LOCUS       NM_057749               2674 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens cyclin E2 (CCNE2), mRNA.
ACCESSION   NM_057749
VERSION     NM_057749.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Li,F., Ling,Y.P., Wang,P., Gu,S.S., Jiang,H. and Zhu,J.
  TITLE     Downregulation of miR-503-5p Promotes the Development of Pancreatic
            Cancer by Targeting Cyclin E2
  JOURNAL   Crit Rev Immunol 44 (4), 51-60 (2024)
   PUBMED   38505921
  REMARK    GeneRIF: Downregulation of miR-503-5p Promotes the Development of
            Pancreatic Cancer by Targeting Cyclin E2.
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Wang,J., Shao,J., Lu,Y., Su,W., Dong,H., Wang,P., Lin,Z., Feng,J.,
            Wang,D., Zhao,H. and Tan,J.
  TITLE     Screening Differential CircRNAs Expression Profiles Reveals the
            Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4
            Signaling Axis in Bladder Carcinoma Progression
  JOURNAL   DNA Cell Biol 41 (2), 128-141 (2022)
   PUBMED   35005988
  REMARK    GeneRIF: Screening Differential CircRNAs Expression Profiles
            Reveals the Regulatory Role of the
            has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in
            Bladder Carcinoma Progression.
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Chignon,A., Argaud,D., Boulanger,M.C., Mkannez,G., Bon-Baret,V.,
            Li,Z., Theriault,S., Bosse,Y. and Mathieu,P.
  TITLE     Genome-wide chromatin contacts of super-enhancer-associated lncRNA
            identify LINC01013 as a regulator of fibrosis in the aortic valve
  JOURNAL   PLoS Genet 18 (1), e1010010 (2022)
   PUBMED   35041643
  REMARK    GeneRIF: Genome-wide chromatin contacts of
            super-enhancer-associated lncRNA identify LINC01013 as a regulator
            of fibrosis in the aortic valve.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2674)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   6  (bases 1 to 2674)
  AUTHORS   Gudas,J.M., Payton,M., Thukral,S., Chen,E., Bass,M., Robinson,M.O.
            and Coats,S.
  TITLE     Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly
            expressed in human cancers
  JOURNAL   Mol Cell Biol 19 (1), 612-622 (1999)
   PUBMED   9858585
REFERENCE   7  (bases 1 to 2674)
  AUTHORS   Zariwala,M., Liu,J. and Xiong,Y.
  TITLE     Cyclin E2, a novel human G1 cyclin and activating partner of CDK2
            and CDK3, is induced by viral oncoproteins
  JOURNAL   Oncogene 17 (21), 2787-2798 (1998)
   PUBMED   9840943
REFERENCE   8  (bases 1 to 2674)
  AUTHORS   Lauper,N., Beck,A.R., Cariou,S., Richman,L., Hofmann,K., Reith,W.,
            Slingerland,J.M. and Amati,B.
  TITLE     Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the
            mammalian cell cycle
  JOURNAL   Oncogene 17 (20), 2637-2643 (1998)
   PUBMED   9840927
REFERENCE   9  (bases 1 to 2674)
  AUTHORS   Aprelikova,O., Xiong,Y. and Liu,E.T.
  TITLE     Both p16 and p21 families of cyclin-dependent kinase (CDK)
            inhibitors block the phosphorylation of cyclin-dependent kinases by
            the CDK-activating kinase
  JOURNAL   J Biol Chem 270 (31), 18195-18197 (1995)
   PUBMED   7629134
REFERENCE   10 (bases 1 to 2674)
  AUTHORS   Desai,D., Wessling,H.C., Fisher,R.P. and Morgan,D.O.
  TITLE     Effects of phosphorylation by CAK on cyclin binding by CDC2 and
            CDK2
  JOURNAL   Mol Cell Biol 15 (1), 345-350 (1995)
   PUBMED   7799941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BJ990268.1, AF091433.1 and
            DB547256.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_057749.2.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin forms a complex with and functions as a regulatory subunit
            of CDK2. This cyclin has been shown to specifically interact with
            CIP/KIP family of CDK inhibitors, and plays a role in cell cycle
            G1/S transition. The expression of this gene peaks at the G1-S
            phase and exhibits a pattern of tissue specificity distinct from
            that of cyclin E1. A significantly increased expression level of
            this gene was observed in tumor-derived cells. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1438125.1,
                                           SRR11853565.27872.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308108.9/ ENSP00000309181.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               BJ990268.1         54-583
            531-2659            AF091433.1         517-2645
            2660-2674           DB547256.1         400-414
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..2674
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /note="cyclin E2"
                     /db_xref="GeneID:9134"
                     /db_xref="HGNC:HGNC:1590"
                     /db_xref="MIM:603775"
     exon            1..25
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            26..65
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1266
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /codon_start=1
