LOCUS       NM_002991               1422 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens C-C motif chemokine ligand 24 (CCL24), transcript
            variant 2, mRNA.
ACCESSION   NM_002991
VERSION     NM_002991.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Greenman,R., Snir,T., Katav,A., Aricha,R., Mishalian,I., Hay,O.,
            Frankel,M., Lawler,J., Saffioti,F., Pinzani,M., Thorburn,D.,
            Peled,A., Mor,A. and Vaknin,I.
  TITLE     The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging
            Patient Serum Proteomics to Preclinical Data
  JOURNAL   Cells 13 (3), 209 (2024)
   PUBMED   38334601
  REMARK    GeneRIF: The Role of CCL24 in Primary Sclerosing Cholangitis:
            Bridging Patient Serum Proteomics to Preclinical Data.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1422)
  AUTHORS   Wang,Z., Xu,H., Chen,M., Lu,Y., Zheng,L. and Ma,L.
  TITLE     CCL24/CCR3 axis plays a central role in angiotensin II-induced
            heart failure by stimulating M2 macrophage polarization and
            fibroblast activation
  JOURNAL   Cell Biol Toxicol 39 (4), 1413-1431 (2023)
   PUBMED   36131165
  REMARK    GeneRIF: CCL24/CCR3 axis plays a central role in angiotensin
            II-induced heart failure by stimulating M2 macrophage polarization
            and fibroblast activation.
REFERENCE   3  (bases 1 to 1422)
  AUTHORS   Al-Jaberi,L., Simonds,M.M. and Brescia,A.M.C.
  TITLE     CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients
            with juvenile idiopathic arthritis requiring advanced treatment
  JOURNAL   Rheumatology (Oxford) 62 (7), 2594-2600 (2023)
   PUBMED   36342195
  REMARK    GeneRIF: CCL24, CXCL9 and CXCL10 are increased in synovial fluid in
            patients with juvenile idiopathic arthritis requiring advanced
            treatment.
            Erratum:[Rheumatology (Oxford). 2024 Jul 26:keae352. doi:
            10.1093/rheumatology/keae352.. PMID: 39059788]
REFERENCE   4  (bases 1 to 1422)
  AUTHORS   Greenman,R., Segal-Salto,M., Barashi,N., Hay,O., Katav,A., Levi,O.,
            Vaknin,I., Aricha,R., Aharoni,S., Snir,T., Mishalian,I., Olam,D.,
            Amer,J., Salhab,A., Safadi,R., Maor,Y., Trivedi,P., Weston,C.J.,
            Saffioti,F., Hall,A., Pinzani,M., Thorburn,D., Peled,A. and Mor,A.
  TITLE     CCL24 regulates biliary inflammation and fibrosis in primary
            sclerosing cholangitis
  JOURNAL   JCI Insight 8 (12), e162270 (2023)
   PUBMED   37345655
  REMARK    GeneRIF: CCL24 regulates biliary inflammation and fibrosis in
            primary sclerosing cholangitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1422)
  AUTHORS   Mancebo-Perez,C., Vidal,M., Aguilar,R., Barrios,D., Bardaji,A.,
            Ome-Kaius,M., Menendez,C., Rogerson,S.J., Dobano,C., Moncunill,G.
            and Requena,P.
  TITLE     Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy
  JOURNAL   Malar J 21 (1), 336 (2022)
   PUBMED   36380370
  REMARK    GeneRIF: Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1422)
  AUTHORS   Gela,A., Kasetty,G., Jovic,S., Ekoff,M., Nilsson,G., Morgelin,M.,
            Kjellstrom,S., Pease,J.E., Schmidtchen,A. and Egesten,A.
  TITLE     Eotaxin-3 (CCL26) exerts innate host defense activities that are
            modulated by mast cell proteases
  JOURNAL   Allergy 70 (2), 161-170 (2015)
   PUBMED   25377782
  REMARK    GeneRIF: CCL24 displays antimicrobial activity against S.
            pneumoniae, S. aureus, Non-typeable H. influenzae, and P.
            aeruginosa.
REFERENCE   7  (bases 1 to 1422)
  AUTHORS   Sabroe,I., Hartnell,A., Jopling,L.A., Bel,S., Ponath,P.D.,
            Pease,J.E., Collins,P.D. and Williams,T.J.
  TITLE     Differential regulation of eosinophil chemokine signaling via CCR3
            and non-CCR3 pathways
  JOURNAL   J Immunol 162 (5), 2946-2955 (1999)
   PUBMED   10072545
REFERENCE   8  (bases 1 to 1422)
  AUTHORS   Nomiyama,H., Osborne,L.R., Imai,T., Kusuda,J., Miura,R., Tsui,L.C.
            and Yoshie,O.
  TITLE     Assignment of the human CC chemokine MPIF-2/eotaxin-2 (SCYA24) to
            chromosome 7q11.23
  JOURNAL   Genomics 49 (2), 339-340 (1998)
   PUBMED   9598329
REFERENCE   9  (bases 1 to 1422)
  AUTHORS   White,J.R., Imburgia,C., Dul,E., Appelbaum,E., O'Donnell,K.,
            O'Shannessy,D.J., Brawner,M., Fornwald,J., Adamou,J.,
            Elshourbagy,N.A., Kaiser,K., Foley,J.J., Schmidt,D.B., Johanson,K.,
            Macphee,C., Moores,K., McNulty,D., Scott,G.F., Schleimer,R.P. and
            Sarau,H.M.
