LOCUS       NM_033031               4697 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cyclin B3 (CCNB3), transcript variant 3, mRNA.
ACCESSION   NM_033031 XM_017029918
VERSION     NM_033031.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Wang,C., Chen,M.X., Zhang,Y., Bai,X., Cao,Q., Han,J., Zhang,N.,
            Zhao,C., Ling,X., Rui,X., Guan,Y., Zhang,J. and Huo,R.
  TITLE     Mutations in CCNB3 affect its location thus causing a multiplicity
            of phenotypes in human oocytes maturation by aberrant CDK1 activity
            and APC/C activity at different stages
  JOURNAL   J Ovarian Res 16 (1), 178 (2023)
   PUBMED   37635245
  REMARK    GeneRIF: Mutations in CCNB3 affect its location thus causing a
            multiplicity of phenotypes in human oocytes maturation by aberrant
            CDK1 activity and APC/C activity at different stages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Palmerini,E., Gambarotti,M., Italiano,A., Nathenson,M.J., Ratan,R.,
            Dileo,P., Provenzano,S., Jones,R.L., DuBois,S.G., Martin-Broto,J.,
            de Alava,E., Baldi,G.G., Grignani,G., Ferraresi,V., Brunello,A.,
            Paoluzzi,L., Bertulli,R., Hindi,N., Montemurro,M., Rothermundt,C.,
            Cocchi,S., Salguero-Aranda,C., Donati,D., Martin,J.D., Abdelhamid
            Ahmed,A.H., Mazzocca,A., Carretta,E., Cesari,M., Pierini,M.,
            Righi,A., Sbaraglia,M., Laginestra,M.A., Scotlandi,K., Dei
            Tos,A.P., Ibrahim,T., Stacchiotti,S. and Vincenzi,B.
  TITLE     A global collaboRAtive study of CIC-rearranged,
            BCOR::CCNB3-rearranged and other ultra-rare unclassified
            undifferentiated small round cell sarcomas (GRACefUl)
  JOURNAL   Eur J Cancer 183, 11-23 (2023)
   PUBMED   36791667
  REMARK    GeneRIF: A global collaboRAtive study of CIC-rearranged,
            BCOR::CCNB3-rearranged and other ultra-rare unclassified
            undifferentiated small round cell sarcomas (GRACefUl).
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Fatemi,N., Salehi,N., Pignata,L., Palumbo,P., Cubellis,M.V.,
            Ramazanali,F., Ray,P., Varkiani,M., Reyhani-Sabet,F., Biglari,A.,
            Sparago,A., Acurzio,B., Palumbo,O., Carella,M., Riccio,A. and
            Totonchi,M.
  TITLE     Biallelic variant in cyclin B3 is associated with failure of
            maternal meiosis II and recurrent digynic triploidy
  JOURNAL   J Med Genet 58 (11), 783-788 (2021)
   PUBMED   32938693
  REMARK    GeneRIF: Biallelic variant in cyclin B3 is associated with failure
            of maternal meiosis II and recurrent digynic triploidy.
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Brady,E.J., Hameed,M., Tap,W.D. and Hwang,S.
  TITLE     Imaging features and clinical course of undifferentiated round cell
            sarcomas with CIC-DUX4 and BCOR-CCNB3 translocations
  JOURNAL   Skeletal Radiol 50 (3), 521-529 (2021)
   PUBMED   32840647
  REMARK    GeneRIF: Imaging features and clinical course of undifferentiated
            round cell sarcomas with CIC-DUX4 and BCOR-CCNB3 translocations.
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Han,H., Bertrand,K.C., Patel,K.R., Fisher,K.E., Roy,A., Muscal,J.A.
            and Venkatramani,R.
  TITLE     BCOR-CCNB3 fusion-positive clear cell sarcoma of the kidney
  JOURNAL   Pediatr Blood Cancer 67 (4), e28151 (2020)
   PUBMED   31876361
  REMARK    GeneRIF: report two patients with clear cell sarcoma of the kidney
            showing BCOR-CCNB3 (where CCNB3 is cyclin B3) fusion
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Pierron,G., Tirode,F., Lucchesi,C., Reynaud,S., Ballet,S.,
            Cohen-Gogo,S., Perrin,V., Coindre,J.M. and Delattre,O.
  TITLE     A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
  JOURNAL   Nat Genet 44 (4), 461-466 (2012)
   PUBMED   22387997
  REMARK    GeneRIF: A new fusion was observed between BCOR (encoding the BCL6
            co-repressor) and CCNB3 (encoding the testis-specific cyclin B3) on
            the X chromosome.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   Di Marzio,P., Choe,S., Ebright,M., Knoblauch,R. and Landau,N.R.
