LOCUS       NM_001291468             647 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 4 like 2 (CCL4L2),
            transcript variant CCL4L2, mRNA.
ACCESSION   NM_001291468
VERSION     NM_001291468.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Ono,K., Murase,R., Matsumoto,N., Kubota,Y., Ishida,H. and
            Fujita,K.I.
  TITLE     Association of VEGFA and CCL4L2 polymorphisms with hand-foot skin
            reaction and survival of regorafenib in Japanese patients with
            colorectal cancer
  JOURNAL   Cancer Chemother Pharmacol 94 (1), 57-66 (2024)
   PUBMED   38459188
  REMARK    GeneRIF: Association of VEGFA and CCL4L2 polymorphisms with
            hand-foot skin reaction and survival of regorafenib in Japanese
            patients with colorectal cancer.
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Tsai,C.H., Lai,A.C., Lin,Y.C., Chi,P.Y., Chen,Y.C., Yang,Y.H.,
            Chen,C.H., Shen,S.Y., Hwang,T.L., Su,M.W., Hsu,I.L., Huang,Y.C.,
            Maitland-van der Zee,A.H., McGeachie,M.J., Tantisira,K.G.,
            Chang,Y.J. and Lee,Y.L.
  TITLE     Neutrophil extracellular trap production and CCL4L2 expression
            influence corticosteroid response in asthma
  JOURNAL   Sci Transl Med 15 (699), eadf3843 (2023)
   PUBMED   37285400
  REMARK    GeneRIF: Neutrophil extracellular trap production and CCL4L2
            expression influence corticosteroid response in asthma.
REFERENCE   3  (bases 1 to 647)
  AUTHORS   Suviolahti,E., Ge,S., Nast,C.C., Mirocha,J., Karasyov,A., White,M.,
            Jordan,S.C. and Toyoda,M.
  TITLE     Genes associated with antibody-dependent cell activation are
            overexpressed in renal biopsies from patients with
            antibody-mediated rejection
  JOURNAL   Transpl Immunol 32 (1), 9-17 (2015)
   PUBMED   25449536
  REMARK    GeneRIF: identified 13 ADCC-activated genes. Six gene expression
            assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2,
            CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney
            biopsies
REFERENCE   4  (bases 1 to 647)
  AUTHORS   Bharuthram,A., Paximadis,M., Picton,A.C. and Tiemessen,C.T.
  TITLE     Comparison of a quantitative Real-Time PCR assay and droplet
            digital PCR for copy number analysis of the CCL4L genes
  JOURNAL   Infect Genet Evol 25, 28-35 (2014)
   PUBMED   24727646
  REMARK    GeneRIF: PCR results show that lower copy numbers of CCL4L2 are
            observed in the Caucasian population nd higher copy numbers are
            observed in the Black population of South Africa.
REFERENCE   5  (bases 1 to 647)
  AUTHORS   Pedrosa,E., Carretero-Iglesia,L., Boada,A., Colobran,R., Faner,R.,
            Pujol-Autonell,I., Palou,E., Esteve,A., Pujol-Borrell,R.,
            Ferrandiz,C., Juan,M. and Carrascosa,J.M.
  TITLE     CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with
            psoriasis severity
  JOURNAL   J Invest Dermatol 131 (9), 1830-1837 (2011)
   PUBMED   21614014
  REMARK    GeneRIF: CCL4L1 allele frequency is higher in severe psoriasis,
            whereas CCL4L2 is more frequent in patients with a milder disease.
REFERENCE   6  (bases 1 to 647)
  AUTHORS   Colobran,R., Adreani,P., Ashhab,Y., Llano,A., Este,J.A.,
            Dominguez,O., Pujol-Borrell,R. and Juan,M.
  TITLE     Multiple products derived from two CCL4 loci: high incidence of a
            new polymorphism in HIV+ patients
  JOURNAL   J Immunol 174 (9), 5655-5664 (2005)
   PUBMED   15843566
REFERENCE   7  (bases 1 to 647)
  AUTHORS   Napolitano,M., Modi,W.S., Cevario,S.J., Gnarra,J.R., Seuanez,H.N.
            and Leonard,W.J.
  TITLE     The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax
            responsiveness of 5' upstream sequences, and chromosomal
            localization
  JOURNAL   J Biol Chem 266 (26), 17531-17536 (1991)
   PUBMED   1894635
REFERENCE   8  (bases 1 to 647)
  AUTHORS   Irving,S.G., Zipfel,P.F., Balke,J., McBride,O.W., Morton,C.C.,
            Burd,P.R., Siebenlist,U. and Kelly,K.