                     /product="G1/S-specific cyclin-E2"
                     /protein_id="NP_477097.1"
                     /db_xref="CCDS:CCDS6264.1"
                     /db_xref="GeneID:9134"
                     /db_xref="HGNC:HGNC:1590"
                     /db_xref="MIM:603775"
                     /translation="MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRRE
                     EVTKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPL
                     PDLSWGCSKEVWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHR
                     ETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGAC
                     SEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIA
                     QLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNV
                     VKSTSPVKLKTFKKIPMEDRHNIQTHTNYLAMLEEVNYINTFRKGGQLSPVCNGGIMT
                     PPKSTEKPPGKH"
     exon            66..162
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            163..216
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..368
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..504
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..651
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..747
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..882
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..994
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1152
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..2674
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="CCNE2"
                     /gene_synonym="CYCE2"
                     /note="major polyA site"
ORIGIN      
        1 gagccgagcg gtagctggtc tggcgaggtt ttatacacct gaaagaagag aatgtcaaga
       61 cgaagtagcc gtttacaagc taagcagcag ccccagccca gccagacgga atccccccaa
      121 gaagcccaga taatccaggc caagaagagg aaaactaccc aggatgtcaa aaaaagaaga
      181 gaggaggtca ccaagaaaca tcagtatgaa attaggaatt gttggccacc tgtattatct
      241 ggggggatca gtccttgcat tatcattgaa acacctcaca aagaaatagg aacaagtgat
      301 ttctccagat ttacaaatta cagatttaaa aatcttttta ttaatccttc acctttgcct
      361 gatttaagct ggggatgttc aaaagaagtc tggctaaaca tgttaaaaaa ggagagcaga
      421 tatgttcatg acaaacattt tgaagttctg cattctgact tggaaccaca gatgaggtcc
      481 atacttctag actggctttt agaggtatgt gaagtataca cacttcatag ggaaacattt
      541 tatcttgcac aagacttttt tgatagattt atgttgacac aaaaggatat aaataaaaat
      601 atgcttcaac tcattggaat tacctcatta ttcattgctt ccaaacttga ggaaatctat
      661 gctcctaaac tccaagagtt tgcttacgtc actgatggtg cttgcagtga agaggatatc
      721 ttaaggatgg aactcattat attaaaggct ttaaaatggg aactttgtcc tgtaacaatc
      781 atctcctggc taaatctctt tctccaagtt gatgctctta aagatgctcc taaagttctt
      841 ctacctcagt attctcagga aacattcatt caaatagctc agcttttaga tctgtgtatt
      901 ctagccattg attcattaga gttccagtac agaatactga ctgctgctgc cttgtgccat
      961 tttacctcca ttgaagtggt taagaaagcc tcaggtttgg agtgggacag tatttcagaa
     1021 tgtgtagatt ggatggtacc ttttgtcaat gtagtaaaaa gtactagtcc agtgaagctg
     1081 aagactttta agaagattcc tatggaagac agacataata tccagacaca tacaaactat
     1141 ttggctatgc tggaggaagt aaattacata aacaccttca gaaaaggggg acagttgtca
     1201 ccagtgtgca atggaggcat tatgacacca ccgaagagca ctgaaaaacc accaggaaaa
     1261 cactaaagaa gataactaag caaacaagtt ggaattcacc aagattgggt agaactggta
     1321 tcactgaact actaaagttt tacagaaagt agtgctgtga ttgattgccc tagccaattc
     1381 acaagttaca ctgccattct gattttaaaa cttacaattg gcactaaaga atacatttaa
     1441 ttatttccta tgttagctgt taaagaaaca gcaggacttg tttacaaaga tgtcttcatt
     1501 cccaaggtta ctggatagaa gccaaccaca gtctatacca tagcaatgtt tttcctttaa
     1561 tccagtgtta ctgtgtttat cttgataaac taggaatttt gtcactggag ttttggactg
     1621 gataagtgct accttaaagg gtatactaag tgatacagta ctttgaatct agttgttaga
     1681 ttctcaaaat tcctacactc ttgactagtg caatttggtt cttgaaaatt aaatttaaac
     1741 ttgtttacaa aggtttagtt ttgtaataag gtgactaatt tatctatagc tgctatagca
     1801 agctattata aaacttgaat ttctacaaat ggtgaaattt aatgtttttt aaactagttt
     1861 atttgccttg ccataacaca ttttttaact aataaggctt agatgaacat ggtgttcaac
     1921 ctgtgctcta aacagtggga gtaccaaaga aattataaac aagataaatg ctgtggctcc
     1981 ttcctaactg gggctttctt gacatgtagg ttgcttggta ataacctttt tgtatatcac
     2041 aatttgggtg aaaaacttaa gtaccctttc aaactattta tatgaggaag tcactttact
     2101 actctaagat atccctaagg aatttttttt tttaatttag tgtgactaag gctttattta
     2161 tgtttgtgaa actgttaagg tcctttctaa attcctccat tgtgagataa ggacagtgtc
     2221 aaagtgataa agcttaacac ttgacctaaa cttctatttt cttaaggaag aagagtatta
     2281 aatatatact gactcctaga aatctattta ttaaaaaaag acatgaaaac ttgctgtaca
     2341 taggctagct atttctaaat attttaaatt agcttttcta aaaaaaaaat ccagcctcat
     2401 aaagtagatt agaaaactag attgctagtt tattttgtta tcagatatgt gaatctcttc
     2461 tccctttgaa gaaactatac atttattgtt acggtatgaa gtcttctgta tagtttgttt
     2521 ttaaactaat atttgtttca gtattttgtc tgaaaagaaa acaccactaa ttgtgtacat
     2581 atgtattata taaacttaac cttttaatac tgtttatttt tagcccattg tttaaaaaat
     2641 aaaagttaaa aaaatttaac tgcttaaaag taaa
//
