LOCUS       NM_012142               3515 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin D1 binding protein 1 (CCNDBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_012142
VERSION     NM_012142.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3515)
  AUTHORS   Shi,Q., Ruan,J., Yang,Y.C., Shi,X.Q., Liu,S.D., Wang,H.Y.,
            Zhang,S.J., Wang,S.Q., Zhong,L. and Sun,C.
  TITLE     rs66651343 and rs12909095 confer lung cancer risk by regulating
            CCNDBP1 expression
  JOURNAL   PLoS One 18 (4), e0284347 (2023)
   PUBMED   37058478
  REMARK    GeneRIF: rs66651343 and rs12909095 confer lung cancer risk by
            regulating CCNDBP1 expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3515)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 3515)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3515)
  AUTHORS   Fujita,H., Aratani,S. and Nakajima,T.
  TITLE     Grap2 cyclin D interacting protein negatively regulates
            CREB-binding protein, inhibiting fibroblast-like synoviocyte growth
  JOURNAL   Mol Med Rep 23 (4) (2021)
   PUBMED   33576455
  REMARK    GeneRIF: Grap2 cyclin D interacting protein negatively regulates
            CREBbinding protein, inhibiting fibroblastlike synoviocyte growth.
REFERENCE   5  (bases 1 to 3515)
  AUTHORS   Dgany,O., Avidan,N., Delaunay,J., Krasnov,T., Shalmon,L.,
            Shalev,H., Eidelitz-Markus,T., Kapelushnik,J., Cattan,D.,
            Pariente,A., Tulliez,M., Cretien,A., Schischmanoff,P.O.,
            Iolascon,A., Fibach,E., Koren,A., Rossler,J., Le Merrer,M.,
            Yaniv,I., Zaizov,R., Ben-Asher,E., Olender,T., Lancet,D.,
            Beckmann,J.S. and Tamary,H.
  TITLE     Congenital dyserythropoietic anemia type I is caused by mutations
            in codanin-1
  JOURNAL   Am J Hum Genet 71 (6), 1467-1474 (2002)
   PUBMED   12434312
REFERENCE   6  (bases 1 to 3515)
  AUTHORS   Chang,M.S., Chen,C.Y., Yeh,H.I., Fan,C.C., Huang,C.J. and Yang,Y.C.
  TITLE     Cloning, expression, and genomic organization of mouse mp29 gene
  JOURNAL   Biochem Biophys Res Commun 299 (2), 241-246 (2002)
   PUBMED   12437976
REFERENCE   7  (bases 1 to 3515)
  AUTHORS   Chang,M.S., Chang,C.L., Huang,C.J. and Yang,Y.C.
  TITLE     p29, a novel GCIP-interacting protein, localizes in the nucleus
  JOURNAL   Biochem Biophys Res Commun 279 (2), 732-737 (2000)
   PUBMED   11118353
REFERENCE   8  (bases 1 to 3515)
  AUTHORS   Terai,S., Aoki,H., Ashida,K. and Thorgeirsson,S.S.
  TITLE     Human homologue of maid: A dominant inhibitory helix-loop-helix
            protein associated with liver-specific gene expression
  JOURNAL   Hepatology 32 (2), 357-366 (2000)
   PUBMED   10915743
REFERENCE   9  (bases 1 to 3515)
  AUTHORS   Xia,C., Bao,Z., Tabassam,F., Ma,W., Qiu,M., Hua,S. and Liu,M.
  TITLE     GCIP, a novel human grap2 and cyclin D interacting protein,
            regulates E2F-mediated transcriptional activity
  JOURNAL   J Biol Chem 275 (27), 20942-20948 (2000)
   PUBMED   10801854
REFERENCE   10 (bases 1 to 3515)
  AUTHORS   Yao,Y., Doki,Y., Jiang,W., Imoto,M., Venkatraj,V.S., Warburton,D.,
            Santella,R.M., Lu,B., Yan,L., Sun,X.H., Su,T., Luo,J. and
            Weinstein,I.B.
  TITLE     Cloning and characterization of DIP1, a novel protein that is
            related to the Id family of proteins
  JOURNAL   Exp Cell Res 257 (1), 22-32 (2000)
   PUBMED   10854051
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA210890.1, AF132034.1,
            AC068724.7 and AI953224.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012142.4.
