LOCUS       NM_002983                780 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 3 (CCL3), transcript
            variant 1, mRNA.
ACCESSION   NM_002983
VERSION     NM_002983.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Yuan,Q., Wu,Y., Xue,C., Zhao,D., Wang,H. and Shen,Y.
  TITLE     KAT7 serves as an oncogenic gene and regulates CCL3 expression via
            STAT1 signaling in osteosarcoma
  JOURNAL   Biochem Biophys Res Commun 722, 150156 (2024)
   PUBMED   38797155
  REMARK    GeneRIF: KAT7 serves as an oncogenic gene and regulates CCL3
            expression via STAT1 signaling in osteosarcoma.
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Li,H., Tang,Y., Liu,Z., Chen,K., Zhang,K., Hu,S., Pan,C., Yang,H.,
            Li,B. and Chen,H.
  TITLE     Lumbar instability remodels cartilage endplate to induce
            intervertebral disc degeneration by recruiting osteoclasts via
            Hippo-CCL3 signaling
  JOURNAL   Bone Res 12 (1), 34 (2024)
   PUBMED   38816384
  REMARK    GeneRIF: Lumbar instability remodels cartilage endplate to induce
            intervertebral disc degeneration by recruiting osteoclasts via
            Hippo-CCL3 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 780)
  AUTHORS   Wang,X., Zhang,L., Zhou,Y., Wang,Y., Wang,X., Zhang,Y., Quan,A.,
            Mao,Y., Zhang,Y., Qi,J., Ren,Z., Gu,L., Yu,R. and Zhou,X.
  TITLE     Chronic Stress Exacerbates the Immunosuppressive Microenvironment
            and Progression of Gliomas by Reducing Secretion of CCL3
  JOURNAL   Cancer Immunol Res 12 (5), 516-529 (2024)
   PUBMED   38437646
  REMARK    GeneRIF: Chronic Stress Exacerbates the Immunosuppressive
            Microenvironment and Progression of Gliomas by Reducing Secretion
            of CCL3.
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Ash,S., Doyle,T.J., Choi,B., San Jose Estepar,R., Castro,V.,
            Enzer,N., Kalhan,R., Liu,G., Bowler,R., Wilson,D.O., San Jose
            Estepar,R., Rosas,I.O. and Washko,G.R.
  TITLE     Utility of peripheral protein biomarkers for the prediction of
            incident interstitial features: a multicentre retrospective cohort
            study
  JOURNAL   BMJ Open Respir Res 11 (1), e002219 (2024)
   PUBMED   38485250
  REMARK    GeneRIF: Utility of peripheral protein biomarkers for the
            prediction of incident interstitial features: a multicentre
            retrospective cohort study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 780)
  AUTHORS   Graham,G.J., Freshney,M.G., Donaldson,D. and Pragnell,I.B.
  TITLE     Purification and biochemical characterisation of human and murine
            stem cell inhibitors (SCI)
  JOURNAL   Growth Factors 7 (2), 151-160 (1992)
   PUBMED   1419072
REFERENCE   6  (bases 1 to 780)
  AUTHORS   Hirashima,M., Ono,T., Nakao,M., Nishi,H., Kimura,A., Nomiyama,H.,
            Hamada,F., Yoshida,M.C. and Shimada,K.
  TITLE     Nucleotide sequence of the third cytokine LD78 gene and mapping of
            all three LD78 gene loci to human chromosome 17
  JOURNAL   DNA Seq 3 (4), 203-212 (1992)
   PUBMED   1296815
REFERENCE   7  (bases 1 to 780)
  AUTHORS   Blum,S., Forsdyke,R.E. and Forsdyke,D.R.
  TITLE     Three human homologs of a murine gene encoding an inhibitor of stem
            cell proliferation
  JOURNAL   DNA Cell Biol 9 (8), 589-602 (1990)
   PUBMED   2271120
REFERENCE   8  (bases 1 to 780)
  AUTHORS   Nakao,M., Nomiyama,H. and Shimada,K.
