LOCUS       NM_005623                862 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 8 (CCL8), mRNA.
ACCESSION   NM_005623
VERSION     NM_005623.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Drosslerova,M., Sterclova,M., Taskova,A., Hytych,V., Richterova,E.,
            Bruzova,M., Spunda,M., Komarc,M. and Koziar Vasakova,M.
  TITLE     CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung
            cancer (NSCLC)
  JOURNAL   Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 167 (4),
            335-339 (2023)
   PUBMED   36628560
  REMARK    GeneRIF: CCL2, CCL8, CXCL12 chemokines in resectable non-small cell
            lung cancer (NSCLC).
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Lou,X., Zhao,K., Xu,J., Shuai,L., Niu,H., Cao,Z., Wang,J. and
            Zhang,Y.
  TITLE     CCL8 as a promising prognostic factor in diffuse large B-cell
            lymphoma via M2 macrophage interactions: A bioinformatic analysis
            of the tumor microenvironment
  JOURNAL   Front Immunol 13, 950213 (2022)
   PUBMED   36072582
  REMARK    GeneRIF: CCL8 as a promising prognostic factor in diffuse large
            B-cell lymphoma via M2 macrophage interactions: A bioinformatic
            analysis of the tumor microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Sheshadri,N., Poria,D.K., Sharan,S., Hu,Y., Yan,C., Koparde,V.N.,
            Balamurugan,K. and Sterneck,E.
  TITLE     PERK signaling through C/EBPdelta contributes to ER stress-induced
            expression of immunomodulatory and tumor promoting chemokines by
            cancer cells
  JOURNAL   Cell Death Dis 12 (11), 1038 (2021)
   PUBMED   34725321
  REMARK    GeneRIF: PERK signaling through C/EBPdelta contributes to ER
            stress-induced expression of immunomodulatory and tumor promoting
            chemokines by cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Kim,E.S., Nam,S.M., Song,H.K., Lee,S., Kim,K., Lim,H.K., Lee,H.,
            Kang,K.T., Kwon,Y.J., Chun,Y.J., Park,S.Y., Jung,J. and Moon,A.
  TITLE     CCL8 mediates crosstalk between endothelial colony forming cells
            and triple-negative breast cancer cells through IL-8, aggravating
            invasion and tumorigenicity
  JOURNAL   Oncogene 40 (18), 3245-3259 (2021)
   PUBMED   33833397
  REMARK    GeneRIF: CCL8 mediates crosstalk between endothelial colony forming
            cells and triple-negative breast cancer cells through IL-8,
            aggravating invasion and tumorigenicity.
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Li,T., Wang,J., Guo,X., Yu,Q., Ding,S., Xu,X., Peng,Y., Zhu,L.,
            Zou,G. and Zhang,X.
  TITLE     Possible involvement of crosstalk between endometrial cells and
            mast cells in the development of endometriosis via CCL8/CCR1
  JOURNAL   Biomed Pharmacother 129, 110476 (2020)
   PUBMED   32768961
  REMARK    GeneRIF: Possible involvement of crosstalk between endometrial
            cells and mast cells in the development of endometriosis via
            CCL8/CCR1.
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL8 is an antimicrobial protein with bacteriocidal
            activity against E. coli.
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Naruse,K., Ueno,M., Satoh,T., Nomiyama,H., Tei,H., Takeda,M.,
            Ledbetter,D.H., Coillie,E.V., Opdenakker,G., Gunge,N., Sakaki,Y.,
            Iio,M. and Miura,R.
  TITLE     A YAC contig of the human CC chemokine genes clustered on
            chromosome 17q11.2
  JOURNAL   Genomics 34 (2), 236-240 (1996)
   PUBMED   8661057
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Van Damme,J., Proost,P., Put,W., Arens,S., Lenaerts,J.P.,
            Conings,R., Opdenakker,G., Heremans,H. and Billiau,A.
  TITLE     Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human
            fibroblasts and leukocytes by cytokines and cytokine inducers.
            Chemical synthesis of MCP-2 and development of a specific RIA
  JOURNAL   J Immunol 152 (11), 5495-5502 (1994)
   PUBMED   8189067
REFERENCE   9  (bases 1 to 862)
  AUTHORS   Van Damme,J., Proost,P., Lenaerts,J.P. and Opdenakker,G.
