LOCUS       NM_001759               6493 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens cyclin D2 (CCND2), mRNA.
ACCESSION   NM_001759
VERSION     NM_001759.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6493)
  AUTHORS   Wang,Q., Song,B., Hao,S., Xiao,Z., Jin,L., Zheng,T. and Chai,F.
  TITLE     [Bioinformatic analysis of CCND2 expression in papillary thyroid
            carcinoma and its impact on immune infiltration]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (5), 981-988 (2024)
   PUBMED   38862457
  REMARK    GeneRIF: [Bioinformatic analysis of CCND2 expression in papillary
            thyroid carcinoma and its impact on immune infiltration].
REFERENCE   2  (bases 1 to 6493)
  AUTHORS   Tang,Y., Zhang,X., Wang,S., Liu,L., Wang,Q., Liu,Y., Yu,Y. and
            Zhai,Q.
  TITLE     Up-regulation of lncRNA WT1-AS ameliorates Abeta-stimulated
            neuronal injury through modulation of miR-186-5p/CCND2 axis in
            Alzheimer's disease
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 200-206 (2024)
   PUBMED   38372094
  REMARK    GeneRIF: Up-regulation of lncRNA WT1-AS ameliorates
            Abeta-stimulated neuronal injury through modulation of
            miR-186-5p/CCND2 axis in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6493)
  AUTHORS   Luo,K., Zhao,X., Shan,Y., Wang,X., Xu,Y., Chen,M., Wang,Q. and
            Song,Y.
  TITLE     GABA regulates the proliferation and apoptosis of head and neck
            squamous cell carcinoma cells by promoting the expression of CCND2
            and BCL2L1
  JOURNAL   Life Sci 334, 122191 (2023)
   PUBMED   37866807
  REMARK    GeneRIF: GABA regulates the proliferation and apoptosis of head and
            neck squamous cell carcinoma cells by promoting the expression of
            CCND2 and BCL2L1.
REFERENCE   4  (bases 1 to 6493)
  AUTHORS   Zhang,H., Yuan,N., Che,H. and Cheng,X.
  TITLE     MiR-188-5p inhibits cell proliferation and migration in ovarian
            cancer via competing for CCND2 with ELAVL1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (3), 69-74 (2023)
   PUBMED   37300687
  REMARK    GeneRIF: MiR-188-5p inhibits cell proliferation and migration in
            ovarian cancer via competing for CCND2 with ELAVL1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6493)
  AUTHORS   Ji,G., Wang,X. and Xi,H.
  TITLE     METTL3-mediated m6A modification of lncRNA SNHG3 accelerates
            gastric cancer progression by modulating miR-186-5p/cyclinD2 axis
  JOURNAL   Int J Immunopathol Pharmacol 37, 3946320231204694 (2023)
   PUBMED   37823387
  REMARK    GeneRIF: METTL3-mediated m[6]A modification of lncRNA SNHG3
            accelerates gastric cancer progression by modulating
            miR-186-5p/cyclinD2 axis.
REFERENCE   6  (bases 1 to 6493)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   7  (bases 1 to 6493)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   8  (bases 1 to 6493)
  AUTHORS   Mirzaa,G.
  TITLE     MPPH Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27854409
REFERENCE   9  (bases 1 to 6493)
  AUTHORS   Xiong,Y., Menninger,J., Beach,D. and Ward,D.C.
  TITLE     Molecular cloning and chromosomal mapping of CCND genes encoding
            human D-type cyclins
  JOURNAL   Genomics 13 (3), 575-584 (1992)
   PUBMED   1386336
REFERENCE   10 (bases 1 to 6493)
  AUTHORS   Inaba,T., Matsushime,H., Valentine,M., Roussel,M.F., Sherr,C.J. and
            Look,A.T.
