LOCUS       NM_001760               2026 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cyclin D3 (CCND3), transcript variant 2, mRNA.
ACCESSION   NM_001760
VERSION     NM_001760.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2026)
  AUTHORS   Zhou,D., Liu,T., Rao,X., Jie,X., Chen,Y., Wu,Z., Deng,H., Zhang,D.,
            Wang,J. and Wu,G.
  TITLE     Targeting diacylglycerol kinase alpha impairs lung tumorigenesis by
            inhibiting cyclin D3
  JOURNAL   Thorac Cancer 14 (13), 1179-1191 (2023)
   PUBMED   36965165
  REMARK    GeneRIF: Targeting diacylglycerol kinase alpha impairs lung
            tumorigenesis by inhibiting cyclin D3.
REFERENCE   2  (bases 1 to 2026)
  AUTHORS   Gupta,R.K. and Mlcochova,P.
  TITLE     Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions
            and interferes with viral spread
  JOURNAL   EMBO J 41 (22), e111653 (2022)
   PUBMED   36161661
  REMARK    GeneRIF: Cyclin D3 restricts SARS-CoV-2 envelope incorporation into
            virions and interferes with viral spread.
REFERENCE   3  (bases 1 to 2026)
  AUTHORS   Sharma,P., Tiufekchiev,S., Lising,V., Chung,S.W., Suk,J.S. and
            Chung,B.M.
  TITLE     Keratin 19 interacts with GSK3beta to regulate its nuclear
            accumulation and degradation of cyclin D3
  JOURNAL   Mol Biol Cell 32 (21), ar21 (2021)
   PUBMED   34406791
  REMARK    GeneRIF: Keratin 19 interacts with GSK3beta to regulate its nuclear
            accumulation and degradation of cyclin D3.
REFERENCE   4  (bases 1 to 2026)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   5  (bases 1 to 2026)
  AUTHORS   Smith,C.C., Viny,A.D., Massi,E., Kandoth,C., Socci,N.D.,
            Rapaport,F., Najm,M., Medina-Martinez,J.S., Papaemmanuil,E.,
            Tarver,T.C., Hsu,H.H., Le,M.H., West,B., Bollag,G., Taylor,B.S.,
            Levine,R.L. and Shah,N.P.
  TITLE     Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3
            Inhibitors in Acute Myeloid Leukemia
  JOURNAL   Clin Cancer Res 27 (14), 4003-4011 (2021)
   PUBMED   34103301
  REMARK    GeneRIF: Recurrent Mutations in Cyclin D3 Confer Clinical
            Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.
REFERENCE   6  (bases 1 to 2026)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   7  (bases 1 to 2026)
  AUTHORS   Motokura,T., Keyomarsi,K., Kronenberg,H.M. and Arnold,A.
  TITLE     Cloning and characterization of human cyclin D3, a cDNA closely
            related in sequence to the PRAD1/cyclin D1 proto-oncogene
  JOURNAL   J Biol Chem 267 (28), 20412-20415 (1992)
   PUBMED   1383201
REFERENCE   8  (bases 1 to 2026)
  AUTHORS   Xiong,Y., Menninger,J., Beach,D. and Ward,D.C.
  TITLE     Molecular cloning and chromosomal mapping of CCND genes encoding
            human D-type cyclins
  JOURNAL   Genomics 13 (3), 575-584 (1992)
   PUBMED   1386336
REFERENCE   9  (bases 1 to 2026)
  AUTHORS   Inaba,T., Matsushime,H., Valentine,M., Roussel,M.F., Sherr,C.J. and
            Look,A.T.
  TITLE     Genomic organization, chromosomal localization, and independent
            expression of human cyclin D genes
  JOURNAL   Genomics 13 (3), 565-574 (1992)
   PUBMED   1386335
REFERENCE   10 (bases 1 to 2026)
  AUTHORS   Motokura,T., Yi,H.F., Kronenberg,H.M., McBride,O.W. and Arnold,A.
  TITLE     Assignment of the human cyclin D3 gene (CCND3) to chromosome
            6p----q13
  JOURNAL   Cytogenet Cell Genet 61 (1), 5-7 (1992)
   PUBMED   1387066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M92287.1, AK057206.1,
            AL160163.24 and BC011616.2.
            
            On Dec 4, 2019 this sequence version replaced NM_001760.4.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin forms a complex with and functions as a regulatory subunit
            of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S
            transition. This protein has been shown to interact with and be
            involved in the phosphorylation of tumor suppressor protein Rb. The
            CDK4 activity associated with this cyclin was reported to be
            necessary for cell cycle progression through G2 phase into mitosis
            after UV radiation. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2008].
