LOCUS       NM_004060               2444 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cyclin G1 (CCNG1), transcript variant 1, mRNA.
ACCESSION   NM_004060
VERSION     NM_004060.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2444)
  AUTHORS   Chen,Y., Liang,W., Du,J., Ma,J., Liang,R. and Tao,M.
  TITLE     PRMT6 functionally associates with PRMT5 to promote colorectal
            cancer progression through epigenetically repressing the expression
            of CDKN2B and CCNG1
  JOURNAL   Exp Cell Res 422 (1), 113413 (2023)
   PUBMED   36400182
  REMARK    GeneRIF: PRMT6 functionally associates with PRMT5 to promote
            colorectal cancer progression through epigenetically repressing the
            expression of CDKN2B and CCNG1.
REFERENCE   2  (bases 1 to 2444)
  AUTHORS   Liu,Y., Fu,X., Wang,X., Liu,Y. and Song,X.
  TITLE     Long non-coding RNA OIP5-AS1 facilitates the progression of ovarian
            cancer via the miR-128-3p/CCNG1 axis
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33760168
  REMARK    GeneRIF: Long noncoding RNA OIP5AS1 facilitates the progression of
            ovarian cancer via the miR1283p/CCNG1 axis.
REFERENCE   3  (bases 1 to 2444)
  AUTHORS   Xu,G., Bu,S., Wang,X. and Ge,H.
  TITLE     Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity
            of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing
            Apoptosis
  JOURNAL   Radiat Res 195 (4), 378-384 (2021)
   PUBMED   33543294
  REMARK    GeneRIF: Silencing the Expression of Cyclin G1 Enhances the
            Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo
            by Inducing Apoptosis.
REFERENCE   4  (bases 1 to 2444)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2444)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2444)
  AUTHORS   Kanaoka,Y., Kimura,S.H., Okazaki,I., Ikeda,M. and Nojima,H.
  TITLE     GAK: a cyclin G associated kinase contains a tensin/auxilin-like
            domain
  JOURNAL   FEBS Lett 402 (1), 73-80 (1997)
   PUBMED   9013862
REFERENCE   7  (bases 1 to 2444)
  AUTHORS   Endo,Y., Fujita,T., Tamura,K., Tsuruga,H. and Nojima,H.
  TITLE     Structure and chromosomal assignment of the human cyclin G gene
  JOURNAL   Genomics 38 (1), 92-95 (1996)
   PUBMED   8954786
REFERENCE   8  (bases 1 to 2444)
  AUTHORS   Okamoto,K., Kamibayashi,C., Serrano,M., Prives,C., Mumby,M.C. and
            Beach,D.
  TITLE     p53-dependent association between cyclin G and the B' subunit of
            protein phosphatase 2A
  JOURNAL   Mol Cell Biol 16 (11), 6593-6602 (1996)
   PUBMED   8887688
REFERENCE   9  (bases 1 to 2444)
  AUTHORS   Bates,S., Rowan,S. and Vousden,K.H.
  TITLE     Characterisation of human cyclin G1 and G2: DNA damage inducible
            genes
  JOURNAL   Oncogene 13 (5), 1103-1109 (1996)
   PUBMED   8806701
REFERENCE   10 (bases 1 to 2444)
  AUTHORS   Horne,M.C., Goolsby,G.L., Donaldson,K.L., Tran,D., Neubauer,M. and
            Wahl,A.F.
  TITLE     Cyclin G1 and cyclin G2 comprise a new family of cyclins with
            contrasting tissue-specific and cell cycle-regulated expression
  JOURNAL   J Biol Chem 271 (11), 6050-6061 (1996)
   PUBMED   8626390
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX644635.1 and BC000196.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004060.3.
