LOCUS       NM_001371938             475 bp    mRNA    linear   PRI 07-DEC-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 26 (CCL26), transcript
            variant 2, mRNA.
ACCESSION   NM_001371938 XM_017011671
VERSION     NM_001371938.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Nelson,M.R., Zhang,X., Podgaetz,E., Wang,X., Zhang,Q., Pan,Z.,
            Spechler,S.J. and Souza,R.F.
  TITLE     Th2 cytokine signaling through IL-4Ralpha increases eotaxin-3
            secretion and tension in human esophageal smooth muscle
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (1), G38-G52 (2024)
   PUBMED   37933466
  REMARK    GeneRIF: Th2 cytokine signaling through IL-4Ralpha increases
            eotaxin-3 secretion and tension in human esophageal smooth muscle.
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Hoyer,A., Chakraborty,S., Lilienthal,I., Konradsen,J.R.,
            Katayama,S. and Soderhall,C.
  TITLE     The functional role of CST1 and CCL26 in asthma development
  JOURNAL   Immun Inflamm Dis 12 (1), e1162 (2024)
   PUBMED   38270326
  REMARK    GeneRIF: The functional role of CST1 and CCL26 in asthma
            development.
REFERENCE   3  (bases 1 to 475)
  AUTHORS   Fang,C., Kang,B., Zhao,P., Ran,J., Wang,L., Zhao,L., Luo,H. and
            Tao,L.
  TITLE     MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic Obstructive
            Pulmonary Disease
  JOURNAL   Can Respir J 2023, 8659293 (2023)
   PUBMED   37200921
  REMARK    GeneRIF: MCP-4 and Eotaxin-3 Are Novel Biomarkers for Chronic
            Obstructive Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 475)
  AUTHORS   Zhang,Z., Ma,F., Liu,J., Xie,L., Cao,W. and Zhang,Y.
  TITLE     [Expression and predictive value of type inflammatory cytokines in
            nasal secretion in eosinophilic chronic rhinosinusitis with nasal
            polyps]
  JOURNAL   Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 36 (12), 934-939
            (2022)
   PUBMED   36543402
  REMARK    GeneRIF: [Expression and predictive value of type inflammatory
            cytokines in nasal secretion in eosinophilic chronic rhinosinusitis
            with nasal polyps].
REFERENCE   5  (bases 1 to 475)
  AUTHORS   Mancebo-Perez,C., Vidal,M., Aguilar,R., Barrios,D., Bardaji,A.,
            Ome-Kaius,M., Menendez,C., Rogerson,S.J., Dobano,C., Moncunill,G.
            and Requena,P.
  TITLE     Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy
  JOURNAL   Malar J 21 (1), 336 (2022)
   PUBMED   36380370
  REMARK    GeneRIF: Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 475)
  AUTHORS   Gela,A., Kasetty,G., Jovic,S., Ekoff,M., Nilsson,G., Morgelin,M.,
            Kjellstrom,S., Pease,J.E., Schmidtchen,A. and Egesten,A.
  TITLE     Eotaxin-3 (CCL26) exerts innate host defense activities that are
            modulated by mast cell proteases
  JOURNAL   Allergy 70 (2), 161-170 (2015)
   PUBMED   25377782
  REMARK    GeneRIF: CCL26 displays antimicrobial activity against S.
            pneumoniae, S. aureus, Non-typeable H. influenzae, and P.
            aeruginosa.
REFERENCE   7  (bases 1 to 475)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   8  (bases 1 to 475)
  AUTHORS   Kitaura,M., Suzuki,N., Imai,T., Takagi,S., Suzuki,R., Nakajima,T.,
            Hirai,K., Nomiyama,H. and Yoshie,O.
  TITLE     Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is
            a functional ligand of CC chemokine receptor 3
  JOURNAL   J Biol Chem 274 (39), 27975-27980 (1999)
   PUBMED   10488147
REFERENCE   9  (bases 1 to 475)
  AUTHORS   Shinkai,A., Yoshisue,H., Koike,M., Shoji,E., Nakagawa,S., Saito,A.,
            Takeda,T., Imabeppu,S., Kato,Y., Hanai,N., Anazawa,H., Kuga,T. and
            Nishi,T.
