LOCUS       NM_001323538            4123 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens cyclin F (CCNF), transcript variant 2, mRNA.
ACCESSION   NM_001323538
VERSION     NM_001323538.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4123)
  AUTHORS   Yang,H., Fouad,S., Smith,P., Bae,E.Y., Ji,Y., Lan,X., Van Ess,A.,
            Buffa,F.M., Fischer,R., Vendrell,I., Kessler,B.M. and
            D'Angiolella,V.
  TITLE     Cyclin F-EXO1 axis controls cell cycle-dependent execution of
            double-strand break repair
  JOURNAL   Sci Adv 10 (32), eado0636 (2024)
   PUBMED   39121215
  REMARK    GeneRIF: Cyclin F-EXO1 axis controls cell cycle-dependent execution
            of double-strand break repair.
REFERENCE   2  (bases 1 to 4123)
  AUTHORS   Kwiatkowski,M., Krajewski,A., Durslewicz,J., Buchholz,K.,
            Grzanka,D., Gagat,M., Zabrzynski,J. and Klimaszewska-Wisniewska,A.
  TITLE     Overexpression of cyclin F/CCNF as an independent prognostic factor
            for poor survival in clear cell renal cell carcinoma
  JOURNAL   Sci Rep 14 (1), 9280 (2024)
   PUBMED   38654021
  REMARK    GeneRIF: Overexpression of cyclin F/CCNF as an independent
            prognostic factor for poor survival in clear cell renal cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4123)
  AUTHORS   Ragagnin,A.M.G., Sundaramoorthy,V., Farzana,F., Gautam,S.,
            Saravanabavan,S., Takalloo,Z., Mehta,P., Do-Ha,D., Parakh,S.,
            Shadfar,S., Hunter,J., Vidal,M., Jagaraj,C.J., Brocardo,M.,
            Konopka,A., Yang,S., Rayner,S.L., Williams,K.L., Blair,I.P.,
            Chung,R.S., Lee,A., Ooi,L. and Atkin,J.D.
  TITLE     ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi
            trafficking, inducing ER stress, ERAD and Golgi fragmentation
  JOURNAL   Sci Rep 13 (1), 20467 (2023)
   PUBMED   37993492
  REMARK    GeneRIF: ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi
            trafficking, inducing ER stress, ERAD and Golgi fragmentation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4123)
  AUTHORS   Davidson,J.M., Wu,S.S.L., Rayner,S.L., Cheng,F., Duncan,K.,
            Russo,C., Newbery,M., Ding,K., Scherer,N.M., Balez,R.,
            Garcia-Redondo,A., Rabano,A., Rosa-Fernandes,L., Ooi,L.,
            Williams,K.L., Morsch,M., Blair,I.P., Di Ieva,A., Yang,S.,
            Chung,R.S. and Lee,A.
  TITLE     The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62
            Insolubility and Foci Formation and is Dysregulated in ALS and FTD
            Pathogenesis
  JOURNAL   Mol Neurobiol 60 (9), 5034-5054 (2023)
   PUBMED   37243816
  REMARK    GeneRIF: The E3 Ubiquitin Ligase SCF Cyclin F Promotes
            Sequestosome-1/p62 Insolubility and Foci Formation and is
            Dysregulated in ALS and FTD Pathogenesis.
REFERENCE   5  (bases 1 to 4123)
  AUTHORS   Farrawell,N.E., Bax,M., McAlary,L., McKenna,J., Maksour,S.,
            Do-Ha,D., Rayner,S.L., Blair,I.P., Chung,R.S., Yerbury,J.J., Ooi,L.
            and Saunders,D.N.
  TITLE     ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis
  JOURNAL   Hum Mol Genet 32 (14), 2386-2398 (2023)
   PUBMED   37220877
  REMARK    GeneRIF: ALS-linked CCNF variant disrupts motor neuron ubiquitin
            homeostasis.
REFERENCE   6  (bases 1 to 4123)
  AUTHORS   Fung,T.K., Siu,W.Y., Yam,C.H., Lau,A. and Poon,R.Y.
