LOCUS       NM_001413923            1730 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens cyclin A1 (CCNA1), transcript variant 1, mRNA.
ACCESSION   NM_001413923
VERSION     NM_001413923.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1730)
  AUTHORS   Du,X., Zang,C. and Wang,Q.
  TITLE     Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming
            growth factor-beta (TGF-beta) pathway in osteoblasts
  JOURNAL   BMC Musculoskelet Disord 25 (1), 206 (2024)
   PUBMED   38454404
  REMARK    GeneRIF: Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing
            transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1730)
  AUTHORS   Ma,Y.R., Yang,Q., Li,H., Song,J.Z., Zhou,X. and Xiang,F.G.
  TITLE     [Cyclin A1 affects the invasion, metastasis, and prognosis of
            hepatocellular carcinoma]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 31 (10), 1043-1050 (2023)
   PUBMED   38016768
  REMARK    GeneRIF: [Cyclin A1 affects the invasion, metastasis, and prognosis
            of hepatocellular carcinoma].
REFERENCE   3  (bases 1 to 1730)
  AUTHORS   Yang,X., Wan,M., Yu,F. and Wu,X.
  TITLE     Histone methyltransferase EZH2 epigenetically affects CCNA1
            expression in acute myeloid leukemia
  JOURNAL   Cell Signal 87, 110144 (2021)
   PUBMED   34509612
  REMARK    GeneRIF: Histone methyltransferase EZH2 epigenetically affects
            CCNA1 expression in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 1730)
  AUTHORS   Bourova-Flin,E., Derakhshan,S., Goudarzi,A., Wang,T., Vitte,A.L.,
            Chuffart,F., Khochbin,S., Rousseaux,S. and Aminishakib,P.
  TITLE     The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3
            expression predicts aggressive forms of oral squamous cell
            carcinoma
  JOURNAL   Br J Cancer 125 (8), 1122-1134 (2021)
   PUBMED   34290392
  REMARK    GeneRIF: The combined detection of Amphiregulin, Cyclin A1 and
            DDX20/Gemin3 expression predicts aggressive forms of oral squamous
            cell carcinoma.
REFERENCE   5  (bases 1 to 1730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1730)
  AUTHORS   Yang,R., Morosetti,R. and Koeffler,H.P.
  TITLE     Characterization of a second human cyclin A that is highly
            expressed in testis and in several leukemic cell lines
  JOURNAL   Cancer Res 57 (5), 913-920 (1997)
   PUBMED   9041194
REFERENCE   7  (bases 1 to 1730)
  AUTHORS   Chen,J., Saha,P., Kornbluth,S., Dynlacht,B.D. and Dutta,A.
  TITLE     Cyclin-binding motifs are essential for the function of p21CIP1
  JOURNAL   Mol Cell Biol 16 (9), 4673-4682 (1996)
   PUBMED   8756624
REFERENCE   8  (bases 1 to 1730)
  AUTHORS   Sweeney,C., Murphy,M., Kubelka,M., Ravnik,S.E., Hawkins,C.F.,
            Wolgemuth,D.J. and Carrington,M.
  TITLE     A distinct cyclin A is expressed in germ cells in the mouse
  JOURNAL   Development 122 (1), 53-64 (1996)
   PUBMED   8565853
REFERENCE   9  (bases 1 to 1730)
  AUTHORS   Hall,M., Bates,S. and Peters,G.
  TITLE     Evidence for different modes of action of cyclin-dependent kinase
            inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to
            cyclins
  JOURNAL   Oncogene 11 (8), 1581-1588 (1995)
   PUBMED   7478582
REFERENCE   10 (bases 1 to 1730)
  AUTHORS   Xu,M., Sheppard,K.A., Peng,C.Y., Yee,A.S. and Piwnica-Worms,H.
  TITLE     Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding
            activity of E2F-1/DP-1 by phosphorylation
  JOURNAL   Mol Cell Biol 14 (12), 8420-8431 (1994)
   PUBMED   7969176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359767.13.
            
            Summary: The protein encoded by this gene belongs to the highly
            conserved cyclin family, whose members are characterized by a
            dramatic periodicity in protein abundance through the cell cycle.
