LOCUS       NP_001752                786 aa            linear   PRI 28-APR-2025
DEFINITION  cyclin-F isoform 1 [Homo sapiens].
ACCESSION   NP_001752
VERSION     NP_001752.2
DBSOURCE    REFSEQ: accession NM_001761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 786)
  AUTHORS   Yang,H., Fouad,S., Smith,P., Bae,E.Y., Ji,Y., Lan,X., Van Ess,A.,
            Buffa,F.M., Fischer,R., Vendrell,I., Kessler,B.M. and
            D'Angiolella,V.
  TITLE     Cyclin F-EXO1 axis controls cell cycle-dependent execution of
            double-strand break repair
  JOURNAL   Sci Adv 10 (32), eado0636 (2024)
   PUBMED   39121215
  REMARK    GeneRIF: Cyclin F-EXO1 axis controls cell cycle-dependent execution
            of double-strand break repair.
REFERENCE   2  (residues 1 to 786)
  AUTHORS   Kwiatkowski,M., Krajewski,A., Durslewicz,J., Buchholz,K.,
            Grzanka,D., Gagat,M., Zabrzynski,J. and Klimaszewska-Wisniewska,A.
  TITLE     Overexpression of cyclin F/CCNF as an independent prognostic factor
            for poor survival in clear cell renal cell carcinoma
  JOURNAL   Sci Rep 14 (1), 9280 (2024)
   PUBMED   38654021
  REMARK    GeneRIF: Overexpression of cyclin F/CCNF as an independent
            prognostic factor for poor survival in clear cell renal cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 786)
  AUTHORS   Ragagnin,A.M.G., Sundaramoorthy,V., Farzana,F., Gautam,S.,
            Saravanabavan,S., Takalloo,Z., Mehta,P., Do-Ha,D., Parakh,S.,
            Shadfar,S., Hunter,J., Vidal,M., Jagaraj,C.J., Brocardo,M.,
            Konopka,A., Yang,S., Rayner,S.L., Williams,K.L., Blair,I.P.,
            Chung,R.S., Lee,A., Ooi,L. and Atkin,J.D.
  TITLE     ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi
            trafficking, inducing ER stress, ERAD and Golgi fragmentation
  JOURNAL   Sci Rep 13 (1), 20467 (2023)
   PUBMED   37993492
  REMARK    GeneRIF: ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi
            trafficking, inducing ER stress, ERAD and Golgi fragmentation.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 786)
  AUTHORS   Davidson,J.M., Wu,S.S.L., Rayner,S.L., Cheng,F., Duncan,K.,
            Russo,C., Newbery,M., Ding,K., Scherer,N.M., Balez,R.,
            Garcia-Redondo,A., Rabano,A., Rosa-Fernandes,L., Ooi,L.,
            Williams,K.L., Morsch,M., Blair,I.P., Di Ieva,A., Yang,S.,
            Chung,R.S. and Lee,A.
  TITLE     The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62
            Insolubility and Foci Formation and is Dysregulated in ALS and FTD
            Pathogenesis
  JOURNAL   Mol Neurobiol 60 (9), 5034-5054 (2023)
   PUBMED   37243816
  REMARK    GeneRIF: The E3 Ubiquitin Ligase SCF Cyclin F Promotes
            Sequestosome-1/p62 Insolubility and Foci Formation and is
            Dysregulated in ALS and FTD Pathogenesis.
REFERENCE   5  (residues 1 to 786)
  AUTHORS   Farrawell,N.E., Bax,M., McAlary,L., McKenna,J., Maksour,S.,
            Do-Ha,D., Rayner,S.L., Blair,I.P., Chung,R.S., Yerbury,J.J., Ooi,L.
            and Saunders,D.N.
  TITLE     ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis
  JOURNAL   Hum Mol Genet 32 (14), 2386-2398 (2023)
   PUBMED   37220877
  REMARK    GeneRIF: ALS-linked CCNF variant disrupts motor neuron ubiquitin
            homeostasis.
REFERENCE   6  (residues 1 to 786)
  AUTHORS   Fung,T.K., Siu,W.Y., Yam,C.H., Lau,A. and Poon,R.Y.
  TITLE     Cyclin F is degraded during G2-M by mechanisms fundamentally
            different from other cyclins
  JOURNAL   J Biol Chem 277 (38), 35140-35149 (2002)
   PUBMED   12122006
  REMARK    GeneRIF: degradation during G2-M by mechanisms fundamentally
            different from other cyclins
REFERENCE   7  (residues 1 to 786)
  AUTHORS   Kong,M., Barnes,E.A., Ollendorff,V. and Donoghue,D.J.
  TITLE     Cyclin F regulates the nuclear localization of cyclin B1 through a
            cyclin-cyclin interaction
  JOURNAL   EMBO J 19 (6), 1378-1388 (2000)
   PUBMED   10716937
REFERENCE   8  (residues 1 to 786)
  AUTHORS   Bai,C., Sen,P., Hofmann,K., Ma,L., Goebl,M., Harper,J.W. and
            Elledge,S.J.
  TITLE     SKP1 connects cell cycle regulators to the ubiquitin proteolysis
            machinery through a novel motif, the F-box
  JOURNAL   Cell 86 (2), 263-274 (1996)
   PUBMED   8706131
REFERENCE   9  (residues 1 to 786)
  AUTHORS   Bai,C., Richman,R. and Elledge,S.J.
