LOCUS       NM_004354               5471 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cyclin G2 (CCNG2), mRNA.
ACCESSION   NM_004354
VERSION     NM_004354.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5471)
  AUTHORS   Huang,Q., Shen,Y.J., Hsueh,C.Y., Guo,Y., Zhang,Y.F., Li,J.Y. and
            Zhou,L.
  TITLE     miR-17-5p drives G2/M-phase accumulation by directly targeting
            CCNG2 and is related to recurrence of head and neck squamous cell
            carcinoma
  JOURNAL   BMC Cancer 21 (1), 1074 (2021)
   PUBMED   34598688
  REMARK    GeneRIF: miR-17-5p drives G2/M-phase accumulation by directly
            targeting CCNG2 and is related to recurrence of head and neck
            squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5471)
  AUTHORS   Li,S., Zhao,C., Gao,J., Zhuang,X., Liu,S., Xing,X., Liu,Q.,
            Chen,C., Wang,S. and Luo,Y.
  TITLE     Cyclin G2 reverses immunosuppressive tumor microenvironment and
            potentiates PD-1 blockade in glioma
  JOURNAL   J Exp Clin Cancer Res 40 (1), 273 (2021)
   PUBMED   34452627
  REMARK    GeneRIF: Cyclin G2 reverses immunosuppressive tumor
            microenvironment and potentiates PD-1 blockade in glioma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5471)
  AUTHORS   Sun,M., Gao,J., Meng,T., Liu,S., Chen,H., Liu,Q., Xing,X., Zhao,C.
            and Luo,Y.
  TITLE     Cyclin G2 upregulation impairs migration, invasion, and network
            formation through RNF123/Dvl2/JNK signaling in the trophoblast cell
            line HTR8/SVneo, a possible role in preeclampsia
  JOURNAL   FASEB J 35 (2), e21169 (2021)
   PUBMED   33205477
  REMARK    GeneRIF: Cyclin G2 upregulation impairs migration, invasion, and
            network formation through RNF123/Dvl2/JNK signaling in the
            trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.
REFERENCE   4  (bases 1 to 5471)
  AUTHORS   Sun,M., Liu,S., Gao,J., Meng,T., Xing,X., Chen,C., Chen,H. and
            Luo,Y.
  TITLE     Cyclin G2 Is Involved in the Proliferation of Placental Trophoblast
            Cells and Their Interactions with Endothelial Cells
  JOURNAL   Med Sci Monit 26, e926414 (2020)
   PUBMED   32941407
  REMARK    GeneRIF: Cyclin G2 Is Involved in the Proliferation of Placental
            Trophoblast Cells and Their Interactions with Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5471)
  AUTHORS   Zhao,C., Gao,J., Li,S., Liu,Q., Hou,X., Xing,X., Wang,D., Sun,M.,
            Wang,S. and Luo,Y.
  TITLE     Cyclin G2 regulates canonical Wnt signalling via interaction with
            Dapper1 to attenuate tubulointerstitial fibrosis in diabetic
            nephropathy
  JOURNAL   J Cell Mol Med 24 (5), 2749-2760 (2020)
   PUBMED   31978940
  REMARK    GeneRIF: Cyclin G2 regulates canonical Wnt signalling via
            interaction with Dapper1 to attenuate tubulointerstitial fibrosis
            in diabetic nephropathy.
REFERENCE   6  (bases 1 to 5471)
  AUTHORS   Bergqvist,M., Brattstrom,D., Brodin,D., Lindkvist,A.,
            Dahlman-Wright,K., Dreilich,M., Wagenius,G. and
            Paulsson-Karlsson,Y.
  TITLE     Genes associated with telomerase activity levels in esophageal
            carcinoma cell lines
  JOURNAL   Dis Esophagus 19 (1), 20-23 (2006)
   PUBMED   16364039
  REMARK    GeneRIF: Involved in progression and regulation of telomerase
REFERENCE   7  (bases 1 to 5471)
  AUTHORS   Bennin,D.A., Don,A.S., Brake,T., McKenzie,J.L., Rosenbaum,H.,
            Ortiz,L., DePaoli-Roach,A.A. and Horne,M.C.
  TITLE     Cyclin G2 associates with protein phosphatase 2A catalytic and
            regulatory B' subunits in active complexes and induces nuclear
            aberrations and a G1/S phase cell cycle arrest
  JOURNAL   J Biol Chem 277 (30), 27449-27467 (2002)
   PUBMED   11956189
  REMARK    GeneRIF: cyclin G2 also associates with various PP2A B' regulatory
            subunits, as previously shown for cyclin G1
REFERENCE   8  (bases 1 to 5471)
  AUTHORS   Tian,Y.L., Liu,F.R., Liu,J., Jiang,L., Luo,Y. and Zhang,X.