  TITLE     Mutational analysis of cell cycle arrest, nuclear localization and
            virion packaging of human immunodeficiency virus type 1 Vpr
  JOURNAL   J Virol 69 (12), 7909-7916 (1995)
   PUBMED   7494303
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Re,F., Braaten,D., Franke,E.K. and Luban,J.
  TITLE     Human immunodeficiency virus type 1 Vpr arrests the cell cycle in
            G2 by inhibiting the activation of p34cdc2-cyclin B
  JOURNAL   J Virol 69 (11), 6859-6864 (1995)
   PUBMED   7474100
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   He,J., Choe,S., Walker,R., Di Marzio,P., Morgan,D.O. and
            Landau,N.R.
  TITLE     Human immunodeficiency virus type 1 viral protein R (Vpr) arrests
            cells in the G2 phase of the cell cycle by inhibiting p34cdc2
            activity
  JOURNAL   J Virol 69 (11), 6705-6711 (1995)
   PUBMED   7474080
REFERENCE   10 (bases 1 to 4697)
  AUTHORS   Jowett,J.B., Planelles,V., Poon,B., Shah,N.P., Chen,M.L. and
            Chen,I.S.
  TITLE     The human immunodeficiency virus type 1 vpr gene arrests infected T
            cells in the G2 + M phase of the cell cycle
  JOURNAL   J Virol 69 (10), 6304-6313 (1995)
   PUBMED   7666531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC235789.3, FO681501.2 and
            AC239396.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before May 2, 2019 this sequence version replaced
            XM_017029918.1, NM_033031.2.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as positive regulators of cyclin-dependent kinases
            (CDKs), and thereby play an essential role in the control of the
            cell cycle. Different cyclins exhibit distinct expression and
            degradation patterns, which contribute to the temporal coordination
            of each mitotic event. Studies of similar genes in chicken and
            drosophila suggest that this cyclin may associate with CDC2 and
            CDK2 kinases, and may be required for proper spindle reorganization
            and restoration of the interphase nucleus. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Oct 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376042.6/ ENSP00000365210.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC235789.3         8806-8991           c
            187-261             FO681501.2         5578-5652
            262-394             FO681501.2         6163-6295
            395-500             FO681501.2         9816-9921
            501-502             AC239396.3         170771-170772       c
            503-633             AC239396.3         164665-164795       c
            634-3625            AC239396.3         148162-151153       c
            3626-3721           AC239396.3         147026-147121       c
            3722-3814           AC239396.3         145710-145802       c
            3815-3952           AC239396.3         117319-117456       c
            3953-4108           AC239396.3         112851-113006       c
            4109-4258           AC239396.3         111883-112032       c
            4259-4389           AC239396.3         108287-108417       c
            4390-4697           AC239396.3         107744-108051       c
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..4697
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /note="cyclin B3"
                     /db_xref="GeneID:85417"
                     /db_xref="HGNC:HGNC:18709"
                     /db_xref="MIM:300456"
     exon            1..186
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            187..261
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..394
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..4486
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     G2/mitotic-specific cyclin-B3"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B3 isoform 3"
                     /protein_id="NP_149020.2"
                     /db_xref="CCDS:CCDS14331.1"
                     /db_xref="GeneID:85417"
                     /db_xref="HGNC:HGNC:18709"
                     /db_xref="MIM:300456"
                     /translation="MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPS
                     SLQESPSSLQGALKKRSAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGL
                     AKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVL
                     KEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHK
                     TEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEE
                     SIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPTTEKETLFQELSVLQ
                     EKHTTEHEMSILKKSLALQKTNFKEDSLVKESLAFKKKPSTEEAIMMPVILKEQCMTE
                     GKRSRLKPLVLQEITSGEKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSI
                     LKEPSSLLKSPTEESPFDEALAFTKKCTIEEAPPTKKPLILKRKHATQGTMSHLKKPL
                     ILQTTSGEKSLIKEPLPFKEEKVSLKKKCTTQEMMSICPELLDFQDMIGEDKNSFFME
                     PMSFRKNPTTEETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPF
                     KMKSTTEEKFLSQEPSALKEKHTTLQEVSLSKESLAIQEKATTEEEFSQELFSLHVKH
                     TNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEKSTMEEESLINKLLALKEELSAEAA
                     TNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEEEFLNKQPLALEGYPSIAEGETLF
                     KKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQEEPSTEKEAVLKEPSVDTEAHF
                     KETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKESLDLQEKPSIKKETLLKKPL
                     ALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVG
                     TSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMITLNEKPTTGKELSFKEP
                     LALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIATMTSVGKSRTTTES
                     SACESASDKPVSPQAKGTPKEITPREDIDEDSSDPSFNPMYAKEIFSYMKEREEQFIL
                     TDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQ
                     LLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAY
                     HFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYW
                     VPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFFEVAKIPALDML
                     KLEEILNCDCEAQGLVL"
     exon            395..502
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            503..633
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..3625
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3721
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3814
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3952
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4108
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4258
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4389
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     exon            4390..4697
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4670..4675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /note="hexamer: AATAAA"
     polyA_site      4697
                     /gene="CCNB3"
                     /gene_synonym="CYCB3"
                     /note="major polyA site"
ORIGIN      
        1 gtggaagcat ttccgtcatt ctgagacagt tgggctgagg cggttggtcg cctctctctc
       61 tctctctctc tgttcctcat ctacattttg attggtttat ttttgtattg ttttctttca
      121 gtttccgata ggtggagaac attctgctaa tagcttttct tccagtccat ttgtggcttg
      181 ttaaaggtgt ctggaactgg attacagttt cttctgattg aacgcagcct ttgaatactg
      241 cctggcctat cgcgaataca tccctgcctt ggacaagacg cagctgaatc tctaagtgat
      301 gctactgcca ctaccacccc agagctccaa acctgtgcct aagaaatctc agtccagcaa
      361 aattgtgccc agtcatcatg acccatctga aaagacgggg gagaattgcc aaacgaagat
      421 atctccatct tcacttcagg agtctccatc ttcacttcag ggagcactca aaaagagatc
      481 agcttttgaa gatctcacta atgcttctca atgtcaacct gtccagccca agaaagaagc
      541 caataaagag tttgtaaaag ttgtttccaa gaagataaac aggaacacac atgctcttgg
      601 actggccaaa aagaataagc ggaatctaaa atggcataag ctggaagtca caccagtagt
      661 agcctctact accgtggtac caaacattat ggagaaacca ctcattctag acatatccac
      721 cacctccaaa acacccaaca ctgaggaggc atctctcttc agaaagccat tagttttaaa
      781 ggaggaaccc actattgagg atgaaaccct tatcaataag tcattatctt taaaaaagtg
      841 ctcaaatcat gaggaggtgt ccttactgga aaagctacag cccctgcagg aggagagtga
      901 cagtgatgat gcgtttgtta tagagccaat gacttttaag aagacacata aaactgagga
      961 ggcagccatc accaagaaga cattatcctt aaagaagaag atgtgtgcaa gtcagcggaa
     1021 gcagtcctgc caggaagagt cgttggctgt gcaggatgtc aatatggaag aggattcctt
     1081 ctttatggag tcaatgagtt ttaagaagaa gcctaaaact gaggagtcaa tccccaccca
     1141 taagttatca tctttaaaga agaaatgtac catttatggg aagatatgcc actttaggaa
     1201 gccaccagta ttgcagacaa ccatctgtgg agcaatgtcc tccattaaga agcctaccac
