LOCUS       NM_053056               4238 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens cyclin D1 (CCND1), mRNA.
ACCESSION   NM_053056 NM_001758
VERSION     NM_053056.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Shen,S., Liu,R., Huang,J., Sun,Y., Tan,Q., Luo,Q. and Liu,R.
  TITLE     MAT1A activation of glycolysis to promote NSCLC progression depends
            on stabilizing CCND1
  JOURNAL   Cell Death Dis 15 (10), 768 (2024)
   PUBMED   39438468
  REMARK    GeneRIF: MAT1A activation of glycolysis to promote NSCLC
            progression depends on stabilizing CCND1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Romdhoni,A.C., Rajanagara,A.S., Albab,C.F., Waskito,L.A.,
            Wibowo,I.N. and Yunus,M.R.M.
  TITLE     The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage
            Nasopharyngeal Carcinoma: A Systematic Review
  JOURNAL   Asian Pac J Cancer Prev 25 (7), 2211-2218 (2024)
   PUBMED   39068551
  REMARK    GeneRIF: The Role of Cyclin d1 in Radiotherapy Resistance of
            Advance Stage Nasopharyngeal Carcinoma: A Systematic Review.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Kuchur,O.A., Pogodaeva,S.S., Shcherbakova,A.V. and Tsymbal,S.A.
  TITLE     Atox1-cyclin D1 loop activity is critical for survival of tumor
            cells with inactivated TP53
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38813981
  REMARK    GeneRIF: Atox1-cyclin D1 loop activity is critical for survival of
            tumor cells with inactivated TP53.
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Guo,R.P., Yang,L.Y., Du,J., Zhao,J.F., Shi,F., Zhang,X. and Su,J.
  TITLE     [Copy number variations of CCND1 gene and chromosome 11 centromere
            in acral melanoma]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 53 (6), 557-562 (2024)
   PUBMED   38825900
  REMARK    GeneRIF: [Copy number variations of CCND1 gene and chromosome 11
            centromere in acral melanoma].
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Li,F., Xiang,J., Liu,J., Wang,X. and Jiang,H.
  TITLE     [Overexpression of lncRNA FEZF1-AS1 promotes progression of
            non-small cell lung cancer via the miR-130a-5p/CCND1 axis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (5), 841-850 (2024)
   PUBMED   38862441
  REMARK    GeneRIF: [Overexpression of lncRNA FEZF1-AS1 promotes progression
            of non-small cell lung cancer via the miR-130a-5p/CCND1 axis].
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Seto,M., Yamamoto,K., Iida,S., Akao,Y., Utsumi,K.R., Kubonishi,I.,
            Miyoshi,I., Ohtsuki,T., Yawata,Y., Namba,M. et al.
  TITLE     Gene rearrangement and overexpression of PRAD1 in lymphoid
            malignancy with t(11;14)(q13;q32) translocation
  JOURNAL   Oncogene 7 (7), 1401-1406 (1992)
   PUBMED   1535701
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Inaba,T., Matsushime,H., Valentine,M., Roussel,M.F., Sherr,C.J. and
            Look,A.T.
  TITLE     Genomic organization, chromosomal localization, and independent
            expression of human cyclin D genes
  JOURNAL   Genomics 13 (3), 565-574 (1992)
   PUBMED   1386335
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Schuuring,E., Verhoeven,E., Mooi,W.J. and Michalides,R.J.
  TITLE     Identification and cloning of two overexpressed genes, U21B31/PRAD1
            and EMS1, within the amplified chromosome 11q13 region in human
            carcinomas
  JOURNAL   Oncogene 7 (2), 355-361 (1992)
   PUBMED   1532244
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Rosenberg,C.L., Wong,E., Petty,E.M., Bale,A.E., Tsujimoto,Y.,
            Harris,N.L. and Arnold,A.
  TITLE     PRAD1, a candidate BCL1 oncogene: mapping and expression in
            centrocytic lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9638-9642 (1991)
   PUBMED   1682919
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Motokura,T., Bloom,T., Kim,H.G., Juppner,H., Ruderman,J.V.,
            Kronenberg,H.M. and Arnold,A.
  TITLE     A novel cyclin encoded by a bcl1-linked candidate oncogene
  JOURNAL   Nature 350 (6318), 512-515 (1991)
   PUBMED   1826542
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM796500.1, BC001501.2,
            AP001888.4 and X59798.1.