  TITLE     Cyclin F is degraded during G2-M by mechanisms fundamentally
            different from other cyclins
  JOURNAL   J Biol Chem 277 (38), 35140-35149 (2002)
   PUBMED   12122006
  REMARK    GeneRIF: degradation during G2-M by mechanisms fundamentally
            different from other cyclins
REFERENCE   7  (bases 1 to 4123)
  AUTHORS   Kong,M., Barnes,E.A., Ollendorff,V. and Donoghue,D.J.
  TITLE     Cyclin F regulates the nuclear localization of cyclin B1 through a
            cyclin-cyclin interaction
  JOURNAL   EMBO J 19 (6), 1378-1388 (2000)
   PUBMED   10716937
REFERENCE   8  (bases 1 to 4123)
  AUTHORS   Bai,C., Sen,P., Hofmann,K., Ma,L., Goebl,M., Harper,J.W. and
            Elledge,S.J.
  TITLE     SKP1 connects cell cycle regulators to the ubiquitin proteolysis
            machinery through a novel motif, the F-box
  JOURNAL   Cell 86 (2), 263-274 (1996)
   PUBMED   8706131
REFERENCE   9  (bases 1 to 4123)
  AUTHORS   Bai,C., Richman,R. and Elledge,S.J.
  TITLE     Human cyclin F
  JOURNAL   EMBO J 13 (24), 6087-6098 (1994)
   PUBMED   7813445
REFERENCE   10 (bases 1 to 4123)
  AUTHORS   Kraus,B., Pohlschmidt,M., Leung,A.L., Germino,G.G., Snarey,A.,
            Schneider,M.C., Reeders,S.T. and Frischauf,A.M.
  TITLE     A novel cyclin gene (CCNF) in the region of the polycystic kidney
            disease gene (PKD1)
  JOURNAL   Genomics 24 (1), 27-33 (1994)
   PUBMED   7896286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY027359.1, AB208829.1,
            AC106820.4 and BQ009827.1.
            
            On May 31, 2019 this sequence version replaced NM_001323538.1.
            
            Summary: This gene encodes a member of the cyclin family. Cyclins
            are important regulators of cell cycle transitions through their
            ability to bind and activate cyclin-dependent protein kinases. This
            member also belongs to the F-box protein family which is
            characterized by an approximately 40 amino acid motif, the F-box.
            The F-box proteins constitute one of the four subunits of the
            ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),
            which function in phosphorylation-dependent ubiquitination. The
            F-box proteins are divided into 3 classes: Fbws containing WD-40
            domains, Fbls containing leucine-rich repeats, and Fbxs containing
            either different protein-protein interaction modules or no
            recognizable motifs. The protein encoded by this gene belongs to
            the Fbxs class and it was one of the first proteins in which the
            F-box motif was identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB208829.1, SRR1660807.2987.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                HY027359.1         57-89
            34-2167             AB208829.1         1-2134
            2168-2168           AC106820.4         47068-47068         c
            2169-4120           AB208829.1         2136-4087
            4121-4123           BQ009827.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..4123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4123
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="cyclin F"
                     /db_xref="GeneID:899"
                     /db_xref="HGNC:HGNC:1591"
                     /db_xref="MIM:600227"
     exon            1..51
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            52..206
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            207..274
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            275..468
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            469..522
