LOCUS       NM_198239               1385 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens cellular communication network factor 6 (CCN6),
            transcript variant 3, mRNA.
ACCESSION   NM_198239
VERSION     NM_198239.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Hochi,H., Kubota,S., Takigawa,M. and Nishida,T.
  TITLE     Dual roles of cellular communication network factor 6 (CCN6) in the
            invasion and metastasis of oral cancer cells to bone via binding to
            BMP2 and RANKL
  JOURNAL   Carcinogenesis 44 (8-9), 695-707 (2023)
   PUBMED   37590989
  REMARK    GeneRIF: Dual roles of cellular communication network factor 6
            (CCN6) in the invasion and metastasis of oral cancer cells to bone
            via binding to BMP2 and RANKL.
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Li,C., Alemany-Ribes,M., Raftery,R.M., Nwoko,U., Warman,M.L. and
            Craft,A.M.
  TITLE     Directed differentiation of human pluripotent stem cells into
            articular cartilage reveals effects caused by absence of WISP3, the
            gene responsible for progressive pseudorheumatoid arthropathy of
            childhood
  JOURNAL   Ann Rheum Dis 82 (12), 1547-1557 (2023)
   PUBMED   37679035
  REMARK    GeneRIF: Directed differentiation of human pluripotent stem cells
            into articular cartilage reveals effects caused by absence of
            WISP3, the gene responsible for progressive pseudorheumatoid
            arthropathy of childhood.
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Zhao,Y., Ruan,J., Li,Z., Su,X., Chen,K., Lin,Y., Cai,Y., Wang,P.,
            Liu,B., Schluter,D., Liang,G. and Wang,X.
  TITLE     OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6
  JOURNAL   Clin Transl Med 13 (8), e1385 (2023)
   PUBMED   37608493
  REMARK    GeneRIF: OTUB1 inhibits breast cancer by non-canonically
            stabilizing CCN6.
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Nam,M.W., Lee,H.K., Kim,C.W., Choi,Y., Ahn,D., Go,R.E. and
            Choi,K.C.
  TITLE     Effects of CCN6 overexpression on the cell motility and activation
            of p38/bone morphogenetic protein signaling pathways in pancreatic
            cancer cells
  JOURNAL   Biomed Pharmacother 163, 114780 (2023)
   PUBMED   37105075
  REMARK    GeneRIF: Effects of CCN6 overexpression on the cell motility and
            activation of p38/bone morphogenetic protein signaling pathways in
            pancreatic cancer cells.
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Ganguly,A., Padhan,D.K., Sengupta,A., Chakraborty,P. and Sen,M.
  TITLE     CCN6 influences transcription and controls mitochondrial mass and
            muscle organization
  JOURNAL   FASEB J 37 (3), e22815 (2023)
   PUBMED   36794678
  REMARK    GeneRIF: CCN6 influences transcription and controls mitochondrial
            mass and muscle organization.
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Kumar,S., Connor,J.R., Dodds,R.A., Halsey,W., Van Horn,M., Mao,J.,
            Sathe,G., Mui,P., Agarwal,P., Badger,A.M., Lee,J.C., Gowen,M. and
            Lark,M.W.
  TITLE     Identification and initial characterization of 5000 expressed
            sequenced tags (ESTs) each from adult human normal and
            osteoarthritic cartilage cDNA libraries
  JOURNAL   Osteoarthritis Cartilage 9 (7), 641-653 (2001)
   PUBMED   11597177
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Hurvitz,J.R., Suwairi,W.M., Van Hul,W., El-Shanti,H.,
            Superti-Furga,A., Roudier,J., Holderbaum,D., Pauli,R.M., Herd,J.K.,
            Van Hul,E.V., Rezai-Delui,H., Legius,E., Le Merrer,M., Al-Alami,J.,
            Bahabri,S.A. and Warman,M.L.
  TITLE     Mutations in the CCN gene family member WISP3 cause progressive
            pseudorheumatoid dysplasia
  JOURNAL   Nat Genet 23 (1), 94-98 (1999)
   PUBMED   10471507
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Pennica,D., Swanson,T.A., Welsh,J.W., Roy,M.A., Lawrence,D.A.,
            Lee,J., Brush,J., Taneyhill,L.A., Deuel,B., Lew,M., Watanabe,C.,
            Cohen,R.L., Melhem,M.F., Finley,G.G., Quirke,P., Goddard,A.D.,
            Hillan,K.J., Gurney,A.L., Botstein,D. and Levine,A.J.
  TITLE     WISP genes are members of the connective tissue growth factor
            family that are up-regulated in wnt-1-transformed cells and
            aberrantly expressed in human colon tumors
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14717-14722 (1998)
   PUBMED   9843955
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Bork,P.
  TITLE     The modular architecture of a new family of growth regulators
            related to connective tissue growth factor
  JOURNAL   FEBS Lett 327 (2), 125-130 (1993)
   PUBMED   7687569
  REMARK    Review article
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Bhavani,G.S., Shah,H., Shukla,A., Dalal,A. and Girisha,K.M.
