LOCUS       NM_001364015            2414 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cyclin G1 (CCNG1), transcript variant 3, mRNA.
ACCESSION   NM_001364015
VERSION     NM_001364015.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2414)
  AUTHORS   Chen,Y., Liang,W., Du,J., Ma,J., Liang,R. and Tao,M.
  TITLE     PRMT6 functionally associates with PRMT5 to promote colorectal
            cancer progression through epigenetically repressing the expression
            of CDKN2B and CCNG1
  JOURNAL   Exp Cell Res 422 (1), 113413 (2023)
   PUBMED   36400182
  REMARK    GeneRIF: PRMT6 functionally associates with PRMT5 to promote
            colorectal cancer progression through epigenetically repressing the
            expression of CDKN2B and CCNG1.
REFERENCE   2  (bases 1 to 2414)
  AUTHORS   Liu,Y., Fu,X., Wang,X., Liu,Y. and Song,X.
  TITLE     Long non-coding RNA OIP5-AS1 facilitates the progression of ovarian
            cancer via the miR-128-3p/CCNG1 axis
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33760168
  REMARK    GeneRIF: Long noncoding RNA OIP5AS1 facilitates the progression of
            ovarian cancer via the miR1283p/CCNG1 axis.
REFERENCE   3  (bases 1 to 2414)
  AUTHORS   Xu,G., Bu,S., Wang,X. and Ge,H.
  TITLE     Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity
            of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing
            Apoptosis
  JOURNAL   Radiat Res 195 (4), 378-384 (2021)
   PUBMED   33543294
  REMARK    GeneRIF: Silencing the Expression of Cyclin G1 Enhances the
            Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo
            by Inducing Apoptosis.
REFERENCE   4  (bases 1 to 2414)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2414)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2414)
  AUTHORS   Kanaoka,Y., Kimura,S.H., Okazaki,I., Ikeda,M. and Nojima,H.
  TITLE     GAK: a cyclin G associated kinase contains a tensin/auxilin-like
            domain
  JOURNAL   FEBS Lett 402 (1), 73-80 (1997)
   PUBMED   9013862
REFERENCE   7  (bases 1 to 2414)
  AUTHORS   Endo,Y., Fujita,T., Tamura,K., Tsuruga,H. and Nojima,H.
  TITLE     Structure and chromosomal assignment of the human cyclin G gene
  JOURNAL   Genomics 38 (1), 92-95 (1996)
   PUBMED   8954786
REFERENCE   8  (bases 1 to 2414)
  AUTHORS   Okamoto,K., Kamibayashi,C., Serrano,M., Prives,C., Mumby,M.C. and
            Beach,D.
  TITLE     p53-dependent association between cyclin G and the B' subunit of
            protein phosphatase 2A
  JOURNAL   Mol Cell Biol 16 (11), 6593-6602 (1996)
   PUBMED   8887688
REFERENCE   9  (bases 1 to 2414)
  AUTHORS   Bates,S., Rowan,S. and Vousden,K.H.
  TITLE     Characterisation of human cyclin G1 and G2: DNA damage inducible
            genes
  JOURNAL   Oncogene 13 (5), 1103-1109 (1996)
   PUBMED   8806701
REFERENCE   10 (bases 1 to 2414)
  AUTHORS   Horne,M.C., Goolsby,G.L., Donaldson,K.L., Tran,D., Neubauer,M. and
            Wahl,A.F.
  TITLE     Cyclin G1 and cyclin G2 comprise a new family of cyclins with
            contrasting tissue-specific and cell cycle-regulated expression
  JOURNAL   J Biol Chem 271 (11), 6050-6061 (1996)
   PUBMED   8626390
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112205.2.