  TITLE     Structural and functional identification of two human,
            tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3)
            belonging to the chemokine family
  JOURNAL   J Exp Med 176 (1), 59-65 (1992)
   PUBMED   1613466
REFERENCE   10 (bases 1 to 862)
  AUTHORS   Chang,H.C., Hsu,F., Freeman,G.J., Griffin,J.D. and Reinherz,E.L.
  TITLE     Cloning and expression of a gamma-interferon-inducible gene in
            monocytes: a new member of a cytokine gene family
  JOURNAL   Int Immunol 1 (4), 388-397 (1989)
   PUBMED   2518726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011193.3.
            
            On Nov 26, 2018 this sequence version replaced NM_005623.2.
            
            Summary: This antimicrobial gene is one of several chemokine genes
            clustered on the q-arm of chromosome 17. Chemokines form a
            superfamily of secreted proteins involved in immunoregulatory and
            inflammatory processes. The superfamily is divided into four
            subfamilies based on the arrangement of N-terminal cysteine
            residues of the mature peptide. This chemokine is a member of the
            CC subfamily which is characterized by two adjacent cysteine
            residues. This cytokine displays chemotactic activity for
            monocytes, lymphocytes, basophils and eosinophils. By recruiting
            leukocytes to sites of inflammation this cytokine may contribute to
            tumor-associated leukocyte infiltration and to the antiviral state
            against HIV infection. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y16645.1, AV733664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            MANE Ensembl match                 :: ENST00000394620.2/
                                                  ENSP00000378118.1
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC011193.3         170778-170920       c
            144-261             AC011193.3         169969-170086       c
            262-862             AC011193.3         168953-169553       c
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..862
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /note="C-C motif chemokine ligand 8"
                     /db_xref="GeneID:6355"
                     /db_xref="HGNC:HGNC:10635"
                     /db_xref="MIM:602283"
     exon            1..143
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..367
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 8 (monocyte chemotactic protein 2); monocyte
                     chemoattractant protein 2; C-C motif chemokine 8;
                     small-inducible cytokine A8; chemokine (C-C motif) ligand
                     8"
                     /codon_start=1
                     /product="C-C motif chemokine 8 precursor"
                     /protein_id="NP_005614.2"
                     /db_xref="CCDS:CCDS11280.1"
                     /db_xref="GeneID:6355"
                     /db_xref="HGNC:HGNC:10635"
                     /db_xref="MIM:602283"
                     /translation="MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIP
                     IQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP"
     exon            144..261
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /inference="alignment:Splign:2.1.0"
     exon            262..862
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /note="hexamer: AATATA"
     polyA_site      862
                     /gene="CCL8"
                     /gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
                     /note="major polyA site"
ORIGIN      
        1 agagaggttg agaacaaccc agaaaccttc acctctcatg ctgaagctca cacccttgcc
       61 ctccaagatg aaggtttctg cagcgcttct gtgcctgctg ctcatggcag ccactttcag
      121 ccctcaggga cttgctcagc cagattcagt ttccattcca atcacctgct gctttaacgt
      181 gatcaatagg aaaattccta tccagaggct ggagagctac acaagaatca ccaacatcca
      241 atgtcccaag gaagctgtga tcttcaagac caaacggggc aaggaggtct gtgctgaccc
      301 caaggagaga tgggtcaggg attccatgaa gcatctggac caaatatttc aaaatctgaa
      361 gccatgagcc ttcatacatg gactgagagt cagagcttga agaaaagctt atttattttc
      421 cccaacctcc cccaggtgca gtgtgacatt attttattat aacatccaca aagagattat
      481 ttttaaataa tttaaagcat aatatttctt aaaaagtatt taattatatt taagttgttg
      541 atgttttaac tctatctgtc atacatccta gtgaatgtaa aatgcaaaat cctggtgatg
      601 tgttttttgt ttttgttttc ctgtgagctc aactaagttc acggcaaaat gtcattgttc
      661 tccctcctac ctgtctgtag tgttgtgggg tcctcccatg gatcatcaag gtgaaacact
      721 ttggtattct ttggcaatca gtgctcctgt aagtcaaatg tgtgctttgt actgctgttg
      781 ttgaaattga tgttactgta tataactatg gaattttgaa aaaaaatttc aaaaagaaaa
      841 aaatatatat aatttaaaac ta
//