  TITLE     Genomic organization, chromosomal localization, and independent
            expression of human cyclin D genes
  JOURNAL   Genomics 13 (3), 565-574 (1992)
   PUBMED   1386335
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006122.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001759.3.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin forms a complex with CDK4 or CDK6 and functions as a
            regulatory subunit of the complex, whose activity is required for
            cell cycle G1/S transition. This protein has been shown to interact
            with and be involved in the phosphorylation of tumor suppressor
            protein Rb. Knockout studies of the homologous gene in mouse
            suggest the essential roles of this gene in ovarian granulosa and
            germ cell proliferation. High level expression of this gene was
            observed in ovarian and testicular tumors. Mutations in this gene
            are associated with
            megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3
            (MPPH3). [provided by RefSeq, Sep 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.226687.1, D13639.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261254.8/ ENSP00000261254.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               AC006122.24        61998-62471         c
            475-690             AC006122.24        60013-60228         c
            691-850             AC006122.24        57314-57473         c
            851-999             AC006122.24        47243-47391         c
            1000-6493           AC006122.24        30880-36373         c
FEATURES             Location/Qualifiers
     source          1..6493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     gene            1..6493
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /note="cyclin D2"
                     /db_xref="GeneID:894"
                     /db_xref="HGNC:HGNC:1583"
                     /db_xref="MIM:123833"
     exon            1..474
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..690
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..850
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..999
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..6493
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6472..6477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /note="hexamer: AATAAA"
     polyA_site      6493
                     /gene="CCND2"
                     /gene_synonym="KIAK0002; MPPH3"
                     /note="major polyA site"
ORIGIN      
        1 agagcggaga agagcgagca ggggagagcg agaccagttt taaggggagg accggtgcga
       61 gtgaggcagc cccgaggctc tgctcgccca ccacccaatc ctcgcctccc ttctgctcca
      121 ccttctctct ctgccctcac ctctcccccg aaaaccccct atttagccaa aggaaggagg
      181 tcaggggaac gctctcccct ccccttccaa aaaacaaaaa cagaaaaacc tttttccagg
      241 ccggggaaag caggagggag aggggccgcc gggctggcca tggagctgct gtgccacgag
      301 gtggacccgg tccgcagggc cgtgcgggac cgcaacctgc tccgagacga ccgcgtcctg
      361 cagaacctgc tcaccatcga ggagcgctac cttccgcagt gctcctactt caagtgcgtg
      421 cagaaggaca tccaacccta catgcgcaga atggtggcca cctggatgct ggaggtctgt
      481 gaggaacaga agtgcgaaga agaggtcttc cctctggcca tgaattacct ggaccgtttc
      541 ttggctgggg tcccgactcc gaagtcccat ctgcaactcc tgggtgctgt ctgcatgttc
      601 ctggcctcca aactcaaaga gaccagcccg ctgaccgcgg agaagctgtg catttacacc
      661 gacaactcca tcaagcctca ggagctgctg gagtgggaac tggtggtgct ggggaagttg
      721 aagtggaacc tggcagctgt cactcctcat gacttcattg agcacatctt gcgcaagctg