  TITLE     Structures of human genes coding for cytokine LD78 and their
            expression
  JOURNAL   Mol Cell Biol 10 (7), 3646-3658 (1990)
   PUBMED   1694014
REFERENCE   9  (bases 1 to 780)
  AUTHORS   Irving,S.G., Zipfel,P.F., Balke,J., McBride,O.W., Morton,C.C.,
            Burd,P.R., Siebenlist,U. and Kelly,K.
  TITLE     Two inflammatory mediator cytokine genes are closely linked and
            variably amplified on chromosome 17q
  JOURNAL   Nucleic Acids Res 18 (11), 3261-3270 (1990)
   PUBMED   1972563
REFERENCE   10 (bases 1 to 780)
  AUTHORS   Zipfel,P.F., Balke,J., Irving,S.G., Kelly,K. and Siebenlist,U.
  TITLE     Mitogenic activation of human T cells induces two closely related
            genes which share structural similarities with a new family of
            secreted factors
  JOURNAL   J Immunol 142 (5), 1582-1590 (1989)
   PUBMED   2521882
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX103455.1 and M23452.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002983.2.
            
            Summary: This locus represents a small inducible cytokine. The
            encoded protein, also known as macrophage inflammatory protein 1
            alpha, plays a role in inflammatory responses through binding to
            the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may
            be associated with both resistance and susceptibility to infection
            by human immunodeficiency virus type 1.[provided by RefSeq, Sep
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.299338.1, BX103455.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2144333,
                                           SAMEA2146411 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000613922.2/ ENSP00000477908.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BX103455.1         18-19
            3-777               M23452.1           1-775
            778-780             BX103455.1         795-797
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..780
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /note="C-C motif chemokine ligand 3"
                     /db_xref="GeneID:6348"
                     /db_xref="HGNC:HGNC:10627"
                     /db_xref="MIM:182283"
     exon            1..158
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..364
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /note="small inducible cytokine A3 (homologous to mouse
                     Mip-1a); SIS-beta; PAT 464.1; G0/G1 switch regulatory
                     protein 19-1; macrophage inflammatory protein 1-alpha;
                     tonsillar lymphocyte LD78 alpha protein"
                     /codon_start=1
                     /product="C-C motif chemokine 3 precursor"
                     /protein_id="NP_002974.1"
                     /db_xref="CCDS:CCDS11307.1"
                     /db_xref="GeneID:6348"
                     /db_xref="HGNC:HGNC:10627"
                     /db_xref="MIM:182283"
                     /translation="MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQ
                     NFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA"
     exon            159..273
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..780
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /note="hexamer: AATAAA"
     polyA_site      780
                     /gene="CCL3"
                     /gene_synonym="G0S19-1; LD78; LD78ALPHA; MIP-1-alpha;
                     MIP1A; SCI; SCYA3"
                     /note="major polyA site"
ORIGIN      
        1 agaaggacac gggcagcaga cagtggtcag tcctttcttg gctctgctga cactcgagcc
       61 cacattccgt cacctgctca gaatcatgca ggtctccact gctgcccttg ctgtcctcct
      121 ctgcaccatg gctctctgca accagttctc tgcatcactt gctgctgaca cgccgaccgc
      181 ctgctgcttc agctacacct cccggcagat tccacagaat ttcatagctg actactttga
      241 gacgagcagc cagtgctcca agcccggtgt catcttccta accaagcgaa gccggcaggt
      301 ctgtgctgac cccagtgagg agtgggtcca gaaatatgtc agcgacctgg agctgagtgc
      361 ctgaggggtc cagaagcttc gaggcccagc gacctcggtg ggcccagtgg ggaggagcag
      421 gagcctgagc cttgggaaca tgcgtgtgac ctccacagct acctcttcta tggactggtt
      481 gttgccaaac agccacactg tgggactctt cttaacttaa attttaattt atttatacta
      541 tttagttttt gtaatttatt ttcgatttca cagtgtgttt gtgattgttt gctctgagag
      601 ttcccctgtc ccctccccct tccctcacac cgcgtctggt gacaaccgag tggctgtcat
      661 cagcctgtgt aggcagtcat ggcaccaaag ccaccagact gacaaatgtg tatcggatgc
      721 ttttgttcag ggctgtgatc ggcctgggga aataataaag atgctctttt aaaaggtaaa
//
