LOCUS       NM_031966               2029 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens cyclin B1 (CCNB1), transcript variant 1, mRNA.
ACCESSION   NM_031966
VERSION     NM_031966.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Zheng,X.F., Sarkar,A., Lotana,H., Syed,A., Nguyen,H., Ivey,R.G.,
            Kennedy,J.J., Whiteaker,J.R., Tomasik,B., Huang,K., Li,F.,
            D'Andrea,A.D., Paulovich,A.G., Shah,K., Spektor,A. and Chowdhury,D.
  TITLE     CDK5-cyclin B1 regulates mitotic fidelity
  JOURNAL   Nature 633 (8031), 932-940 (2024)
   PUBMED   39232161
  REMARK    GeneRIF: CDK5-cyclin B1 regulates mitotic fidelity.
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Oda,S., Yokoyama,A., Kishii,R. and Nagasawa,M.
  TITLE     Serum/glucocorticoid-regulated kinase 1 contributes to the
            proliferation of varicella-zoster virus and induction of cyclin B1
            expression
  JOURNAL   Arch Virol 169 (5), 116 (2024)
   PUBMED   38722402
  REMARK    GeneRIF: Serum/glucocorticoid-regulated kinase 1 contributes to the
            proliferation of varicella-zoster virus and induction of cyclin B1
            expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Kang,J., Jung,H. and Kim,H.
  TITLE     Prognostic value of cyclin B1 and cyclin B2 expression in breast
            cancer: A systematic review and updated meta-analysis
  JOURNAL   Medicine (Baltimore) 103 (3), e37016 (2024)
   PUBMED   38241547
  REMARK    GeneRIF: Prognostic value of cyclin B1 and cyclin B2 expression in
            breast cancer: A systematic review and updated meta-analysis.
REFERENCE   4  (bases 1 to 2029)
  AUTHORS   Cavalcante,I.L., Silva Barros,C.C.D., Colares,D.F., Cruz,V.M.S., de
            Andrade,B.A.B., Nonaka,C.F.W., Rabenhorst,S.H.B. and
            Cavalcante,R.B.
  TITLE     BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and
            polymorphous adenocarcinoma of minor salivary glands
  JOURNAL   Pathol Res Pract 253, 154961 (2024)
   PUBMED   38043194
  REMARK    GeneRIF: BubR1 and cyclin B1 immunoexpression in pleomorphic
            adenoma and polymorphous adenocarcinoma of minor salivary glands.
REFERENCE   5  (bases 1 to 2029)
  AUTHORS   Zhao,X. and He,L.
  TITLE     Hsa-circ-0006091 modulates the proliferation of hepatocellular
            carcinoma via the miR-622/CCNB1 axis
  JOURNAL   Turk J Med Sci 53 (5), 1367-1378 (2023)
   PUBMED   38813026
  REMARK    GeneRIF: Hsa-circ-0006091 modulates the proliferation of
            hepatocellular carcinoma via the miR-622/CCNB1 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2029)
  AUTHORS   Parker,L.L. and Piwnica-Worms,H.
  TITLE     Inactivation of the p34cdc2-cyclin B complex by the human WEE1
            tyrosine kinase
  JOURNAL   Science 257 (5078), 1955-1957 (1992)
   PUBMED   1384126
REFERENCE   7  (bases 1 to 2029)
  AUTHORS   Sartor,H., Ehlert,F., Grzeschik,K.H., Muller,R. and Adolph,S.
  TITLE     Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31
            and 5q12, respectively
  JOURNAL   Genomics 13 (3), 911-912 (1992)
   PUBMED   1386342
REFERENCE   8  (bases 1 to 2029)
  AUTHORS   Bailly,E., Pines,J., Hunter,T. and Bornens,M.
  TITLE     Cytoplasmic accumulation of cyclin B1 in human cells: association
            with a detergent-resistant compartment and with the centrosome
  JOURNAL   J Cell Sci 101 (Pt 3), 529-545 (1992)
   PUBMED   1387877
REFERENCE   9  (bases 1 to 2029)
  AUTHORS   Pines,J. and Hunter,T.
  TITLE     Human cyclins A and B1 are differentially located in the cell and
            undergo cell cycle-dependent nuclear transport
  JOURNAL   J Cell Biol 115 (1), 1-17 (1991)
   PUBMED   1717476
REFERENCE   10 (bases 1 to 2029)
  AUTHORS   Strausfeld,U., Labbe,J.C., Fesquet,D., Cavadore,J.C., Picard,A.,
            Sadhu,K., Russell,P. and Doree,M.
  TITLE     Dephosphorylation and activation of a p34cdc2/cyclin B complex in
            vitro by human CDC25 protein
  JOURNAL   Nature 351 (6323), 242-245 (1991)
   PUBMED   1828290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI253686.1, AC010273.8,
            BC006510.2, BM979016.1 and AI972071.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031966.3.
