LOCUS       NM_001901               2338 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens cellular communication network factor 2 (CCN2), mRNA.
ACCESSION   NM_001901
VERSION     NM_001901.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2338)
  AUTHORS   Sun,C., Fan,W., Basha,S., Tian,T., Jin-Smith,B., Barkin,J., Xie,H.,
            Zhou,J., Yin,X.M., Ling,C., Sun,B., Petersen,B. and Pi,L.
  TITLE     Extracellular matrix protein 1 binds to connective tissue growth
            factor against liver fibrosis and ductular reaction
  JOURNAL   Hepatol Commun 8 (11), e0564 (2024)
   PUBMED   39470347
  REMARK    GeneRIF: Extracellular matrix protein 1 binds to connective tissue
            growth factor against liver fibrosis and ductular reaction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2338)
  AUTHORS   Li,S., Shao,R., Li,S., Zhao,J., Deng,Q., Li,P., Wei,Z., Xu,S.,
            Chen,L., Li,B., Zou,W. and Zhang,Z.
  TITLE     A monoallelic variant in CCN2 causes an autosomal dominant
            spondyloepimetaphyseal dysplasia with low bone mass
  JOURNAL   Bone Res 12 (1), 60 (2024)
   PUBMED   39414788
  REMARK    GeneRIF: A monoallelic variant in CCN2 causes an autosomal dominant
            spondyloepimetaphyseal dysplasia with low bone mass.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2338)
  AUTHORS   Leguit,R.J., Broekhuizen,R., de Witte,M., Raymakers,R.A.P. and
            Goldschmeding,R.
  TITLE     CCN2/CTGF expression does not correlate with fibrosis in
            myeloproliferative neoplasms, consistent with noncanonical TGF-beta
            signaling driving myelofibrosis
  JOURNAL   Virchows Arch 484 (5), 837-845 (2024)
   PUBMED   38602559
  REMARK    GeneRIF: CCN2/CTGF expression does not correlate with fibrosis in
            myeloproliferative neoplasms, consistent with noncanonical TGF-beta
            signaling driving myelofibrosis.
REFERENCE   4  (bases 1 to 2338)
  AUTHORS   Xiao,P., Zhu,Y., Xu,H., Li,J., Tao,A., Wang,H., Cheng,D., Dou,X.
            and Guo,L.
  TITLE     CTGF regulates mineralization in human mature chondrocyte by
            controlling Pit-1 and modulating ANK via the BMP/Smad signalling
  JOURNAL   Cytokine 174, 156460 (2024)
   PUBMED   38134555
  REMARK    GeneRIF: CTGF regulates mineralization in human mature chondrocyte
            by controlling Pit-1 and modulating ANK via the BMP/Smad
            signalling.
REFERENCE   5  (bases 1 to 2338)
  AUTHORS   Choi,K.M., Kim,B., Lee,S.M., Han,J., Bae,H.S., Han,S.B., Lee,D.,
            Ham,I.H., Hur,H., Kim,E. and Kim,J.Y.
  TITLE     Characterization of gastric cancer-stimulated signaling pathways
            and function of CTGF in cancer-associated fibroblasts
  JOURNAL   Cell Commun Signal 22 (1), 8 (2024)
   PUBMED   38167009
  REMARK    GeneRIF: Characterization of gastric cancer-stimulated signaling
            pathways and function of CTGF in cancer-associated fibroblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2338)
  AUTHORS   Oemar,B.S., Werner,A., Garnier,J.M., Do,D.D., Godoy,N., Nauck,M.,
            Marz,W., Rupp,J., Pech,M. and Luscher,T.F.
  TITLE     Human connective tissue growth factor is expressed in advanced
            atherosclerotic lesions
  JOURNAL   Circulation 95 (4), 831-839 (1997)
   PUBMED   9054739
REFERENCE   7  (bases 1 to 2338)
  AUTHORS   Martinerie,C., Viegas-Pequignot,E., Guenard,I., Dutrillaux,B.,
            Nguyen,V.C., Bernheim,A. and Perbal,B.