            
            Transcript Variant: This variant (2) encodes isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011616.2, M92287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372991.9/ ENSP00000362082.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1360              M92287.1           7-1366
            1361-1708           AK057206.1         1192-1539
            1709-1709           AL160163.24        100842-100842       c
            1710-2022           AK057206.1         1541-1853
            2023-2026           BC011616.2         1945-1948
FEATURES             Location/Qualifiers
     source          1..2026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2026
                     /gene="CCND3"
                     /note="cyclin D3"
                     /db_xref="GeneID:896"
                     /db_xref="HGNC:HGNC:1585"
                     /db_xref="MIM:123834"
     exon            1..357
                     /gene="CCND3"
                     /inference="alignment:Splign:2.1.0"
     exon            358..573
                     /gene="CCND3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..733
                     /gene="CCND3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..870
                     /gene="CCND3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..2026
                     /gene="CCND3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCND3"
                     /note="hexamer: AATAAA"
     polyA_site      2026
                     /gene="CCND3"
                     /note="major polyA site"
ORIGIN      
        1 gtcagggaag cggcgcgcgc gcgcgggcgg cgggcgggct ggggatccgc cgcgcagtgc
       61 cagcgccagc gccagacccg cgccccgcgc tctccggccc gtcgcctgcc ttgggactcg
      121 cgagcccgca ctcccgccct gcctgttcgc tgcccgagta tggagctgct gtgttgcgaa
      181 ggcacccggc acgcgccccg ggccgggccg gacccgcggc tgctggggga ccagcgtgtc
      241 ctgcagagcc tgctccgcct ggaggagcgc tacgtacccc gcgcctccta cttccagtgc
      301 gtgcagcggg agatcaagcc gcacatgcgg aagatgctgg cttactggat gctggaggta
      361 tgtgaggagc agcgctgtga ggaggaagtc ttccccctgg ccatgaacta cctggatcgc
      421 tacctgtctt gcgtccccac ccgaaaggcg cagttgcagc tcctgggtgc ggtctgcatg
      481 ctgctggcct ccaagctgcg cgagaccacg cccctgacca tcgaaaaact gtgcatctac
      541 accgaccacg ctgtctctcc ccgccagttg cgggactggg aggtgctggt cctagggaag
      601 ctcaagtggg acctggctgc tgtgattgca catgatttcc tggccttcat tctgcaccgg
      661 ctctctctgc cccgtgaccg acaggccttg gtcaaaaagc atgcccagac ctttttggcc
      721 ctctgtgcta cagattatac ctttgccatg tacccgccat ccatgatcgc cacgggcagc
      781 attggggctg cagtgcaagg cctgggtgcc tgctccatgt ccggggatga gctcacagag
      841 ctgctggcag ggatcactgg cactgaagtg gactgcctgc gggcctgtca ggagcagatc
      901 gaagctgcac tcagggagag cctcagggaa gcctctcaga ccagctccag cccagcgccc
      961 aaagcccccc ggggctccag cagccaaggg cccagccaga ccagcactcc tacagatgtc
     1021 acagccatac acctgtagcc ctggagaggc cctctggagt ggccactaag cagaggaggg
     1081 gccgctgcca cccacctccc tgcctccagg aaccacacca catctaagcc tgaaggggcg
     1141 tctgttcccc cttcacaaag cccaagggat ctggtcctac ccatccccgc agtgtgcact
     1201 aaggggcccg gccagccatg tctgcatttc ggtggctagt caagctcctc ctccctgcat
     1261 ctgaccagca gcgcctttcc caactctagc tgggggtggg ccaggctgat gggacagaat
     1321 tggatacata caccagcatt ccttttgaac gccccccccc acccctgggg gctctcatgt
     1381 tttcaactgc caaaatgctc tagtgccttc taaaggtgtt gtcccttcta gggttattgc
     1441 atttggattg gggtccctct aaaatttaat gcatgataga cacatatgag ggggaatagt
     1501 ctagatggct cctctcagta ctttggaggc ccctatgtag tccgtgctga cagctgctcc
     1561 tagagggagg ggcctaggcc tcagccagag aagctataaa ttcctctttg ctttgctttc
     1621 tgctcagctt ctcctgtgtg attgacagct ttgctgctga aggctcattt taatttatta
     1681 attgctttga gcacaacttt aagaggacat aatggggtcc tggccatccc acaagtggtg
     1741 gtaaccctgg tggttgctgt tttcctccct tctgctactg gcaaaaggat ctttgtggcc
     1801 aaggagctgc tatagcctgg ggtggggtca tgccctcctc tcccattgtc cctctgcccc
     1861 atcctccagc agggaaaatg cagcagggat gccctggagg tggctgagcc cctgtctaga
     1921 gagggaggca agccctgttg acacaggtct ttcctaaggc tgcaaggttt aggctggtgg
     1981 cccaggacca tcatcctact gtaataaaga tgattgtgaa ataaaa
//