            
            On Aug 31, 2019 this sequence version replaced NM_053056.2.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance throughout the cell
            cycle. Cyclins function as regulators of CDK kinases. Different
            cyclins exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. This
            cyclin forms a complex with and functions as a regulatory subunit
            of CDK4 or CDK6, whose activity is required for cell cycle G1/S
            transition. This protein has been shown to interact with tumor
            suppressor protein Rb and the expression of this gene is regulated
            positively by Rb. Mutations, amplification and overexpression of
            this gene, which alters cell cycle progression, are observed
            frequently in a variety of human cancers. [provided by RefSeq, Dec
            2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023620.2, X59798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227507.3/ ENSP00000227507.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BM796500.1         52-138
            88-1227             BC001501.2         73-1212
            1228-4026           AP001888.4         12952-15750
            4027-4238           X59798.1           4018-4229
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..4238
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /note="cyclin D1"
                     /db_xref="GeneID:595"
                     /db_xref="HGNC:HGNC:1582"
                     /db_xref="MIM:168461"
     exon            1..356
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1046
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /note="B-cell CLL/lymphoma 1; BCL-1 oncogene; PRAD1
                     oncogene; B-cell lymphoma 1 protein"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D1"
                     /protein_id="NP_444284.1"
                     /db_xref="CCDS:CCDS8191.1"
                     /db_xref="GeneID:595"
                     /db_xref="HGNC:HGNC:1582"
                     /db_xref="MIM:168461"
                     /translation="MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSY
                     FKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLL
                     GATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDF
                     IEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLR
                     SPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEE
                     EEEEVDLACTPTDVRDVDI"
     exon            357..572
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /inference="alignment:Splign:2.1.0"
     exon            573..732
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /inference="alignment:Splign:2.1.0"
     exon            733..881
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /inference="alignment:Splign:2.1.0"
     exon            882..4238
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4218..4223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /note="hexamer: AATAAA"
     polyA_site      4238
                     /gene="CCND1"
                     /gene_synonym="BCL1; D11S287E; PRAD1; U21B31"
                     /note="major polyA site"
ORIGIN      
        1 agagggctgt cggcgcagta gcagcgagca gcagagtccg cacgctccgg cgaggggcag
       61 aagagcgcga gggagcgcgg ggcagcagaa gcgagagccg agcgcggacc cagccaggac
      121 ccacagccct ccccagctgc ccaggaagag ccccagccat ggaacaccag ctcctgtgct
      181 gcgaagtgga aaccatccgc cgcgcgtacc ccgatgccaa cctcctcaac gaccgggtgc
      241 tgcgggccat gctgaaggcg gaggagacct gcgcgccctc ggtgtcctac ttcaaatgtg
      301 tgcagaagga ggtcctgccg tccatgcgga agatcgtcgc cacctggatg ctggaggtct
      361 gcgaggaaca gaagtgcgag gaggaggtct tcccgctggc catgaactac ctggaccgct
      421 tcctgtcgct ggagcccgtg aaaaagagcc gcctgcagct gctgggggcc acttgcatgt
      481 tcgtggcctc taagatgaag gagaccatcc ccctgacggc cgagaagctg tgcatctaca
      541 ccgacaactc catccggccc gaggagctgc tgcaaatgga gctgctcctg gtgaacaagc
      601 tcaagtggaa cctggccgca atgaccccgc acgatttcat tgaacacttc ctctccaaaa
      661 tgccagaggc ggaggagaac aaacagatca tccgcaaaca cgcgcagacc ttcgttgccc
      721 tctgtgccac agatgtgaag ttcatttcca atccgccctc catggtggca gcggggagcg
      781 tggtggccgc agtgcaaggc ctgaacctga ggagccccaa caacttcctg tcctactacc
