LOCUS       NM_001761               4230 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens cyclin F (CCNF), transcript variant 1, mRNA.
ACCESSION   NM_001761
VERSION     NM_001761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4230)
  AUTHORS   Yang,H., Fouad,S., Smith,P., Bae,E.Y., Ji,Y., Lan,X., Van Ess,A.,
            Buffa,F.M., Fischer,R., Vendrell,I., Kessler,B.M. and
            D'Angiolella,V.
  TITLE     Cyclin F-EXO1 axis controls cell cycle-dependent execution of
            double-strand break repair
  JOURNAL   Sci Adv 10 (32), eado0636 (2024)
   PUBMED   39121215
  REMARK    GeneRIF: Cyclin F-EXO1 axis controls cell cycle-dependent execution
            of double-strand break repair.
REFERENCE   2  (bases 1 to 4230)
  AUTHORS   Kwiatkowski,M., Krajewski,A., Durslewicz,J., Buchholz,K.,
            Grzanka,D., Gagat,M., Zabrzynski,J. and Klimaszewska-Wisniewska,A.
  TITLE     Overexpression of cyclin F/CCNF as an independent prognostic factor
            for poor survival in clear cell renal cell carcinoma
  JOURNAL   Sci Rep 14 (1), 9280 (2024)
   PUBMED   38654021
  REMARK    GeneRIF: Overexpression of cyclin F/CCNF as an independent
            prognostic factor for poor survival in clear cell renal cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4230)
  AUTHORS   Ragagnin,A.M.G., Sundaramoorthy,V., Farzana,F., Gautam,S.,
            Saravanabavan,S., Takalloo,Z., Mehta,P., Do-Ha,D., Parakh,S.,
            Shadfar,S., Hunter,J., Vidal,M., Jagaraj,C.J., Brocardo,M.,
            Konopka,A., Yang,S., Rayner,S.L., Williams,K.L., Blair,I.P.,
            Chung,R.S., Lee,A., Ooi,L. and Atkin,J.D.
  TITLE     ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi
            trafficking, inducing ER stress, ERAD and Golgi fragmentation
  JOURNAL   Sci Rep 13 (1), 20467 (2023)
   PUBMED   37993492
  REMARK    GeneRIF: ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi
            trafficking, inducing ER stress, ERAD and Golgi fragmentation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4230)
  AUTHORS   Davidson,J.M., Wu,S.S.L., Rayner,S.L., Cheng,F., Duncan,K.,
            Russo,C., Newbery,M., Ding,K., Scherer,N.M., Balez,R.,
            Garcia-Redondo,A., Rabano,A., Rosa-Fernandes,L., Ooi,L.,
            Williams,K.L., Morsch,M., Blair,I.P., Di Ieva,A., Yang,S.,
            Chung,R.S. and Lee,A.
  TITLE     The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62
            Insolubility and Foci Formation and is Dysregulated in ALS and FTD
            Pathogenesis
  JOURNAL   Mol Neurobiol 60 (9), 5034-5054 (2023)
   PUBMED   37243816
  REMARK    GeneRIF: The E3 Ubiquitin Ligase SCF Cyclin F Promotes
            Sequestosome-1/p62 Insolubility and Foci Formation and is
            Dysregulated in ALS and FTD Pathogenesis.
REFERENCE   5  (bases 1 to 4230)
  AUTHORS   Farrawell,N.E., Bax,M., McAlary,L., McKenna,J., Maksour,S.,
            Do-Ha,D., Rayner,S.L., Blair,I.P., Chung,R.S., Yerbury,J.J., Ooi,L.
            and Saunders,D.N.
  TITLE     ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis
  JOURNAL   Hum Mol Genet 32 (14), 2386-2398 (2023)
   PUBMED   37220877
  REMARK    GeneRIF: ALS-linked CCNF variant disrupts motor neuron ubiquitin
            homeostasis.
REFERENCE   6  (bases 1 to 4230)
  AUTHORS   Fung,T.K., Siu,W.Y., Yam,C.H., Lau,A. and Poon,R.Y.