            
            Summary: The eukaryotic cell cycle is governed by cyclin-dependent
            protein kinases (CDKs) whose activities are regulated by cyclins
            and CDK inhibitors. The protein encoded by this gene is a member of
            the cyclin family and contains the cyclin box. The encoded protein
            lacks the protein destabilizing (PEST) sequence that is present in
            other family members. Transcriptional activation of this gene can
            be induced by tumor protein p53. Two transcript variants encoding
            the same protein have been identified for this gene. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.154213.1,
                                           SRR1660805.82127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC112205.2         7298-7477
            181-444             AC112205.2         8984-9247
            445-698             AC112205.2         10805-11058
            699-777             AC112205.2         11613-11691
            778-876             AC112205.2         11772-11870
            877-1071            AC112205.2         12101-12295
            1072-2414           AC112205.2         13401-14743
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2414
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="cyclin G1"
                     /db_xref="GeneID:900"
                     /db_xref="HGNC:HGNC:1592"
                     /db_xref="MIM:601578"
     exon            1..180
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1068
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="isoform a is encoded by transcript variant 3;
                     cyclin-G"
                     /codon_start=1
                     /product="cyclin-G1 isoform a"
                     /protein_id="NP_001350944.1"
                     /db_xref="CCDS:CCDS4360.1"
                     /db_xref="GeneID:900"
                     /db_xref="HGNC:HGNC:1592"
                     /db_xref="MIM:601578"
                     /translation="MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNG
                     LRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCF
                     YLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQL
                     YYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCV
                     ELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQ
                     LKHSYYRITHLPTIPEMVP"
     exon            181..444
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            445..698
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            699..777
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            778..876
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1071
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2414
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2394..2399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="hexamer: AATAAA"
     polyA_site      2414
                     /gene="CCNG1"
                     /gene_synonym="CCNG"
                     /note="major polyA site"
ORIGIN      
        1 attcctcgtt agggcaggcg cggccccttc ggctccgagc tgaccctgat cagggccgag
       61 ttgtctcggc ggcgctgccg aggcctccac ccaggacagt ccccctcccc gggcctctct
      121 cctcttgcct acgagtcccc tctcctcgta ggcctctcgg atctgatatc gtggggtgag
      181 atgatagagg tactgacaac aactgactct cagaaactgc tacaccagct gaatgccctg
      241 ttggaacagg agtctagatg tcagccaaag gtctgtggtt tgagactaat tgagtctgca
      301 cacgataatg gcctcagaat gactgcaaga ctaagggact ttgaagtaaa agatcttctt
      361 agtctaactc agttctttgg ctttgacaca gagacatttt ctctagctgt gaatttactg
      421 gacagattcc tgtctaaaat gaaggtacag cccaagcacc ttgggtgtgt tggactgagc
      481 tgcttttatt tggctgtaaa atcaatagaa gaggaaagga atgtcccatt ggcaactgac
      541 ttgatccgaa taagtcaata taggtttacg gtttcagact tgatgagaat ggaaaagatt
      601 gtattggaga aggtgtgttg gaaagtcaaa gctactactg cctttcaatt tctgcaactg
      661 tattattcac tccttcaaga gaacttgcca cttgaaagga gaaatagcat taattttgaa
      721 agactagaag ctcaactgaa ggcatgtcat tgcaggatca tattttctaa agcaaagcct
      781 tctgtgttgg cattgtctat cattgcatta gagatccaag cacagaagtg tgtagagtta
      841 acagaaggaa tagaatgtct tcagaaacat tccaagataa atggcagaga tctgaccttc
      901 tggcaagagc ttgtatccaa atgtttaact gaatattcat caaataagtg ttccaaacca
      961 aatgttcaga agttgaaatg gattgtttct gggcgtactg cacggcaatt gaagcatagc
     1021 tactacagaa taactcacct tccaacaatt cctgaaatgg tcccttaact ggattattac
     1081 agcaccaaaa aacttctctg aagcctttct ccacaacctt gttctatgga ttccataatg
     1141 ttacaatgga tttaagctat gaagcctcaa aacatcacga gataagcatg atggtctcag
     1201 acttgggaaa actgcctaat attatgctgt agtggaatta tgtttagatt tgaattcatc
     1261 tgtgaagcat tcaaatcaaa gctaaaagcc taaatgtgaa atgctaatga caagcctgag
     1321 aaggtaaact gtgaatcttc atttctatca ttgatctaac tttagatatt ggatcaatat
     1381 atttaggtgg tattgaaaat gctattggag gagtcacact aatactatca actatcagtc
     1441 ttcccacagc ttcaatcact gtcattattc taatcctact cctacttaaa ttttaagtta
     1501 tgaggtttat gtcaaaagca acatttcaca aatgtacttt taaggcataa taagggttaa
     1561 cattctaggc agtataaaca caccccataa tgcaagtaat aggtaatcta gagatgtgga
     1621 ctttattgct atatgggaat tacatttaaa tttgagggca ttttatataa agaaaaatac
     1681 agacctataa agtttggcat attcattaag ttatctttta atattttttt ctagaaaaca
     1741 ggtgacattt gtatctacga taaaaatttt tatacagaac ctactgcctc aaactgaatc
     1801 ccatcaagaa aactagtttc tattgtatta gtaactcaaa ataaattatc acttcgaaaa
     1861 cttgctttcc cacactaagg taagttcaga ctagattgaa cactccagaa ttttttacta
     1921 cagactgttt ttaagttaga agtgatggca attttataaa tagagaatat acttccactg
     1981 atgcccttac tgtgccaaaa caaaaatctt aagaaaagca agtagacacc ttcataacta
     2041 tgaatgaagc tgctgaagta gtgtttagga tcctccatgg cagttagtga atgtaagaag
     2101 tacagtgtta aagtgttgta aacagttact cagtgcaatg tatagcctga gtctatccat
     2161 gatggctata tccaatttga catcacgtta tggatcagta cacaatgaaa aaccaaagaa
     2221 ccacagtata tcttattctt aacttttgta aaccatgttt tatgggtaac tttttagttt
     2281 tcccaaaagg ctgataaatt tcaatatttt gaatacatca ttgttaattt tgagttggca
     2341 gaggtaaact aaccaactac cattatgttt tagtactaag ggatatacct ttcaataaag
     2401 ttaatgaaat tcaa
//
