LOCUS       NM_001554               2278 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens cellular communication network factor 1 (CCN1), mRNA.
ACCESSION   NM_001554
VERSION     NM_001554.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2278)
  AUTHORS   Wang,C., Paiva,T.O., Speziale,P. and Dufrene,Y.F.
  TITLE     Nanomechanics of CCN1-Mediated Staphylococcus aureus Phagocytosis
  JOURNAL   Nano Lett 24 (28), 8567-8574 (2024)
   PUBMED   38959438
  REMARK    GeneRIF: Nanomechanics of CCN1-Mediated Staphylococcus aureus
            Phagocytosis.
REFERENCE   2  (bases 1 to 2278)
  AUTHORS   Kim,H., Son,S., Ko,Y., Lim,H., Lee,J., Lee,K.M. and Shin,I.
  TITLE     CYR61 confers chemoresistance by upregulating survivin expression
            in triple-negative breast cancer
  JOURNAL   Carcinogenesis 45 (7), 510-519 (2024)
   PUBMED   38446998
  REMARK    GeneRIF: CYR61 confers chemoresistance by upregulating survivin
            expression in triple-negative breast cancer.
REFERENCE   3  (bases 1 to 2278)
  AUTHORS   Hu,K., Xie,L., Wu,W., Zhang,J., Li,Y., He,J., Zhang,Y., Lu,D.,
            Koeffler,H.P., Lin,L. and Yin,D.
  TITLE     CYR61 Acts as an Intracellular Microtubule-Associated Protein and
            Coordinates Mitotic Progression via PLK1-FBW7 Pathway
  JOURNAL   Int J Biol Sci 20 (8), 3140-3155 (2024)
   PUBMED   38904029
  REMARK    GeneRIF: CYR61 Acts as an Intracellular Microtubule-Associated
            Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2278)
  AUTHORS   Li,T., Qian,Y., Li,H., Wang,T., Jiang,Q., Wang,Y., Zhu,Y., Li,S.,
            He,X., Shi,G., Su,W., Lu,Y. and Chen,Y.
  TITLE     Cellular communication network factor 1 promotes retinal leakage in
            diabetic retinopathy via inducing neutrophil stasis and neutrophil
            extracellular traps extrusion
  JOURNAL   Cell Commun Signal 22 (1), 275 (2024)
   PUBMED   38755602
  REMARK    GeneRIF: Cellular communication network factor 1 promotes retinal
            leakage in diabetic retinopathy via inducing neutrophil stasis and
            neutrophil extracellular traps extrusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2278)
  AUTHORS   Zhang,C., Wei,W., Tu,S., Liang,B., Li,C., Li,Y., Luo,W., Wu,Y.,
            Dai,X., Wang,Y., Zheng,L., Hao,L., Zhang,C., Luo,Z., Chen,Y.G. and
            Yan,X.
  TITLE     Upregulation of CYR61 by TGF-beta and YAP signaling exerts a
            counter-suppression of hepatocellular carcinoma
  JOURNAL   J Biol Chem 300 (4), 107208 (2024)
   PUBMED   38521502
  REMARK    GeneRIF: Upregulation of CYR61 by TGF-beta and YAP signaling exerts
            a counter-suppression of hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 2278)
  AUTHORS   Schutze,N., Lechner,A., Groll,C., Siggelkow,H., Hufner,M.,
            Kohrle,J. and Jakob,F.
  TITLE     The human analog of murine cystein rich protein 61 [correction of
            16] is a 1alpha,25-dihydroxyvitamin D3 responsive immediate early
            gene in human fetal osteoblasts: regulation by cytokines, growth
            factors, and serum
  JOURNAL   Endocrinology 139 (4), 1761-1770 (1998)
   PUBMED   9528960
REFERENCE   7  (bases 1 to 2278)
  AUTHORS   Kolesnikova,T.V. and Lau,L.F.
