LOCUS       NM_001364023            2104 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cyclin G1 (CCNG1), transcript variant 9, mRNA.
ACCESSION   NM_001364023
VERSION     NM_001364023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2104)
  AUTHORS   Chen,Y., Liang,W., Du,J., Ma,J., Liang,R. and Tao,M.
  TITLE     PRMT6 functionally associates with PRMT5 to promote colorectal
            cancer progression through epigenetically repressing the expression
            of CDKN2B and CCNG1
  JOURNAL   Exp Cell Res 422 (1), 113413 (2023)
   PUBMED   36400182
  REMARK    GeneRIF: PRMT6 functionally associates with PRMT5 to promote
            colorectal cancer progression through epigenetically repressing the
            expression of CDKN2B and CCNG1.
REFERENCE   2  (bases 1 to 2104)
  AUTHORS   Liu,Y., Fu,X., Wang,X., Liu,Y. and Song,X.
  TITLE     Long non-coding RNA OIP5-AS1 facilitates the progression of ovarian
            cancer via the miR-128-3p/CCNG1 axis
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33760168
  REMARK    GeneRIF: Long noncoding RNA OIP5AS1 facilitates the progression of
            ovarian cancer via the miR1283p/CCNG1 axis.
REFERENCE   3  (bases 1 to 2104)
  AUTHORS   Xu,G., Bu,S., Wang,X. and Ge,H.
  TITLE     Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity
            of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing
            Apoptosis
  JOURNAL   Radiat Res 195 (4), 378-384 (2021)
   PUBMED   33543294
  REMARK    GeneRIF: Silencing the Expression of Cyclin G1 Enhances the
            Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo
            by Inducing Apoptosis.
REFERENCE   4  (bases 1 to 2104)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2104)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2104)
  AUTHORS   Kanaoka,Y., Kimura,S.H., Okazaki,I., Ikeda,M. and Nojima,H.
  TITLE     GAK: a cyclin G associated kinase contains a tensin/auxilin-like
            domain
  JOURNAL   FEBS Lett 402 (1), 73-80 (1997)
   PUBMED   9013862
REFERENCE   7  (bases 1 to 2104)
  AUTHORS   Endo,Y., Fujita,T., Tamura,K., Tsuruga,H. and Nojima,H.
  TITLE     Structure and chromosomal assignment of the human cyclin G gene
  JOURNAL   Genomics 38 (1), 92-95 (1996)
   PUBMED   8954786
REFERENCE   8  (bases 1 to 2104)
  AUTHORS   Okamoto,K., Kamibayashi,C., Serrano,M., Prives,C., Mumby,M.C. and
            Beach,D.
  TITLE     p53-dependent association between cyclin G and the B' subunit of
            protein phosphatase 2A
  JOURNAL   Mol Cell Biol 16 (11), 6593-6602 (1996)
   PUBMED   8887688
REFERENCE   9  (bases 1 to 2104)
  AUTHORS   Bates,S., Rowan,S. and Vousden,K.H.
  TITLE     Characterisation of human cyclin G1 and G2: DNA damage inducible
            genes
  JOURNAL   Oncogene 13 (5), 1103-1109 (1996)
   PUBMED   8806701
REFERENCE   10 (bases 1 to 2104)
  AUTHORS   Horne,M.C., Goolsby,G.L., Donaldson,K.L., Tran,D., Neubauer,M. and
            Wahl,A.F.
  TITLE     Cyclin G1 and cyclin G2 comprise a new family of cyclins with
            contrasting tissue-specific and cell cycle-regulated expression
  JOURNAL   J Biol Chem 271 (11), 6050-6061 (1996)
   PUBMED   8626390
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112205.2.
