LOCUS       NM_001239               1280 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin H (CCNH), transcript variant 1, mRNA.
ACCESSION   NM_001239
VERSION     NM_001239.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1280)
  AUTHORS   Schutz,M., Wangen,C., Sommerer,M., Kogler,M., Eickhoff,J.,
            Degenhart,C., Klebl,B., Naing,Z., Egilmezer,E., Hamilton,S.T.,
            Rawlinson,W.D., Sticht,H. and Marschall,M.
  TITLE     Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97
            undergoes regulatory interaction with human cyclin H and CDK7 to
            codetermine viral replication efficiency
  JOURNAL   Virus Res 335, 199200 (2023)
   PUBMED   37591314
  REMARK    GeneRIF: Cytomegalovirus cyclin-dependent kinase ortholog
            vCDK/pUL97 undergoes regulatory interaction with human cyclin H and
            CDK7 to codetermine viral replication efficiency.
REFERENCE   2  (bases 1 to 1280)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1280)
  AUTHORS   Mao,L., Ling,X. and Chen,J.
  TITLE     Cyclin H Regulates Lung Cancer Progression as a Carcinoma Inducer
  JOURNAL   Comput Math Methods Med 2021, 6646077 (2021)
   PUBMED   33777168
  REMARK    GeneRIF: Cyclin H Regulates Lung Cancer Progression as a Carcinoma
            Inducer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1280)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1280)
  AUTHORS   Eki,T., Okumura,K., Abe,M., Kagotani,K., Taguchi,H., Murakami,Y.,
            Pan,Z.Q. and Hanaoka,F.
  TITLE     Mapping of the human genes encoding cyclin H (CCNH) and the
            CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to
            chromosome bands 5q13.3-q14 and 14q23, respectively
  JOURNAL   Genomics 47 (1), 115-120 (1998)
   PUBMED   9465303
REFERENCE   6  (bases 1 to 1280)
  AUTHORS   Aprelikova,O., Xiong,Y. and Liu,E.T.
  TITLE     Both p16 and p21 families of cyclin-dependent kinase (CDK)
            inhibitors block the phosphorylation of cyclin-dependent kinases by
            the CDK-activating kinase
  JOURNAL   J Biol Chem 270 (31), 18195-18197 (1995)
   PUBMED   7629134
REFERENCE   7  (bases 1 to 1280)
  AUTHORS   Shiekhattar,R., Mermelstein,F., Fisher,R.P., Drapkin,R.,
            Dynlacht,B., Wessling,H.C., Morgan,D.O. and Reinberg,D.
  TITLE     Cdk-activating kinase complex is a component of human transcription
            factor TFIIH
  JOURNAL   Nature 374 (6519), 283-287 (1995)
   PUBMED   7533895
REFERENCE   8  (bases 1 to 1280)
  AUTHORS   Fisher,R.P. and Morgan,D.O.
  TITLE     A novel cyclin associates with MO15/CDK7 to form the CDK-activating
            kinase
  JOURNAL   Cell 78 (4), 713-724 (1994)
   PUBMED   8069918
REFERENCE   9  (bases 1 to 1280)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 1280)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP244381.1, BC005280.1 and
            BC016705.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001239.3.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin forms a complex with CDK7 kinase and ring finger protein
            MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2
            kinases, thus functions as a CDK-activating kinase (CAK). This
            cyclin and its kinase partner are components of TFIIH, as well as
            RNA polymerase II protein complexes. They participate in two
            different transcriptional regulation processes, suggesting an
            important link between basal transcription control and the cell
            cycle machinery. A pseudogene of this gene is found on chromosome
            4. Alternate splicing results in multiple transcript
            variants.[provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) differs in the 3' UTR and
            coding sequence compared to variant 3. The resulting isoform (1)
            has a shorter and distinct C-terminus compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.105794.1,
                                           SRR1803613.37097.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256897.9/ ENSP00000256897.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BP244381.1         95-135
            42-1274             BC005280.1         1-1233
            1275-1280           BC016705.1         1229-1234
FEATURES             Location/Qualifiers
     source          1..1280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..1280
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /note="cyclin H"
                     /db_xref="GeneID:902"
                     /db_xref="HGNC:HGNC:1594"
                     /db_xref="MIM:601953"
     exon            1..253
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1108
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CDK-activating kinase complex subunit; cyclin-dependent
                     kinase-activating kinase complex subunit; CAK complex
                     subunit; MO15-associated protein"
                     /codon_start=1
                     /product="cyclin-H isoform 1"
                     /protein_id="NP_001230.1"
                     /db_xref="CCDS:CCDS4064.1"
                     /db_xref="GeneID:902"
                     /db_xref="HGNC:HGNC:1594"
                     /db_xref="MIM:601953"
                     /translation="MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPND
                     PVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPR
                     IIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIV
                     HNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAIL
                     SSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQK
                     LERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL"
     exon            254..376
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            377..450
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            451..661
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            662..825
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            826..896
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1008
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1069
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1280
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /note="hexamer: AATAAA"
     polyA_site      1280
                     /gene="CCNH"
                     /gene_synonym="CAK; CycH; p34; p37"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgccag cgccggctag ccggacgccc taggcttccg cgagatcttc ggtgggggta
       61 cgggtgtttt acgccaggac gctgatgcgt ttgggttctc gtctgcagac cctctggacc
      121 tggtcacgat tccataatgt accacaacag tagtcagaag cggcactgga ccttctccag
      181 cgaggagcag ctggcaagac tgcgggctga cgccaaccgc aaattcagat gcaaagccgt
      241 ggccaacggg aaggttcttc cgaatgatcc agtctttctt gagcctcatg aagaaatgac
      301 actctgcaaa tactatgaga aaaggttatt ggaattctgt tcggtgttta agccagcaat
      361 gccaagatct gttgtgggta cggcttgtat gtatttcaaa cgtttttatc ttaataactc
      421 agtaatggaa tatcacccca ggataataat gctcacttgt gcatttttgg cctgcaaagt
      481 agatgaattc aatgtatcta gtcctcagtt tgttggaaac ctccgggaga gtcctcttgg
      541 acaggagaag gcacttgaac agatactgga atatgaacta cttcttatac agcaacttaa
      601 tttccacctt attgtccaca atccttacag accatttgag ggcttcctca tcgacttaaa
      661 gacccgctat cccatattgg agaatccaga gattttgagg aaaacagctg atgactttct
      721 taatagaatt gcattgacgg atgcttacct tttatacaca ccttcccaaa ttgccctgac
      781 tgccatttta tctagtgcct ccagggctgg aattactatg gaaagttatt tatcagagag
      841 tctgatgctg aaagagaaca gaacttgcct gtcacagtta ctagatataa tgaaaagcat
      901 gagaaactta gtaaagaagt atgaaccacc cagatctgaa gaagttgctg ttctgaaaca
      961 gaagttggag cgatgtcatt ctgctgagct tgcacttaac gtaatcacga agaagaggaa
     1021 aggctatgaa gatgatgatt acgtctcaaa gaaatccaaa catgaggagg aagaatggac
     1081 tgatgacgac ctggtagaat ctctctaacc atttgaagtt gatttctcaa tgctaactaa
     1141 tcaagagaag taggaagcat atcaaacgtt taactttatt taaaaagtat aatgtgaaaa
     1201 cataaaatat attaaaactt ttctattgtt ttctttccct ttcacagtaa ctttatgtaa
     1261 aataaaccat cttcaaaaga
//