            
            Summary: This gene was identified by the interaction of its gene
            product with Grap2, a leukocyte-specific adaptor protein important
            for immune cell signaling. The protein encoded by this gene was
            shown to interact with cyclin D. Transfection of this gene in cells
            was reported to reduce the phosphorylation of Rb gene product by
            cyclin D-dependent protein kinase, and inhibit E2F1-mediated
            transcription activity. This protein was also found to interact
            with helix-loop-helix protein E12 and is thought to be a negative
            regulator of liver-specific gene expression. Several alternatively
            spliced variants have been found for this gene. [provided by
            RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.484140.1,
                                           SRR1803613.266684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300213.9/ ENSP00000300213.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA210890.1         286-335
            51-1536             AF132034.1         1-1486
            1537-3456           AC068724.7         134735-136654
            3457-3515           AI953224.1         20-78               c
FEATURES             Location/Qualifiers
     source          1..3515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2"
     gene            1..3515
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /note="cyclin D1 binding protein 1"
                     /db_xref="GeneID:23582"
                     /db_xref="HGNC:HGNC:1587"
                     /db_xref="MIM:607089"
     exon            1..205
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1179
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /note="human homolog of Maid; grap2 and
                     cyclin-D-interacting protein; cyclin D-type
                     binding-protein 1; D-type cyclin-interacting protein 1"
                     /codon_start=1
                     /product="cyclin-D1-binding protein 1"
                     /protein_id="NP_036274.3"
                     /db_xref="CCDS:CCDS10092.1"
                     /db_xref="GeneID:23582"
                     /db_xref="HGNC:HGNC:1587"
                     /db_xref="MIM:607089"
                     /translation="MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETT
                     EEFNREMFWRRLNEAAVTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAV
                     YYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQ
                     QMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNH
                     EDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDD
                     IVDISDEISPSVDDLALSIYPPMCHLTVRINSAKLVSVLKKALEITKASHVTPQPEDS
                     WIPLLINAIDHCMNRIKELTQSELEL"
     exon            206..265
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            266..345
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            346..427
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            428..524
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            525..598
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            599..675
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            676..956
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1017
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1064
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..3515
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1508..1513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /note="hexamer: AATAAA"
     polyA_site      1536
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /note="major polyA site"
     regulatory      3491..3496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /note="hexamer: AATAAA"
     polyA_site      3515
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
ORIGIN      
        1 cttgacgctg tggcccggaa gtggagcggc tgtcgcagtg cggctccggc agtggcagcg
       61 gaggcctgtg tttgcggcct tcggcaagcg actgagatgg cgagcgcaac tgcacctgca
      121 gccgcagtcc ccaccctggc ttcgcctttg gagcagctcc ggcacttggc ggaggagctg