            Cyclins function as regulators of CDK kinases. Different cyclins
            exhibit distinct expression and degradation patterns which
            contribute to the temporal coordination of each mitotic event. The
            cyclin encoded by this gene was shown to be expressed in testis and
            brain, as well as in several leukemic cell lines, and is thought to
            primarily function in the control of the germline meiotic cell
            cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two
            distinct kinase activities, one appearing in S phase, the other in
            G2, and thus regulate separate functions in cell cycle. This cyclin
            was found to bind to important cell cycle regulators, such as Rb
            family proteins, transcription factor E2F-1, and the p21 family
            proteins. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3560823.1, U66838.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000255465.8/
                                                ENSP00000255465.5
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AL359767.13        56201-56435
            236-424             AL359767.13        56739-56927
            425-671             AL359767.13        61335-61581
            672-796             AL359767.13        61773-61897
            797-1020            AL359767.13        62350-62573
            1021-1225           AL359767.13        63685-63889
            1226-1339           AL359767.13        64824-64937
            1340-1473           AL359767.13        65877-66010
            1474-1730           AL359767.13        66320-66576
FEATURES             Location/Qualifiers
     source          1..1730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..1730
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /note="cyclin A1"
                     /db_xref="GeneID:8900"
                     /db_xref="HGNC:HGNC:1577"
                     /db_xref="MIM:604036"
     exon            1..235
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            236..424
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1525
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /note="testicular tissue protein Li 34"
                     /codon_start=1
                     /product="cyclin-A1"
                     /protein_id="NP_001400852.1"
                     /db_xref="GeneID:8900"
                     /db_xref="HGNC:HGNC:1577"
                     /db_xref="MIM:604036"
                     /translation="MHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLT
                     ANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGD
                     RDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTD
                     VINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRA
                     ETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYT
                     KRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADP
                     FLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHR
                     PQQAIREKYKASKYLCVSLMEPPAVLLLQ"
     exon            425..671
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            672..796
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1020
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1225
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1339
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1473
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1730
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /note="hexamer: AATAAA"
     polyA_site      1730
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /note="major polyA site"
ORIGIN      
        1 agttgttccg gacacataga aagataacga cgggaagagc ggggcccgct ttggggtcca
       61 ggcaggtttt ggggcctcct gtctggtggg aggaggccgc agcgcagcac cctgctcgtc
      121 acttgggatg gagaccggct ttcccgcaat catgtaccct ggatctttta ttgggggctg
      181 gggagaagag tatctcagct gggaaggacc ggggctccca gatttcgtct tccagcagca
      241 gcccgtggag tctgaagcaa tgcactgcag caaccccaag agtggagttg tgctggctac
      301 agtggcccga ggtcccgatg cttgtcagat actcaccaga gccccgctgg gccaggatcc
      361 cccgcagagg acagtgctag ggctgctaac tgcaaatggg cagtacagga ggacctgtgg
      421 ccaggggatc acaagaatca ggtgttattc tggatcagaa aatgccttcc ctccagctgg
      481 aaagaaagca ctccctgact gtggggtcca agagcccccc aagcaagggt ttgacatcta
      541 catggatgaa ctagagcagg gggacagaga cagctgctcg gtcagagagg ggatggcatt
      601 tgaggatgtg tatgaagtag acaccggcac actcaagtca gacctgcact tcctgctgga
      661 tttcaacaca gtttccccta tgctggtaga ttcatctctc ctctcccagt ctgaagatat
      721 atccagtctt ggcacagatg tgataaatgt gactgaatat gctgaagaaa tttatcagta
      781 ccttagggaa gctgaaataa ggcacagacc caaagcacac tacatgaaga agcagccaga
      841 catcacggaa ggcatgcgca cgattctggt ggactggctg gtggaggttg gggaagaata
      901 taaacttcga gcagagaccc tgtatctggc tgtcaacttc ctggacaggt tcctttcatg
      961 tatgtctgtt ctgagaggga aactgcagct cgtaggaaca gcagctatgc ttttggcttc
     1021 gaaatatgaa gagatatatc ctcctgaagt agacgagttt gtctatatca ccgatgatac
     1081 atacacaaaa cgacaactgt taaaaatgga acacttgctt ctgaaagttc tagcttttga
     1141 tctgacagta ccaaccacca accagtttct ccttcagtac ttgaggcgac aaggagtgtg
     1201 cgtcaggact gagaacctgg ctaagtacgt agcagagctg agtctacttg aagcagatcc
     1261 attcttgaaa tatcttcctt cactgatagc tgcagcagct ttttgcctgg caaactatac
     1321 tgtgaacaag cacttttggc cagaaaccct tgctgcattt acagggtatt cattaagtga
     1381 aattgtgcct tgcctgagtg agcttcataa agcgtacctt gatatacccc atcgacctca
     1441 gcaagcaatt agggagaagt acaaggcttc aaagtacctg tgtgtgtccc tcatggagcc
     1501 acctgcagtt cttcttctac aataagtttc tgaatggaag cacttccaga acttcacctc
     1561 catatcagaa gtgccaataa tcgtcatagg cttctgcacg ttggatcaac taatgttgtt
     1621 tacaatatag atgacatttt aaaaatgtaa atgaatttag tttcccttag actttagtag
     1681 tttgtaatat agtccaacat tttttaaaca ataaactgct tgtcttatga
//
