LOCUS       NM_001237               2748 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens cyclin A2 (CCNA2), mRNA.
ACCESSION   NM_001237
VERSION     NM_001237.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2748)
  AUTHORS   Cao,M.G., Wang,Y., Yang,Z.M., Wang,Y., Wang,M.Q., Zhuo,S., Yang,Y.
            and Liu,C.S.
  TITLE     The effect of miR-381 on proliferation and prognosis of breast
            cancer by altering CCNA2 expression
  JOURNAL   J Obstet Gynaecol 44 (1), 2360547 (2024)
   PUBMED   38904638
  REMARK    GeneRIF: The effect of miR-381 on proliferation and prognosis of
            breast cancer by altering CCNA2 expression.
REFERENCE   2  (bases 1 to 2748)
  AUTHORS   He,Q., Qu,M., Xu,C., Wu,L., Xu,Y., Su,J., Bao,H., Shen,T., He,Y.,
            Cai,J., Xu,D., Zeng,L.H. and Wu,X.
  TITLE     Smoking-induced CCNA2 expression promotes lung adenocarcinoma
            tumorigenesis by boosting AT2/AT2-like cell differentiation
  JOURNAL   Cancer Lett 592, 216922 (2024)
   PUBMED   38704137
  REMARK    GeneRIF: Smoking-induced CCNA2 expression promotes lung
            adenocarcinoma tumorigenesis by boosting AT2/AT2-like cell
            differentiation.
REFERENCE   3  (bases 1 to 2748)
  AUTHORS   Zhang,J., Di,Y., Zhang,B., Li,T., Li,D. and Zhang,H.
  TITLE     CDK1 and CCNA2 play important roles in oral squamous cell carcinoma
  JOURNAL   Medicine (Baltimore) 103 (16), e37831 (2024)
   PUBMED   38640322
  REMARK    GeneRIF: CDK1 and CCNA2 play important roles in oral squamous cell
            carcinoma.
REFERENCE   4  (bases 1 to 2748)
  AUTHORS   Hutchenreuther,J., Nguyen,J., Quesnel,K., Vincent,K.M.,
            Petitjean,L., Bourgeois,S., Boyd,M., Bou-Gharios,G., Postovit,L.M.
            and Leask,A.
  TITLE     Cancer-associated Fibroblast-specific Expression of the
            Matricellular Protein CCN1 Coordinates Neovascularization and
            Stroma Deposition in Melanoma Metastasis
  JOURNAL   Cancer Res Commun 4 (2), 556-570 (2024)
   PUBMED   38363129
  REMARK    GeneRIF: Cancer-associated Fibroblast-specific Expression of the
            Matricellular Protein CCN1 Coordinates Neovascularization and
            Stroma Deposition in Melanoma Metastasis.
REFERENCE   5  (bases 1 to 2748)
  AUTHORS   Li,Z., Li,Q. and Chen,Z.
  TITLE     Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by
            Targeting Mir-188-3p/CCNA2 Axis
  JOURNAL   Horm Metab Res 55 (7), 498-505 (2023)
   PUBMED   37276868
  REMARK    GeneRIF: Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer
            by Targeting Mir-188-3p/CCNA2 Axis.
REFERENCE   6  (bases 1 to 2748)
  AUTHORS   Bailly,E., Pines,J., Hunter,T. and Bornens,M.
  TITLE     Cytoplasmic accumulation of cyclin B1 in human cells: association
            with a detergent-resistant compartment and with the centrosome
  JOURNAL   J Cell Sci 101 (Pt 3), 529-545 (1992)
   PUBMED   1387877
REFERENCE   7  (bases 1 to 2748)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   8  (bases 1 to 2748)
  AUTHORS   Faha,B., Ewen,M.E., Tsai,L.H., Livingston,D.M. and Harlow,E.
  TITLE     Interaction between human cyclin A and adenovirus E1A-associated
            p107 protein
  JOURNAL   Science 255 (5040), 87-90 (1992)
   PUBMED   1532458
REFERENCE   9  (bases 1 to 2748)
  AUTHORS   Paterlini,P., De Mitri,M.S., Martin,C., Munnich,A. and Brechot,C.
  TITLE     A TaqI polymorphism in the human cyclin A gene
  JOURNAL   Nucleic Acids Res 19 (9), 2516 (1991)
   PUBMED   1675006
REFERENCE   10 (bases 1 to 2748)
  AUTHORS   Wang,J., Chenivesse,X., Henglein,B. and Brechot,C.
  TITLE     Hepatitis B virus integration in a cyclin A gene in a
            hepatocellular carcinoma
  JOURNAL   Nature 343 (6258), 555-557 (1990)
   PUBMED   1967822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079341.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001237.4.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members function as regulators of
            the cell cycle. This protein binds and activates cyclin-dependent
            kinase 2 and thus promotes transition through G1/S and G2/M.