  TITLE     Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in
            human umbilical vein endothelial cells
  JOURNAL   Oncogene 16 (6), 747-754 (1998)
   PUBMED   9488038
REFERENCE   8  (bases 1 to 2278)
  AUTHORS   Kireeva,M.L., Lam,S.C. and Lau,L.F.
  TITLE     Adhesion of human umbilical vein endothelial cells to the
            immediate-early gene product Cyr61 is mediated through integrin
            alphavbeta3
  JOURNAL   J Biol Chem 273 (5), 3090-3096 (1998)
   PUBMED   9446626
REFERENCE   9  (bases 1 to 2278)
  AUTHORS   Jay,P., Berge-Lefranc,J.L., Marsollier,C., Mejean,C., Taviaux,S.
            and Berta,P.
  TITLE     The human growth factor-inducible immediate early gene, CYR61, maps
            to chromosome 1p
  JOURNAL   Oncogene 14 (14), 1753-1757 (1997)
   PUBMED   9135077
REFERENCE   10 (bases 1 to 2278)
  AUTHORS   Genini,M., Schwalbe,P., Scholl,F.A. and Schafer,B.W.
  TITLE     Isolation of genes differentially expressed in human primary
            myoblasts and embryonal rhabdomyosarcoma
  JOURNAL   Int J Cancer 66 (4), 571-577 (1996)
   PUBMED   8635876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA764894.1, BC009199.2 and
            BP387218.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001554.4.
            
            Summary: The secreted protein encoded by this gene is growth
            factor-inducible and promotes the adhesion of endothelial cells.
            The encoded protein interacts with several integrins and with
            heparan sulfate proteoglycan. This protein also plays a role in
            cell proliferation, differentiation, angiogenesis, apoptosis, and
            extracellular matrix formation. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314571.1, SRR1803615.101477.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451137.7/ ENSP00000398736.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA764894.1         3-18
            17-1915             BC009199.2         1-1899
            1916-2278           BP387218.1         121-483
FEATURES             Location/Qualifiers
     source          1..2278
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..2278
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /note="cellular communication network factor 1"
                     /db_xref="GeneID:3491"
                     /db_xref="HGNC:HGNC:2654"
                     /db_xref="MIM:602369"
     exon            1..287
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1370
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /note="cysteine-rich, anigogenic inducer, 61;
                     cysteine-rich heparin-binding protein 61; protein CYR61;
                     IBP-10; IGFBP-10; CCN family member 1; cysteine rich
                     angiogenic inducer 61; IGF-binding protein 10;
                     insulin-like growth factor-binding protein 10"
                     /codon_start=1
                     /product="CCN family member 1 precursor"
                     /protein_id="NP_001545.2"
                     /db_xref="CCDS:CCDS706.1"
                     /db_xref="GeneID:3491"
                     /db_xref="HGNC:HGNC:2654"
                     /db_xref="MIM:602369"
                     /translation="MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVG
                     LVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEY
                     NSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEE
                     WVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPR
                     ILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPV
                     YSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMR
                     FRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD"
     exon            288..501
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            502..858
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1067
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..2278
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /note="hexamer: AAGAAA"
     polyA_site      2033
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /note="major polyA site"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
                     /note="hexamer: AATAAA"
     polyA_site      2278
                     /gene="CCN1"
                     /gene_synonym="CYR61; GIG1; IGFBP10"
ORIGIN      
        1 agaccgcgag cgagagcgcc cccgagcagc gcccgcgccc tccgcgcctt ctccgccggg
       61 acctcgagcg aaagacgccc gcccgccgcc cagccctcgc ctccctgccc accgggccca
      121 ccgcgccgcc accccgaccc cgctgcgcac ggcctgtccg ctgcacacca gcttgttggc
      181 gtcttcgtcg ccgcgctcgc cccgggctac tcctgcgcgc cacaatgagc tcccgcatcg
      241 ccagggcgct cgccttagtc gtcacccttc tccacttgac caggctggcg ctctccacct
      301 gccccgctgc ctgccactgc cccctggagg cgcccaagtg cgcgccggga gtcgggctgg
      361 tccgggacgg ctgcggctgc tgtaaggtct gcgccaagca gctcaacgag gactgcagca
      421 aaacgcagcc ctgcgaccac accaaggggc tggaatgcaa cttcggcgcc agctccaccg
      481 ctctgaaggg gatctgcaga gctcagtcag agggcagacc ctgtgaatat aactccagaa
      541 tctaccaaaa cggggaaagt ttccagccca actgtaaaca tcagtgcaca tgtattgatg
      601 gcgccgtggg ctgcattcct ctgtgtcccc aagaactatc tctccccaac ttgggctgtc
      661 ccaaccctcg gctggtcaaa gttaccgggc agtgctgcga ggagtgggtc tgtgacgagg
      721 atagtatcaa ggaccccatg gaggaccagg acggcctcct tggcaaggag ctgggattcg
      781 atgcctccga ggtggagttg acgagaaaca atgaattgat tgcagttgga aaaggcagct
      841 cactgaagcg gctccctgtt tttggaatgg agcctcgcat cctatacaac cctttacaag
      901 gccagaaatg tattgttcaa acaacttcat ggtcccagtg ctcaaagacc tgtggaactg
      961 gtatctccac acgagttacc aatgacaacc ctgagtgccg ccttgtgaaa gaaacccgga
     1021 tttgtgaggt gcggccttgt ggacagccag tgtacagcag cctgaaaaag ggcaagaaat
     1081 gcagcaagac caagaaatcc cccgaaccag tcaggtttac ttacgctgga tgtttgagtg
     1141 tgaagaaata ccggcccaag tactgcggtt cctgcgtgga cggccgatgc tgcacgcccc
     1201 agctgaccag gactgtgaag atgcggttcc gctgcgaaga tggggagaca ttttccaaga
     1261 acgtcatgat gatccagtcc tgcaaatgca actacaactg cccgcatgcc aatgaagcag
     1321 cgtttccctt ctacaggctg ttcaatgaca ttcacaaatt tagggactaa atgctacctg
     1381 ggtttccagg gcacacctag acaaacaagg gagaagagtg tcagaatcag aatcatggag
     1441 aaaatgggcg ggggtggtgt gggtgatggg actcattgta gaaaggaagc cttgctcatt
     1501 cttgaggagc attaaggtat ttcgaaactg ccaagggtgc tggtgcggat ggacactaat
     1561 gcagccacga ttggagaata ctttgcttca tagtattgga gcacatgtta ctgcttcatt
     1621 ttggagcttg tggagttgat gactttctgt tttctgtttg taaattattt gctaagcata
     1681 ttttctctag gcttttttcc ttttggggtt ctacagtcgt aaaagagata ataagattag
     1741 ttggacagtt taaagctttt attcgtcctt tgacaaaagt aaatgggagg gcattccatc
     1801 ccttcctgaa gggggacact ccatgagtgt ctgtgagagg cagctatctg cactctaaac
     1861 tgcaaacaga aatcaggtgt tttaagactg aatgttttat ttatcaaaat gtagcttttg
     1921 gggagggagg ggaaatgtaa tactggaata atttgtaaat gattttaatt ttatattcag
     1981 tgaaaagatt ttatttatgg aattaaccat ttaataaaga aatatttacc taatatctga
     2041 gtgtatgcca ttcggtattt ttagaggtgc tccaaagtca ttaggaacaa cctagctcac
     2101 gtactcaatt attcaaacag gacttattgg gatacagcag tgaattaagc tattaaaata
     2161 agataatgat tgcttttata ccttcagtag agaaaagtct ttgcatataa agtaatgttt
     2221 aaaaaacatg tattgaacac gacattgtat gaagcacaat aaagattctg aagctaaa
//
