LOCUS       NM_004701               1488 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cyclin B2 (CCNB2), mRNA.
ACCESSION   NM_004701
VERSION     NM_004701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Ren,C., Wang,Q., Xu,Z., Pan,Y., Wang,S. and Liu,X.
  TITLE     Upregulation of CCNB2 and a novel lncRNAs-related risk model
            predict prognosis in clear cell renal cell carcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 64 (2024)
   PUBMED   38300330
  REMARK    GeneRIF: Upregulation of CCNB2 and a novel lncRNAs-related risk
            model predict prognosis in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Kang,J., Jung,H. and Kim,H.
  TITLE     Prognostic value of cyclin B1 and cyclin B2 expression in breast
            cancer: A systematic review and updated meta-analysis
  JOURNAL   Medicine (Baltimore) 103 (3), e37016 (2024)
   PUBMED   38241547
  REMARK    GeneRIF: Prognostic value of cyclin B1 and cyclin B2 expression in
            breast cancer: A systematic review and updated meta-analysis.
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Liu,Q., Yuan,Y., Shang,X. and Xin,L.
  TITLE     Cyclin B2 impairs the p53 signaling in nasopharyngeal carcinoma
  JOURNAL   BMC Cancer 24 (1), 25 (2024)
   PUBMED   38166895
  REMARK    GeneRIF: Cyclin B2 impairs the p53 signaling in nasopharyngeal
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Liu,S., Yuan,X., Gui,P., Liu,R., Durojaye,O., Hill,D.L., Fu,C.,
            Yao,X., Dou,Z. and Liu,X.
  TITLE     Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding
            accurate mitotic checkpoint
  JOURNAL   EMBO Rep 23 (6), e54171 (2022)
   PUBMED   35384228
  REMARK    GeneRIF: Mad2 promotes Cyclin B2 recruitment to the kinetochore for
            guiding accurate mitotic checkpoint.
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Huang,J., Zhou,H., Diao,Y. and Yang,Z.
  TITLE     Hsa_circ_0000285 knockdown inhibits the progression of
            hepatocellular carcinoma by sponging miR-582-3p to regulate CCNB2
            expression
  JOURNAL   Hum Exp Toxicol 41, 9603271221115400 (2022)
   PUBMED   35839486
  REMARK    GeneRIF: Hsa_circ_0000285 knockdown inhibits the progression of
            hepatocellular carcinoma by sponging miR-582-3p to regulate CCNB2
            expression.
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Di Marzio,P., Choe,S., Ebright,M., Knoblauch,R. and Landau,N.R.
  TITLE     Mutational analysis of cell cycle arrest, nuclear localization and
            virion packaging of human immunodeficiency virus type 1 Vpr
  JOURNAL   J Virol 69 (12), 7909-7916 (1995)
   PUBMED   7494303
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Re,F., Braaten,D., Franke,E.K. and Luban,J.
  TITLE     Human immunodeficiency virus type 1 Vpr arrests the cell cycle in
            G2 by inhibiting the activation of p34cdc2-cyclin B
  JOURNAL   J Virol 69 (11), 6859-6864 (1995)
   PUBMED   7474100
REFERENCE   8  (bases 1 to 1488)
  AUTHORS   He,J., Choe,S., Walker,R., Di Marzio,P., Morgan,D.O. and
            Landau,N.R.
  TITLE     Human immunodeficiency virus type 1 viral protein R (Vpr) arrests
            cells in the G2 phase of the cell cycle by inhibiting p34cdc2
            activity
  JOURNAL   J Virol 69 (11), 6705-6711 (1995)
   PUBMED   7474080
REFERENCE   9  (bases 1 to 1488)
  AUTHORS   Jowett,J.B., Planelles,V., Poon,B., Shah,N.P., Chen,M.L. and
            Chen,I.S.
  TITLE     The human immunodeficiency virus type 1 vpr gene arrests infected T
            cells in the G2 + M phase of the cell cycle
  JOURNAL   J Virol 69 (10), 6304-6313 (1995)
   PUBMED   7666531
REFERENCE   10 (bases 1 to 1488)
  AUTHORS   Pines,J. and Hunter,T.
  TITLE     Human cyclins A and B1 are differentially located in the cell and
            undergo cell cycle-dependent nuclear transport
  JOURNAL   J Cell Biol 115 (1), 1-17 (1991)
   PUBMED   1717476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001404.1 and AF002822.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004701.3.
