LOCUS       NM_002514               2463 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens cellular communication network factor 3 (CCN3), mRNA.
ACCESSION   NM_002514
VERSION     NM_002514.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2463)
  AUTHORS   Babey,M.E., Krause,W.C., Chen,K., Herber,C.B., Torok,Z.,
            Nikkanen,J., Rodriguez,R., Zhang,X., Castro-Navarro,F., Wang,Y.,
            Wheeler,E.E., Villeda,S., Leach,J.K., Lane,N.E., Scheller,E.L.,
            Chan,C.K.F., Ambrosi,T.H. and Ingraham,H.A.
  TITLE     A maternal brain hormone that builds bone
  JOURNAL   Nature 632 (8024), 357-365 (2024)
   PUBMED   38987585
  REMARK    GeneRIF: A maternal brain hormone that builds bone.
REFERENCE   2  (bases 1 to 2463)
  AUTHORS   Son,S., Kim,H., Lim,H., Lee,J.H., Lee,K.M. and Shin,I.
  TITLE     CCN3/NOV promotes metastasis and tumor progression via
            GPNMB-induced EGFR activation in triple-negative breast cancer
  JOURNAL   Cell Death Dis 14 (2), 81 (2023)
   PUBMED   36737605
  REMARK    GeneRIF: CCN3/NOV promotes metastasis and tumor progression via
            GPNMB-induced EGFR activation in triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2463)
  AUTHORS   Hirose,K., Kuwahara,M., Nakata,E., Tetsunaga,T., Yamada,K.,
            Saiga,K., Takigawa,M., Ozaki,T., Kubota,S. and Hattori,T.
  TITLE     Elevated Expression of CCN3 in Articular Cartilage Induces
            Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing
  JOURNAL   Int J Mol Sci 23 (23), 15311 (2022)
   PUBMED   36499638
  REMARK    GeneRIF: Elevated Expression of CCN3 in Articular Cartilage Induces
            Osteoarthritis in Hip Joints Irrespective of Age and Weight
            Bearing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2463)
  AUTHORS   Liang,T., Shen,L., Ji,Y., Jia,L., Dou,Y. and Guo,L.
  TITLE     NOV/CCN3 Promotes Cell Migration and Invasion in Intrahepatic
            Cholangiocarcinoma via miR-92a-3p
  JOURNAL   Genes (Basel) 12 (11), 1659 (2021)
   PUBMED   34828265
  REMARK    GeneRIF: NOV/CCN3 Promotes Cell Migration and Invasion in
            Intrahepatic Cholangiocarcinoma via miR-92a-3p.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2463)
  AUTHORS   Siddiqui,S., Pandey,V., Ali,S., Singh,A., Sharma,D., Yadav,M. and
            Raikwar,A.
  TITLE     CCN3 Proteins as a diagnostic marker in osteosarcoma patients: A
            case control study
  JOURNAL   Cancer Treat Res Commun 28, 100381 (2021)
   PUBMED   33946014
  REMARK    GeneRIF: CCN3 Proteins as a diagnostic marker in osteosarcoma
            patients: A case control study.
REFERENCE   6  (bases 1 to 2463)
  AUTHORS   Burren,C.P., Wilson,E.M., Hwa,V., Oh,Y. and Rosenfeld,R.G.
  TITLE     Binding properties and distribution of insulin-like growth factor
            binding protein-related protein 3 (IGFBP-rP3/NovH), an additional
            member of the IGFBP Superfamily
  JOURNAL   J Clin Endocrinol Metab 84 (3), 1096-1103 (1999)
   PUBMED   10084601
REFERENCE   7  (bases 1 to 2463)
  AUTHORS   Perbal,B., Martinerie,C., Sainson,R., Werner,M., He,B. and
            Roizman,B.
  TITLE     The C-terminal domain of the regulatory protein NOVH is sufficient
            to promote interaction with fibulin 1C: a clue for a role of NOVH
            in cell-adhesion signaling
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 869-874 (1999)
   PUBMED   9927660
REFERENCE   8  (bases 1 to 2463)
  AUTHORS   Martinerie,C., Chevalier,G., Rauscher,F.J. 3rd and Perbal,B.