  TITLE     Cyclin F is degraded during G2-M by mechanisms fundamentally
            different from other cyclins
  JOURNAL   J Biol Chem 277 (38), 35140-35149 (2002)
   PUBMED   12122006
  REMARK    GeneRIF: degradation during G2-M by mechanisms fundamentally
            different from other cyclins
REFERENCE   7  (bases 1 to 4230)
  AUTHORS   Kong,M., Barnes,E.A., Ollendorff,V. and Donoghue,D.J.
  TITLE     Cyclin F regulates the nuclear localization of cyclin B1 through a
            cyclin-cyclin interaction
  JOURNAL   EMBO J 19 (6), 1378-1388 (2000)
   PUBMED   10716937
REFERENCE   8  (bases 1 to 4230)
  AUTHORS   Bai,C., Sen,P., Hofmann,K., Ma,L., Goebl,M., Harper,J.W. and
            Elledge,S.J.
  TITLE     SKP1 connects cell cycle regulators to the ubiquitin proteolysis
            machinery through a novel motif, the F-box
  JOURNAL   Cell 86 (2), 263-274 (1996)
   PUBMED   8706131
REFERENCE   9  (bases 1 to 4230)
  AUTHORS   Bai,C., Richman,R. and Elledge,S.J.
  TITLE     Human cyclin F
  JOURNAL   EMBO J 13 (24), 6087-6098 (1994)
   PUBMED   7813445
REFERENCE   10 (bases 1 to 4230)
  AUTHORS   Kraus,B., Pohlschmidt,M., Leung,A.L., Germino,G.G., Snarey,A.,
            Schneider,M.C., Reeders,S.T. and Frischauf,A.M.
  TITLE     A novel cyclin gene (CCNF) in the region of the polycystic kidney
            disease gene (PKD1)
  JOURNAL   Genomics 24 (1), 27-33 (1994)
   PUBMED   7896286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z36714.1, BC012349.1,
            AB208829.1 and DB523776.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001761.2.
            
            Summary: This gene encodes a member of the cyclin family. Cyclins
            are important regulators of cell cycle transitions through their
            ability to bind and activate cyclin-dependent protein kinases. This
            member also belongs to the F-box protein family which is
            characterized by an approximately 40 amino acid motif, the F-box.
            The F-box proteins constitute one of the four subunits of the
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class and it was one of the first proteins in which the
            F-box motif was identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z36714.1, SRR1803617.234804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397066.9/ ENSP00000380256.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-734               Z36714.1           9-742
            735-3141            BC012349.1         712-3118
            3142-4005           AB208829.1         3002-3865
            4006-4230           DB523776.1         231-455
FEATURES             Location/Qualifiers
     source          1..4230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4230
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="cyclin F"
                     /db_xref="GeneID:899"
                     /db_xref="HGNC:HGNC:1591"
                     /db_xref="MIM:600227"
     exon            1..51
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2396
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 1; G2/mitotic-specific cyclin-F"
                     /codon_start=1
                     /product="cyclin-F isoform 1"
                     /protein_id="NP_001752.2"
                     /db_xref="CCDS:CCDS10467.1"
                     /db_xref="GeneID:899"
                     /db_xref="HGNC:HGNC:1591"
                     /db_xref="MIM:600227"
                     /translation="MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHIL
                     KWLSVEDILAVRAVHSQLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEA
                     AVKLGIAYLYNEGLSVSDEARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVS
                     GSCCKAVVHESLRAECQLQRTHKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGC
                     LTSSYLLWESDRRTDVSDPGRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEV
                     RASSEIVCQLFQASQAVSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLT
                     VECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVR
                     MMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPA
                     RLAAAALLLARLTHGQTQPWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQV
                     SLTAVKQRFEDKRYGEISQEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPS
                     GRRTKRKRENSLQEDRGSFVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGE
                     KEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPG
                     PKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCH
                     HQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMNLGLVRL"
     exon            52..206
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            207..313
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            314..381
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            382..575
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            576..629
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            630..734
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            735..812
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            813..964
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1129
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1253
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1434
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1522
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1622
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1750
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1920
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..4230
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4206..4211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="hexamer: ATTAAA"
     polyA_site      4230
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="major polyA site"
ORIGIN      
        1 aggcgggctc cggcggcagc gacgcgagcg cggcgatggg gagcggcggc gtggtccact
       61 gtaggtgtgc caagtgtttc tgttatccta caaagcgaag aataaggagg aggccccgaa
      121 acctgaccat cttgagtctc cccgaagatg tgctctttca catcctgaaa tggctttctg
      181 tagaggacat cctggccgtc cgagctgtac actcccagct gaaggacctg gtggacaacc
      241 acgccagtgt gtgggcatgt gccagcttcc aggagctgtg gccgtctcca gggaacctga
      301 agctctttga aagggctgct gaaaagggga atttcgaagc tgctgtgaag ctgggcatag
      361 cctacctcta caatgaaggc ctgtctgtgt ctgatgaggc ccgcgcagaa gtgaatggcc
      421 tgaaggcctc tcgcttcttc agtctcgctg agcggctgaa tgtgggtgcc gcacctttca
      481 tctggctctt catccgccct ccgtggtcgg tgagcggaag ctgctgcaag gccgtggttc
      541 acgagagcct cagggcagag tgccagctgc agaggactca caaagcatcc atattgcact
      601 gcttgggcag agtgctgagt ctgttcgagg atgaggagaa gcagcagcag gcccatgacc
      661 tgtttgagga ggctgctcat cagggatgtc tgaccagctc ctacctcctc tgggaaagcg
      721 acaggaggac agatgtgtca gatcctgggc gatgcctcca cagcttccga aaactcaggg
      781 actacgctgc caaaggctgc tgggaagcgc agctgtcttt agccaaagcc tgtgcaaatg
      841 caaaccagct tggactggag gtgagagctt ccagtgagat cgtctgccag ctatttcagg
      901 cttcccaggc tgtcagtaaa caacaagtct tctccgtgca gaagggactc aatgacacaa
      961 tgaggtacat tctgatcgac tggctggtgg aagttgccac catgaaggac ttcacaagcc
     1021 tgtgcctgca cctgaccgtg gagtgtgtgg accggtacct gcggaggagg ctggtgccgc
     1081 ggtacaggct ccagctgctg ggcatcgcct gcatggtcat ctgcacccgg tttatcagta
     1141 aagagatcct gaccatccgg gaggccgtat ggctcacgga caacacttac aagtacgagg
     1201 acctggtgag aatgatgggc gagatcgtct ccgccttgga agggaagatt cgagtcccca