            
            Summary: Cyclin B2 is a member of the cyclin family, specifically
            the B-type cyclins. The B-type cyclins, B1 and B2, associate with
            p34cdc2 and are essential components of the cell cycle regulatory
            machinery. B1 and B2 differ in their subcellular localization.
            Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is
            primarily associated with the Golgi region. Cyclin B2 also binds to
            transforming growth factor beta RII and thus cyclin B2/cdc2 may
            play a key role in transforming growth factor beta-mediated cell
            cycle control. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.421077.1,
                                           SRR5189658.100032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288207.7/ ENSP00000288207.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1482              AK001404.1         26-1507
            1483-1488           AF002822.1         1379-1384
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..1488
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /note="cyclin B2"
                     /db_xref="GeneID:9133"
                     /db_xref="HGNC:HGNC:1580"
                     /db_xref="MIM:602755"
     exon            1..147
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1320
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B2"
                     /protein_id="NP_004692.1"
                     /db_xref="CCDS:CCDS10170.1"
                     /db_xref="GeneID:9133"
                     /db_xref="HGNC:HGNC:1580"
                     /db_xref="MIM:602755"
                     /translation="MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVLEEIGNRVTT
                     RAAQVAKKAQNTKVPVQPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKE
                     ENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRD
                     INGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLL
                     ASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKA
                     GEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTG
                     YTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDLAS
                     PLIGRS"
     exon            148..276
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            277..390
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            391..561
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            562..720
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            721..957
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1098
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1209
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1488
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /note="hexamer: AATAAA"
     polyA_site      1488
                     /gene="CCNB2"
                     /gene_synonym="HsT17299"
                     /note="major polyA site"
ORIGIN      
        1 gaagatcccc agcgctgcgg gctcggagag cagtcctaac ggcgcctcgt acgctagtgt
       61 cctccctttt cagtccgcgt ccctccctgg gccgggctgg cactcttgcc ttccccgtcc
      121 ctcatggcgc tgctccgacg cccgacggtg tccagtgatt tggagaatat tgacacagga
      181 gttaattcta aagttaagag tcatgtgact attaggcgaa ctgttttaga agaaattgga
      241 aatagagtta caaccagagc agcacaagta gctaagaaag ctcagaacac caaagttcca
      301 gttcaaccca ccaaaacaac aaatgtcaac aaacaactga aacctactgc ttctgtcaaa
      361 ccagtacaga tggaaaagtt ggctccaaag ggtccttctc ccacacctga ggatgtctcc
      421 atgaaggaag agaatctctg ccaagctttt tctgatgcct tgctctgcaa aatcgaggac
      481 attgataacg aagattggga gaaccctcag ctctgcagtg actacgttaa ggatatctat
      541 cagtatctca ggcagctgga ggttttgcag tccataaacc cacatttctt agatggaaga
      601 gatataaatg gacgcatgcg tgccatccta gtggattggc tggtacaagt ccactccaag
      661 tttaggcttc tgcaggagac tctgtacatg tgcgttggca ttatggatcg atttttacag
      721 gttcagccag tttcccggaa gaagcttcaa ttagttggga ttactgctct gctcttggct
      781 tccaagtatg aggagatgtt ttctccaaat attgaagact ttgtttacat cacagacaat
      841 gcttatacca gttcccaaat ccgagaaatg gaaactctaa ttttgaaaga attgaaattt
      901 gagttgggtc gacccttgcc actacacttc ttaaggcgag catcaaaagc cggggaggtt
      961 gatgttgaac agcacacttt agccaagtat ttgatggagc tgactctcat cgactatgat
     1021 atggtgcatt atcatccttc taaggtagca gcagctgctt cctgcttgtc tcagaaggtt
     1081 ctaggacaag gaaaatggaa cttaaagcag cagtattaca caggatacac agagaatgaa
     1141 gtattggaag tcatgcagca catggccaag aatgtggtga aagtaaatga aaacttaact
     1201 aaattcatcg ccatcaagaa taagtatgca agcagcaaac tcctgaagat cagcatgatc
     1261 cctcagctga actcaaaagc cgtcaaagac cttgcctccc cactgatagg aaggtcctag
     1321 gctgccgtgg cccctgggga tgtgtgcttc attgtgccct ttttcttatt ggtttagaac
     1381 tcttgatttt gtacatagtc ctctggtcta tctcatgaaa cctcttctca gaccagtttt
     1441 ctaaacatat attgaggaaa aataaagcga ttggtttttc ttaaggta
//
