LOCUS       NM_148672               3126 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 28 (CCL28), transcript
            variant 1, mRNA.
ACCESSION   NM_148672
VERSION     NM_148672.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3126)
  AUTHORS   Chen,Y., Zhang,Z., Pan,F., Li,P., Yao,W., Chen,Y., Xiong,L.,
            Wang,T., Li,Y. and Huang,G.
  TITLE     Pericytes recruited by CCL28 promote vascular normalization after
            anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung
            adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 210 (2024)
   PUBMED   39075504
  REMARK    GeneRIF: Pericytes recruited by CCL28 promote vascular
            normalization after anti-angiogenesis therapy through
            RA/RXRA/ANGPT1 pathway in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3126)
  AUTHORS   Dominguez-Lopez,A., Blanco-Vazquez,M., Calderon-Garcia,A.A.,
            Garcia-Vazquez,C., Gonzalez-Garcia,M.J., Calonge,M. and
            Enriquez-de-Salamanca,A.
  TITLE     Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry
            eye disease: An in vitro and clinical investigation
  JOURNAL   Exp Eye Res 241, 109854 (2024)
   PUBMED   38453037
  REMARK    GeneRIF: Analysis of the mucosal chemokines CCL28, CXCL14, and
            CXCL17 in dry eye disease: An in vitro and clinical investigation.
REFERENCE   3  (bases 1 to 3126)
  AUTHORS   Li,J., Han,Z., Zhu,Z. and Wei,L.
  TITLE     LncRNA H19 aggravates primary graft dysfunction after lung
            transplantation via KLF5-mediated activation of CCL28
  JOURNAL   Am J Transplant 23 (10), 1536-1550 (2023)
   PUBMED   37394140
  REMARK    GeneRIF: LncRNA H19 aggravates primary graft dysfunction after lung
            transplantation via KLF5-mediated activation of CCL28.
REFERENCE   4  (bases 1 to 3126)
  AUTHORS   Dhanushkodi,N.R., Prakash,S., Quadiri,A., Zayou,L., Srivastava,R.,
            Tran,J., Dang,V., Shaik,A.M., Chilukurri,A., Suzer,B., Vera,P.,
            Sun,M., Nguyen,P., Lee,A., Salem,A., Loi,J., Singer,M.,
            Nakayama,T., Vahed,H., Nesburn,A.B. and BenMohamed,L.
  TITLE     Mucosal CCL28 Chemokine Improves Protection against Genital Herpes
            through Mobilization of Antiviral Effector Memory CCR10+CD44+
            CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the
            Infected Vaginal Mucosa
  JOURNAL   J Immunol 211 (1), 118-129 (2023)
   PUBMED   37222480
  REMARK    GeneRIF: Mucosal CCL28 Chemokine Improves Protection against
            Genital Herpes through Mobilization of Antiviral Effector Memory
            CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells
            into the Infected Vaginal Mucosa.
REFERENCE   5  (bases 1 to 3126)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
  REMARK    GeneRIF: CCL28 may play dual roles in mucosal immunity as a
            chemoattractant for cells expressing CCR10 and/or CCR3 such as
            plasma cells and also as a broad-spectrum antimicrobial protein
            secreted into low-salt body fluids.
REFERENCE   6  (bases 1 to 3126)
  AUTHORS   Kunkel,E.J. and Butcher,E.C.
  TITLE     Chemokines and the tissue-specific migration of lymphocytes
  JOURNAL   Immunity 16 (1), 1-4 (2002)
   PUBMED   11825560
  REMARK    Review article
REFERENCE   7  (bases 1 to 3126)
  AUTHORS   Mickanin,C.S., Bhatia,U. and Labow,M.
  TITLE     Identification of a novel beta-chemokine, MEC, down-regulated in
            primary breast tumors
  JOURNAL   Int J Oncol 18 (5), 939-944 (2001)
   PUBMED   11295038
REFERENCE   8  (bases 1 to 3126)
  AUTHORS   Pan,J., Kunkel,E.J., Gosslar,U., Lazarus,N., Langdon,P.,
            Broadwell,K., Vierra,M.A., Genovese,M.C., Butcher,E.C. and Soler,D.