     1261 ctgtggtgga ttacaaggag gtcctgctga cgctagtccc tgtggagctg agaacccagc
     1321 acctgtgcag cttcctctgc gagctctccc tgctgcacac cagcctgtcc gcctacgccc
     1381 cagcccgcct ggctgccgca gccctgctcc tggccagact gacgcacggg cagacacagc
     1441 cctggaccac tcagctgtgg gacctcaccg gattctccta tgaagacctc attccctgcg
     1501 tcttgagcct ccataagaag tgcttccatg atgacgcccc caaggactac aggcaagtct
     1561 ctctgaccgc cgtgaagcag cggtttgagg acaagcgcta tggagaaatc agccaggaag
     1621 aggtgctgag ctacagccag ttgtgtgctg cattaggagt gacacaagac agccccgacc
     1681 ccccgacttt cctcagcaca ggggagatcc acgccttcct cagctctccc tcggggcgga
     1741 gaaccaaacg gaagcgggag aacagcctcc aggaagacag aggcagcttc gttaccaccc
     1801 ccactgcgga gctgtccagc caggaggaga cgctgctggg cagcttcctc gactggagcc
     1861 tggactgctg ctctggctat gaaggcgacc aggagagtga gggcgagaag gagggcgacg
     1921 tgacagctcc cagcggcatc ctcgatgtca ccgtggtcta cctgaaccca gaacagcatt
     1981 gctgccagga atccagtgat gaggaggctt gtccagagga caagggaccc caggacccac
     2041 aggcactggc gctggacacc cagatccctg caacccctgg acccaaaccc ctggtccgca
     2101 ccagccggga gccagggaag gacgtcacga cctcagggta ctcctccgtc agcaccgcaa
     2161 gtcccacaag ctccgtggac ggtggcttgg gggccctgcc ccaacctacc tcagtgctgt
     2221 ccctggacag tgactcgcac acacagccct gccaccatca ggccaggaag tcatgtttac
     2281 agtgtcgtcc cccaagtccc ccggagagca gtgttcccca gcaacaggtg aagcggataa
     2341 acctatgcat acacagtgag gaggaggaca tgaacctggg ccttgtgagg ctgtaagtgt
     2401 gtcagcacat ttgccgcagt ggatgtgtac tgagggggct ggaggcgaag ggtgggagca
     2461 tagcatagga acgctgcata gaccatggag gcctttgcgc agagagcaga gaggatgact
     2521 tgcggccacc aagtttctgt ctccgcggga gtcccgtgca agccatcaga atgttgaaat
     2581 gagggtgaag agctcagatc cctctctttg gaaagtttag cctggaagca gttggccaca
     2641 ctgtgtggag ggcacctctc tgtcccttcc gtgtctcact gtctctggaa gcttcagccc
     2701 atgtgtgtcc tggtgttccc agccccacca gagccccgtg ccgggagctg acagctttca
     2761 cgcttaaggc acgtgtgacc tgggtagtca gacaccactt gagcccctgc ccacatctgc
     2821 tggtttgggg cttcagtggg gagctgacag ctgtgagcac accactgtcc cctcatccac
     2881 ctcggcctgc atggggcacc cacttccttc tgggtggggc ttccatggta agggggcctg
     2941 cgtccctgca cactgcgagg actgccttgg ccacaggccc actccctacg acacgtgact
     3001 cgttttagag ctctgtccca gaggcgttcg tatgtgaccc acagatggcg tcaatgtgaa
     3061 cacctctctt tgtgctgaat ttctgggcca ttcttttcct gtcttatttc taaatttcct
     3121 tcttccaaga tgaaaacaaa agaaaaactt aaaacagaag gtattaaaaa aacaagagat
     3181 tcccaccatt atttaggttc acctgcaaaa caaaaatctt actccagccc ctcaatgcca
     3241 tcctgacaca ctttatgcaa aaagaatttt cccagatagg ctagccagaa aaaacttcaa
     3301 gtcctctgta acatctgagg tgaccaagag gcagaagagc agagcagtcg ggggccgtgt
     3361 cctggctgat cccaactgca gctctgctgt gggggcccgt gggagggagg cagacccctg
     3421 ggctttcctg ctggccacgg agactctgct cctgcatgga aagggagcct gggagccagc
     3481 agcccacgcc tggggagcct gcctggggcc atgtgaccat ggcctctccc tgggaacggg
     3541 ctgaccacaa cacaccctgc tgccatccac ttctgtttac tctgcaaatg taagaaagaa
     3601 ccacttggcc agaagtgtcc cccagatgct tttttttttt tttttttgga gacagttttg
     3661 ctcttgtctc cccggctgga gtgcagtggc atgatctcaa ctctcaactc actgtaacct
     3721 ccgcctcccg gatactcctg cctcagcctc ctgggtagct gggattacaa gcacccaacc
     3781 acgcccagct aatttttgta ttttcggtag agacgggatt tcaccatgtt ggccaggcta
     3841 gtctcgaact catgacctca agtgatccgc ccacttcggt ctcccaaagt gctgggatta
     3901 caggcatgag ccacggcgcc tggcccccaa atgctcttga accggaaacc cagggatggg
     3961 agatgctcac tgagctgctg cttttatgtg tgctggtgct atgtgtgttc atgtccgcgg
     4021 cagctgtctt tttgctacta taagggaatt ctggccaccc tgggtggggt gtggtcgggg
     4081 tgagaaccca agcgttggaa ctgtagaccc gtcctgtcga ctgtgtgccc ctgggcatgt
     4141 gtgagcctca gtttcctcat ctgtaagggg ggcaatgata cctacctcac aggggtgttg
     4201 tgaggattaa atgtgaggag gatagtggca
//