  TITLE     [Ectopic expression of cyclin G2 inhibits cell proliferation in
            HeLa cancer cell line]
  JOURNAL   Ai Zheng 21 (6), 577-581 (2002)
   PUBMED   12452053
  REMARK    GeneRIF: ectopic expression of cyclin G2 inhibits cell
            proliferation
REFERENCE   9  (bases 1 to 5471)
  AUTHORS   Bates,S., Rowan,S. and Vousden,K.H.
  TITLE     Characterisation of human cyclin G1 and G2: DNA damage inducible
            genes
  JOURNAL   Oncogene 13 (5), 1103-1109 (1996)
   PUBMED   8806701
REFERENCE   10 (bases 1 to 5471)
  AUTHORS   Horne,M.C., Goolsby,G.L., Donaldson,K.L., Tran,D., Neubauer,M. and
            Wahl,A.F.
  TITLE     Cyclin G1 and cyclin G2 comprise a new family of cyclins with
            contrasting tissue-specific and cell cycle-regulated expression
  JOURNAL   J Biol Chem 271 (11), 6050-6061 (1996)
   PUBMED   8626390
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC344594.1, U47414.1,
            AC104771.4 and CA429362.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004354.2.
            
            Summary: The eukaryotic cell cycle is governed by cyclin-dependent
            protein kinases (CDKs) whose activities are regulated by cyclins
            and CDK inhibitors. The 8 species of cyclins reported in mammals,
            cyclins A through H, share a conserved amino acid sequence of about
            90 residues called the cyclin box. The amino acid sequence of
            cyclin G is well conserved among mammals. The nucleotide sequence
            of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1,
            cyclin G2 contains a C-terminal PEST protein destabilization motif,
            suggesting that cyclin G2 expression is tightly regulated through
            the cell cycle. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.195415.1,
                                           SRR1660805.56692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316355.10/ ENSP00000315743.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               DC344594.1         4-170
            168-1371            U47414.1           3-1206
            1372-4883           AC104771.4         109866-113377
            4884-5471           CA429362.1         16-603              c
FEATURES             Location/Qualifiers
     source          1..5471
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..5471
                     /gene="CCNG2"
                     /note="cyclin G2"
                     /db_xref="GeneID:901"
                     /db_xref="HGNC:HGNC:1593"
                     /db_xref="MIM:603203"
     exon            1..300
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1335
                     /gene="CCNG2"
                     /codon_start=1
                     /product="cyclin-G2"
                     /protein_id="NP_004345.1"
                     /db_xref="CCDS:CCDS3581.1"
                     /db_xref="GeneID:901"
                     /db_xref="HGNC:HGNC:1593"
                     /db_xref="MIM:603203"
                     /translation="MKDLGAEHLAGHEGVQLLGLLNVYLEQEERFQPREKGLSLIEAT
                     PENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIG
                     VCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALN
                     FLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSVLALCLLNLEVETL
                     KSVELLEILLLVKKHSKINDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRT
                     AQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPPSDQECTFFFNF
                     KVAQTLCFPS"
     exon            301..438
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..576
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..827
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..906
