LOCUS       NM_002985               1217 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 5 (CCL5), transcript
            variant 1, mRNA.
ACCESSION   NM_002985
VERSION     NM_002985.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Tachizaki,M., Kobori,Y., Kawaguchi,S., Seya,K., Tanaka,H. and
            Imaizumi,T.
  TITLE     Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress
            TLR3-mediated CCL5 expression in human renal proximal tubular
            epithelial cells
  JOURNAL   Mol Biol Rep 51 (1), 974 (2024)
   PUBMED   39259342
  REMARK    GeneRIF: Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress
            TLR3-mediated CCL5 expression in human renal proximal tubular
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Guan,Y., Liu,X., Tian,J., Yang,G., Xu,F., Guo,N., Guo,L., Wan,Z.,
            Huang,Z., Gao,M. and Chong,T.
  TITLE     CCL5 promotes the epithelial-mesenchymal transition of circulating
            tumor cells in renal cancer
  JOURNAL   J Transl Med 22 (1), 817 (2024)
   PUBMED   39227943
  REMARK    GeneRIF: CCL5 promotes the epithelial-mesenchymal transition of
            circulating tumor cells in renal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Lim,J.K., Burns,J.M., Lu,W. and DeVico,A.L.
  TITLE     Multiple pathways of amino terminal processing produce two
            truncated variants of RANTES/CCL5
  JOURNAL   J Leukoc Biol 78 (2), 442-452 (2005)
   PUBMED   15923218
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Iwata,S., Yamaguchi,N., Munakata,Y., Ikushima,H., Lee,J.F.,
            Hosono,O., Schlossman,S.F. and Morimoto,C.
  TITLE     CD26/dipeptidyl peptidase IV differentially regulates the
            chemotaxis of T cells and monocytes toward RANTES: possible
            mechanism for the switch from innate to acquired immune response
  JOURNAL   Int Immunol 11 (3), 417-426 (1999)
   PUBMED   10221653
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Cocchi,F., DeVico,A.L., Garzino-Demo,A., Arya,S.K., Gallo,R.C. and
            Lusso,P.
  TITLE     Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major
            HIV-suppressive factors produced by CD8+ T cells
  JOURNAL   Science 270 (5243), 1811-1815 (1995)
   PUBMED   8525373
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Chung,C.W., Cooke,R.M., Proudfoot,A.E. and Wells,T.N.
  TITLE     The three-dimensional solution structure of RANTES
  JOURNAL   Biochemistry 34 (29), 9307-9314 (1995)
   PUBMED   7542919
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Nelson,P.J., Kim,H.T., Manning,W.C., Goralski,T.J. and Krensky,A.M.
  TITLE     Genomic organization and transcriptional regulation of the RANTES
            chemokine gene
  JOURNAL   J Immunol 151 (5), 2601-2612 (1993)
   PUBMED   7689610
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Kameyoshi,Y., Dorschner,A., Mallet,A.I., Christophers,E. and
            Schroder,J.M.
  TITLE     Cytokine RANTES released by thrombin-stimulated platelets is a
            potent attractant for human eosinophils
  JOURNAL   J Exp Med 176 (2), 587-592 (1992)
   PUBMED   1380064
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Donlon,T.A., Krensky,A.M., Wallace,M.R., Collins,F.S., Lovett,M.
            and Clayberger,C.
  TITLE     Localization of a human T-cell-specific gene, RANTES (D17S136E), to
            chromosome 17q11.2-q12
  JOURNAL   Genomics 6 (3), 548-553 (1990)
   PUBMED   1691736
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Schall,T.J., Jongstra,J., Dyer,B.J., Jorgensen,J., Clayberger,C.,
            Davis,M.M. and Krensky,A.M.
  TITLE     A human T cell-specific molecule is a member of a new gene family
  JOURNAL   J Immunol 141 (3), 1018-1025 (1988)
   PUBMED   2456327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD695497.1, BC008600.1,
            AA486131.1, AA443491.1, AW769950.1 and BG272739.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 31, 2019 this sequence version replaced NM_002985.2.