  TITLE     Progressive Pseudorheumatoid Dysplasia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   26610319
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512299.20 and Z99289.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 21, 2019 this sequence version replaced NM_198239.1.
            
            Summary: This gene encodes a member of the WNT1 inducible signaling
            pathway (WISP) protein subfamily, which belongs to the connective
            tissue growth factor (CTGF) family. WNT1 is a member of a family of
            cysteine-rich, glycosylated signaling proteins that mediate diverse
            developmental processes. The CTGF family members are characterized
            by four conserved cysteine-rich domains: insulin-like growth
            factor-binding domain, von Willebrand factor type C module,
            thrombospondin domain and C-terminal cystine knot-like domain. This
            gene is overexpressed in colon tumors. It may be downstream in the
            WNT1 signaling pathway that is relevant to malignant
            transformation. Mutations of this gene are associated with
            progressive pseudorheumatoid dysplasia, an autosomal recessive
            skeletal disorder, indicating that the gene is essential for normal
            postnatal skeletal growth and cartilage homeostasis. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) represents the longer
            transcript and encodes the longer isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035250.1, AY358349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000368666.7/
                                                ENSP00000357655.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AL512299.20        53626-53927
            303-600             Z99289.2           4053-4350
            601-843             Z99289.2           7817-8059
            844-1037            Z99289.2           11267-11460
            1038-1385           Z99289.2           12401-12748
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..1385
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /note="cellular communication network factor 6"
                     /db_xref="GeneID:8838"
                     /db_xref="HGNC:HGNC:12771"
                     /db_xref="MIM:603400"
     exon            1..302
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1319
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; epididymis secretory sperm binding protein;
                     WNT1 inducible signaling pathway protein 3; CCN family
                     member 6"
                     /codon_start=1
                     /product="cellular communication network factor 6 isoform
                     1 precursor"
                     /protein_id="NP_937882.2"
                     /db_xref="CCDS:CCDS5098.1"
                     /db_xref="GeneID:8838"
                     /db_xref="HGNC:HGNC:12771"
                     /db_xref="MIM:603400"
                     /translation="MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQR
                     KQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDY
                     SVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKL
                     AGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTP
                     CSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSK
                     AEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITS
                     CVCQRNCREPGDIFSELKIL"
     exon            303..600
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..843
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1037
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1385
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1361..1366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /note="hexamer: AATAAA"
     polyA_site      1385
                     /gene="CCN6"
                     /gene_synonym="LIBC; PPAC; PPD; PPRD; WISP-3; WISP3"
                     /note="major polyA site"
ORIGIN      
        1 attcctgacc tgtgacacgc tcactgcgaa ggcaggttat tagaagagtc ccatgaaagt
       61 aaacagggta ttaaaacgga tccttaaaaa tgaaagtgca ggctgaaagt tggtagtgtg
      121 ggaggtagag ggtgtgtgtt cttgtgcaga ggagcgtggg gtttgcagag gagacagggg
      181 agctttgtgt acccggagca atgaacaagc ggcgacttct ctacccctca gggtggctcc
      241 acggtcccag cgacatgcag gggctcctct tctccactct tctgcttgct ggcctggcac
      301 agttctgctg cagggtacag ggcactggac cattagatac aacacctgaa ggaaggcctg
      361 gagaagtgtc agatgcacct cagcgtaaac agttttgtca ctggccctgc aaatgccctc
      421 agcagaagcc ccgttgccct cctggagtga gcctggtgag agatggctgt ggatgctgta
      481 aaatctgtgc caagcaacca ggggaaatct gcaatgaagc tgacctctgt gacccacaca
      541 aagggctgta ttgtgactac tcagtagaca ggcctaggta cgagactgga gtgtgtgcat
      601 accttgtagc tgttgggtgc gagttcaacc aggtacatta tcataatggc caagtgtttc
      661 agcccaaccc cttgttcagc tgcctctgtg tgagtggggc cattggatgc acacctctgt
      721 tcataccaaa gctggctggc agtcactgct ctggagctaa aggtggaaag aagtctgatc
      781 agtcaaactg tagcctggaa ccattactac agcagctttc aacaagctac aaaacaatgc
      841 cagcttatag aaatctccca cttatttgga aaaaaaaatg tcttgtgcaa gcaacaaaat
      901 ggactccctg ctccagaaca tgtgggatgg gaatatctaa cagggtgacc aatgaaaaca
      961 gcaactgtga aatgagaaaa gagaaaagac tgtgttacat tcagccttgc gacagcaata
     1021 tattaaagac aataaagatt cccaaaggaa aaacatgcca acctactttc caactctcca
     1081 aagctgaaaa atttgtcttt tctggatgct caagtactca gagttacaaa cccacttttt
     1141 gtggaatatg cttggataag agatgctgta tccctaataa gtctaaaatg attactattc
     1201 aatttgattg cccaaatgag gggtcattta aatggaagat gctgtggatt acatcttgtg
     1261 tgtgtcagag aaactgcaga gaacctggag atatattttc tgagctcaag attctgtaaa
     1321 accaagcaaa tgggggaaaa gttagtcaat cctgtcatat aataaaaaaa ttagtgagta
     1381 taaaa
//
