcaa cctttaccca gaaacatttg ctctggctag cagtcttttg
      781 gataggtttt tagctaccgt aaaggctcat ccaaaatact tgagttgtat tgcaatcagc
      841 tgttttttcc tagctgccaa gactgttgag gaagatgaga gaattccagt actaaaggta
      901 ttggcaagag acagtttctg tggatgttcc tcatctgaaa ttttgagaat ggagagaatt
      961 attctggata agttgaattg ggatcttcac acagccacac cattggattt tcttcatatt
     1021 ttccatgcca ttgcagtgtc aactaggcct cagttacttt tcagtttgcc caaattgagc
     1081 ccatctcaac atttggcagt ccttaccaag caactacttc actgtatggc ctgcaaccaa
     1141 cttctgcaat tcagaggatc catgcttgct ctggccatgg ttagtctgga aatggagaaa
     1201 ctcattcctg attggctttc tcttacaatt gaactgcttc agaaagcaca gatggatagc
     1261 tcccagttga tccattgtcg ggagcttgtg gcacatcacc tttctactct gcagtcttcc
     1321 ctgcctctga attccgttta tgtctaccgt cccctcaagc acaccctggt gacctgtgac
     1381 aaaggagtgt tcagattaca tccctcctct gtcccaggcc cagacttctc caaggacaac
     1441 agcaagccag aagtgccagt cagaggtaca gcagcctttt accatcatct cccagctgcc
     1501 agtgggtgca agcagacctc tactaaacgc aaagtagagg aaatggaagt ggatgacttc
     1561 tatgatggaa tcaaacggct ctataatgaa gataatgtct cagaaaatgt gggttctgtg
     1621 tgtggcactg atttatcaag acaagaggga catgcttccc cttgtccacc tttgcagcct
     1681 gtttctgtca tgtagtttca acaagtgcta cctttgagtg taaactaagg tagactactt
     1741 tgggaatgag aacatgcaaa atcaggaaag gctgtagaag gaaatatacc ttaacaggct
     1801 gatttggagt gagccagaaa aaaaaaataa aactctcatt atttgtgtgg ctaattataa
     1861 ttcagcgtta tttaagcaca taaagaccaa aaaaaaaaaa aagaaatcca aaagatccaa
     1921 acttttttta aacttaaaaa atctctttgt agtatgtcag ttgcactttt tttctgccat
     1981 aatgtaacgt agcttgcccc gtcaaaaatt caattaaaat tcatggccag caatcctgtt
     2041 ccccctcagc atcctgattt aattttcctg ttgcttttgc ttgcttctcc atttaatagt
     2101 tactgaactt tatgcatgtt gatctatatt gattttcact gcagttgaat gaacaaatta
     2161 tttcagtgtg acagccatga ctcaagttcc aattagtctg aaaagggtac tttggaattg
     2221 tcccatatta atcagagatg gcaaaagaaa aagttctcat attaccaggt tgattttgtg
     2281 tctcatttca aattttaatt taaaattatg gttttcattt ttgtttacct taaagtgatg
     2341 cttaaaagtg gcatgtaatt aggacactta ggtttgttga aagcattttc gacatttgta
     2401 taaaagaatt tgtgataaat atatccaggt gctcaccaaa gaaacatgta ttaacaactt
     2461 aaattagatt tttctaactg atagttttca ctcatttata atcagtagga gagactgtct
     2521 agatgttggg gcagctctat gatttaagtc tgtaacatgt tataactgaa tttagtaccc
     2581 tagttttgtt aagctattag gattttctaa tagaacttac tccccctgcc tccccagcct
     2641 tatgtttctt ttaatgactt ctggatcctg agctcccttt gcagtctgaa aaaggtattg
     2701 cagtcagaac tgtgtactga tgataaaagc ctctggtagc aataaaaagt tgtccttaa
//