  TITLE     Two inflammatory mediator cytokine genes are closely linked and
            variably amplified on chromosome 17q
  JOURNAL   Nucleic Acids Res 18 (11), 3261-3270 (1990)
   PUBMED   1972563
REFERENCE   9  (bases 1 to 647)
  AUTHORS   Brown,K.D., Zurawski,S.M., Mosmann,T.R. and Zurawski,G.
  TITLE     A family of small inducible proteins secreted by leukocytes are
            members of a new superfamily that includes leukocyte and
            fibroblast-derived inflammatory agents, growth factors, and
            indicators of various activation processes
  JOURNAL   J Immunol 142 (2), 679-687 (1989)
   PUBMED   2521353
REFERENCE   10 (bases 1 to 647)
  AUTHORS   Lipes,M.A., Napolitano,M., Jeang,K.T., Chang,N.T. and Leonard,W.J.
  TITLE     Identification, cloning, and characterization of an immune
            activation gene
  JOURNAL   Proc Natl Acad Sci U S A 85 (24), 9704-9708 (1988)
   PUBMED   2462251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY766450.1.
            
            On May 31, 2019 this sequence version replaced NM_001291468.1.
            
            Summary: This gene is one of several cytokine genes that are
            clustered on the q-arm of chromosome 17. Cytokines are a family of
            secreted proteins that function in inflammatory and
            immunoregulatory processes. The protein encoded by this family
            member is similar to the chemokine (C-C motif) ligand 4 product,
            which inhibits HIV entry by binding to the cellular receptor CCR5.
            The copy number of this gene varies among individuals, where most
            individuals have one to five copies. This gene copy contains a
            non-consensus splice acceptor site at the 3' terminal exon found in
            other highly similar gene copies, and it thus uses other
            alternative splice sites for the 3' terminal exon, resulting in
            multiple transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (CCL4L2) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY766450.1, CD368561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620576.5/ ENSP00000479354.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-647               AY766450.1         1-647
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..647
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /note="C-C motif chemokine ligand 4 like 2"
                     /db_xref="GeneID:9560"
                     /db_xref="HGNC:HGNC:24066"
                     /db_xref="MIM:610757"
     exon            1..155
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..343
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant CCL4L2; macrophage inflammatory protein-1b2; C-C
                     motif chemokine 4-like; MIP-1-beta; macrophage
                     inflammatory protein 1-beta; monocyte adherence-induced
                     protein 5-alpha; chemokine (C-C motif) ligand 4-like 2"
                     /codon_start=1
                     /product="C-C motif chemokine 4-like isoform 1 precursor"
                     /protein_id="NP_001278397.1"
                     /db_xref="CCDS:CCDS32627.2"
                     /db_xref="GeneID:9560"
                     /db_xref="HGNC:HGNC:24066"
                     /db_xref="MIM:610757"
                     /translation="MKLCVTVLSLLVLVAAFCSLALSAPMGSDPPTACCFSYTARKLP
                     RNFVVDYYETSSLCSQPAVVGKQVCADPSESWVQEYVYDLELN"
     exon            156..270
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /inference="alignment:Splign:2.1.0"
     exon            271..647
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      622..627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /note="hexamer: AATAAA"
     polyA_site      647
                     /gene="CCL4L2"
                     /gene_synonym="AT744.2; CCL4L; SCYA4L; SCYQ4L2"
                     /note="major polyA site"
ORIGIN      
        1 agcacaggac acagctaggt tctgaagctt ctgagttctg cagcctcacc tctgagaaaa
       61 cctctttgcc accaatacca tgaagctctg cgtgactgtc ctgtctctcc tcgtgctagt
      121 agctgccttc tgctctctag cactctcagc accaatgggc tcagaccctc ccaccgcctg
      181 ctgcttttct tacaccgcga ggaagcttcc tcgcaacttt gtggtagatt actatgagac
      241 cagcagcctc tgctcccagc cagctgtggt aggcaagcaa gtctgcgctg accccagtga
      301 gtcctgggtc caggagtacg tgtatgacct ggaactgaac tgagctgctc agagacagga
      361 agtcttcagg gaaggtcacc tgagcctgga tgcttctcca tgagccgcat ctcctccata
      421 ctcaggactc ctctccgcag ttcctgtctc ttctcttaat gtaatctctt ttatgtgctg
      481 tattattgta ttaggtgtta tttccattat ttatattagt ttagccaaag gataagtgtc
      541 ccctatgggg atggtccact ctcactcttt ctctgctgtt gcaaatacat ggataacacc
      601 gttaattcca tgtgttttca taataaaact ttaaaataaa atgcaaa
//
