LOCUS       NM_005624                991 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens C-C motif chemokine ligand 25 (CCL25), transcript
            variant 1, mRNA.
ACCESSION   NM_005624
VERSION     NM_005624.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Li J, Muhammad J, Xie T, Sun J, Lei Y, Wei Z, Pan S, Qin H, Shao L,
            Jiang D and Zhang Q.
  TITLE     LINC00853 restrains T cell acute lymphoblastic leukemia invasion
            and infiltration by regulating CCR9/CCL25
  JOURNAL   Mol Immunol 140, 267-275 (2021)
   PUBMED   34808497
  REMARK    GeneRIF: LINC00853 restrains T cell acute lymphoblastic leukemia
            invasion and infiltration by regulating CCR9/CCL25.
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Ahmad I,
            Tetali C, Sweiss N, Amin MA, Zomorrodi RK and Shahrara S.
  TITLE     CCL25 and CCR9 is a unique pathway that potentiates pannus
            formation by remodeling RA macrophages into mature osteoclasts
  JOURNAL   Eur J Immunol 51 (4), 903-914 (2021)
   PUBMED   33347617
  REMARK    GeneRIF: CCL25 and CCR9 is a unique pathway that potentiates pannus
            formation by remodeling RA macrophages into mature osteoclasts.
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Atanes P, Lee V, Huang GC and Persaud SJ.
  TITLE     The role of the CCL25-CCR9 axis in beta-cell function: potential
            for therapeutic intervention in type 2 diabetes
  JOURNAL   Metabolism 113, 154394 (2020)
   PUBMED   33058852
  REMARK    GeneRIF: The role of the CCL25-CCR9 axis in beta-cell function:
            potential for therapeutic intervention in type 2 diabetes.
REFERENCE   4  (bases 1 to 991)
  AUTHORS   Chen L, Zhang S, Shen Y, Qi L, Zhang Z, Tian H and Zou Z.
  TITLE     Thymusexpressed chemokine secreted by breast cancer cells promotes
            metastasis and inhibits apoptosis
  JOURNAL   Oncol Rep 43 (6), 1875-1884 (2020)
   PUBMED   32323823
  REMARK    GeneRIF: Thymusexpressed chemokine secreted by breast cancer cells
            promotes metastasis and inhibits apoptosis.
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Chen H, Cong X, Wu C, Wu X, Wang J, Mao K, Li J, Zhu G, Liu F, Meng
            X, Song J, Sun X, Wang X, Liu S, Zhang S, Yang X, Song Y, Yang YG
            and Sun T.
  TITLE     Intratumoral delivery of CCL25 enhances immunotherapy against
            triple-negative breast cancer by recruiting CCR9(+) T cells
  JOURNAL   Sci Adv 6 (5), eaax4690 (2020)
   PUBMED   32064335
  REMARK    GeneRIF: Intratumoral delivery of CCL25 enhances immunotherapy
            against triple-negative breast cancer by recruiting CCR9(+) T
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 991)
  AUTHORS   Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and
            Oppenheim JJ.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL25 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 991)
  AUTHORS   Zaballos A, Gutierrez J, Varona R, Ardavin C and Marquez G.
  TITLE     Cutting edge: identification of the orphan chemokine receptor
            GPR-9-6 as CCR9, the receptor for the chemokine TECK
  JOURNAL   J Immunol 162 (10), 5671-5675 (1999)
   PUBMED   10229797
REFERENCE   8  (bases 1 to 991)
  AUTHORS   Nomiyama H, Amano K, Kusuda J, Imai T, Miura R, Yoshie O and
            Matsuda Y.
  TITLE     The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2
  JOURNAL   Genomics 51 (2), 311-312 (1998)
   PUBMED   9722960
REFERENCE   9  (bases 1 to 991)
  AUTHORS   Vicari AP, Figueroa DJ, Hedrick JA, Foster JS, Singh KP, Menon S,
            Copeland NG, Gilbert DJ, Jenkins NA, Bacon KB and Zlotnik A.
  TITLE     TECK: a novel CC chemokine specifically expressed by thymic
            dendritic cells and potentially involved in T cell development
  JOURNAL   Immunity 7 (2), 291-301 (1997)
   PUBMED   9285413
REFERENCE   10 (bases 1 to 991)
  AUTHORS   Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M and Kaziro Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008946.7.