      781 ccccagcagc gggagaagct gtctctgatc cgcaagcatg ctcagacctt cattgctctg
      841 tgtgccaccg actttaagtt tgccatgtac ccaccgtcga tgatcgcaac tggaagtgtg
      901 ggagcagcca tctgtgggct ccagcaggat gaggaagtga gctcgctcac ttgtgatgcc
      961 ctgactgagc tgctggctaa gatcaccaac acagacgtgg attgtctcaa agcttgccag
     1021 gagcagattg aggcggtgct cctcaatagc ctgcagcagt accgtcagga ccaacgtgac
     1081 ggatccaagt cggaggatga actggaccaa gccagcaccc ctacagacgt gcgggatatc
     1141 gacctgtgag gatgccagtt gggccgaaag agagagacgc gtccataatc tggtctcttc
     1201 ttctttctgg ttgtttttgt tctttgtgtt ttagggtgaa acttaaaaaa aaaattctgc
     1261 ccccacctag atcatattta aagatctttt agaagtgaga gaaaaaggtc ctacgaaaac
     1321 ggaataataa aaagcatttg gtgcctattt gaagtacagc ataagggaat cccttgtata
     1381 tgcgaacagt tattgtttga ttatgtaaaa gtaatagtaa aatgcttaca ggaaaacctg
     1441 cagagtagtt agagaatatg tatgcctgca atatgggaac aaattagagg agactttttt
     1501 ttttcatgtt atgagctagc acatacaccc ccttgtagta taatttcaag gaactgtgta
     1561 cgccatttat ggcatgatta gattgcaaag caatgaactc aagaaggaat tgaaataagg
     1621 agggacatga tggggaagga gtacaaaaca atctctcaac atgattgaac catttgggat
     1681 ggagaagcac ctttgctctc agccacctgt tactaagtca ggagtgtagt tggatctcta
     1741 cattaatgtc ctcttgctgt ctacagtagc tgctacctaa aaaaagatgt tttattttgc
     1801 cagttggaca caggtgattg gctcctgggt ttcatgttct gtgacatcct gcttcttctt
     1861 ccaaatgcag ttcattgcag acaccaccat attgctatct aatggggaaa tgtagctatg
     1921 ggccataacc aaaactcaca tgaaacggag gcagatggag accaagggtg ggatccagaa
     1981 tggagtcttt tctgttattg tatttaaaag ggtaatgtgg ccttggcatt tcttcttaga
     2041 aaaaaactaa tttttggtgc tgattggcat gtctggttca cagtttagca ttgttataaa
     2101 ccattccatt cgaaaagcac tttgaaaaat tgttcccgag cgatagatgg gatggtttat
     2161 gcaagtcatg ctgaatactc ctcccctctt ctcttttgcc ccctcccttc ctgcccccag
     2221 tctgggttac tcttcgcttc tggtatctgg cgttctttgg tacacagttc tggtgttcct
     2281 accaggactc aagagacacc ccttcctgct gacattccca tcacaacatt cctcagacaa
     2341 gcctgtaaac taaaatctgt taccattctg atggcacaga aggatcttaa ttcccatctc
     2401 tatacttctc ctttggacat ggaaagaaaa gttattgctg gtgcaaagat agatggctga
     2461 acatcagggt gtggcatttt gttccctttt ccgttttttt ttttttattg ttgttgttaa
     2521 ttttattgca aagttgtatt cagcgtactt gaatttttct tcctctccac ttcttagagg
     2581 cattcagtta gcaaagaggt tggagcaaca actttttttt ttttttttgc acaattgtaa
     2641 ttgacaggta atgaagctat ttgttaaaat atttgccttt ttaagtaaaa aagaaaaatc
     2701 agaacagggc tatttgaaga attattttat acacagattc tgccttgttt catagtatga
     2761 gggttgaaga cggaaaacaa tctaagggtc tctcattttt ttaattttgt tttgttcagt
     2821 ttggtttttt tttttttttg cgctgctaag aagctaaagt catccatcct tattcacgtt
     2881 gacagtacct agctgtaatg tttcacagag tgtgctgcta ttttataaac atttttataa
     2941 tatattattt tactgcttaa attccaagtc ctgaagtaga tggttgagat atgagttctt
     3001 cgtactggaa aagcccttcc gtagtttgtt ttcttctggt agcatattca tggttgtttt
     3061 tttttttctt ttttggtttt ttggtttttt ttttttcctc tgatcacatt cttcaaagac
     3121 ggagtattct ttacctcagg tttactggac aaaatcaata actacaaaag gcaatgattc
     3181 acgcttttgt tttcataata cctcacaacc gtacagtttc tgcttgggag cccattcgca
     3241 tgaggaatac agaagcagtg tgagcagggc tgactccctc tcaggtggaa ggcagggcgg
     3301 tctcactccc agggaccttt ttggtcatgg aggccatcgg gctcccagtt agaccctggt
     3361 atcctcatca tgatggaaaa aatacattga accaagggat cctccctccc cttcaaggca
     3421 gacgttcagt acaaacattt atgcggtagg ctcagatgtc gtaatttgca cttaggtacc
     3481 aggtgtcagg aaacagacta aaaagaattc caccaggctg tttggagatc ctcatcttgg
     3541 agctttttca aaagcggggc ttcatctgca aagggccctt tcatcttgaa gtttttcccc
     3601 tccgtctttc ccctcccctg gcatggacac cttgtgttta ggatcatctc tgcaggtttc
