LOCUS       NM_021178               1470 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cyclin B1 interacting protein 1 (CCNB1IP1), transcript
            variant 1, mRNA.
ACCESSION   NM_021178
VERSION     NM_021178.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Zhou,Y., Yan,H., Zhou,Q., Wang,P., Yang,F., Yuan,Z., Du,Q. and
            Zhai,B.
  TITLE     CCNB1IP1 prevents ubiquitination-mediated destabilization of MYCN
            and potentiates tumourigenesis of MYCN-amplificated neuroblastoma
  JOURNAL   Clin Transl Med 13 (7), e1328 (2023)
   PUBMED   37461251
  REMARK    GeneRIF: CCNB1IP1 prevents ubiquitination-mediated destabilization
            of MYCN and potentiates tumourigenesis of MYCN-amplificated
            neuroblastoma.
REFERENCE   2  (bases 1 to 1470)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1470)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1470)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1470)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1470)
  AUTHORS   Strong,E.R. and Schimenti,J.C.
  TITLE     Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein
            Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase
  JOURNAL   Genes (Basel) 1 (3), 440-451 (2010)
   PUBMED   21779533
REFERENCE   7  (bases 1 to 1470)
  AUTHORS   Gronholm,M., Muranen,T., Toby,G.G., Utermark,T., Hanemann,C.O.,
            Golemis,E.A. and Carpen,O.
  TITLE     A functional association between merlin and HEI10, a cell cycle
            regulator
  JOURNAL   Oncogene 25 (32), 4389-4398 (2006)
   PUBMED   16532029
  REMARK    GeneRIF: The cyclin B-binding protein and cell cycle regulator
            HEI10 is identified as a novel merlin-binding partner; interaction
            with merlin affects HEI10 protein levels.
REFERENCE   8  (bases 1 to 1470)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 1470)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 1470)
  AUTHORS   Toby,G.G., Gherraby,W., Coleman,T.R. and Golemis,E.A.
  TITLE     A novel RING finger protein, human enhancer of invasion 10, alters
            mitotic progression through regulation of cyclin B levels
  JOURNAL   Mol Cell Biol 23 (6), 2109-2122 (2003)
   PUBMED   12612082
  REMARK    GeneRIF: HEI10 defines a divergent class of E3 ubiquitin ligase,
            functioning in progression through G(2)/M.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB029392.1, AK026233.1, AF216381.1 and AI301662.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021178.4.
            
            Summary: HEI10 is a member of the E3 ubiquitin ligase family and
            functions in progression of the cell cycle through G(2)/M.[supplied
            by OMIM, Apr 2004].
            
            Transcript Variant: This variant (1) and variants 2 and 4 encode
            the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.442583.1, AK226037.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358932.9/ ENSP00000351810.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB029392.1         34-34
            2-845               AK026233.1         2-845
            846-1290            AF216381.1         390-834
            1291-1470           AI301662.1         5-184               c
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1470
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /note="cyclin B1 interacting protein 1"
                     /db_xref="GeneID:57820"
                     /db_xref="HGNC:HGNC:19437"
                     /db_xref="MIM:608249"
     exon            1..26
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     exon            27..226
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     exon            227..304
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     exon            305..419
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     exon            420..753
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..1290
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /EC_number="2.3.2.27"
                     /note="human enhancer of invasion 10; epididymis secretory
                     sperm binding protein; cyclin B1 interacting protein 1, E3
                     ubiquitin protein ligase; RING-type E3 ubiquitin
                     transferase CCNB1IP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CCNB1IP1"
                     /protein_id="NP_067001.3"
                     /db_xref="CCDS:CCDS9547.1"
                     /db_xref="GeneID:57820"
                     /db_xref="HGNC:HGNC:19437"
                     /db_xref="MIM:608249"
                     /translation="MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRS
                     PAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEIVLDISSRALAFWTYQVHQ
                     ERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDI
                     SEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPL
                     DNTPVRNRGDGDGDFQFRPFFAGSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKR
                     I"
     exon            754..1087
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1470
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1446..1451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /note="hexamer: AATAAA"
     polyA_site      1470
                     /gene="CCNB1IP1"
                     /gene_synonym="C14orf18; HEI10"
                     /note="major polyA site"
ORIGIN      
        1 ctttccctct ccgttttggt gggctggttg aagatgaaat ccactgagga gggaagtcca
       61 gcaccctgtg tgccagtcca gaactggccc atctgtagac cccctgaaaa tcatatgggc
      121 ttggatttgg atattctcaa cagaaagggt taaaggctga tggtacctaa agcctggtac
      181 ttgaattttg atcaagataa gctgccttaa gttctcttca ttacacaaat gatcctagat
      241 aattgataga tcctgtggtt caactggatt tctagataga agctggattc atgtgatgcc
      301 agaggagtaa aatttcaaga gactgaaacc agatctgagt ttcgctgttc cagtctggac
      361 ctctttggtg ctgtaaatcc tggatatact gtagatgagt actgcgtttt tcttttatgg
      421 cctctcttca gcttctggag acctcactat cctattatgt ctttgtgtga agacatgctg
      481 ctttgtaatt atcgaaagtg tcgcatcaaa ctctctggct atgcatgggt cactgcctgc
      541 tctcacatct tctgtgatca gcatggcagt ggtgagttta gtcgctcacc agctatctgt
      601 cctgcctgca acagtaccct ttctggaaag ctagatattg tccgcacaga actcagtcca
      661 tcagaggaat ataaagctat ggtattggca ggactgcgac cagagatcgt gttggacatt
      721 agctcccgag cgctggcctt ctggacatat caggtacatc aggaacgtct ctatcaagaa
      781 tacaatttca gcaaggctga gggccatctg aaacagatgg agaagatata tactcagcaa
      841 atacaaagca aggatgtaga attgacctct atgaaagggg aggttacctc catgaagaaa
      901 gtactagaag aatacaagaa aaagttcagt gacatctctg agaaacttat ggagcgcaat
      961 cgtcagtatc aaaagctcca aggcctctat gatagcctta ggctacgaaa catcactatt
     1021 gctaaccatg aaggcaccct tgaaccatcc atgattgcac agtctggtgt tcttggcttc
     1081 ccattaggta acaactccaa gtttcctttg gataatacac ctgttcgaaa tcggggcgat
     1141 ggagatggag attttcagtt cagaccattt tttgcgggtt ctcccacagc acctgaaccc
     1201 agcaacagct tttttagttt tgtctctcca agtcgtgaat tagagcagca gcaagtttct
     1261 agcagggcct tcaaagtaaa aagaatttga gccacgcata gtgtcacgca cctgtgatcc
     1321 cagctactta ggaggttgag gctgggagga tcacttgagc ccaggagtct gaggctttag
     1381 tgatctaaga tcatgccact gcactccagc ctgggcaaca gagtgagacc ctgtttctaa
     1441 aaaaaaataa agataattta gctaacttta
//
