LOCUS       NM_001238               1954 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cyclin E1 (CCNE1), transcript variant 1, mRNA.
ACCESSION   NM_001238
VERSION     NM_001238.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Lee,S.J., Jeon,S.H., Cho,S., Kim,C.M., Yoo,J.K., Oh,S.H., Kim,J.H.,
            Yang,Y.D. and Kim,J.K.
  TITLE     hsa-miR-CHA2, a novel microRNA, exhibits anticancer effects by
            suppressing cyclin E1 in human non-small cell lung cancer cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167250 (2024)
   PUBMED   38763409
  REMARK    GeneRIF: hsa-miR-CHA2, a novel microRNA, exhibits anticancer
            effects by suppressing cyclin E1 in human non-small cell lung
            cancer cells.
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Marlin,R., Loger,J.S., Joachim,C., Ebring,C., Robert-Siegwald,G.,
            Pennont,S., Rose,M., Raguette,K., Suez-Panama,V.,
            Ulric-Gervaise,S., Lusbec,S., Bera,O., Vallard,A., Aline-Fardin,A.,
            Colomba,E. and Jean-Laurent,M.
  TITLE     Copy number signatures and CCNE1 amplification reveal the
            involvement of replication stress in high-grade endometrial tumors
            oncogenesis
  JOURNAL   Cell Oncol (Dordr) 47 (4), 1441-1457 (2024)
   PUBMED   38564163
  REMARK    GeneRIF: Copy number signatures and CCNE1 amplification reveal the
            involvement of replication stress in high-grade endometrial tumors
            oncogenesis.
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Rustgi,N., Wu,S., Samec,T., Walker,P., Xiu,J., Lou,E., Goel,S.,
            Saeed,A. and Moy,R.H.
  TITLE     Molecular Landscape and Clinical Implication of CCNE1-amplified
            Esophagogastric Cancer
  JOURNAL   Cancer Res Commun 4 (6), 1399-1409 (2024)
   PUBMED   38717153
  REMARK    GeneRIF: Molecular Landscape and Clinical Implication of
            CCNE1-amplified Esophagogastric Cancer.
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Audrey,A., Kok,Y.P., Yu,S., de Haan,L., van de Kooij,B., van den
            Tempel,N., Chen,M., de Boer,H.R., van der Vegt,B. and van
            Vugt,M.A.T.M.
  TITLE     RAD52-dependent mitotic DNA synthesis is required for genome
            stability in Cyclin E1-overexpressing cells
  JOURNAL   Cell Rep 43 (4), 114116 (2024)
   PUBMED   38625790
  REMARK    GeneRIF: RAD52-dependent mitotic DNA synthesis is required for
            genome stability in Cyclin E1-overexpressing cells.
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Mumberg,D., Wick,M., Burger,C., Haas,K., Funk,M. and Muller,R.
  TITLE     Cyclin ET, a new splice variant of human cyclin E with a unique
            expression pattern during cell cycle progression and
            differentiation
  JOURNAL   Nucleic Acids Res 25 (11), 2098-2105 (1997)
   PUBMED   9153308
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Sewing,A., Ronicke,V., Burger,C., Funk,M. and Muller,R.
  TITLE     Alternative splicing of human cyclin E
  JOURNAL   J Cell Sci 107 (Pt 2), 581-588 (1994)
   PUBMED   8207080
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Koff,A., Giordano,A., Desai,D., Yamashita,K., Harper,J.W.,
            Elledge,S., Nishimoto,T., Morgan,D.O., Franza,B.R. and Roberts,J.M.
  TITLE     Formation and activation of a cyclin E-cdk2 complex during the G1
            phase of the human cell cycle
  JOURNAL   Science 257 (5077), 1689-1694 (1992)
   PUBMED   1388288
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Hinds,P.W., Mittnacht,S., Dulic,V., Arnold,A., Reed,S.I. and
            Weinberg,R.A.
  TITLE     Regulation of retinoblastoma protein functions by ectopic
            expression of human cyclins
  JOURNAL   Cell 70 (6), 993-1006 (1992)
   PUBMED   1388095
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Koff,A., Cross,F., Fisher,A., Schumacher,J., Leguellec,K.,
            Philippe,M. and Roberts,J.M.
  TITLE     Human cyclin E, a new cyclin that interacts with two members of the
            CDC2 gene family
  JOURNAL   Cell 66 (6), 1217-1228 (1991)
   PUBMED   1833068
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Lew,D.J., Dulic,V. and Reed,S.I.
  TITLE     Isolation of three novel human cyclins by rescue of G1 cyclin (Cln)
            function in yeast
  JOURNAL   Cell 66 (6), 1197-1206 (1991)
   PUBMED   1833066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008798.10, AK291549.1,
            BC035498.2 and BQ018270.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001238.3.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin forms a complex with and functions as a regulatory subunit
            of CDK2, whose activity is required for cell cycle G1/S transition.