     1261 tgagaaggag acacttttcc aagagctatc tgtattgcaa gagaaacaca ccactgagca
     1321 tgagatgtcc atcttgaaga aatcattggc cttgcagaag accaacttta aagaggattc
     1381 ccttgttaag gagtcgttag cctttaagaa gaagcctagc actgaggagg caatcatgat
     1441 gccagtaata ttgaaggagc agtgcatgac tgaggggaag aggtcccgtc tgaagccatt
     1501 agtattgcag gagatcacct ctggagagaa gtcgctcatt atgaagccat tgtccattaa
     1561 agaaaagcca tctactgaga aggagtcctt ttcccaggaa ccatctgcat tgcaaaagaa
     1621 gcacaccact caggaggagg tttccatctt aaaggagccc tcgtccttgc taaagtctcc
     1681 aactgaggag tcaccttttg atgaggcttt ggcttttaca aagaagtgta ccattgagga
     1741 ggcacccccc accaagaagc ctttaatttt aaagaggaag catgccactc aggggacaat
     1801 gtcccacttg aagaaaccac taatattaca gaccacctct ggagaaaagt cacttattaa
     1861 ggagccactg ccctttaaag aagaaaaagt gtctttaaag aaaaagtgta ccacacaaga
     1921 gatgatgtcc atctgtccag aactgttgga ctttcaggat atgattggtg aagataagaa
     1981 ttctttcttt atggagccaa tgtcatttag gaagaaccct acaactgagg agacagtact
     2041 taccaagaca tcgttgtctt tacaggaaaa gaaaattact caggggaaga tgtcccactt
     2101 aaagaagcca ctggtcttgc agaagatcac ttctgaggag gagtcattct ataagaagct
     2161 gttgcccttt aagatgaaat ctacaacgga agaaaagttc ctctcccagg aaccatctgc
     2221 attgaaagag aagcatacca ccttgcagga agtgtccctc tcaaaagagt cattggccat
     2281 ccaagagaag gctaccactg aggaggaatt ctctcaggaa ctattttcat tgcatgttaa
     2341 gcataccaac aaaagtgggt ccctcttcca ggaggctttg gtcttgcaag agaagactga
     2401 tgccgaagag gattccttga agaacttgtt ggctttgcag gagaaaagca ccatggaaga
     2461 agagtccctt atcaataagc tattggctct gaaggaggag ctttctgctg aggcagccac
     2521 aaacatacag acacaattat ctttaaagaa gaagtccact tctcatggaa aagtgttctt
     2581 cctgaagaag cagttggctt tgaatgagac catcaatgaa gaggagttcc ttaataagca
     2641 gccactggcc ttggaggggt atcccagcat tgcggagggg gagaccctct tcaagaagct
     2701 tttggccatg caggaggagc ccagcattga gaaggaagct gtcctcaagg agcccactat
     2761 tgacacagaa gctcacttta aggaaccttt ggccttgcag gaggagccca gcactgagaa
     2821 ggaggctgtc ctcaaggagc ccagtgttga cacagaagct cactttaagg aaactttggc
     2881 cttgcaggag aagcccagca ttgagcagga ggccctcttt aagcgacact cagctttgtg
     2941 ggagaagccc agcactgaga aggagaccat cttcaaggag tctttggact tgcaagagaa
     3001 gcccagcatt aagaaagaga ccctcctcaa aaagccatta gccttgaaga tgtctaccat
     3061 caatgaggca gtcctcttcg aagatatgat agctctgaat gagaaaccca ccactgggaa
     3121 ggagttgtcc ttcaaggagc cattagcctt acaagagagt cccacctaca aggaagacac
     3181 ctttctcaaa acattgttgg tcccccaagt tggaaccagc ccaaatgtgt ctagcactgc
     3241 ccctgaatcc ataaccagca agtccagcat tgctaccatg accagtgtgg gcaaatctgg
     3301 taccatcaat gaggcattcc tcttcgaaga tatgataact ctgaatgaga aacccaccac
     3361 tgggaaggag ttgtccttca aggagccatt ggccttacaa gagagtccca cctgcaagga
     3421 agacaccttt ctggaaacat tcttgatccc ccaaattgga accagcccat atgtgtttag
     3481 caccacccct gaatccataa cagagaagtc cagcattgca accatgacca gcgtgggcaa
     3541 gtccaggacc accaccgagt ccagtgcatg tgaatctgct tctgataaac ctgtctcacc
     3601 acaggccaag ggaacaccaa aggagataac cccacgggaa gatattgatg aggacagcag
     3661 tgatccaagt ttcaacccaa tgtatgccaa ggaaatcttc agttacatga aagagagaga
     3721 ggaacagttt atacttacag attacatgaa caggcagatt gaaatcacca gtgacatgag
     3781 ggccattctt gtggactggt tggtggaggt gcaggtgtcc tttgagatga cccatgagac
     3841 cctgtacttg gcagtgaagc tggtggatct ctacctaatg aaggcagtat gcaagaagga
     3901 taagttacaa ctccttggtg ccactgcctt tatgattgca gcaaaatttg aggagcacaa
     3961 ctcacctcgt gtggatgact ttgtgtacat ctgtgatgat aattatcagc gatctgaggt
     4021 actcagcatg gaaatcaaca tcctgaacgt cctcaaatgt gacattaaca ttcccatcgc
     4081 ctaccatttt ctgcgcagat atgctaggtg tatccacacc aacatgaaga cactgacctt
     4141 gtcccgctac atctgcgaga tgaccctgca ggaataccac tatgtccagg agaaggcttc
     4201 caagctagct gctgcctcct tactcctggc cctctacatg aagaagctcg gatactgggt
     4261 tcccttcctg gagcattaca gtggctacag tatctctgag cttcacccct tggtcagaca
     4321 gctgaacaaa ctgctgactt tcagttctta cgatagtctc aaggctgtgt attacaagta
     4381 ttctcacccg gtcttctttg aagtcgccaa aatccctgcc ttggatatgt tgaagctgga
     4441 ggagattttg aactgtgatt gtgaggctca gggcctggta ctctagcagc agccacaggg
     4501 ctaagcatgc atgttaacag ggtatattta ttctatgttc gaatttgtct tttgatcgct
     4561 tttattcatt tttcctttct ttgtcttttc ccaaactgat aatgttataa atatttatgt
     4621 tgcttgtttt tatgaaagaa aaaatattgt catatttgac tacaaattta ataaaaaatt
     4681 aatggttatt gttaaaa
//