      181 cggttgctcc tgcctcgagt gcgggtcggc gaagcccagg agaccaccga ggagtttaat
      241 cgagagatgt tctggagaag actcaatgag gcagctgtga ctgtgtcaag ggaagccacg
      301 actctgacca tagtcttctc tcagcttcca ctgccgtctc cacaggaaac ccagaagttc
      361 tgtgaacaag tccatgctgc catcaaggca tttattgcag tgtactattt gcttccaaag
      421 gatcagggga tcaccctgag aaagctggta cggggcgcca ccctggacat cgtggatggc
      481 atggctcagc tcatggaagt actttccgtc actccaactc agagccctga gaacaatgac
      541 cttatttcct acaacagtgt ctgggttgcg tgccagcaga tgcctcagat accaagagat
      601 aacaaagctg cagctctttt gatgctgacc aagaatgtgg attttgtgaa ggatgcacat
      661 gaagaaatgg agcaggctgt ggaagaatgt gacccttact ctggcctctt gaatgatact
      721 gaggagaaca actctgacaa ccacaatcat gaggatgatg tgttggggtt tcccagcaat
      781 caggacttgt attggtcaga ggacgatcaa gagctcataa tcccatgcct tgcgctggtg
      841 agagcatcca aagcctgcct gaagaaaatt cggatgttag tggcagagaa tgggaagaag
      901 gatcaggtgg cacagctgga tgacattgtg gatatttctg atgaaatcag ccctagtgtg
      961 gatgatttgg ctctgagcat atatccacct atgtgtcacc tgaccgtgcg aatcaattct
     1021 gcgaaacttg tatctgtttt aaagaaggca cttgaaatta caaaagcaag tcatgtgacc
     1081 cctcagccag aagatagttg gatcccttta cttattaatg ccattgatca ttgcatgaat
     1141 agaatcaagg agctcactca gagtgaactt gaattatgac ttttcaggct catttgtact
     1201 ctcttcccct ctcatcgtca tggtcaggct ctgatacctg cttttaaaat ggagctagaa
     1261 tgcttgctgg attgaaaggg agtgcctatc tatatttagc aagagacact attaccaaag
     1321 attgttggtt aggccagatt gacacctatt tataaaccat atgcgtatat ttttctgtgc
     1381 tatatatgaa aaataattgc atgatttctc attcctgagt catttctcag agattcctag
     1441 gaaagctgcc ttattctctt tttgcagtaa agtatgttgt tttcattgta aagatgttga
     1501 tggtctcaat aaaatgctaa cttgccagtg attaaatgag tgcccttcca aagtttcttt
     1561 ttaccagaaa tacagtggat tgagactaga acattgcttt catttgggtt tgtaggttta
     1621 aaaatctgat tctaatcaga agtatattta gaacaaaaca ctttatttat aaaagatgac
     1681 tccaaaattc atcttagtat ttcaccatgt tatatattat tatcagcaag tccttctgaa
     1741 tattatcaca gattactcca tgtctctaaa atatattggc attgagctca tttgttaggt
     1801 ttgcccacct tattgaacag atttattttc cttatacata cttgtgttgt ccttggttac
     1861 gtgtgtcccc aaatgtaaat accaaatttt tataaatcaa aaatttttta gtgtgtaaga
     1921 gattttatgt aattttaagg gccttttcag ttcatccttt tgcaaaacca tcaccactta
     1981 attatacttt tgcatcagtc tagaagactg catattggaa agcagtgtaa atctataatg
     2041 atgtatattc tggtgagctg aatagggcat tatgcatgtc ctacaggtct ccgccacctc
     2101 tcatgcccat catcttcctt ttgtaggtgt aattcataac atatgccttt ctgctgtctt
     2161 taggtataat cagcaacagc agtcattctt tgagtgacta atgtatactt ggggttgggg
     2221 ttgaaattcc ttaagccaaa tgagttttag cttactgttt tgaagtgcca ttttgtattg
     2281 ttaacaagtg tcatgaaggg aaggaactaa aatcaaactg acagagtgtc aaggcaacaa
     2341 aataacataa acaaaataat aacattgtac aacagtctag ttcttttatc ctttcatata
     2401 gagcctattt tttatatact tttatatttc tctactggac caaattcatg ttattaacat
     2461 cagactttaa ttgtgggata cttaatgaat atagaactct aatataaaga cttacctcta
     2521 gctgaattat tctctcaggt cctgtattgt ataacttcgt tcagtcatgt ttggatcttt
     2581 aaggataatg atcagggaaa gcactgatca atgtaatttt tttttttttt tttttttttt
     2641 tgagatggag tcttgctctg tcccccaagc tggagtgcag tggcacactc tcggctcact
     2701 gcaacctccg cctcccaggt tctcaagcaa ttctctggct tcagcctctc aagtagctgg
     2761 gactacagat gcacaccacc atgtccagct aatttttgta tttttagtag agatggggtt
     2821 tcaccatgtt ggccaggctg gtctcaaact cctgacctca ggtgatctgc ccacgtcagc
     2881 ctcccaaagt gctgggatta cagatgtgag ccaccgagcc cagcttgatc aatgtaattt
     2941 taagattacc taaaaattcc attttgggat aatatcccac ttcatcagaa atattagaat
     3001 gatttaagtg ttaggtcctt tcccttatct gtaagttaat gaatgtatta atgagcagta
     3061 aaatggttgc aaaaaacctg aacctgaaca atctgaatgt actccttaaa ggtatctgag
     3121 caccttttca acctgaatga ctactcattt atctgataaa gtgatgtagt ttggatattc
     3181 aaccctgcaa acctcatgct gaaattggat tcccagtgtt ggaggtgggg cctaatggga
     3241 ggtgtttgga tccctcatga atggcttcgt tccattggtg gggtaatgag taagttctcg
     3301 ctctatatgt ccctccccca ccccagagct ggctgttaaa acgaggctgg cacctggcac
     3361 ttacccctac ccctcaaccc attcttgccc tgtgatctct gctcacgttg cctcccttca
     3421 tcttcctgca taagtggaag cagcctgaag ccctcactgt ttcttgtaca gcctgcagag
     3481 ccgtgagcca aataaagctc ttttctttta aacta
//
