LOCUS       NM_006664                417 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 27 (CCL27), mRNA.
ACCESSION   NM_006664
VERSION     NM_006664.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 417)
  AUTHORS   Liu,Z., Zheng,Y., Yuan,M., Zhang,G. and Yang,G.
  TITLE     Association of CTACK, IL-2, and IL-13 with increased risk of lung
            cancer: A Mendelian randomization study
  JOURNAL   Cytokine 181, 156680 (2024)
   PUBMED   38885591
  REMARK    GeneRIF: Association of CTACK, IL-2, and IL-13 with increased risk
            of lung cancer: A Mendelian randomization study.
REFERENCE   2  (bases 1 to 417)
  AUTHORS   Tao,R., Mao,Y., Li,Y., Sun,M., Cao,X., Chen,N., Xu,S., Wang,D. and
            Zhao,Y.
  TITLE     Connexin26 Modulates Radiation-Induced Skin Damage by Regulating
            Chemokine CCL27 through MAPK Signaling
  JOURNAL   Radiat Res 200 (3), 281-288 (2023)
   PUBMED   37450610
  REMARK    GeneRIF: Connexin26 Modulates Radiation-Induced Skin Damage by
            Regulating Chemokine CCL27 through MAPK Signaling.
REFERENCE   3  (bases 1 to 417)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   4  (bases 1 to 417)
  AUTHORS   Li,B., Wei,C., Zhong,Y., Huang,J. and Li,R.
  TITLE     The CCL27-CCR10 axis contributes to promoting proliferation,
            migration, and invasion of lung squamous cell carcinoma
  JOURNAL   Histol Histopathol 38 (3), 349-357 (2023)
   PUBMED   36169116
  REMARK    GeneRIF: The CCL27-CCR10 axis contributes to promoting
            proliferation, migration, and invasion of lung squamous cell
            carcinoma.
REFERENCE   5  (bases 1 to 417)
  AUTHORS   Mao,M.J., Xue,N., Wang,X.P., Chi,P.D., Liu,Y.J., Huang,Q., Dai,S.Q.
            and Liu,W.L.
  TITLE     Chemokine CCL27 is a novel plasma biomarker for identification the
            nasopharyngeal carcinoma patients from the Epstein-Barr virus
            capsid antigen-specific IgA seropositive population
  JOURNAL   BMC Cancer 18 (1), 9 (2018)
   PUBMED   29295705
  REMARK    GeneRIF: Plasma CCL27 levels were significantly lower in the
            VCA-IgA-negative normal subjects than in either the
            VCA-IgA-positive healthy donorsor the NPC patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 417)
  AUTHORS   Homey,B., Wang,W., Soto,H., Buchanan,M.E., Wiesenborn,A.,
            Catron,D., Muller,A., McClanahan,T.K., Dieu-Nosjean,M.C.,
            Orozco,R., Ruzicka,T., Lehmann,P., Oldham,E. and Zlotnik,A.
  TITLE     Cutting edge: the orphan chemokine receptor G protein-coupled
            receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27
            (CTACK/ALP/ILC)
  JOURNAL   J Immunol 164 (7), 3465-3470 (2000)
   PUBMED   10725697
REFERENCE   7  (bases 1 to 417)
  AUTHORS   Jarmin,D.I., Rits,M., Bota,D., Gerard,N.P., Graham,G.J.,
            Clark-Lewis,I. and Gerard,C.
  TITLE     Cutting edge: identification of the orphan receptor
            G-protein-coupled receptor 2 as CCR10, a specific receptor for the
            chemokine ESkine
  JOURNAL   J Immunol 164 (7), 3460-3464 (2000)
   PUBMED   10725696
REFERENCE   8  (bases 1 to 417)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   9  (bases 1 to 417)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
REFERENCE   10 (bases 1 to 417)
  AUTHORS   Ishikawa-Mochizuki,I., Kitaura,M., Baba,M., Nakayama,T., Izawa,D.,
            Imai,T., Yamada,H., Hieshima,K., Suzuki,R., Nomiyama,H. and
            Yoshie,O.
  TITLE     Molecular cloning of a novel CC chemokine, interleukin-11 receptor
            alpha-locus chemokine (ILC), which is located on chromosome 9p13
            and a potential homologue of a CC chemokine encoded by molluscum
            contagiosum virus
  JOURNAL   FEBS Lett 460 (3), 544-548 (1999)
   PUBMED   10556532
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB010445.1 and CA433929.1.
            
            On May 17, 2019 this sequence version replaced NM_006664.3.
            
            Summary: This gene is one of several CC cytokine genes clustered on
            the p-arm of chromosome 9. Cytokines are a family of secreted
            proteins involved in immunoregulatory and inflammatory processes.
            The CC cytokines are proteins characterized by two adjacent
            cysteines. The protein encoded by this gene is chemotactic for
            skin-associated memory T lymphocytes. This cytokine may also play a
            role in mediating homing of lymphocytes to cutaneous sites. It
            specifically binds to chemokine receptor 10 (CCR10). Studies of a
            similar murine protein indicate that these protein-receptor
            interactions have a pivotal role in T cell-mediated skin
            inflammation. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243542.1, AB010445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259631.5/ ENSP00000259631.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AB010445.1         36-439
            405-417             CA433929.1         24-36               c
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..417
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /note="C-C motif chemokine ligand 27"
                     /db_xref="GeneID:10850"
                     /db_xref="HGNC:HGNC:10626"
                     /db_xref="MIM:604833"
     exon            1..94
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..363
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 27; cutaneous T-cell attracting chemokine; CC
                     chemokine ILC; IL-11 Ralpha-locus chemokine; skinkine; C-C
                     motif chemokine 27; small-inducible cytokine A27; IL-11
                     R-alpha-locus chemokine; chemokine (C-C motif) ligand 27"
                     /codon_start=1
                     /product="C-C motif chemokine 27 precursor"
                     /protein_id="NP_006655.1"
                     /db_xref="CCDS:CCDS6569.1"
                     /db_xref="GeneID:10850"
                     /db_xref="HGNC:HGNC:10626"
                     /db_xref="MIM:604833"
                     /translation="MKGPPTFCSLLLLSLLLSPDPTAAFLLPPSTACCTQLYRKPLSD
                     KLLRKVIQVELQEADGDCHLQAFVLHLAQRSICIHPQNPSLSQWFEHQERKLHGTLPK
                     LNFGMLRKMG"
     exon            95..227
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /inference="alignment:Splign:2.1.0"
     exon            228..417
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      382..387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /note="hexamer: AATAAA"
     regulatory      400..405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /note="hexamer: AATAAT"
     polyA_site      404
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
                     /note="major polyA site"
     polyA_site      417
                     /gene="CCL27"
                     /gene_synonym="ALP; CTACK; CTAK; ESKINE; ILC; PESKY;
                     SCYA27"
ORIGIN      
        1 aaggaagagt ctaggctgag caacatgaag gggcccccaa ccttctgcag cctcctgctg
       61 ctgtcattgc tcctgagccc agaccctaca gcagcattcc tactgccacc cagcactgcc
      121 tgctgtactc agctctaccg aaagccactc tcagacaagc tactgaggaa ggtcatccag
      181 gtggaactgc aggaggctga cggggactgt cacctccagg ctttcgtgct tcacctggct
      241 caacgcagca tctgcatcca cccccagaac cccagcctgt cacagtggtt tgagcaccaa
      301 gagagaaagc tccatgggac tctgcccaag ctgaattttg ggatgctaag gaaaatgggc
      361 tgaagccccc aatagccaaa taataaagca gcattggata ataatttctg agtataa
//