            
            Summary: The eukaryotic cell cycle is governed by cyclin-dependent
            protein kinases (CDKs) whose activities are regulated by cyclins
            and CDK inhibitors. The protein encoded by this gene is a member of
            the cyclin family and contains the cyclin box. The encoded protein
            lacks the protein destabilizing (PEST) sequence that is present in
            other family members. Transcriptional activation of this gene can
            be induced by tumor protein p53. Two transcript variants encoding
            the same protein have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1050135.1,
                                           SRR3476690.502285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340828.7/ ENSP00000344635.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               BX644635.1         16-305
            291-2444            BC000196.1         165-2318
FEATURES             Location/Qualifiers
     source          1..2444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2444
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="cyclin G1"
                     /db_xref="GeneID:900"
                     /db_xref="HGNC:HGNC:1592"
                     /db_xref="MIM:601578"
     exon            1..210
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1098
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="isoform a is encoded by transcript variant 1;
                     cyclin-G"
                     /codon_start=1
                     /product="cyclin-G1 isoform a"
                     /protein_id="NP_004051.1"
                     /db_xref="CCDS:CCDS4360.1"
                     /db_xref="GeneID:900"
                     /db_xref="HGNC:HGNC:1592"
                     /db_xref="MIM:601578"
                     /translation="MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNG
                     LRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCF
                     YLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQL
                     YYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCV
                     ELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQ
                     LKHSYYRITHLPTIPEMVP"
     exon            211..474
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            475..728
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            729..807
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            808..906
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1101
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..2444
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="hexamer: AATAAA"
     polyA_site      2444
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="major polyA site"
ORIGIN      
        1 cccttcggct ccgagctgac cctgatcagg gccgagttgt ctcggcggcg ctgccgaggc
       61 ctccacccag gacagtcccc ctccccgggc ctctctcctc ttgcctacga gtcccctctc
      121 ctcgtaggcc tctcggatct gatatcgtgg ggtgaggtga gcaggcccgg ggagggtggt
      181 taccgctgag gagctgcagt ctctgtcaag atgatagagg tactgacaac aactgactct
      241 cagaaactgc tacaccagct gaatgccctg ttggaacagg agtctagatg tcagccaaag
      301 gtctgtggtt tgagactaat tgagtctgca cacgataatg gcctcagaat gactgcaaga
      361 ctaagggact ttgaagtaaa agatcttctt agtctaactc agttctttgg ctttgacaca
      421 gagacatttt ctctagctgt gaatttactg gacagattcc tgtctaaaat gaaggtacag
      481 cccaagcacc ttgggtgtgt tggactgagc tgcttttatt tggctgtaaa atcaatagaa
      541 gaggaaagga atgtcccatt ggcaactgac ttgatccgaa taagtcaata taggtttacg
      601 gtttcagact tgatgagaat ggaaaagatt gtattggaga aggtgtgttg gaaagtcaaa
      661 gctactactg cctttcaatt tctgcaactg tattattcac tccttcaaga gaacttgcca
      721 cttgaaagga gaaatagcat taattttgaa agactagaag ctcaactgaa ggcatgtcat
      781 tgcaggatca tattttctaa agcaaagcct tctgtgttgg cattgtctat cattgcatta
      841 gagatccaag cacagaagtg tgtagagtta acagaaggaa tagaatgtct tcagaaacat
      901 tccaagataa atggcagaga tctgaccttc tggcaagagc ttgtatccaa atgtttaact
      961 gaatattcat caaataagtg ttccaaacca aatgttcaga agttgaaatg gattgtttct
     1021 gggcgtactg cacggcaatt gaagcatagc tactacagaa taactcacct tccaacaatt
     1081 cctgaaatgg tcccttaact ggattattac agcaccaaaa aacttctctg aagcctttct
     1141 ccacaacctt gttctatgga ttccataatg ttacaatgga tttaagctat gaagcctcaa
     1201 aacatcacga gataagcatg atggtctcag acttgggaaa actgcctaat attatgctgt
     1261 agtggaatta tgtttagatt tgaattcatc tgtgaagcat tcaaatcaaa gctaaaagcc
     1321 taaatgtgaa atgctaatga caagcctgag aaggtaaact gtgaatcttc atttctatca
     1381 ttgatctaac tttagatatt ggatcaatat atttaggtgg tattgaaaat gctattggag
     1441 gagtcacact aatactatca actatcagtc ttcccacagc ttcaatcact gtcattattc
     1501 taatcctact cctacttaaa ttttaagtta tgaggtttat gtcaaaagca acatttcaca
     1561 aatgtacttt taaggcataa taagggttaa cattctaggc agtataaaca caccccataa
     1621 tgcaagtaat aggtaatcta gagatgtgga ctttattgct atatgggaat tacatttaaa
     1681 tttgagggca ttttatataa agaaaaatac agacctataa agtttggcat attcattaag
     1741 ttatctttta atattttttt ctagaaaaca ggtgacattt gtatctacga taaaaatttt
     1801 tatacagaac ctactgcctc aaactgaatc ccatcaagaa aactagtttc tattgtatta
     1861 gtaactcaaa ataaattatc acttcgaaaa cttgctttcc cacactaagg taagttcaga
     1921 ctagattgaa cactccagaa ttttttacta cagactgttt ttaagttaga agtgatggca
     1981 attttataaa tagagaatat acttccactg atgcccttac tgtgccaaaa caaaaatctt
     2041 aagaaaagca agtagacacc ttcataacta tgaatgaagc tgctgaagta gtgtttagga
     2101 tcctccatgg cagttagtga atgtaagaag tacagtgtta aagtgttgta aacagttact
     2161 cagtgcaatg tatagcctga gtctatccat gatggctata tccaatttga catcacgtta
     2221 tggatcagta cacaatgaaa aaccaaagaa ccacagtata tcttattctt aacttttgta
     2281 aaccatgttt tatgggtaac tttttagttt tcccaaaagg ctgataaatt tcaatatttt
     2341 gaatacatca ttgttaattt tgagttggca gaggtaaact aaccaactac cattatgttt
     2401 tagtactaag ggatatacct ttcaataaag ttaatgaaat tcaa
//