      841 gcctcacacg cttcctctcc agagtgatca agtgtgaccc ggactgcctc cgggcctgcc
      901 aggagcagat cgaagccctg ctggagtcaa gcctgcgcca ggcccagcag aacatggacc
      961 ccaaggccgc cgaggaggag gaagaggagg aggaggaggt ggacctggct tgcacaccca
     1021 ccgacgtgcg ggacgtggac atctgagggc gccaggcagg cgggcgccac cgccacccgc
     1081 agcgagggcg gagccggccc caggtgctcc cctgacagtc cctcctctcc ggagcatttt
     1141 gataccagaa gggaaagctt cattctcctt gttgttggtt gttttttcct ttgctctttc
     1201 ccccttccat ctctgactta agcaaaagaa aaagattacc caaaaactgt ctttaaaaga
     1261 gagagagaga aaaaaaaaat agtatttgca taaccctgag cggtggggga ggagggttgt
     1321 gctacagatg atagaggatt ttatacccca ataatcaact cgtttttata ttaatgtact
     1381 tgtttctctg ttgtaagaat aggcattaac acaaaggagg cgtctcggga gaggattagg
     1441 ttccatcctt tacgtgttta aaaaaaagca taaaaacatt ttaaaaacat agaaaaattc
     1501 agcaaaccat ttttaaagta gaagagggtt ttaggtagaa aaacatattc ttgtgctttt
     1561 cctgataaag cacagctgta gtggggttct aggcatctct gtactttgct tgctcatatg
     1621 catgtagtca ctttataagt cattgtatgt tattatattc cgtaggtaga tgtgtaacct
     1681 cttcacctta ttcatggctg aagtcacctc ttggttacag tagcgtagcg tgcccgtgtg
     1741 catgtccttt gcgcctgtga ccaccacccc aacaaaccat ccagtgacaa accatccagt
     1801 ggaggtttgt cgggcaccag ccagcgtagc agggtcggga aaggccacct gtcccactcc
     1861 tacgatacgc tactataaag agaagacgaa atagtgacat aatatattct atttttatac
     1921 tcttcctatt tttgtagtga cctgtttatg agatgctggt tttctaccca acggccctgc
     1981 agccagctca cgtccaggtt caacccacag ctacttggtt tgtgttcttc ttcatattct
     2041 aaaaccattc catttccaag cactttcagt ccaataggtg taggaaatag cgctgttttt
     2101 gttgtgtgtg cagggagggc agttttctaa tggaatggtt tgggaatatc catgtacttg
     2161 tttgcaagca ggactttgag gcaagtgtgg gccactgtgg tggcagtgga ggtggggtgt
     2221 ttgggaggct gcgtgccagt caagaagaaa aaggtttgca ttctcacatt gccaggatga
     2281 taagttcctt tccttttctt taaagaagtt gaagtttagg aatcctttgg tgccaactgg
     2341 tgtttgaaag tagggacctc agaggtttac ctagagaaca ggtggttttt aagggttatc
     2401 ttagatgttt cacaccggaa ggtttttaaa cactaaaata tataatttat agttaaggct
     2461 aaaaagtata tttattgcag aggatgttca taaggccagt atgatttata aatgcaatct
     2521 ccccttgatt taaacacaca gatacacaca cacacacaca cacacacaaa ccttctgcct
     2581 ttgatgttac agatttaata cagtttattt ttaaagatag atccttttat aggtgagaaa
     2641 aaaacaatct ggaagaaaaa aaccacacaa agacattgat tcagcctgtt tggcgtttcc
     2701 cagagtcatc tgattggaca ggcatgggtg caaggaaaat tagggtactc aacctaagtt
     2761 cggttccgat gaattcttat cccctgcccc ttcctttaaa aaacttagtg acaaaataga
     2821 caatttgcac atcttggcta tgtaattctt gtaattttta tttaggaagt gttgaaggga
     2881 ggtggcaaga gtgtggaggc tgacgtgtga gggaggacag gcgggaggag gtgtgaggag
     2941 gaggctcccg aggggaaggg gcggtgccca caccggggac aggccgcagc tccattttct
     3001 tattgcgctg ctaccgttga cttccaggca cggtttggaa atattcacat cgcttctgtg
     3061 tatctctttc acattgtttg ctgctattgg aggatcagtt ttttgtttta caatgtcata
     3121 tactgccatg tactagtttt agttttctct tagaacattg tattacagat gccttttttg
     3181 tagttttttt tttttttatg tgatcaattt tgacttaatg tgattactgc tctattccaa
     3241 aaaggttgct gtttcacaat acctcatgct tcacttagcc atggtggacc cagcgggcag
     3301 gttctgcctg ctttggcggg cagacacgcg ggcgcgatcc cacacaggct ggcgggggcc
     3361 ggccccgagg ccgcgtgcgt gagaaccgcg ccggtgtccc cagagaccag gctgtgtccc
     3421 tcttctcttc cctgcgcctg tgatgctggg cacttcatct gatcgggggc gtagcatcat
     3481 agtagttttt acagctgtgt tattctttgc gtgtagctat ggaagttgca taattattat
     3541 tattattatt ataacaagtg tgtcttacgt gccaccacgg cgttgtacct gtaggactct
     3601 cattcgggat gattggaata gcttctggaa tttgttcaag ttttgggtat gtttaatctg
     3661 ttatgtacta gtgttctgtt tgttattgtt ttgttaatta caccataatg ctaatttaaa
     3721 gagactccaa atctcaatga agccagctca cagtgctgtg tgccccggtc acctagcaag
     3781 ctgccgaacc aaaagaattt gcaccccgct gcgggcccac gtggttgggg ccctgccctg
     3841 gcagggtcat cctgtgctcg gaggccatct cgggcacagg cccaccccgc cccacccctc
     3901 cagaacacgg ctcacgctta cctcaaccat cctggctgcg gcgtctgtct gaaccacgcg
     3961 ggggccttga gggacgcttt gtctgtcgtg atggggcaag ggcacaagtc ctggatgttg
     4021 tgtgtatcga gaggccaaag gctggtggca agtgcacggg gcacagcgga gtctgtcctg
     4081 tgacgcgcaa gtctgagggt ctgggcggcg ggcggctggg tctgtgcatt tctggttgca
     4141 ccgcggcgct tcccagcacc aacatgtaac cggcatgttt ccagcagaag acaaaaagac
     4201 aaacatgaaa gtctagaaat aaaactggta aaacccca
//