  TITLE     A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial
            cells in mucosal tissues
  JOURNAL   J Immunol 165 (6), 2943-2949 (2000)
   PUBMED   10975800
REFERENCE   9  (bases 1 to 3126)
  AUTHORS   Wang,W., Soto,H., Oldham,E.R., Buchanan,M.E., Homey,B., Catron,D.,
            Jenkins,N., Copeland,N.G., Gilbert,D.J., Nguyen,N., Abrams,J.,
            Kershenovich,D., Smith,K., McClanahan,T., Vicari,A.P. and
            Zlotnik,A.
  TITLE     Identification of a novel chemokine (CCL28), which binds CCR10
            (GPR2)
  JOURNAL   J Biol Chem 275 (29), 22313-22323 (2000)
   PUBMED   10781587
REFERENCE   10 (bases 1 to 3126)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX486632.1 and AC025457.5.
            
            On Sep 24, 2014 this sequence version replaced NM_148672.2.
            
            Summary: This antimicrobial gene belongs to the subfamily of small
            cytokine CC genes. Cytokines are a family of secreted proteins
            involved in immunoregulatory and inflammatory processes. The CC
            cytokines are proteins characterized by two adjacent cysteines. The
            cytokine encoded by this gene displays chemotactic activity for
            resting CD4 or CD8 T cells and eosinophils. The product of this
            gene binds to chemokine receptors CCR3 and CCR10. This chemokine
            may play a role in the physiology of extracutaneous epithelial
            tissues, including diverse mucosal organs. Multiple transcript
            variants encoding two different isoforms have been found for this
            gene. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062668.1, BX486632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2150585
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000361115.4/
                                                  ENSP00000354416.4
            Protein has antimicrobial activity :: PMID: 12538707
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               BX486632.1         2-525
            525-3126            AC025457.5         30099-32700         c
FEATURES             Location/Qualifiers
     source          1..3126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..3126
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /note="C-C motif chemokine ligand 28"
                     /db_xref="GeneID:56477"
                     /db_xref="HGNC:HGNC:17700"
                     /db_xref="MIM:605240"
     exon            1..139
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..459
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; CC chemokine CCL28; mucosae-associated
                     epithelial chemokine; small inducible cytokine subfamily A
                     (Cys-Cys), member 28; C-C motif chemokine 28; chemokine
                     (C-C motif) ligand 28; small inducible cytokine A28"
                     /codon_start=1
                     /product="C-C motif chemokine 28 isoform a precursor"
                     /protein_id="NP_683513.1"
                     /db_xref="CCDS:CCDS3944.1"
                     /db_xref="GeneID:56477"
                     /db_xref="HGNC:HGNC:17700"
                     /db_xref="MIM:605240"
                     /translation="MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLE
                     RVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRK
                     KHHGKRNSNRAHQGKHETYGHKTPY"
     exon            140..266
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /inference="alignment:Splign:2.1.0"
     exon            267..3126
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3006..3011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /note="hexamer: AATAAA"
     polyA_site      3027
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /note="hexamer: AATAAA"
     polyA_site      3126
                     /gene="CCL28"
                     /gene_synonym="CCK1; MEC; SCYA28"
                     /note="major polyA site"