  TITLE     Physical mapping of human loci homologous to the chicken nov
            proto-oncogene
  JOURNAL   Oncogene 7 (12), 2529-2534 (1992)
   PUBMED   1334251
REFERENCE   8  (bases 1 to 2338)
  AUTHORS   Igarashi,A., Bradham,D.M., Okochi,H. and Grotendorst,G.R.
  TITLE     Connective tissue growth factor
  JOURNAL   J Dermatol 19 (11), 642-643 (1992)
   PUBMED   1293144
REFERENCE   9  (bases 1 to 2338)
  AUTHORS   Sutter,T.R., Guzman,K., Dold,K.M. and Greenlee,W.F.
  TITLE     Targets for dioxin: genes for plasminogen activator inhibitor-2 and
            interleukin-1 beta
  JOURNAL   Science 254 (5030), 415-418 (1991)
   PUBMED   1925598
REFERENCE   10 (bases 1 to 2338)
  AUTHORS   Bradham,D.M., Igarashi,A., Potter,R.L. and Grotendorst,G.R.
  TITLE     Connective tissue growth factor: a cysteine-rich mitogen secreted
            by human vascular endothelial cells is related to the SRC-induced
            immediate early gene product CEF-10
  JOURNAL   J Cell Biol 114 (6), 1285-1294 (1991)
   PUBMED   1654338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354866.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001901.3.
            
            Summary: The protein encoded by this gene is a mitogen that is
            secreted by vascular endothelial cells. The encoded protein plays a
            role in chondrocyte proliferation and differentiation, cell
            adhesion in many cell types, and is related to platelet-derived
            growth factor. Certain polymorphisms in this gene have been linked
            with a higher incidence of systemic sclerosis. [provided by RefSeq,
            Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087839.1, AK290884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367976.4/ ENSP00000356954.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AL354866.10        33029-33294         c
            267-489             AL354866.10        32692-32914         c
            490-741             AL354866.10        32214-32465         c
            742-953             AL354866.10        31871-32082         c
            954-2338            AL354866.10        30098-31482         c
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..2338
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /note="cellular communication network factor 2"
                     /db_xref="GeneID:1490"
                     /db_xref="HGNC:HGNC:2500"
                     /db_xref="MIM:121009"
     exon            1..266
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1250
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /note="hypertrophic chondrocyte-specific protein 24;
                     insulin-like growth factor-binding protein 8; CCN family
                     member 2; IGF-binding protein 8; connective tissue growth
                     factor"
                     /codon_start=1
                     /product="CCN family member 2 precursor"
                     /protein_id="NP_001892.2"
                     /db_xref="CCDS:CCDS5151.1"
                     /db_xref="GeneID:1490"
                     /db_xref="HGNC:HGNC:2500"
                     /db_xref="MIM:121009"
                     /translation="MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCP
                     AGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCHFGSPANRKIGVCTAKDGAP
                     CIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKC
                     CEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGIS
                     TRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSM
                     KTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDND
                     IFESLYYRKMYGDMA"
     exon            267..489
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /inference="alignment:Splign:2.1.0"
     exon            490..741
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /inference="alignment:Splign:2.1.0"
     exon            742..953
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /inference="alignment:Splign:2.1.0"
     exon            954..2338
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /note="hexamer: AATAAA"
     polyA_site      2338
                     /gene="CCN2"
                     /gene_synonym="CTGF; HCS24; IBP-8; IGFBP8; KMD; NOV2;
                     SEMDLSL"
                     /note="major polyA site"
ORIGIN      
        1 acacaacaac tcttccccgc tgagaggaga cagccagtgc gactccaccc tccagctcga
       61 cggcagccgc cccggccgac agccccgaga cgacagcccg gcgcgtcccg gtccccacct
      121 ccgaccaccg ccagcgctcc aggccccgcc gctccccgct cgccgccacc gcgccctccg
      181 ctccgcccgc agtgccaacc atgaccgccg ccagtatggg ccccgtccgc gtcgccttcg
      241 tggtcctcct cgccctctgc agccggccgg ccgtcggcca gaactgcagc gggccgtgcc
      301 ggtgcccgga cgagccggcg ccgcgctgcc cggcgggcgt gagcctcgtg ctggacggct
      361 gcggctgctg ccgcgtctgc gccaagcagc tgggcgagct gtgcaccgag cgcgacccat
      421 gcgacccgca caagggccta ttctgtcact tcggctcccc ggccaaccgc aagatcggcg
      481 tgtgcaccgc caaagatggt gctccctgca tcttcggtgg tacggtgtac cgcagcggag
      541 agtccttcca gagcagctgc aagtaccagt gcacgtgcct ggacggggcg gtgggctgca
      601 tgcccctgtg cagcatggac gttcgtctgc ccagccctga ctgccccttc ccgaggaggg
      661 tcaagctgcc cgggaaatgc tgcgaggagt gggtgtgtga cgagcccaag gaccaaaccg
      721 tggttgggcc tgccctcgcg gcttaccgac tggaagacac gtttggccca gacccaacta
      781 tgattagagc caactgcctg gtccagacca cagagtggag cgcctgttcc aagacctgtg
      841 ggatgggcat ctccacccgg gttaccaatg acaacgcctc ctgcaggcta gagaagcaga
      901 gccgcctgtg catggtcagg ccttgcgaag ctgacctgga agagaacatt aagaagggca
      961 aaaagtgcat ccgtactccc aaaatctcca agcctatcaa gtttgagctt tctggctgca
     1021 ccagcatgaa gacataccga gctaaattct gtggagtatg taccgacggc cgatgctgca
     1081 ccccccacag aaccaccacc ctgccggtgg agttcaagtg ccctgacggc gaggtcatga
     1141 agaagaacat gatgttcatc aagacctgtg cctgccatta caactgtccc ggagacaatg
     1201 acatctttga atcgctgtac tacaggaaga tgtacggaga catggcatga agccagagag
     1261 tgagagacat taactcatta gactggaact tgaactgatt cacatctcat ttttccgtaa
     1321 aaatgatttc agtagcacaa gttatttaaa tctgtttttc taactggggg aaaagattcc
     1381 cacccaattc aaaacattgt gccatgtcaa acaaatagtc tatcaacccc agacactggt
     1441 ttgaagaatg ttaagacttg acagtggaac tacattagta cacagcacca gaatgtatat
     1501 taaggtgtgg ctttaggagc agtgggaggg taccagcaga aaggttagta tcatcagata
     1561 gcatcttata cgagtaatat gcctgctatt tgaagtgtaa ttgagaagga aaattttagc
     1621 gtgctcactg acctgcctgt agccccagtg acagctagga tgtgcattct ccagccatca
     1681 agagactgag tcaagttgtt ccttaagtca gaacagcaga ctcagctctg acattctgat
     1741 tcgaatgaca ctgttcagga atcggaatcc tgtcgattag actggacagc ttgtggcaag
     1801 tgaatttgcc tgtaacaagc cagatttttt aaaatttata ttgtaaatat tgtgtgtgtg
     1861 tgtgtgtgtg tatatatata tatatgtaca gttatctaag ttaatttaaa gttgtttgtg
     1921 cctttttatt tttgttttta atgctttgat atttcaatgt tagcctcaat ttctgaacac
     1981 cataggtaga atgtaaagct tgtctgatcg ttcaaagcat gaaatggata cttatatgga
     2041 aattctgctc agatagaatg acagtccgtc aaaacagatt gtttgcaaag gggaggcatc
     2101 agtgtccttg gcaggctgat ttctaggtag gaaatgtggt agcctcactt ttaatgaaca
     2161 aatggccttt attaaaaact gagtgactct atatagctga tcagtttttt cacctggaag
     2221 catttgtttc tactttgata tgactgtttt tcggacagtt tatttgttga gagtgtgacc
     2281 aaaagttaca tgtttgcacc tttctagttg aaaataaagt gtatattttt tctataaa
//