  TITLE     A novel human CC chemokine, eotaxin-3, which is expressed in
            IL-4-stimulated vascular endothelial cells, exhibits potent
            activity toward eosinophils
  JOURNAL   J Immunol 163 (3), 1602-1610 (1999)
   PUBMED   10415065
REFERENCE   10 (bases 1 to 475)
  AUTHORS   Guo,R.F., Ward,P.A., Hu,S.M., McDuffie,J.E., Huber-Lang,M. and
            Shi,M.M.
  TITLE     Molecular cloning and characterization of a novel human CC
            chemokine, SCYA26
  JOURNAL   Genomics 58 (3), 313-317 (1999)
   PUBMED   10373330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005102.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 29, 2019 this sequence version replaced XM_017011671.1.
            
            Summary: This gene is one of two Cys-Cys (CC) cytokine genes
            clustered on the q arm of chromosome 7. Cytokines are a family of
            secreted proteins involved in immunoregulatory and inflammatory
            processes. The CC cytokines are proteins characterized by two
            adjacent cysteines. The cytokine encoded by this gene displays
            chemotactic activity for normal peripheral blood eosinophils and
            basophils. This protein also has antimicrobial activity, displaying
            an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable
            H. influenzae, and P. aeruginosa. The product of this gene is one
            of three related chemokines that specifically activate chemokine
            receptor CCR3. This chemokine may contribute to the eosinophil
            accumulation in atopic diseases. [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (2) has a shorter 5' UTR compared
            to variant 1 since it represents use of the main transcription
            initiation site, as defined by CAGE data. All three variants encode
            the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF590082.1, BG211121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000005180.9/
                                                  ENSP00000005180.4
            Protein has antimicrobial activity :: PMID: 25377782
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC005102.1         94998-95105
            109-223             AC005102.1         95206-95320
            224-475             AC005102.1         97420-97671
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..475
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /note="C-C motif chemokine ligand 26"
                     /db_xref="GeneID:10344"
                     /db_xref="HGNC:HGNC:10625"
                     /db_xref="MIM:604697"
     exon            1..108
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..320
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 26; chemokine N1; macrophage inflammatory protein
                     4-alpha; small inducible cytokine A26; CC chemokine IMAC;
                     C-C motif chemokine 26; eotaxin-3; thymic stroma
                     chemokine-1; MIP-4-alpha; chemokine (C-C motif) ligand 26"
                     /codon_start=1
                     /product="C-C motif chemokine 26 precursor"
                     /protein_id="NP_001358867.1"
                     /db_xref="CCDS:CCDS5578.1"
                     /db_xref="GeneID:10344"
                     /db_xref="HGNC:HGNC:10625"
                     /db_xref="MIM:604697"
                     /translation="MMGLSLASAVLLASLLSLHLGTATRGSDISKTCCFQYSHKPLPW
                     TWVRSYEFTSNSCSQRAVIFTTKRGKKVCTHPRKKWVQKYISLLKTPKQL"
     exon            109..223
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..475
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      457..462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /note="hexamer: AATAAA"
     polyA_site      475
                     /gene="CCL26"
                     /gene_synonym="IMAC; MIP-4a; MIP-4alpha; SCYA26; TSC-1"
                     /note="major polyA site"
ORIGIN      
        1 gggagaaacc tgagaagggc ctgatttgca gcatcatgat gggcctctcc ttggcctctg
       61 ctgtgctcct ggcctccctc ctgagtctcc accttggaac tgccacacgt gggagtgaca
      121 tatccaagac ctgctgcttc caatacagcc acaagcccct tccctggacc tgggtgcgaa
      181 gctatgaatt caccagtaac agctgctccc agcgggctgt gatattcact accaaaagag
      241 gcaagaaagt ctgtacccat ccaaggaaaa aatgggtgca aaaatacatt tctttactga
      301 aaactccgaa acaattgtga ctcagctgaa ttttcatccg aggacgcttg gaccccgctc
      361 ttggctctgc agccctctgg ggagcctgcg gaatcttttc tgaaggctac atggacccgc
      421 tggggaggag agggtgtttc ctcccagagt tactttaata aaggttgttc ataga
//
