LOCUS       NM_005190               2153 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin C (CCNC), transcript variant 1, mRNA.
ACCESSION   NM_005190
VERSION     NM_005190.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Lloyd,R.L., Urban,V., Munoz-Martinez,F., Ayestaran,I., Thomas,J.C.,
            de Renty,C., O'Connor,M.J., Forment,J.V., Galanty,Y. and
            Jackson,S.P.
  TITLE     Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by
            suppressing transcription-associated replication stress
  JOURNAL   Nucleic Acids Res 49 (15), 8665-8683 (2021)
   PUBMED   34329458
  REMARK    GeneRIF: Loss of Cyclin C or CDK8 provides ATR inhibitor resistance
            by suppressing transcription-associated replication stress.
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Tang,M., Pei,G., Su,D., Wang,C., Feng,X., Srivastava,M., Chen,Z.,
            Zhao,Z. and Chen,J.
  TITLE     Genome-wide CRISPR screens reveal cyclin C as synthetic survival
            target of BRCA2
  JOURNAL   Nucleic Acids Res 49 (13), 7476-7491 (2021)
   PUBMED   34197614
  REMARK    GeneRIF: Genome-wide CRISPR screens reveal cyclin C as synthetic
            survival target of BRCA2.
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Tassan,J.P., Jaquenoud,M., Leopold,P., Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of human cyclin-dependent kinase 8, a putative
            protein kinase partner for cyclin C
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8871-8875 (1995)
   PUBMED   7568034
REFERENCE   7  (bases 1 to 2153)
  AUTHORS   Yoshizumi,M., Lee,W.S., Hsieh,C.M., Tsai,J.C., Li,J.,
            Perrella,M.A., Patterson,C., Endege,W.O., Schlegel,R. and Lee,M.E.
  TITLE     Disappearance of cyclin A correlates with permanent withdrawal of
            cardiomyocytes from the cell cycle in human and rat hearts
  JOURNAL   J Clin Invest 95 (5), 2275-2280 (1995)
   PUBMED   7738192
REFERENCE   8  (bases 1 to 2153)
  AUTHORS   Demetrick,D.J., Matsumoto,S., Hannon,G.J., Okamoto,K., Xiong,Y.,
            Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of the genes for the human cell cycle proteins
            cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)
  JOURNAL   Cytogenet Cell Genet 69 (3-4), 190-192 (1995)
   PUBMED   7698009
REFERENCE   9  (bases 1 to 2153)
  AUTHORS   Lew,D.J., Dulic,V. and Reed,S.I.
  TITLE     Isolation of three novel human cyclins by rescue of G1 cyclin (Cln)
            function in yeast
  JOURNAL   Cell 66 (6), 1197-1206 (1991)
   PUBMED   1833066
REFERENCE   10 (bases 1 to 2153)
  AUTHORS   Nozawa,T., Hatano,M., Yamamoto,H. and Kwan,T.
  TITLE     Magnetic circular dichroism on the reversible oxygenation of
            dimethylmesoporphyrin-IX-atopyridinecobalt (II)
  JOURNAL   Bioinorg Chem 5 (3), 267-273 (1976)
   PUBMED   1260071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041123.1 and BC056153.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005190.3.
            
            Summary: The protein encoded by this gene is a member of the cyclin
            family of proteins. The encoded protein interacts with
            cyclin-dependent kinase 8 and induces the phophorylation of the
            carboxy-terminal domain of the large subunit of RNA polymerase II.