     3661 ctaggtctga atctgcgagt agatgaacct gcagcaagca gcgtttatgg tgcttccttc
     3721 tccctcctct gtctcaaact gcgcaggcaa gcactatgca agcccaggcc ctctgctgag
     3781 cggtactaaa cggtcgggtt ttcaatcaca ctgaattggc aggataagaa aaataggtca
     3841 gataagtatg ggatgatagt tgaagggagg tgaagaggct gcttctctac agaggtgaaa
     3901 ttccagatga gtcagtctct tgggaagtgt gtttagaagg gttcaggact ttgtgagtta
     3961 gcatgaccct aaaattctag gggatttctg gtgggacaat gggtggtgaa ttctgaagtt
     4021 ttggagaggg aagtggagca gccagcaagt aagctagcca gagttttctc aagagccagc
     4081 tttgctcagc acactctcct gggccccaag gagtcccacg gaatggggaa agcgggaacc
     4141 ctggagttct tgggaatctt ggagcctaaa gagaaaccga ggtgcaaatt catttcatgg
     4201 tgactgaccc ttgagcttaa acagaagcag caaatgaaag aaccggacaa ataaggaagg
     4261 gcacaagcct acccgactct atttacagtc tgtaactttc cactcttcct gtagtcccga
     4321 ggcccctggg tccttctagc ttttctcttt cccatccttg gggccttgtg tgatgatggg
     4381 tgtggggctg ccgatgggaa agtcgggggt tgttaggctt ttctgcctgc tcctgcttaa
     4441 acacaagaag gaatcctgga ttttgccctc tccttagctc ttagtctctt tggtaggagt
     4501 tttgttccag aggagctctc ccccttggat ttgaacttgc tctttttgtt gttgttgttc
     4561 tttctcttct ttttcttacc tcccactaaa ggggttccaa attatcctgg tctttttcta
     4621 ccttgttgtg tttctatctc gtctttactt ccatctgttt gtttttttct ccatcagtgg
     4681 gggccgagtt gttcccccag cctgccaaat tttgatcctt cccctctttt ggccaaatcc
     4741 tagggggaag aaatcctagt atgccaaaaa tatatgctaa gcataattaa actccatgcg
     4801 ggtccataac agccaagaag cctgcaggag aaagccaagg gcagttccct ccgcagaaca
     4861 ccccatgcgt gctgagaggc gagctccttg aagaaggggc tgttcttcca ggaggcctta
     4921 ttttgaactg cctcaggacc ccactggaga gcacagcatg ccttactact gggtcatcct
     4981 tggtctatgt gctctgtact ggaggctctg ttctgcctct tatcagccag gtcaggggca
     5041 cacatggctt aagtgacaaa gccagaggag aagacaaccc tgacagcatc acgctgcatc
     5101 ccattgctag caggattggc aactcttcag acggagctgc gcttccctgc agtctagcac
     5161 ctctagggcc tctccagact gtgccctggg agctctggga ctgaaaggtt aagaacataa
     5221 ggcaggatca gatgactctc tccaagaggg caggggaatt ttctctccat gggccacagg
     5281 ggacagggct gggagaagaa atagacttgc accttatgtc atgtaaataa ttgattttct
     5341 agttcaagaa gataatattg gtagtgtggg aattggaggt aggaagggga ggaagtctga
     5401 gtaagccagt tggcttctaa gccaaaagga ttcctctttg tttatctctg agacagtcca
     5461 accttgagaa tagctttaaa agggaaatta atgctgagat gataaagtcc ccttaagcca
     5521 acaaaccctc tgtagctata gaatgagtgc aggtttctat tggtgtggac tcagagcaat
     5581 ttacaagagc tgttcatgca gccatccatt tgtgcaaaat agggtaagaa gattcaagag
     5641 gatatttatt acttcctcat accacatggc ttttgatgat tctggattct aaacaaccca
     5701 gaatggtcat ttcaggcaca acgatactac attcgtgtgt gtctgctttt aaacttggct
     5761 gggctatcag accctattct cggctcaggt tttgagaagc catcagcaaa tgtgtacgtg
     5821 catgctgtag ctgcagcctg catcccttcg cctgcagcct actttgggga aataaagtgc
     5881 cttactgact gtagccatta cagtatccaa tgtcttttga caggtgcctg tccttgaaaa
     5941 acaaagtttc tatttttatt tttaattggt ttagttctta actgctggcc aactcttaca
     6001 tccccagcaa atcatcgggc cattggattt tttccattat gttcatcacc cttatatcat
     6061 gtacctcaga tctctctctc tctcctctct ctcagttatg tagtttcttg tcttggactt
     6121 ttttttttct tttctttttc tttttttttt tgctttaaaa caagtgtgat gccatatcaa
     6181 gtccatgtta ttctctcaca gtgtactcta taagaggtgt gggtgtctgt ttggtcagga
     6241 tgttagaaag tgctgataag tagcatgatc agtgtatgcg aaaaggtttt taggaagtat
     6301 ggcaaaaatg ttgtattggc tatgatggtg acatgatata gtcagctgcc ttttaagagg
     6361 tcttatctgt tcagtgttaa gtgatttaaa aaaataataa cctgttttct gactagttta
     6421 aagatggatt tgaaaatggt tttgaatgca attaggttat gctatttgga caataaactc
     6481 accttgacct aaa
//