  TITLE     Regulation of nov by WT1: a potential role for nov in nephrogenesis
  JOURNAL   Oncogene 12 (7), 1479-1492 (1996)
   PUBMED   8622864
REFERENCE   9  (bases 1 to 2463)
  AUTHORS   Martinerie,C., Huff,V., Joubert,I., Badzioch,M., Saunders,G.,
            Strong,L. and Perbal,B.
  TITLE     Structural analysis of the human nov proto-oncogene and expression
            in Wilms tumor
  JOURNAL   Oncogene 9 (9), 2729-2732 (1994)
   PUBMED   7520150
REFERENCE   10 (bases 1 to 2463)
  AUTHORS   Martinerie,C., Viegas-Pequignot,E., Guenard,I., Dutrillaux,B.,
            Nguyen,V.C., Bernheim,A. and Perbal,B.
  TITLE     Physical mapping of human loci homologous to the chicken nov
            proto-oncogene
  JOURNAL   Oncogene 7 (12), 2529-2534 (1992)
   PUBMED   1334251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA162276.1, AY082381.1 and
            AC021733.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002514.3.
            
            Summary: The protein encoded by this gene is a small secreted
            cysteine-rich protein and a member of the CCN family of regulatory
            proteins. CNN family proteins associate with the extracellular
            matrix and play an important role in cardiovascular and skeletal
            development, fibrosis and cancer development. [provided by RefSeq,
            Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.264775.1,
                                           SRR1660803.147809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259526.4/ ENSP00000259526.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA162276.1         141-155
            16-1164             AY082381.1         1-1149
            1165-2463           AC021733.12        98584-99882
FEATURES             Location/Qualifiers
     source          1..2463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..2463
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /note="cellular communication network factor 3"
                     /db_xref="GeneID:4856"
                     /db_xref="HGNC:HGNC:7885"
                     /db_xref="MIM:164958"
     exon            1..171
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1161
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /note="protein NOV homolog; CCN family member 3;
                     IGF-binding protein 9; insulin-like growth factor-binding
                     protein 9; nephroblastoma-overexpressed gene protein
                     homolog; nephroblastoma overexpressed; nephro
                     blastoma-overexpressed gene protein homolog"
                     /codon_start=1
                     /product="CCN family member 3 precursor"
                     /protein_id="NP_002505.1"
                     /db_xref="CCDS:CCDS6328.1"
                     /db_xref="GeneID:4856"
                     /db_xref="HGNC:HGNC:7885"
                     /db_xref="MIM:164958"
                     /translation="MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCP
                     ATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGIC
                     TAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRK
                     VEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSK
                     SCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHL
                     QFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCH
                     TNCPKNNEAFLQELELKTTRGKM"
     exon            172..397
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /inference="alignment:Splign:2.1.0"
     exon            398..649
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /inference="alignment:Splign:2.1.0"