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1005
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1211
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..5471
                     /gene="CCNG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNG2"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="CCNG2"
                     /note="major polyA site"
     regulatory      5447..5452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNG2"
                     /note="hexamer: AATAAA"
     polyA_site      5471
                     /gene="CCNG2"
ORIGIN      
        1 actcttaaca aaaacaaggg gctcggggag gtttccgctg aggcggcggg ggtgcggcgg
       61 tgggctggtc ttccgcggcc ggcgttgcgc cgcggcggag ggtgggcgcg cggggagcgg
      121 gatggagccg gggctgtgag gccgaggcgg cggtgcctgg gaggaagggt cggatgccgg
      181 accgggggca ccgctgaggc ggtgggtccc cgacctgcga gacaggtttg gaagcccccg
      241 ctgcgcccag tccgtgcgga ccgcgaggcc gcgggcgggt ggaggcgcgt ctccggcacg
      301 atgaaggatt tgggggcaga gcacttggca ggtcatgaag gggtccaact tctcgggttg
      361 ttgaacgtct acctggaaca agaagagaga ttccaacctc gagaaaaagg gctgagtttg
      421 attgaggcta ccccggagaa tgataacact ttgtgtccag gattgagaaa tgccaaagtt
      481 gaagatttaa ggagtttagc caactttttt ggatcttgca ctgaaacttt tgtcctggct
      541 gtcaatattt tggacaggtt cttggctctt atgaaggtga aacctaaaca tttgtcttgc
      601 attggagtct gttctttttt gctggctgct agaatagttg aagaagactg caatattcca
      661 tccactcatg atgtgatccg gattagtcag tgtaaatgta ctgcttctga cataaaacgg
      721 atggaaaaaa taatttcaga aaaattgcac tatgaattgg aagctactac tgccttaaac
      781 tttttgcact tataccatac tattatactt tgtcatactt cagaaaggaa agaaatactg
      841 agccttgata aactagaagc tcagctgaaa gcttgcaact gccgactcat cttttcaaaa
      901 gcaaaaccat ctgtattagc cttgtgcctt ctcaatttgg aagtggaaac tttgaaatct
      961 gttgaattac tggaaattct cttgctagtt aaaaaacatt ccaagattaa tgacactgag
     1021 ttcttctact ggagagagtt ggtttctaaa tgcctagccg agtattcttc tcctgaatgt
     1081 tgcaaaccag atcttaagaa gttggtttgg atcgtttcaa ggcgcacagc ccagaacctc
     1141 cacaacagct actatagtgt tcctgagctg ccaacgatac ctgagggggg ttgttttgat
     1201 gaaagtgaaa gtgaggactc ttgtgaagat atgagttgtg gagaggagag tctcagcagc
     1261 tctcctccca gtgatcaaga gtgcaccttc tttttcaact tcaaagtggc acaaacactg
     1321 tgctttccat cttagaaatc tgattgttct gtcagaattt atatttacag gtttcaaagc
     1381 aataaatggg ggaataggta gtttcctggt ttagccccca tctagtcagg aattaatata
     1441 ctggaatacc taccttctat ttgttattca gatcagatct ggcctatttt catatttatc
     1501 ctaagccatc aaatggggta gtgcctctta aaccattaac agtactttag acattggcac
     1561 tttatttttc tcgtagatct ttagctactt tggggaggag ggaaggtgct gataccttca
     1621 atttgttact tttcaagatt tttaaaaata actagtgtag cttatcttaa acattttata
     1681 aaaccttcag atgtctttaa gcagattgga agtatgcaag tgcttcctta gcagggacag
     1741 tggataatcc ttaatggttt atcatagatt tcaccctccc cccttctcag aagagtgagt
     1801 atgctcttaa atgtcaaaca catttttgtt gttttgtttt ttaaatgatc agtgtctatt
     1861 tgatgtgatg cagatcttat aaatttggga attataatat tgacatttct gtgattttta
     1921 tatatgtaat gtcttaattg agatttctgt taaggcagaa ataattaggc tagggctctt
     1981 agttttcatt cctattgccc aagtattgtc aaactatggt attattttaa tgttacttta
     2041 aaaatccata atctgctagt tttgcatgta cttatatgaa aacagtgcag taagttgaaa
     2101 actcagtatc tatggaattg ataaatgttg atctggtgta gtatatttta tcgcattttc
     2161 ttatattaaa aaatgtctgc atgattacat tttatttcct ttgtaattta catttcagaa
     2221 tagtgtattg ctatatgggt gccaagattg aatatgaaga acccgagtgt ttgtagtatt
     2281 atagttttaa gcaaatctgt gtggtgatac agccataaga atggggctta tataaactct
     2341 gtacatgtaa gattttgtac agagaatttt taactttata aattgtatat gaacatgtaa
     2401 atcttttaaa atgtacataa aatactgtat ttttttacct tgtgtgtgat agtctagtca
     2461 ttgcatgtaa atataattta ttatgtattc tgtagtataa atcatacatt gatgacttac
