LOCUS       NM_006273                810 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 7 (CCL7), mRNA.
ACCESSION   NM_006273
VERSION     NM_006273.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 810)
  AUTHORS   Chang,T.T., Li,Y.Z., Mo,H.W., Chen,C., Lin,L.Y., Chang,C.C. and
            Chen,J.W.
  TITLE     Inhibition of CCL7 improves endothelial dysfunction and
            vasculopathy in mouse models of diabetes mellitus
  JOURNAL   Sci Transl Med 16 (763), eadn1507 (2024)
   PUBMED   39231238
  REMARK    GeneRIF: Inhibition of CCL7 improves endothelial dysfunction and
            vasculopathy in mouse models of diabetes mellitus.
REFERENCE   2  (bases 1 to 810)
  AUTHORS   Huang,S., He,L., Zhao,Y., Wei,Y., Wang,Q., Gao,Y. and Jiang,X.
  TITLE     TREM1+ tumor-associated macrophages secrete CCL7 to promote
            hepatocellular carcinoma metastasis
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 320 (2024)
   PUBMED   38914803
  REMARK    GeneRIF: TREM1[+] tumor-associated macrophages secrete CCL7 to
            promote hepatocellular carcinoma metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 810)
  AUTHORS   Tian,S., Chen,X., Wu,W., Lin,H., Qing,X., Liu,S., Wang,B., Xiao,Y.,
            Shao,Z. and Peng,Y.
  TITLE     Nucleus pulposus cells regulate macrophages in degenerated
            intervertebral discs via the integrated stress response-mediated
            CCL2/7-CCR2 signaling pathway
  JOURNAL   Exp Mol Med 56 (2), 408-421 (2024)
   PUBMED   38316963
  REMARK    GeneRIF: Nucleus pulposus cells regulate macrophages in degenerated
            intervertebral discs via the integrated stress response-mediated
            CCL2/7-CCR2 signaling pathway.
REFERENCE   4  (bases 1 to 810)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   5  (bases 1 to 810)
  AUTHORS   Chidimatsu,H., Tsunedomi,R., Nakagami,Y., Xu,M., Nakajima,M.,
            Nakashima-Nakasuga,C., Tomochika,S., Yoshida,S., Suzuki,N.,
            Watanabe,Y., Matsui,H., Shindo,Y., Tokumitsu,Y., Iida,M.,
            Takeda,S., Ioka,T., Ueno,T., Tanabe,T., Hoshii,Y., Hazama,S. and
            Nagano,H.
  TITLE     Serum CCL7 Is a Novel Prognostic Biomarker of Metastatic Colorectal
            Cancer
  JOURNAL   Anticancer Res 43 (1), 105-114 (2023)
   PUBMED   36585204
  REMARK    GeneRIF: Serum CCL7 Is a Novel Prognostic Biomarker of Metastatic
            Colorectal Cancer.
REFERENCE   6  (bases 1 to 810)
  AUTHORS   Ben-Baruch,A., Xu,L., Young,P.R., Bengali,K., Oppenheim,J.J. and
            Wang,J.M.
  TITLE     Monocyte chemotactic protein-3 (MCP3) interacts with multiple
            leukocyte receptors. C-C CKR1, a receptor for macrophage
            inflammatory protein-1 alpha/Rantes, is also a functional receptor
            for MCP3
  JOURNAL   J Biol Chem 270 (38), 22123-22128 (1995)
   PUBMED   7545673
REFERENCE   7  (bases 1 to 810)
  AUTHORS   Opdenakker,G., Fiten,P., Nys,G., Froyen,G., Van Roy,N.,
            Speleman,F., Laureys,G. and Van Damme,J.
  TITLE     The human MCP-3 gene (SCYA7): cloning, sequence analysis, and
            assignment to the C-C chemokine gene cluster on chromosome
            17q11.2-q12
  JOURNAL   Genomics 21 (2), 403-408 (1994)
   PUBMED   7916328
REFERENCE   8  (bases 1 to 810)
  AUTHORS   Opdenakker,G., Froyen,G., Fiten,P., Proost,P. and Van Damme,J.
  TITLE     Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of
            the cDNA and comparison with other chemokines
  JOURNAL   Biochem Biophys Res Commun 191 (2), 535-542 (1993)
   PUBMED   8461011
REFERENCE   9  (bases 1 to 810)
  AUTHORS   Minty,A., Chalon,P., Guillemot,J.C., Kaghad,M., Liauzun,P.,
            Magazin,M., Miloux,B., Minty,C., Ramond,P., Vita,N. et al.