     exon            650..864
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /inference="alignment:Splign:2.1.0"
     exon            865..2463
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /note="hexamer: AATAAA"
     polyA_site      2389
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /note="major polyA site"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
                     /note="hexamer: ATTAAA"
     polyA_site      2463
                     /gene="CCN3"
                     /gene_synonym="IBP-9; IGFBP-9; IGFBP9; NOV; NOVh"
ORIGIN      
        1 aagcaccgga ccagggggaa ggcgagcagt gccaatctac agcgaagaaa gtctcgtttg
       61 gtaaaagcga gaggggaaag cctgagcatg cagagtgtgc agagcacgag cttttgtctc
      121 cgaaagcagt gcctttgcct gaccttcctg cttctccatc tcctgggaca ggtcgctgcg
      181 actcagcgct gccctcccca gtgcccgggc cggtgccctg cgacgccgcc gacctgcgcc
      241 cccggggtgc gcgcggtgct ggacggctgc tcatgctgtc tggtgtgtgc ccgccagcgt
      301 ggcgagagct gctcagatct ggagccatgc gacgagagca gtggcctcta ctgtgatcgc
      361 agcgcggacc ccagcaacca gactggcatc tgcacggcgg tagagggaga taactgtgtg
      421 ttcgatgggg tcatctaccg cagtggagag aaatttcagc caagctgcaa attccagtgc
      481 acctgcagag atgggcagat tggctgtgtg ccccgctgtc agctggatgt gctactgcct
      541 gagcctaact gcccagctcc aagaaaagtt gaggtgcctg gagagtgctg tgaaaagtgg
      601 atctgtggcc cagatgagga ggattcactg ggaggcctta cccttgcagc ttacaggcca
      661 gaagccaccc taggagtaga agtctctgac tcaagtgtca actgcattga acagaccaca
      721 gagtggacag catgctccaa gagctgtggt atggggttct ccacccgggt caccaatagg
      781 aaccgtcaat gtgagatgct gaaacagact cggctctgca tggtgcggcc ctgtgaacaa
      841 gagccagagc agccaacaga taagaaagga aaaaagtgtc tccgcaccaa gaagtcactc
      901 aaagccatcc acctgcagtt caagaactgc accagcctgc acacctacaa gcccaggttc
      961 tgtggggtct gcagtgatgg ccgctgctgc actccccaca ataccaaaac catccaggca
     1021 gagtttcagt gctccccagg gcaaatagtc aagaagccag tgatggtcat tgggacctgc
     1081 acctgtcaca ccaactgtcc taagaacaat gaggccttcc tccaggagct ggagctgaag
     1141 actaccagag ggaaaatgta acctgtcact caagaagcac acctacagag cacctgtagc
     1201 tgctgcgcca cccaccatca aaggaatata agaaaagtaa tgaagaatca cgatttcatc
     1261 cttgaatcct atgtattttc ctaatgtgat catatgagga cctttatatc tgtcttttat
     1321 ttaacaaaaa atgtaattaa ctgtaaactt ggaatcaagg taagctcagg atatggctta
     1381 ggaatgactt actttcctgt ggttttatta caaatgcaaa tttctataaa tttaagaaaa
     1441 caagtatata atttactttg tagactgttt cacattgcac tcatcatatt ttgttgtgca
     1501 ctagtgcaat tccaagaaaa tatcactgta atgagtcagt gaagtctaga atcatactta
     1561 acatttcatt gtacaagtat tacaaccata tattgaggtt cattgggaag attctctatt
     1621 ggctcccttt ttgggtaaac cagctctgaa cttccaagct ccaaatccaa ggaaacatgc
     1681 agctcttcaa catgacatcc agagatgact attacttttc tgtttagttt tacactagga
     1741 aacgtgttgt atctacagta atgaaatgtt tactaagtgg actggtgtca taaactttct
     1801 ccatttaaga cacattgact cctttccaat agaaagaaac taaacagaaa actcccaata
     1861 caaagatgac tggtccctca tagccctcag acatttatat attggaagct gctgaggccc
     1921 ccaagttttt taattaagca gaaacagcat attagcaggg attctctcat ctaactgatg
     1981 agtaaactga ggcccaaagc acttgcttac atcctctgat agctgtttca aatgtgcatt
     2041 ttgtggaatt ttgagaaaaa tagagcaaaa tcaacatgac tggtggtgag agaccacaca
     2101 ttttatgaga gtttggaatt attgtagaca tgcccaaaac ttatccttgg gccataatta
     2161 tgaaaactca tgatcaagat atatgtgtat acatacatgt atctggtttg tcaggctaca
     2221 aggtaggctg caaaattaaa tctagacatt cttttaatgc caccacacgt gttccgcttc
     2281 tctcttttaa agtatttata aaaatataaa ttgtacattt tgtaaaatat tatgtttgat
     2341 ttctctactt gtcatatcac taaataaaca cgattttatt gctgcgtgac tctgtattac
     2401 tttggtgcat aaaagttgaa cattgttgtt tactgaaaat aaaattaaaa tttatgaatt
     2461 aaa
//