     2521 atttttactg gtaagtcaac atccgttgga tgttttctga agtggctctt tttgaagtga
     2581 taatagattg taattcaaaa taaaattatt aatgaattct ccttgtttgg gatcacatct
     2641 taatttttaa tctgttaaaa gttcttgatg tattttaatg agaagacttt aggtgaggct
     2701 acagtgattc cagagtgagc cttctaactg gctagcagaa gttctctagg tttggcatct
     2761 gtgccttgga gatactgaaa gagaatctgt catttgacaa ttgacctctt tgtgggatgg
     2821 actcattaag tatgctctca gagactggta tattaccaga atgcctatta attttcagtg
     2881 agaggcaaca ggtattaagt agaacagaat gctcaggttg gcagattaga acgatctttc
     2941 aggagacaaa gcaagtttta atcagttgtt tggttaataa gtatggggtg ttcgctgtga
     3001 tagggccccg ccagcttctg gctcttgtgg acctcaaaag tatcaggtgg ttttgcaagt
     3061 ggtggtcctt tcccctgccc caccccaata ggttccccat ctgtctagtt tgatttttgt
     3121 agacctttgt tttctctagt tagaaaatca ggtacactga atatggtttt catgtaacac
     3181 ctcttctctg gagatagggg tatgttttcc tacccttcta gtggagaatc ctacttgagg
     3241 atgacctttc ctctcttact aaataatatt agtaaatagt gggcaatata ttctgctttc
     3301 agattttgat ttgttgagat gtaaaagttg tttggggctt accaaatctc aagactctct
     3361 ttagctcctg caggattgta ttgcttttct tactggatat ttttcctggg taagcatctt
     3421 tgtggcttca tctcttcccc ctgtggtttt cagtgtattt agtcgagacc tctctgctga
     3481 gcttgcaacc tgtttattca catggcctgc catgccactt ggaggtttct gattactccc
     3541 aaacctgctg gttctttatg tctttctcag cgaataattc catctattca tgttggaaac
     3601 ttaggtgata tgctcatctc cttttgcctg tttatggagg tcaccagcct ctatcatttg
     3661 tatgatttcg tttacactgt ttatatctct ctgtcccccc tttttctgcc attggcatgg
     3721 tttagacctg tactctttat cagcagaggt actgtaatat atttgtgatc cctcagcttc
     3781 caggcttact cctggtctct gccttcctat ctacatatcc ttttaaaata aaattttaac
     3841 tatctcctga aaaattgttg agtaggtcac gcacaatcag gagaaaaatc tattcatgac
     3901 atacaagtct ctgtctaatc tgaacactgc acctgtctct ggcctttttt tcttgtcatt
     3961 tcctagacct taaaaaatgt gtattgagaa agaactctgt tagctataca gaagatgaac
     4021 tgggcaatat agagtagcag catggagacc agtctgactg aactaaggca gtggaagtgt
     4081 ggatgaggaa gagaggtgaa aattgagaag cgctatcctt tctctttggg cattattagg
     4141 aggctcacag acaagtccag gagcctggtt ataccctcct gtgccattca accaggtggc
     4201 tttcccatga ctgtgatgaa taaaattgag aagcccctgc ccttttcaga gcagagggtg
     4261 aggagaaagc taccattttg tcctcatcct tacccccgtt gacttggcga gagatttgac
     4321 ctttcaggtt ttgatcctgt cattttctag gatgtggtgc acgcactttg ctgttgcgca
     4381 tggtgaagta ttgtgcctag gtcctgggtc ttcatctgtt tggctctgct actgtttcct
     4441 cctcccagga agtgtggtta gacaaataat gtgttttaat tacctgtcac actcaggatt
     4501 aatacatact caggttaact gtagagaggc attggcttca gaacactcct cgtgacaatt
     4561 ttaaccattt tctttgtcta gagtctgcct ttttcttttt tacaatttct tttatttcaa
     4621 cactaggttt caatatggtg ttcctgctac ctcccacctc cctcctccct catcacacat
     4681 gcaaattgtc agcttattga gacaacccac ttagattcat atatggacaa ggacaaggta
     4741 ttttgcattt gttactggaa ttcagttttc ctaactattt actaccagaa atggtcaata
     4801 acttactttg tgtttagcaa atcaaattgt gtgatagata gtttcccagt atgatggcca
     4861 gtcagtcttt ccatccctgt gcctacatgc tgctcttccc gtccacaagt ggagtctgtt
     4921 tctcttgagt tttggctggc cttatgaatg gctttgctta ctgaagtgca gcagaagaaa
     4981 tttagtatat gtccaagcct aggctttaag agactggcag ctttcctttt atcctttttg
     5041 gaagctagcc accatgctgc aaagaagctc agctggatta ctgaaagatg agaggccatg
     5101 tggagagaga ctcttgagga tgagagatta tcttggatgt tccagcctta agctcccagc
     5161 tgaatgtggg tgtatcctca gctacaccac agaaaacaga ggaactactc agtcgatccc
     5221 aatcaaccca cagactcact agaaataaca aattattgtt ttaagccacg aggttttggg
     5281 ggagggttgt taaacagtaa tagataagtg agacagattg cttgttattt atggtcaaat
     5341 ggtgattatc tctggtgaga ttacaggtga tgtttttttt aagttatgcc tatctgtagt
     5401 ttcctttttt tcctaaaatt gatttgaatt attagtgtat taacagaata aagaatgaac
     5461 tttaaaacac a
//