  TITLE     Molecular cloning of the MCP-3 chemokine gene and regulation of its
            expression
  JOURNAL   Eur Cytokine Netw 4 (2), 99-110 (1993)
   PUBMED   8318676
REFERENCE   10 (bases 1 to 810)
  AUTHORS   Van Damme,J., Proost,P., Lenaerts,J.P. and Opdenakker,G.
  TITLE     Structural and functional identification of two human,
            tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3)
            belonging to the chemokine family
  JOURNAL   J Exp Med 176 (1), 59-65 (1992)
   PUBMED   1613466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X71087.1 and AC005549.1.
            
            On May 17, 2019 this sequence version replaced NM_006273.3.
            
            Summary: This gene encodes monocyte chemotactic protein 3, a
            secreted chemokine which attracts macrophages during inflammation
            and metastasis. It is a member of the C-C subfamily of chemokines
            which are characterized by having two adjacent cysteine residues.
            The protein is an in vivo substrate of matrix metalloproteinase 2,
            an enzyme which degrades components of the extracellular matrix.
            This gene is part of a cluster of C-C chemokine family members on
            chromosome 17q. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. There is an
            upstream in-frame AUG at nt 46-48. This AUG was not annotated as
            the translation start baecuase it has a weak Kozak signal and is
            not conserved in vertebrates.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X71087.1, BC092436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000378569.2/
                                                ENSP00000367832.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               X71087.1           1-387
            388-810             AC005549.1         44525-44947         c
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..810
                     /gene="CCL7"
                     /gene_synonym="FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7"
                     /note="C-C motif chemokine ligand 7"
                     /db_xref="GeneID:6354"
                     /db_xref="HGNC:HGNC:10634"
                     /db_xref="MIM:158106"
     exon            1..146
                     /gene="CCL7"
                     /gene_synonym="FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..370
                     /gene="CCL7"
                     /gene_synonym="FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7"
                     /note="monocyte chemoattractant protein 3; small inducible
                     cytokine A7 (monocyte chemotactic protein 3); C-C motif
                     chemokine 7; small-inducible cytokine A7; chemokine (C-C
                     motif) ligand 7"
                     /codon_start=1
                     /product="C-C motif chemokine 7 precursor"
                     /protein_id="NP_006264.2"
                     /db_xref="CCDS:CCDS11278.1"
                     /db_xref="GeneID:6354"
                     /db_xref="HGNC:HGNC:10634"
                     /db_xref="MIM:158106"
                     /translation="MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIP
                     KQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL"
     exon            147..264
                     /gene="CCL7"
                     /gene_synonym="FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7"
                     /inference="alignment:Splign:2.1.0"
     exon            265..810
                     /gene="CCL7"
                     /gene_synonym="FIC; MARC; MCP-3; MCP3; NC28; SCYA6; SCYA7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagagggg ctgagaccaa accagaaacc tccaattctc atgtggaagc ccatgccctc
       61 accctccaac atgaaagcct ctgcagcact tctgtgtctg ctgctcacag cagctgcttt
      121 cagcccccag gggcttgctc agccagttgg gattaatact tcaactacct gctgctacag
      181 atttatcaat aagaaaatcc ctaagcagag gctggagagc tacagaagga ccaccagtag
      241 ccactgtccc cgggaagctg taatcttcaa gaccaaactg gacaaggaga tctgtgctga
      301 ccccacacag aagtgggtcc aggactttat gaagcacctg gacaagaaaa cccaaactcc
      361 aaagctttga acattcatga ctgaactgaa aacaagccat gacttgagaa acaaataatt
      421 tgtataccct gtcctttctc agagtggttc tgagattatt ttaatctaat tctaaggaat
      481 atgagcttta tgtaataatg tgaatcatgg tttttcttag tagattttaa aagttattaa
      541 tattttaatt taatcttcca tggattttgg tgggttttga acataaagcc ttggatgtat
      601 atgtcatctc agtgctgtaa aaactgtggg atgctcctcc cttctctacc tcatgggggt
      661 attgtataag tccttgcaag aatcagtgca aagatttgct ttaattgtta agatatgatg
      721 tccctatgga agcatattgt tattatataa ttacatattt gcatatgtat gactcccaaa
      781 ttttcacata aaatagattt ttgtataaca
//