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            523..627
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            628..705
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            706..857
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             853..2289
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 1; G2/mitotic-specific cyclin-F"
                     /codon_start=1
                     /product="cyclin-F isoform 2"
                     /protein_id="NP_001310467.1"
                     /db_xref="GeneID:899"
                     /db_xref="HGNC:HGNC:1591"
                     /db_xref="MIM:600227"
                     /translation="MRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRL
                     QLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTV
                     VDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQ
                     PWTTQLWDLTGFSYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEIS
                     QEEVLSYSQLCAALGVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGS
                     FVTTPTAELSSQEETLLGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVY
                     LNPEQHCCQESSDEEACPEDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTS
                     GYSSVSTASPTSSVDGGLGALPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPES
                     SVPQQQVKRINLCIHSEEEDMNLGLVRL"
     exon            858..1022
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1146
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1327
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1415
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1515
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1643
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1813
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..4123
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4099..4104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="hexamer: ATTAAA"
     polyA_site      4123
                     /gene="CCNF"
                     /gene_synonym="FBX1; FBXO1; FTDALS5"
                     /note="major polyA site"
ORIGIN      
        1 aggcgggctc cggcggcagc gacgcgagcg cggcgatggg gagcggcggc gtggtccact
       61 gtaggtgtgc caagtgtttc tgttatccta caaagcgaag aataaggagg aggccccgaa
      121 acctgaccat cttgagtctc cccgaagatg tgctctttca catcctgaaa tggctttctg
      181 tagaggacat cctggccgtc cgagctggct gctgaaaagg ggaatttcga agctgctgtg
      241 aagctgggca tagcctacct ctacaatgaa ggcctgtctg tgtctgatga ggcccgcgca
      301 gaagtgaatg gcctgaaggc ctctcgcttc ttcagtctcg ctgagcggct gaatgtgggt
      361 gccgcacctt tcatctggct cttcatccgc cctccgtggt cggtgagcgg aagctgctgc
      421 aaggccgtgg ttcacgagag cctcagggca gagtgccagc tgcagaggac tcacaaagca
      481 tccatattgc actgcttggg cagagtgctg agtctgttcg aggatgagga gaagcagcag
      541 caggcccatg acctgtttga ggaggctgct catcagggat gtctgaccag ctcctacctc
      601 ctctgggaaa gcgacaggag gacagatgtg tcagatcctg ggcgatgcct ccacagcttc
      661 cgaaaactca gggactacgc tgccaaaggc tgctgggaag cgcagctgtc tttagccaaa
      721 gcctgtgcaa atgcaaacca gcttggactg gaggtgagag cttccagtga gatcgtctgc
      781 cagctatttc aggcttccca ggctgtcagt aaacaacaag tcttctccgt gcagaaggga
      841 ctcaatgaca caatgaggta cattctgatc gactggctgg tggaagttgc caccatgaag
      901 gacttcacaa gcctgtgcct gcacctgacc gtggagtgtg tggaccggta cctgcggagg
      961 aggctggtgc cgcggtacag gctccagctg ctgggcatcg cctgcatggt catctgcacc
     1021 cggtttatca gtaaagagat cctgaccatc cgggaggccg tatggctcac ggacaacact
     1081 tacaagtacg aggacctggt gagaatgatg ggcgagatcg tctccgcctt ggaagggaag
     1141 attcgagtcc ccactgtggt ggattacaag gaggtcctgc tgacgctagt ccctgtggag