ORIGIN      
        1 aggacacctt tagcctcatt tcctgatcga acagcctcac ttgtgttgct gtcagtgcca
       61 gtagggcagg caggaatgca gcagagagga ctcgccatcg tggccttggc tgtctgtgcg
      121 gccctacatg cctcagaagc catacttccc attgcctcca gctgttgcac ggaggtttca
      181 catcatattt ccagaaggct cctggaaaga gtgaatatgt gtcgcatcca gagagctgat
      241 ggggattgtg acttggctgc tgtcatcctt catgtcaagc gcagaagaat ctgtgtcagc
      301 ccgcacaacc atactgttaa gcagtggatg aaagtgcaag ctgccaagaa aaatggtaaa
      361 ggaaatgttt gccacaggaa gaaacaccat ggcaagagga acagtaacag ggcacatcag
      421 gggaaacacg aaacatacgg ccataaaact ccttattaga gagtctacag ataaatctac
      481 agagacaatt cctcaagtgg acttggccat gattggttgt aagtttatca tctgaattct
      541 ccttattgta gacaacagaa caaaacaaaa tattggtttt taaaaaatga acaattgtgc
      601 ggtatgcaaa tgtagccaat aatatactca actggaaaat gaaatgaaaa gataatactg
      661 gctgggtatg gtggttcaca ccttttatcc cagcacttcg ggaggctgag gcaggaggat
      721 cacttgagac caggagtttg agaccagcct gggcaacata gcaagacctc atttctacaa
      781 acaaaaaaaa aattggcccg gcatggtagt acttgcctat aatcccagcc acatgggagg
      841 ctgaggtggg aggatcactt gagtctggga gagtttgagg ttgcagtgag cagcctgggt
      901 gacagaatga gaccctgtct ctaaaaataa taataataat gatagtgtat atcttcatat
      961 aatattttaa gaggagcata tagatataac ttctcccaac tttttaatta tagttttcca
     1021 aacttacaga gaagttaaaa gaatggtaca atgaacatct atatatcttt caccacaata
     1081 ttaatcattg ttaatattgt gtcacatttg ctttctctct cctctctttg tatgtgtttc
     1141 tatataaaat attataactt ttaaaatata tcttgttttg ctaaaccatt tgaaaataag
     1201 ttgcaaaaat catgacactt cacccctagt ttctttttgg tgttataact tgacataccc
     1261 taaaataaag acatttttct acataatcac cttatcagtt ttatacctaa aaaattaata
     1321 atttcatcta atatattcca tattcaaatt ttcccaacta tttagagagc attttatgta
     1381 gttttttttt cactccagta atcaatcaag gttgacatac atattgcaaa taattgttat
     1441 ttttctttaa tatctttcaa tctaagaaag ttcctctgtc tttttttttt aatttttaaa
     1501 attattttgt tgagggaggg tcttgctgtg tcttccaggc tggagtgcag tggcacaatt
     1561 ttgattttgg ctcactgaag cctcaacttc tagggctcaa gcaatcctcc cacctcagcc
     1621 tcccgagtat ctgggatcaa ggtgcatacc caccacacct ggctaatttt gtttattttt
     1681 tgtagagaca gggtctcact atgttgccca ggttgatctc aaactcctgg gctcaagcga
     1741 tcctcccacc ttagcctccc aaagtactgg gattataggt gtgagccaca gtgcctggcc
     1801 taattatttt cttgtgatca aattcaggtt taatgttttt ggttaagaat ttcctacgtg
     1861 aattcgtgta cttattttgt catttagagt tcataaatat tagggtttat tttctaaata
     1921 gaatagttta aactaaatat aacttcaaaa cgtctagttt gagtagctac cgttgtttgg
     1981 attgaaattt tctgatactg aaaagaacaa aaagcctgcc tttctgccca gaaccttttg
     2041 cctcccccag tcagttcttg gagcagcact agttaggggc ccagagttcg gccttctgtg
     2101 tggtgatttt acgctctgcc taaacaagga gcctacatct tttagctcct attccaccct
     2161 tctcacacgt ttttgttgtt gtttggttgt ttttttttga gacagagtct cactctgttg
     2221 cccaggctgg agtgcagtgg cacaatctcg gctcattgca acctccgcct cccgcgttca
     2281 agtgattctc ttgcctcagc ctcccaagta actgatatta caggcgccca gccaccacac
     2341 cccgctgatt tttgtatttt tagtagagac ggggttttcc cacgttggcc gggctggtct
     2401 caaactcttg acctcaagtg aaccacccgc ctgtgcctcc caaagtgctg gaattaccag
     2461 cgtgagccac catgccgggc tcacacgttt gagttgatac cattgtgcca ttcctctttt
     2521 ggcctctttt ttgtccatag aggcttcaag atagataggt aagagcccag tagtgttcat
     2581 aagaagccaa tagagagcag gagccacttt atcaggtggc aggtgtcctg ggcctccctg
     2641 ctggctagtc ccaagcggtg gtgttgccag gatgtcttgg aggtgataat gggacacaca
     2701 gaggcactga gtctccatag gttaaaatgc caccaaaact ggcctttgcc taatatccct
     2761 cattgactat ttagcattta atttatttat tttcctgaca tttctgcaag ctttgtattt
     2821 atatttccac tttatagatg aggaaatttg aggctcttag aggtaaaatg acttgcccag
     2881 gtcacacagg aagtggcaga gacaagcttt ttaaataaga aaaaattaat aaaatataat
     2941 atgagagtaa cttaaaatat taataaacca caattttaaa ttaattaacc gtgataacca
     3001 acattaataa aagttaagat accaaaacac tggtgtctaa ttctttcaac taacaacttg
     3061 aattattttc cattttaaat taattaaccg tgataaccaa cattaataaa agttaagata
     3121 ccaaaa
//