  TITLE     Human cyclin F
  JOURNAL   EMBO J 13 (24), 6087-6098 (1994)
   PUBMED   7813445
REFERENCE   10 (residues 1 to 786)
  AUTHORS   Kraus,B., Pohlschmidt,M., Leung,A.L., Germino,G.G., Snarey,A.,
            Schneider,M.C., Reeders,S.T. and Frischauf,A.M.
  TITLE     A novel cyclin gene (CCNF) in the region of the polycystic kidney
            disease gene (PKD1)
  JOURNAL   Genomics 24 (1), 27-33 (1994)
   PUBMED   7896286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z36714.1, BC012349.1,
            AB208829.1 and DB523776.1.
            
            On Dec 1, 2006 this sequence version replaced NP_001752.1.
            
            Summary: This gene encodes a member of the cyclin family. Cyclins
            are important regulators of cell cycle transitions through their
            ability to bind and activate cyclin-dependent protein kinases. This
            member also belongs to the F-box protein family which is
            characterized by an approximately 40 amino acid motif, the F-box.
            The F-box proteins constitute one of the four subunits of the
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class and it was one of the first proteins in which the
            F-box motif was identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z36714.1, SRR1803617.234804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397066.9/ ENSP00000380256.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     Protein         1..786
                     /product="cyclin-F isoform 1"
                     /note="F-box only protein 1; G2/mitotic-specific cyclin-F"
                     /calculated_mol_wt=87509
     Region          20..28
                     /region_name="Nuclear localization signal 1.
                     /evidence=ECO:0000269|PubMed:10716937"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          29..76
                     /region_name="F-box domain"
     Region          31..82
                     /region_name="F-box_FBXO1"
                     /note="F-box domain found in F-box only protein 1 (FBXO1)
                     and similar proteins; cd22082"
                     /db_xref="CDD:438854"
     Site            order(35,39,42..43,46..47,51,53..54,58..60,62)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438854"
     Region          <88..124
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          307..401
                     /region_name="CYCLIN_CCNF_rpt1"
                     /note="first cyclin box found in G2/mitotic-specific
                     cyclin-F (CCNF) and similar proteins; cd20521"
                     /db_xref="CDD:410225"
     Region          310..313
                     /region_name="D box 1.
                     /evidence=ECO:0000269|PubMed:27653696"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          343..346
                     /region_name="D box 2.
                     /evidence=ECO:0000269|PubMed:27653696"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          349..352
                     /region_name="D box 3.
                     /evidence=ECO:0000269|PubMed:27653696"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          351..354
                     /region_name="D box 4.
                     /evidence=ECO:0000269|PubMed:27653696"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          429..540
                     /region_name="CYCLIN_SF"
                     /note="Cyclin box fold superfamily; cl40454"
                     /db_xref="CDD:477360"
     Region          564..593
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          568..574
                     /region_name="Nuclear localization signal 2.
                     /evidence=ECO:0000269|PubMed:10716937"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          582..766
                     /region_name="PEST"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          675..738
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     Region          767..770
                     /region_name="D box 5.
                     /evidence=ECO:0000269|PubMed:27653696"
                     /note="propagated from UniProtKB/Swiss-Prot (P41002.2)"
     CDS             1..786
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /coded_by="NM_001761.3:36..2396"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS10467.1"
                     /db_xref="GeneID:899"
                     /db_xref="HGNC:HGNC:1591"
                     /db_xref="MIM:600227"
ORIGIN      
        1 mgsggvvhcr cakcfcyptk rrirrrprnl tilslpedvl fhilkwlsve dilavravhs
       61 qlkdlvdnha svwacasfqe lwpspgnlkl feraaekgnf eaavklgiay lyneglsvsd
      121 earaevnglk asrffslaer lnvgaapfiw lfirppwsvs gscckavvhe slraecqlqr
      181 thkasilhcl grvlslfede ekqqqahdlf eeaahqgclt ssyllwesdr rtdvsdpgrc
      241 lhsfrklrdy aakgcweaql slakacanan qlglevrass eivcqlfqas qavskqqvfs
      301 vqkglndtmr yilidwlvev atmkdftslc lhltvecvdr ylrrrlvpry rlqllgiacm
      361 victrfiske iltireavwl tdntykyedl vrmmgeivsa legkirvptv vdykevlltl
      421 vpvelrtqhl csflcelsll htslsayapa rlaaaallla rlthgqtqpw ttqlwdltgf
      481 syedlipcvl slhkkcfhdd apkdyrqvsl tavkqrfedk rygeisqeev lsysqlcaal
      541 gvtqdspdpp tflstgeiha flsspsgrrt krkrenslqe drgsfvttpt aelssqeetl
      601 lgsfldwsld ccsgyegdqe segekegdvt apsgildvtv vylnpeqhcc qessdeeacp
      661 edkgpqdpqa laldtqipat pgpkplvrts repgkdvtts gyssvstasp tssvdgglga
      721 lpqptsvlsl dsdshtqpch hqarksclqc rppsppessv pqqqvkrinl cihseeedmn
      781 lglvrl
//