            The level of mRNAs for this gene peaks in the G1 phase of the cell
            cycle. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.980579.1,
                                           SRR5189658.74859.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520429.6/ ENSP00000428982.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               BC041123.1         138-302
            166-2153            BC056153.1         142-2129
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..2153
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /note="cyclin C"
                     /db_xref="GeneID:892"
                     /db_xref="HGNC:HGNC:1581"
                     /db_xref="MIM:123838"
     exon            1..165
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..985
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /note="isoform a is encoded by transcript variant 1; SRB11
                     homolog"
                     /codon_start=1
                     /product="cyclin-C isoform a"
                     /protein_id="NP_005181.2"
                     /db_xref="CCDS:CCDS34502.1"
                     /db_xref="GeneID:892"
                     /db_xref="HGNC:HGNC:1581"
                     /db_xref="MIM:123838"
                     /translation="MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFF
                     TNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGV
                     VSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLL
                     QYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFA
                     ELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQ
                     NSSYSQS"
     exon            166..272
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            273..357
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            358..427
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            428..479
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            480..535
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            536..571
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            572..663
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            664..731
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            732..811
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            812..930
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     exon            931..2153
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /note="hexamer: AATAAA"
     polyA_site      2153
                     /gene="CCNC"
                     /gene_synonym="CycC; hSRB11; SRB11"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccgccg cggagcggag tcgagccgag ctgatttgat cgaggagcgc ggttaccgga
       61 cgggctgggt ctatggtcgc tccgcgggcc gctccgccgg ctggtgcttt tttatcaggg
      121 caagctgtgt tccatggcag ggaacttttg gcagagctcc cactatttgc aatggatttt
      181 ggataaacaa gatctgttga aggagcgcca aaaggattta aagtttctct cagaggaaga
      241 atattggaag ttacaaatat tttttacaaa tgttatccaa gcattaggtg aacatcttaa
      301 attaagacaa caagttattg ccactgctac ggtatatttc aagagattct atgccaggta
      361 ttctctgaaa agtatagatc ctgtattaat ggctcctaca tgtgtgtttt tggcatccaa
      421 agtagaggaa tttggagtag tttcaaatac aagattgatt gctgctgcta cttctgtatt
      481 aaaaactaga ttttcatatg cctttccaaa ggaatttcct tataggatga atcatatatt
      541 agaatgtgaa ttctatctgt tagaactaat ggattgttgc ttgatagtgt atcatcctta
      601 tagacctttg ctccagtatg tgcaggacat gggccaagaa gacatgttgc ttccccttgc
      661 atggaggata gtgaatgata cctacagaac ggatctttgc ctactgtatc ctcctttcat
      721 gatagcttta gcttgcctac atgtagcctg tgttgtacag cagaaagatg ccaggcaatg
      781 gtttgctgag ctttctgtgg atatggaaaa gattttggaa ataatcaggg ttattttaaa
      841 actatatgag cagtggaaga atttcgatga gagaaaagag atggcaacca ttcttagtaa
      901 gatgccaaaa ccaaaaccac ctccaaacag tgaaggagag cagggtccaa atggaagtca
      961 gaactctagc tacagccaat cttaaaacat tccgaagaat tccatagtgg accacttgga
     1021 aataaaccat tggacagatt tcagtaatgt cttcagtgga acacaaatga aaatgaatag
     1081 cttgtttctg tcaagcatat tggaaagtga ttttattttt gcaaaataag tttttcttta
     1141 atatgattct agtacataat tgattaaaat ctcttgatta taaatgtttg gaaaggttct
     1201 aaggggacct acagacagac atacatagac atttcaaaat taatagcttt tgattagtat
     1261 aatatttctt aatttggata ataaaaattg tagcttttta ttaagccagg aaacatgaag
     1321 cataatttgt ttaaaattct ctttggtcat tgagggacca aaaaaggacg taaaatttac
     1381 agtcaatcta tgagggtttt tttccctcca taagtttaac tttaaaactg tatttaagga
     1441 atcaaatctt acaaaatcct ggaagatttt ggtaatgatg ttgataattt cagggaaatt
     1501 aatcaagtac ctatattgat ttaaaagtgt attttattca gtagtttgag gatcttgcca
     1561 tggaagatac tagcccagcc tagcagaaaa gtgcaatatg tatagcatac tttgacattt
     1621 taaacatgat agtccataac cattttgaaa tgctgggcaa actacatgaa gttatttata
     1681 attaattcac agctaatcag gcattttgaa agcttaattg gattcaaaaa ccataatgtt
     1741 ggaatttggt aaaattttaa tgttgatttt tactgtgaaa aggtttttat aagatataca
     1801 caccctagtt taatgttgtg tcttggtgtg gatttacaga tttactacag gtattctgaa
     1861 ccaggaacac aatcaggttt caggccagtt tgatactggc tgtccttaat tctaatatga
     1921 gagtaggaca tcatactaaa tgttatgtca gtgggactgt actgtctgtg gaacttagca
     1981 aattaatcat tttcttcaga cttgaaggag agtgataaat aaaatttgga gtcataggat
     2041 attgatgcac aatttaagga ttaaacattt ttaatcaatt gtggatgatg gcttattaaa
     2101 tgttgacttc ctagtataaa actgcaagaa taaaagtaac ttctccagct gta
//