            
            On Apr 28, 2021 this sequence version replaced NM_005624.3.
            
            Summary: This antimicrobial gene belongs to the subfamily of small
            cytokine CC genes. Cytokines are a family of secreted proteins
            involved in immunoregulatory and inflammatory processes. The CC
            cytokines are proteins characterized by two adjacent cysteines. The
            cytokine encoded by this gene displays chemotactic activity for
            dendritic cells, thymocytes, and activated macrophages but is
            inactive on peripheral blood lymphocytes and neutrophils. The
            product of this gene binds to chemokine receptor CCR9. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.1074222.1,
                                           ERR279835.315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000315626.6/
                                                  ENSP00000324756.6
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC008946.7         57506-57568
            64-186              AC008946.7         57746-57868
            187-304             AC008946.7         60898-61015
            305-438             AC008946.7         61112-61245
            439-558             AC008946.7         62547-62666
            559-991             AC008946.7         66964-67396
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..991
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /note="C-C motif chemokine ligand 25"
                     /db_xref="GeneID:6370"
                     /db_xref="HGNC:HGNC:10624"
                     /db_xref="MIM:602565"
     exon            1..63
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            64..186
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..566
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; small inducible cytokine subfamily A (Cys-Cys),
                     member 25; chemokine TECK; thymus expressed chemokine;
                     TECKvar; C-C motif chemokine 25; small-inducible cytokine
                     A25; chemokine (C-C motif) ligand 25"
                     /codon_start=1
                     /product="C-C motif chemokine 25 isoform 1 precursor"
                     /protein_id="NP_005615.2"
                     /db_xref="CCDS:CCDS12194.1"
                     /db_xref="GeneID:6370"
                     /db_xref="HGNC:HGNC:10624"
                     /db_xref="MIM:602565"
                     /translation="MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLR
                     RAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHH
                     NTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL"
     exon            187..304
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            305..438
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            439..558
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            559..991
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      965..970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /note="hexamer: AATAAA"
     polyA_site      991
                     /gene="CCL25"
                     /gene_synonym="Ck beta-15; Ckb15; SCYA25; TECK"
                     /note="major polyA site"
ORIGIN      
        1 gcagatggga cagcttggcc tacagcccgg cgggcatcag ctcccttgac ccagtggata
       61 tcggtggccc cgttattcgt ccaggtgccc agggaggagg acccgcctgc agcatgaacc
      121 tgtggctcct ggcctgcctg gtggccggct tcctgggagc ctgggccccc gctgtccaca
      181 cccaaggtgt ctttgaggac tgctgcctgg cctaccacta ccccattggg tgggctgtgc
      241 tccggcgcgc ctggacttac cggatccagg aggtgagcgg gagctgcaat ctgcctgctg
      301 cgatattcta cctccccaag agacacagga aggtgtgtgg gaaccccaaa agcagggagg
      361 tgcagagagc catgaagctc ctggatgctc gaaataaggt ttttgcaaag ctccaccaca
      421 acacgcagac cttccaagca ggccctcatg ctgtaaagaa gttgagttct ggaaactcca
      481 agttatcatc gtccaagttt agcaatccca tcagcagcag taagaggaat gtctccctcc
      541 tgatatcagc taattcagga ctgtgagccg gctcatttct gggctccatc ggcacaggag
      601 gggccggatc tttctccgat aaaaccgtcg ccctacagac ccagctgtcc ccacgcctct
      661 gtcttttggg tcaagtctta atccctgcac ctgagttggt cctccctctg cacccccacc
      721 acctcctgcc cgtctggcaa ctggaaagag ggagttggcc tgattttaag ccttttgccg
      781 ctccggggac cagcagcaat cctgggcagc cagtggctct tgtagagaag acttaggata
      841 cctctctcac tttctgtttc ttgccgtcca ccccgggcca tgccagtgtg tccctctggg
      901 tccctccaaa actctggtca gttcaaggat gcccctccca ggctatgctt ttctataact
      961 tttaaataaa ccttgggggg tgatggagtc a
//