            
            Summary: This gene is one of several chemokine genes clustered on
            the q-arm of chromosome 17. Chemokines form a superfamily of
            secreted proteins involved in immunoregulatory and inflammatory
            processes. The superfamily is divided into four subfamilies based
            on the arrangement of the N-terminal cysteine residues of the
            mature peptide. This chemokine, a member of the CC subfamily,
            functions as a chemoattractant for blood monocytes, memory T helper
            cells and eosinophils. It causes the release of histamine from
            basophils and activates eosinophils. This cytokine is one of the
            major HIV-suppressive factors produced by CD8+ cells. It functions
            as one of the natural ligands for the chemokine receptor chemokine
            (C-C motif) receptor 5 (CCR5), and it suppresses in vitro
            replication of the R5 strains of HIV-1, which use CCR5 as a
            coreceptor. Alternative splicing results in multiple transcript
            variants that encode different isoforms. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.504862.1,
                                           SRR14038197.312996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000605140.6/ ENSP00000475057.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CD695497.1         156-186
            32-791              BC008600.1         1-760
            792-821             AA486131.1         97-126
            822-999             AA443491.1         204-381             c
            1000-1214           AW769950.1         7-221               c
            1215-1217           BG272739.1         8-10                c
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1217
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /note="C-C motif chemokine ligand 5"
                     /db_xref="GeneID:6352"
                     /db_xref="HGNC:HGNC:10632"
                     /db_xref="MIM:187011"
     exon            1..131
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..331
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; T-cell specific protein p288; regulated upon
                     activation, normally T-expressed, and presumably secreted;
                     beta-chemokine RANTES; small inducible cytokine subfamily
                     A (Cys-Cys), member 5; C-C motif chemokine 5; eosinophil
                     chemotactic cytokine; chemokine (C-C motif) ligand 5"
                     /codon_start=1
                     /product="C-C motif chemokine 5 isoform 1 precursor"
                     /protein_id="NP_002976.2"
                     /db_xref="CCDS:CCDS11300.1"
                     /db_xref="GeneID:6352"
                     /db_xref="HGNC:HGNC:10632"
                     /db_xref="MIM:187011"
                     /translation="MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPR
                     AHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS"
     exon            132..243
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1217
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /note="hexamer: ATTAAA"
     polyA_site      1217
                     /gene="CCL5"
                     /gene_synonym="D17S136E; eoCP; RANTES; SCYA5; SIS-delta;
                     SISd; TCP228"
                     /note="major polyA site"
ORIGIN      
        1 cctgcagagg atcaagacag cacgtggacc tcgcacagcc tctcccacag gtaccatgaa
       61 ggtctccgcg gcagccctcg ctgtcatcct cattgctact gccctctgcg ctcctgcatc
      121 tgcctcccca tattcctcgg acaccacacc ctgctgcttt gcctacattg cccgcccact
      181 gccccgtgcc cacatcaagg agtatttcta caccagtggc aagtgctcca acccagcagt
      241 cgtctttgtc acccgaaaga accgccaagt gtgtgccaac ccagagaaga aatgggttcg
      301 ggagtacatc aactctttgg agatgagcta ggatggagag tccttgaacc tgaacttaca
      361 caaatttgcc tgtttctgct tgctcttgtc ctagcttggg aggcttcccc tcactatcct
      421 accccacccg ctccttgaag ggcccagatt ctaccacaca gcagcagtta caaaaacctt
      481 ccccaggctg gacgtggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg
      541 gtggatcact tgaggtcagg agttcgagac cagcctggcc aacatgatga aaccccatct
      601 ctactaaaaa tacaaaaaat tagccgggcg tggtagcggg cgcctgtagt cccagctact
      661 cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagccgag
      721 atcgcgccac tgcactccag cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa
      781 aaaaaaaaaa atacaaaaat tagccgggcg tggtggccca cgcctgtaat cccagctact
      841 cgggaggcta aggcaggaaa attgtttgaa cccaggaggt ggaggctgca gtgagctgag
      901 attgtgccac ttcactccag cctgggtgac aaagtgagac tccgtcacaa caacaacaac
      961 aaaaagcttc cccaactaaa gcctagaaga gcttctgagg cgctgctttg tcaaaaggaa
     1021 gtctctaggt tctgagctct ggctttgcct tggctttgcc agggctctgt gaccaggaag
     1081 gaagtcagca tgcctctaga ggcaaggagg ggaggaacac tgcactctta agcttccgcc
     1141 gtctcaaccc ctcacaggag cttactggca aacatgaaaa atcggcttac cattaaagtt
     1201 ctcaatgcaa ccataaa
//