            [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4643867.21931.1,
                                           ERR4643888.33318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274026.10/ ENSP00000274026.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AC079341.6         83255-83722         c
            469-712             AC079341.6         82242-82485         c
            713-825             AC079341.6         80818-80930         c
            826-1049            AC079341.6         80381-80604         c
            1050-1257           AC079341.6         79211-79418         c
            1258-1371           AC079341.6         78639-78752         c
            1372-1505           AC079341.6         77883-78016         c
            1506-2748           AC079341.6         76283-77525         c
FEATURES             Location/Qualifiers
     source          1..2748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..2748
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /note="cyclin A2"
                     /db_xref="GeneID:890"
                     /db_xref="HGNC:HGNC:1578"
                     /db_xref="MIM:123835"
     exon            1..468
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1554
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /note="cyclin-A"
                     /codon_start=1
                     /product="cyclin-A2"
                     /protein_id="NP_001228.2"
                     /db_xref="CCDS:CCDS3723.1"
                     /db_xref="GeneID:890"
                     /db_xref="HGNC:HGNC:1578"
                     /db_xref="MIM:123835"
                     /translation="MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQP
                     RTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIH
                     VDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDM
                     SIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWL
                     VEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVA
                     EFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
                     FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLM
                     DLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL"
     exon            469..712
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     exon            713..825
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1049
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1257
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1371
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1505
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..2748
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="CCNA2"
                     /gene_synonym="CCN1; CCNA"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggctgc tcgctgcatc tctgggcgtc tttggctcgc cacgctgggc agtgcctgcc
       61 tgcgcctttc gcaacctcct cggccctgcg tggtctcgag ctgggtgagc gagcgggcgg
      121 gctggtaggc tggcctgggc tgcgaccggc ggctacgact attctttggc cgggtcggtg
      181 cgagtggtcg gctgggcaga gtgcacgctg cttggcgccg caggctgatc ccgccgtcca
      241 ctcccgggag cagtgatgtt gggcaactct gcgccggggc ctgcgacccg cgaggcgggc
      301 tcggcgctgc tagcattgca gcagacggcg ctccaagagg accaggagaa tatcaacccg
      361 gaaaaggcag cgcccgtcca acaaccgcgg acccgggccg cgctggcggt actgaagtcc
      421 gggaacccgc ggggtctagc gcagcagcag aggccgaaga cgagacgggt tgcacccctt
      481 aaggatcttc ctgtaaatga tgagcatgtc accgttcctc cttggaaagc aaacagtaaa
      541 cagcctgcgt tcaccattca tgtggatgaa gcagaaaaag aagctcagaa gaagccagct
      601 gaatctcaaa aaatagagcg tgaagatgcc ctggctttta attcagccat tagtttacct
      661 ggacccagaa aaccattggt ccctcttgat tatccaatgg atggtagttt tgagtcacca
      721 catactatgg acatgtcaat tatattagaa gatgaaaagc cagtgagtgt taatgaagta
      781 ccagactacc atgaggatat tcacacatac cttagggaaa tggaggttaa atgtaaacct
      841 aaagtgggtt acatgaagaa acagccagac atcactaaca gtatgagagc tatcctcgtg
      901 gactggttag ttgaagtagg agaagaatat aaactacaga atgagaccct gcatttggct
      961 gtgaactaca ttgataggtt cctgtcttcc atgtcagtgc tgagaggaaa acttcagctt
     1021 gtgggcactg ctgctatgct gttagcctca aagtttgaag aaatataccc cccagaagta
     1081 gcagagtttg tgtacattac agatgatacc tacaccaaga aacaagttct gagaatggag
     1141 catctagttt tgaaagtcct tacttttgac ttagctgctc caacagtaaa tcagtttctt
     1201 acccaatact ttctgcatca gcagcctgca aactgcaaag ttgaaagttt agcaatgttt
     1261 ttgggagaat taagtttgat agatgctgac ccatacctca agtatttgcc atcagttatt
     1321 gctggagctg cctttcattt agcactctac acagtcacgg gacaaagctg gcctgaatca
     1381 ttaatacgaa agactggata taccctggaa agtcttaagc cttgtctcat ggaccttcac
     1441 cagacctacc tcaaagcacc acagcatgca caacagtcaa taagagaaaa gtacaaaaat
     1501 tcaaagtatc atggtgtttc tctcctcaac ccaccagaga cactaaatct gtaacaatga
     1561 aagactgcct ttgttttcta agatgtaaat cactcaaagt atatggtgta cagtttttaa
     1621 cttaggtttt aattttacaa tcatttctga atacagaagt tgtggccaag tacaaattat
     1681 ggtatctatt actttttaaa tggttttaat ttgtatatct tttgtatatg tatctgtctt
     1741 agatatttgg ctaattttaa gtggttttgt taaagtatta atgatgccag ctgtcaggat
     1801 aataaattga tttggaaaac tttgcaagtc aaatttaact tcttcaggat tttgcttagt
     1861 aaagaagttt acttggttta ctatataatg ggaagtgaaa agccttcctc taaaattaaa
     1921 gtaggtttag gaaaacagac cctcaaattc tgacattcat tttcctaagc aactggatca
     1981 atttgctgac ttgggcataa tctaatctaa gcatatctga atacagtatt cagagataga
     2041 tacagtagag attccccaga ctttttcgct ctttgtaaaa cctgtttgtt taggttttgc
     2101 gaggtaaact caacagaggt tgggagtgga agagggtggg aagcttatat gcaaattaac
     2161 agacgagaaa tgctccagaa ggtttattat tttaaagcac attaaaaaca aaaaactatt
     2221 tttaaaatcc tgctagattt tataatggat ttgtgaataa aaaataccca gggttctcag
     2281 aatggaataa atatcccttt taatagttat atatacagat atacaactgt tagctttaat
     2341 tggcagctct cttctttttt cttcttttca ctggcttttt acttggtgct ttttcttgtt
     2401 ttgcactggt ggtctgtgtt ctgtgaataa agcaaagtaa gaatttacta agagtatgtt
     2461 aagttttgga ttattgaaat aagaggcatt tcttagtttt ccagtaggat ctaaaatgtg
     2521 tcagctatga gtaagactgg catccaagaa gtttatatta tagatttagg tcctaatttt
     2581 tataaatcac aaggtaaaaa aatcacagaa cagatggatc tctaatgaaa aagggatgtc
     2641 tttttgttta tagtcatgtg gcaagatgag agtaaaacca gagagcaaac ctctataagt
     2701 gttgagtata tgtatacatt tgaaataaac cagaaatttg ttacctta
//
