LOCUS       NM_003881               1279 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens cellular communication network factor 5 (CCN5),
            transcript variant 3, mRNA.
ACCESSION   NM_003881
VERSION     NM_003881.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Xu,D., Feng,H., Ren,Z., Li,X., Jiang,C., Chen,Y., Liu,L., Chen,W.,
            Cui,Z. and Cang,S.
  TITLE     SNHG3/WISP2 Axis Promotes Hela Cell Migration and Invasion via
            Activating Wnt/beta-Catenin Signaling
  JOURNAL   Cancer Genomics Proteomics 20 (6suppl), 744-753 (2023)
   PUBMED   38035707
  REMARK    GeneRIF: SNHG3/WISP2 Axis Promotes Hela Cell Migration and Invasion
            via Activating Wnt/beta-Catenin Signaling.
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Zheng,Y., Shen,P., Tong,M., Li,H., Ren,C., Wu,F., Li,H., Yang,H.,
            Cai,B., Du,W., Zhao,X., Yao,S. and Quan,R.
  TITLE     WISP2 downregulation inhibits the osteogenic differentiation of
            BMSCs in congenital scoliosis by regulating Wnt/beta-catenin
            pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166783 (2023)
   PUBMED   37302424
  REMARK    GeneRIF: WISP2 downregulation inhibits the osteogenic
            differentiation of BMSCs in congenital scoliosis by regulating
            Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Zheng,D., Bashir,M. and Li,Z.
  TITLE     ERalpha prevents tumorigenesis of both liver and breast cancer
            cells through CCN5
  JOURNAL   Biochem Biophys Res Commun 672, 103-112 (2023)
   PUBMED   37343316
  REMARK    GeneRIF: ERalpha prevents tumorigenesis of both liver and breast
            cancer cells through CCN5.
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Zhu,J., Dai,H., Li,X., Guo,L., Sun,X., Zheng,Z. and Xu,C.
  TITLE     LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the
            miR-877-5p/WISP2 axis
  JOURNAL   Pathol Res Pract 243, 154360 (2023)
   PUBMED   36801505
  REMARK    GeneRIF: LncRNA TRG-AS1 inhibits bone metastasis of breast cancer
            by the miR-877-5p/WISP2 axis.
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Zhang,H., Song,W., Ma,X., Yu,M., Chen,L. and Tao,Y.
  TITLE     Acetylation stabilizes the signaling protein WISP2 by preventing
            its degradation to suppress the progression of acute myeloid
            leukemia
  JOURNAL   J Biol Chem 299 (3), 102971 (2023)
   PUBMED   36736423
  REMARK    GeneRIF: Acetylation stabilizes the signaling protein WISP2 by
            preventing its degradation to suppress the progression of acute
            myeloid leukemia.
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Inadera,H., Dong,H.Y. and Matsushima,K.
  TITLE     WISP-2 is a secreted protein and can be a marker of estrogen
            exposure in MCF-7 cells
  JOURNAL   Biochem Biophys Res Commun 294 (3), 602-608 (2002)
   PUBMED   12056810
REFERENCE   7  (bases 1 to 1279)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 1279)
  AUTHORS   Saxena,N., Banerjee,S., Sengupta,K., Zoubine,M.N. and Banerjee,S.K.
  TITLE     Differential expression of WISP-1 and WISP-2 genes in normal and
            transformed human breast cell lines
  JOURNAL   Mol Cell Biochem 228 (1-2), 99-104 (2001)
   PUBMED   11855747
  REMARK    GeneRIF: Overexpression of WISP2 is associated with breast cancer
REFERENCE   9  (bases 1 to 1279)
  AUTHORS   Kumar,S., Hand,A.T., Connor,J.R., Dodds,R.A., Ryan,P.J.,
            Trill,J.J., Fisher,S.M., Nuttall,M.E., Lipshutz,D.B., Zou,C.,
            Hwang,S.M., Votta,B.J., James,I.E., Rieman,D.J., Gowen,M. and
            Lee,J.C.
  TITLE     Identification and cloning of a connective tissue growth
            factor-like cDNA from human osteoblasts encoding a novel regulator
            of osteoblast functions
  JOURNAL   J Biol Chem 274 (24), 17123-17131 (1999)
   PUBMED   10358067
REFERENCE   10 (bases 1 to 1279)
  AUTHORS   Pennica,D., Swanson,T.A., Welsh,J.W., Roy,M.A., Lawrence,D.A.,
            Lee,J., Brush,J., Taneyhill,L.A., Deuel,B., Lew,M., Watanabe,C.,
            Cohen,R.L., Melhem,M.F., Finley,G.G., Quirke,P., Goddard,A.D.,
            Hillan,K.J., Gurney,A.L., Botstein,D. and Levine,A.J.