            This protein accumulates at the G1-S phase boundary and is degraded
            as cells progress through S phase. Overexpression of this gene has
            been observed in many tumors, which results in chromosome
            instability, and thus may contribute to tumorigenesis. This protein
            was found to associate with, and be involved in, the
            phosphorylation of NPAT protein (nuclear protein mapped to the ATM
            locus), which participates in cell-cycle regulated histone gene
            expression and plays a critical role in promoting cell-cycle
            progression in the absence of pRB. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1, also known as cyclin EL)
            encodes isoform 1, also known as isoform E1L.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.439579.1, BC035498.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262643.8/ ENSP00000262643.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC008798.10        38007-38009
            4-1662              AK291549.1         1-1659
            1663-1950           BC035498.2         1650-1937
            1951-1954           BQ018270.1         24-27               c
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1954
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /note="cyclin E1"
                     /db_xref="GeneID:898"
                     /db_xref="HGNC:HGNC:1589"
                     /db_xref="MIM:123837"
     exon            1..162
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..209
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1419
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     G1/S-specific cyclin-E1"
                     /codon_start=1
                     /product="G1/S-specific cyclin-E1 isoform 1"
                     /protein_id="NP_001229.1"
                     /db_xref="CCDS:CCDS12419.1"
                     /db_xref="GeneID:898"
                     /db_xref="HGNC:HGNC:1589"
                     /db_xref="MIM:123837"
                     /translation="MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDE
                     EMAKIDRTARDQCGSQPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRG
                     SPLPVLSWANREEVWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYK
                     LHRETFYLAQDFFDRYMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTD
                     GACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFI
                     QIAELLDLCVLDVDCLEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPF
                     AMVIRETGSSKLKHFRGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSG
                     LLTPPQSGKKQSSGPEMA"
     exon            210..297
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..366
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..512
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..648
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..795
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..891
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1026
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1138
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1296
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1954
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /note="hexamer: AATAAA"
     polyA_site      1954
                     /gene="CCNE1"
                     /gene_synonym="CCNE; pCCNE1"
                     /note="major polyA site"
ORIGIN      
        1 aggagcagcc ggcgcggccg ccagcgcggt gtagggggca ggcgcggatc ccgccaccgc
       61 cgcgcgctcg gcccgccgac tcccggcgcc gccgccgcca ctgccgtcgc cgccgccgcc
      121 tgccgggact ggagcgcgcc gtccgccgcg gacaagaccc tggcctcagg ccggagcagc
      181 cccatcatgc cgagggagcg cagggagcgg gatgcgaagg agcgggacac catgaaggag
      241 gacggcggcg cggagttctc ggctcgctcc aggaagagga aggcaaacgt gaccgttttt
      301 ttgcaggatc cagatgaaga aatggccaaa atcgacagga cggcgaggga ccagtgtggg
      361 agccagcctt gggacaataa tgcagtctgt gcagacccct gctccctgat ccccacacct
      421 gacaaagaag atgatgaccg ggtttaccca aactcaacgt gcaagcctcg gattattgca
      481 ccatccagag gctccccgct gcctgtactg agctgggcaa atagagagga agtctggaaa
      541 atcatgttaa acaaggaaaa gacatactta agggatcagc actttcttga gcaacaccct
      601 cttctgcagc caaaaatgcg agcaattctt ctggattggt taatggaggt gtgtgaagtc
      661 tataaacttc acagggagac cttttacttg gcacaagatt tctttgaccg gtatatggcg
      721 acacaagaaa atgttgtaaa aactctttta cagcttattg ggatttcatc tttatttatt
      781 gcagccaaac ttgaggaaat ctatcctcca aagttgcacc agtttgcgta tgtgacagat
      841 ggagcttgtt caggagatga aattctcacc atggaattaa tgattatgaa ggcccttaag
      901 tggcgtttaa gtcccctgac tattgtgtcc tggctgaatg tatacatgca ggttgcatat
      961 ctaaatgact tacatgaagt gctactgccg cagtatcccc agcaaatctt tatacagatt
     1021 gcagagctgt tggatctctg tgtcctggat gttgactgcc ttgaatttcc ttatggtata
     1081 cttgctgctt cggccttgta tcatttctcg tcatctgaat tgatgcaaaa ggtttcaggg
     1141 tatcagtggt gcgacataga gaactgtgtc aagtggatgg ttccatttgc catggttata
     1201 agggagacgg ggagctcaaa actgaagcac ttcaggggcg tcgctgatga agatgcacac
     1261 aacatacaga cccacagaga cagcttggat ttgctggaca aagcccgagc aaagaaagcc
     1321 atgttgtctg aacaaaatag ggcttctcct ctccccagtg ggctcctcac cccgccacag
     1381 agcggtaaga agcagagcag cgggccggaa atggcgtgac caccccatcc ttctccacca
     1441 aagacagttg cgcgcctgct ccacgttctc ttctgtctgt tgcagcggag gcgtgcgttt
     1501 gcttttacag atatctgaat ggaagagtgt ttcttccaca acagaagtat ttctgtggat
     1561 ggcatcaaac agggcaaagt gttttttatt gaatgcttat aggttttttt taaataagtg
     1621 ggtcaagtac accagccacc tccagacacc agtgcgtgct cccgatgctg ctatggaagg
     1681 tgctacttga cctaagggac tcccacaaca acaaaagctt gaagctgtgg agggccacgg
     1741 tggcgtggct ctcctcgcag gtgttctggg ctccgttgta ccaagtggag caggtggttg
     1801 cgggcaagcg ttgtgcagag cccatagcca gctgggcagg gggctgccct ctccacatta
     1861 tcagttgaca gtgtacaatg cctttgatga actgttttgt aagtgctgct atatctatcc
     1921 attttttaat aaagataata ctgtttttga gaca
//