            
            Summary: The protein encoded by this gene is a regulatory protein
            involved in mitosis. The gene product complexes with p34(cdc2) to
            form the maturation-promoting factor (MPF). The encoded protein is
            necessary for proper control of the G2/M transition phase of the
            cell cycle. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.183438.1,
                                           SRR5189658.127349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256442.10/ ENSP00000256442.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BI253686.1         141-177
            38-38               AC010273.8         10541-10541         c
            39-1477             BC006510.2         21-1459
            1478-2024           BM979016.1         14-560              c
            2025-2029           AI972071.1         9-13                c
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..2029
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="cyclin B1"
                     /db_xref="GeneID:891"
                     /db_xref="HGNC:HGNC:1579"
                     /db_xref="MIM:123836"
     exon            1..134
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1415
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     G2/mitotic-specific cyclin-B1"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B1 isoform 1"
                     /protein_id="NP_114172.1"
                     /db_xref="CCDS:CCDS3997.1"
                     /db_xref="GeneID:891"
                     /db_xref="HGNC:HGNC:1579"
                     /db_xref="MIM:123836"
                     /translation="MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTA
                     LGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPE
                     PEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAED
                     GADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRL
                     LQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNT
                     YTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDY
                     DMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQ
                     GLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV"
     exon            135..305
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            306..476
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            477..659
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            660..818
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1055
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1196
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1307
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..2029
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="major polyA site"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="hexamer: AATAAA"
     polyA_site      1540
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
     regulatory      1812..1817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="hexamer: AGTAAA"
     polyA_site      1831
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="CCNB1"
                     /gene_synonym="CCNB"
ORIGIN      
        1 ggcgtgctgc ggcggaacgg ctgttggttt ctgctgggtg taggtccttg gctggtcggg
       61 cctccggtgt tctgcttctc cccgctgagc tgctgcctgg tgaagaggaa gccatggcgc
      121 tccgagtcac caggaactcg aaaattaatg ctgaaaataa ggcgaagatc aacatggcag
      181 gcgcaaagcg cgttcctacg gcccctgctg caacctccaa gcccggactg aggccaagaa
      241 cagctcttgg ggacattggt aacaaagtca gtgaacaact gcaggccaaa atgcctatga
      301 agaaggaagc aaaaccttca gctactggaa aagtcattga taaaaaacta ccaaaacctc
      361 ttgaaaaggt acctatgctg gtgccagtgc cagtgtctga gccagtgcca gagccagaac
      421 ctgagccaga acctgagcct gttaaagaag aaaaactttc gcctgagcct attttggttg
      481 atactgcctc tccaagccca atggaaacat ctggatgtgc ccctgcagaa gaagacctgt
      541 gtcaggcttt ctctgatgta attcttgcag taaatgatgt ggatgcagaa gatggagctg
      601 atccaaacct ttgtagtgaa tatgtgaaag atatttatgc ttatctgaga caacttgagg
      661 aagagcaagc agtcagacca aaatacctac tgggtcggga agtcactgga aacatgagag
      721 ccatcctaat tgactggcta gtacaggttc aaatgaaatt caggttgttg caggagacca
      781 tgtacatgac tgtctccatt attgatcggt tcatgcagaa taattgtgtg cccaagaaga
      841 tgctgcagct ggttggtgtc actgccatgt ttattgcaag caaatatgaa gaaatgtacc
      901 ctccagaaat tggtgacttt gcttttgtga ctgacaacac ttatactaag caccaaatca
      961 gacagatgga aatgaagatt ctaagagctt taaactttgg tctgggtcgg cctctacctt
     1021 tgcacttcct tcggagagca tctaagattg gagaggttga tgtcgagcaa catactttgg
     1081 ccaaatacct gatggaacta actatgttgg actatgacat ggtgcacttt cctccttctc
     1141 aaattgcagc aggagctttt tgcttagcac tgaaaattct ggataatggt gaatggacac
     1201 caactctaca acattacctg tcatatactg aagaatctct tcttccagtt atgcagcacc
     1261 tggctaagaa tgtagtcatg gtaaatcaag gacttacaaa gcacatgact gtcaagaaca
     1321 agtatgccac atcgaagcat gctaagatca gcactctacc acagctgaat tctgcactag
     1381 ttcaagattt agccaaggct gtggcaaagg tgtaacttgt aaacttgagt tggagtacta
     1441 tatttacaaa taaaattggc accatgtgcc atctgtacat attactgttg catttacttt
     1501 taataaagct tgtggcccct tttacttttt tatagcttaa ctaatttgaa tgtggttact
     1561 tcctactgta gggtagcgga aaagttgtct taaaaggtat ggtggggata tttttaaaaa
     1621 ctccttttgg tttacctggg gatccaattg atgtatatgt ttatatactg ggttcttgtt
     1681 ttatatacct ggcttttact ttattaatat gagttactga aggtgatgga ggtatttgaa
     1741 aattttactt ccataggaca tactgcatgt aagccaagtc atggagaatc tgctgcatag
     1801 ctctatttta aagtaaaagt ctaccaccga atccctagtc cccctgtttt ctgtttcttc
     1861 ttgtgattgc tgccataatt ctaagttatt tacttttacc actatttaag ttatcaactt
     1921 tagctagtat cttcaaactt tcactttgaa aaatgagaat tttatattct aagccagttt
     1981 tcattttggt tttgtgtttt ggttaataaa acaatactca aatacaaaa
//