  TITLE     WISP genes are members of the connective tissue growth factor
            family that are up-regulated in wnt-1-transformed cells and
            aberrantly expressed in human colon tumors
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14717-14722 (1998)
   PUBMED   9843955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017782.2 and BU623413.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003881.3.
            
            Summary: This gene encodes a member of the WNT1 inducible signaling
            pathway (WISP) protein subfamily, which belongs to the connective
            tissue growth factor (CTGF) family. WNT1 is a member of a family of
            cysteine-rich, glycosylated signaling proteins that mediate diverse
            developmental processes. The CTGF family members are characterized
            by four conserved cysteine-rich domains: insulin-like growth
            factor-binding domain, von Willebrand factor type C module,
            thrombospondin domain and C-terminal cystine knot-like (CT) domain.
            The encoded protein lacks the CT domain which is implicated in
            dimerization and heparin binding. It is 72% identical to the mouse
            protein at the amino acid level. This gene may be downstream in the
            WNT1 signaling pathway that is relevant to malignant
            transformation. Its expression in colon tumors is reduced while the
            other two WISP members are overexpressed in colon tumors. It is
            expressed at high levels in bone tissue, and may play an important
            role in modulating bone turnover. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) retains an intron in its 5'
            UTR compared to variant 1. Both variants 1 and 3 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF083500.1, BC064379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000190983.5/ ENSP00000190983.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1276              BC017782.2         125-1400
            1277-1279           BU623413.1         20-22               c
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1279
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /note="cellular communication network factor 5"
                     /db_xref="GeneID:8839"
                     /db_xref="HGNC:HGNC:12770"
                     /db_xref="MIM:603399"
     exon            1..82
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..775
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; connective tissue growth factor-like protein;
                     CCN family member 5; connective tissue growth
                     factor-related protein 58; WNT1 inducible signaling
                     pathway protein 2"
                     /codon_start=1
                     /product="CCN family member 5 isoform 1 precursor"
                     /protein_id="NP_003872.1"
                     /db_xref="CCDS:CCDS13336.1"
                     /db_xref="GeneID:8839"
                     /db_xref="HGNC:HGNC:12770"
                     /db_xref="MIM:603399"
                     /translation="MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVP
                     LVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEV
                     NGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPE
                     WVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSN
                     QNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF"
     exon            83..299
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..554
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1279
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1261..1266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /note="hexamer: AATACA"
     polyA_site      1279
                     /gene="CCN5"
                     /gene_synonym="CT58; CTGF-L; WISP2"
                     /note="major polyA site"
ORIGIN      
        1 caaagctggc tctgcagggg acatgagagg cacaccgaag acccacctcc tggccttctc
       61 cctcctctgc ctcctctcaa aggtgcgtac ccagctgtgc ccgacaccat gtacctgccc
      121 ctggccacct ccccgatgcc cgctgggagt acccctggtg ctggatggct gtggctgctg
      181 ccgggtatgt gcacggcggc tgggggagcc ctgcgaccaa ctccacgtct gcgacgccag
      241 ccagggcctg gtctgccagc ccggggcagg acccggtggc cggggggccc tgtgcctctt
      301 ggcagaggac gacagcagct gtgaggtgaa cggccgcctg tatcgggaag gggagacctt
      361 ccagccccac tgcagcatcc gctgccgctg cgaggacggc ggcttcacct gcgtgccgct
      421 gtgcagcgag gatgtgcggc tgcccagctg ggactgcccc caccccagga gggtcgaggt
      481 cctgggcaag tgctgccctg agtgggtgtg cggccaagga gggggactgg ggacccagcc
      541 ccttccagcc caaggacccc agttttctgg ccttgtctct tccctgcccc ctggtgtccc
      601 ctgcccagaa tggagcacgg cctggggacc ctgctcgacc acctgtgggc tgggcatggc
      661 cacccgggtg tccaaccaga accgcttctg ccgactggag acccagcgcc gcctgtgcct
      721 gtccaggccc tgcccaccct ccaggggtcg cagtccacaa aacagtgcct tctagagccg
      781 ggctgggaat ggggacacgg tgtccaccat ccccagctgg tggccctgtg cctgggccct
      841 gggctgatgg aagatggtcc gtgcccaggc ccttggctgc aggcaacact ttagcttggg
      901 tccaccatgc agaacaccaa tattaacacg ctgcctggtc tgtctggatc ccgaggtatg
      961 gcagaggtgc aagacctagt cccctttcct ctaactcact gcctaggagg ctggccaagg
     1021 tgtccagggt cctctagccc actccctgcc tacacacaca gcctatatca aacatgcaca
     1081 cgggcgagct ttctctccga cttcccctgg gcaagagatg ggacaagcag tcccttaata
     1141 ttgaggctgc agcaggtgct gggctggact ggccattttt ctgggggtag gatgaagaga
     1201 aggcacacag agattctgga tctcctgctg ccttttctgg agtttgtaaa attgttcctg
     1261 aatacaagcc tatgcgtga
//