     1201 ctgagaaccc agcacctgtg cagcttcctc tgcgagctct ccctgctgca caccagcctg
     1261 tccgcctacg ccccagcccg cctggctgcc gcagccctgc tcctggccag actgacgcac
     1321 gggcagacac agccctggac cactcagctg tgggacctca ccggattctc ctatgaagac
     1381 ctcattccct gcgtcttgag cctccataag aagtgcttcc atgatgacgc ccccaaggac
     1441 tacaggcaag tctctctgac cgccgtgaag cagcggtttg aggacaagcg ctatggagaa
     1501 atcagccagg aagaggtgct gagctacagc cagttgtgtg ctgcattagg agtgacacaa
     1561 gacagccccg accccccgac tttcctcagc acaggggaga tccacgcctt cctcagctct
     1621 ccctcggggc ggagaaccaa acggaagcgg gagaacagcc tccaggaaga cagaggcagc
     1681 ttcgttacca cccccactgc ggagctgtcc agccaggagg agacgctgct gggcagcttc
     1741 ctcgactgga gcctggactg ctgctctggc tatgaaggcg accaggagag tgagggcgag
     1801 aaggagggcg acgtgacagc tcccagcggc atcctcgatg tcaccgtggt ctacctgaac
     1861 ccagaacagc attgctgcca ggaatccagt gatgaggagg cttgtccaga ggacaaggga
     1921 ccccaggacc cacaggcact ggcgctggac acccagatcc ctgcaacccc tggacccaaa
     1981 cccctggtcc gcaccagccg ggagccaggg aaggacgtca cgacctcagg gtactcctcc
     2041 gtcagcaccg caagtcccac aagctccgtg gacggtggct tgggggccct gccccaacct
     2101 acctcagtgc tgtccctgga cagtgactcg cacacacagc cctgccacca tcaggccagg
     2161 aagtcatgtt tacagtgtcg tcccccaagt cccccggaga gcagtgttcc ccagcaacag
     2221 gtgaagcgga taaacctatg catacacagt gaggaggagg acatgaacct gggccttgtg
     2281 aggctgtaag tgtgtcagca catttgccgc agtggatgtg tactgagggg gctggaggcg
     2341 aagggtggga gcatagcata ggaacgctgc atagaccatg gaggcctttg cgcagagagc
     2401 agagaggatg acttgcggcc accaagtttc tgtctccgcg ggagtcccgt gcaagccatc
     2461 agaatgttga aatgagggtg aagagctcag atccctctct ttggaaagtt tagcctggaa
     2521 gcagttggcc acactgtgtg gagggcacct ctctgtccct tccgtgtctc actgtctctg
     2581 gaagcttcag cccatgtgtg tcctggtgtt cccagcccca ccagagcccc gtgccgggag
     2641 ctgacagctt tcacgcttaa ggcacgtgtg acctgggtag tcagacacca cttgagcccc
     2701 tgcccacatc tgctggtttg gggcttcagt ggggagctga cagctgtgag cacaccactg
     2761 tcccctcatc cacctcggcc tgcatggggc acccacttcc ttctgggtgg ggcttccatg
     2821 gtaagggggc ctgcgtccct gcacactgcg aggactgcct tggccacagg cccactccct
     2881 acgacacgtg actcgtttta gagctctgtc ccagaggcgt tcgtatgtga cccacagatg
     2941 gcgtcaatgt gaacacctct ctttgtgctg aatttctggg ccattctttt cctgtcttat
     3001 ttctaaattt ccttcttcca agatgaaaac aaaagaaaaa cttaaaacag aaggtattaa
     3061 aaaaacaaga gattcccacc attatttagg ttcacctgca aaacaaaaat cttactccag
     3121 cccctcaatg ccatcctgac acactttatg caaaaagaat tttcccagat aggctagcca
     3181 gaaaaaactt caagtcctct gtaacatctg aggtgaccaa gaggcagaag agcagagcag
     3241 tcgggggccg tgtcctggct gatcccaact gcagctctgc tgtgggggcc cgtgggaggg
     3301 aggcagaccc ctgggctttc ctgctggcca cggagactct gctcctgcat ggaaagggag
     3361 cctgggagcc agcagcccac gcctggggag cctgcctggg gccatgtgac catggcctct
     3421 ccctgggaac gggctgacca caacacaccc tgctgccatc cacttctgtt tactctgcaa
     3481 atgtaagaaa gaaccacttg gccagaagtg tcccccagat gctttttttt tttttttttt
     3541 ggagacagtt ttgctcttgt ctccccggct ggagtgcagt ggcatgatct caactctcaa
     3601 ctcactgtaa cctccgcctc ccggatactc ctgcctcagc ctcctgggta gctgggatta
     3661 caagcaccca accacgccca gctaattttt gtattttcgg tagagacggg atttcaccat
     3721 gttggccagg ctagtctcga actcatgacc tcaagtgatc cgcccacttc ggtctcccaa
     3781 agtgctggga ttacaggcat gagccacggc gcctggcccc caaatgctct tgaaccggaa
     3841 acccagggat gggagatgct cactgagctg ctgcttttat gtgtgctggt gctatgtgtg
     3901 ttcatgtccg cggcagctgt ctttttgcta ctataaggga attctggcca ccctgggtgg
     3961 ggtgtggtcg gggtgagaac ccaagcgttg gaactgtaga cccgtcctgt cgactgtgtg
     4021 cccctgggca tgtgtgagcc tcagtttcct catctgtaag gggggcaatg atacctacct
     4081 cacaggggtg ttgtgaggat taaatgtgag gaggatagtg gca
//