            
            Summary: The eukaryotic cell cycle is governed by cyclin-dependent
            protein kinases (CDKs) whose activities are regulated by cyclins
            and CDK inhibitors. The protein encoded by this gene is a member of
            the cyclin family and contains the cyclin box. The encoded protein
            lacks the protein destabilizing (PEST) sequence that is present in
            other family members. Transcriptional activation of this gene can
            be induced by tumor protein p53. Two transcript variants encoding
            the same protein have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.7492.1, AK297190.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC112205.2         7298-7386
            90-134              AC112205.2         7487-7531
            135-388             AC112205.2         10805-11058
            389-467             AC112205.2         11613-11691
            468-566             AC112205.2         11772-11870
            567-761             AC112205.2         12101-12295
            762-2104            AC112205.2         13401-14743
FEATURES             Location/Qualifiers
     source          1..2104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2104
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="cyclin G1"
                     /db_xref="GeneID:900"
                     /db_xref="HGNC:HGNC:1592"
                     /db_xref="MIM:601578"
     exon            1..89
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            90..134
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            135..388
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..758
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="isoform e is encoded by transcript variant 9;
                     cyclin-G"
                     /codon_start=1
                     /product="cyclin-G1 isoform e"
                     /protein_id="NP_001350952.1"
                     /db_xref="CCDS:CCDS93817.1"
                     /db_xref="GeneID:900"
                     /db_xref="HGNC:HGNC:1592"
                     /db_xref="MIM:601578"
                     /translation="MRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSIN
                     FERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGR
                     DLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMV
                     P"
     exon            389..467
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            468..566
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            567..761
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            762..2104
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="hexamer: AATAAA"
     polyA_site      2104
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="major polyA site"
ORIGIN      
        1 attcctcgtt agggcaggcg cggccccttc ggctccgagc tgaccctgat cagggccgag
       61 ttgtctcggc ggcgctgccg aggcctccac ccggggaggg tggttaccgc tgaggagctg
      121 cagtctctgt caaggtacag cccaagcacc ttgggtgtgt tggactgagc tgcttttatt
      181 tggctgtaaa atcaatagaa gaggaaagga atgtcccatt ggcaactgac ttgatccgaa
      241 taagtcaata taggtttacg gtttcagact tgatgagaat ggaaaagatt gtattggaga
      301 aggtgtgttg gaaagtcaaa gctactactg cctttcaatt tctgcaactg tattattcac
      361 tccttcaaga gaacttgcca cttgaaagga gaaatagcat taattttgaa agactagaag
      421 ctcaactgaa ggcatgtcat tgcaggatca tattttctaa agcaaagcct tctgtgttgg
      481 cattgtctat cattgcatta gagatccaag cacagaagtg tgtagagtta acagaaggaa
      541 tagaatgtct tcagaaacat tccaagataa atggcagaga tctgaccttc tggcaagagc
      601 ttgtatccaa atgtttaact gaatattcat caaataagtg ttccaaacca aatgttcaga
      661 agttgaaatg gattgtttct gggcgtactg cacggcaatt gaagcatagc tactacagaa
      721 taactcacct tccaacaatt cctgaaatgg tcccttaact ggattattac agcaccaaaa
      781 aacttctctg aagcctttct ccacaacctt gttctatgga ttccataatg ttacaatgga
      841 tttaagctat gaagcctcaa aacatcacga gataagcatg atggtctcag acttgggaaa
      901 actgcctaat attatgctgt agtggaatta tgtttagatt tgaattcatc tgtgaagcat
      961 tcaaatcaaa gctaaaagcc taaatgtgaa atgctaatga caagcctgag aaggtaaact
     1021 gtgaatcttc atttctatca ttgatctaac tttagatatt ggatcaatat atttaggtgg
     1081 tattgaaaat gctattggag gagtcacact aatactatca actatcagtc ttcccacagc
     1141 ttcaatcact gtcattattc taatcctact cctacttaaa ttttaagtta tgaggtttat
     1201 gtcaaaagca acatttcaca aatgtacttt taaggcataa taagggttaa cattctaggc
     1261 agtataaaca caccccataa tgcaagtaat aggtaatcta gagatgtgga ctttattgct
     1321 atatgggaat tacatttaaa tttgagggca ttttatataa agaaaaatac agacctataa
     1381 agtttggcat attcattaag ttatctttta atattttttt ctagaaaaca ggtgacattt
     1441 gtatctacga taaaaatttt tatacagaac ctactgcctc aaactgaatc ccatcaagaa
     1501 aactagtttc tattgtatta gtaactcaaa ataaattatc acttcgaaaa cttgctttcc
     1561 cacactaagg taagttcaga ctagattgaa cactccagaa ttttttacta cagactgttt
     1621 ttaagttaga agtgatggca attttataaa tagagaatat acttccactg atgcccttac
     1681 tgtgccaaaa caaaaatctt aagaaaagca agtagacacc ttcataacta tgaatgaagc
     1741 tgctgaagta gtgtttagga tcctccatgg cagttagtga atgtaagaag tacagtgtta
     1801 aagtgttgta aacagttact cagtgcaatg tatagcctga gtctatccat gatggctata
     1861 tccaatttga catcacgtta tggatcagta cacaatgaaa aaccaaagaa ccacagtata
     1921 tcttattctt aacttttgta aaccatgttt tatgggtaac tttttagttt tcccaaaagg
     1981 ctgataaatt tcaatatttt gaatacatca ttgttaattt tgagttggca gaggtaaact
     2041 aaccaactac cattatgttt tagtactaag ggatatacct ttcaataaag ttaatgaaat
     2101 tcaa
//