  TITLE     Cloning and functional characterization of a novel human CC
            chemokine that binds to the CCR3 receptor and activates human
            eosinophils
  JOURNAL   J Leukoc Biol 62 (5), 667-675 (1997)
   PUBMED   9365122
REFERENCE   10 (bases 1 to 1422)
  AUTHORS   Patel,V.P., Kreider,B.L., Li,Y., Li,H., Leung,K., Salcedo,T.,
            Nardelli,B., Pippalla,V., Gentz,S., Thotakura,R., Parmelee,D.,
            Gentz,R. and Garotta,G.
  TITLE     Molecular and functional characterization of two novel human C-C
            chemokines as inhibitors of two distinct classes of myeloid
            progenitors
  JOURNAL   J Exp Med 185 (7), 1163-1172 (1997)
   PUBMED   9104803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005102.1.
            
            On Jul 1, 2019 this sequence version replaced NM_002991.2.
            
            Summary: This gene belongs to the subfamily of small cytokine CC
            genes. Cytokines are a family of secreted proteins involved in
            immunoregulatory and inflammatory processes. The CC cytokines are
            proteins characterized by two adjacent cysteines. The cytokine
            encoded by this gene displays chemotactic activity on resting T
            lymphocytes, a minimal activity on neutrophils, and is negative on
            monocytes and activated T lymphocytes. This protein also has
            antimicrobial activity, displaying an antibacterial effect on S.
            pneumoniae, S. aureus, Non-typeable H. influenzae, and P.
            aeruginosa. Finally, the protein is a strong suppressor of colony
            formation by a multipotential hematopoietic progenitor cell line.
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP338501.1, BP338653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2159764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000222902.7/
                                                  ENSP00000222902.2
            Protein has antimicrobial activity :: PMID: 25377782
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC005102.1         53403-53566
            165-282             AC005102.1         53786-53903
            283-1422            AC005102.1         55245-56384
FEATURES             Location/Qualifiers
     source          1..1422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1422
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /note="C-C motif chemokine ligand 24"
                     /db_xref="GeneID:6369"
                     /db_xref="HGNC:HGNC:10623"
                     /db_xref="MIM:602495"
     exon            1..164
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..451
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 24; myeloid progenitor inhibitory factor 2;
                     eotaxin-2; CK-beta-6; C-C motif chemokine 24;
                     small-inducible cytokine A24; eosinophil chemotactic
                     protein 2; chemokine (C-C motif) ligand 24"
                     /codon_start=1
                     /product="C-C motif chemokine 24 precursor"
                     /protein_id="NP_002982.2"
                     /db_xref="CCDS:CCDS34670.1"
                     /db_xref="GeneID:6369"
                     /db_xref="HGNC:HGNC:10623"
                     /db_xref="MIM:602495"
                     /translation="MAGLMTIVTSLLFLGVCAHHIIPTGSVVIPSPCCMFFVSKRIPE
                     NRVVSYQLSSRSTCLKAGVIFTTKKGQQFCGDPKQEWVQRYMKNLDAKQKKASPRARA
                     VAVKGPVQRYPGNQTTC"
     exon            165..282
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /inference="alignment:Splign:2.1.0"
     exon            283..1422
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /note="hexamer: AATAAA"
     polyA_site      1422
                     /gene="CCL24"
                     /gene_synonym="Ckb-6; MPIF-2; MPIF2; SCYA24"
                     /note="major polyA site"
ORIGIN      
        1 actctgcaag gacccgagct atttatccct aggtcctttc ctcctgcacg tcagctttga
       61 gccccgagct ggtgcttctg ctctctgaga catggcaggc ctgatgacca tagtaaccag
      121 ccttctgttc cttggtgtct gtgcccacca catcatccct acgggctctg tggtcatccc
      181 ctctccctgc tgcatgttct ttgtttccaa gagaattcct gagaaccgag tggtcagcta
      241 ccagctgtcc agcaggagca catgcctcaa ggcaggagtg atcttcacca ccaagaaggg
      301 ccagcagttc tgtggcgacc ccaagcagga gtgggtccag aggtacatga agaacctgga
      361 cgccaagcag aagaaggctt cccctagggc cagggcagtg gctgtcaagg gccctgtcca
      421 gagatatcct ggcaaccaaa ccacctgcta atccccgccc agccctccag ccctgagttt
      481 gggcctgagc tgcttggcgg gctactcggg gcctggagaa gccacagtga tggggggaag
      541 agctaatttt cctgtttctt agcaacactc tccagggatg tgtctcttct atgaaaaacc
      601 cgagggagca ggtgatgtgg ttcccggggg ctgagcaatg gctccaagca tccaaggccc
      661 cttgcctttc tggagctggg tgagaagatc ccagaaggag agcagtggca actctttgcc
      721 ttctcctcct gacctggttc tgatgctttt tctttttttt ttttttctga gacggagtct
      781 cgctctgtca cccaggctgg agtgcagtgg cacaatctcg gttcactgca acctccgcct
      841 cctgggttca agtgattctc gtgcctcagc ctcccgagta cctgggacta caggtgtgta
      901 ccaccacacc caactaactt ttgtattttt agtagagatg aggtttcacc atgttggcca
      961 ggctggtctc aaactcctgg cctcaagtga tctacctgcc tcggcctccc aaagtgctgg
     1021 gattacaggc atgagccacc acacccagcc tactcaaact tttatgttga aaaaaaaaaa
     1081 tcataatttt ttttttttta aaggaaatga acgtggagga ctggggtgaa gggccagcct
     1141 gggtagttta atctttttgg gaagacatga ctttaaggag attccctgct ttgtgacagg
     1201 ttgctccatg ctgtcttggg gacaagggcc tgtactgcct tcaaatctgg gctcacccca
     1261 cattttggtg aggggaagat agggtggggg gattaggggg agaaaagact ctagcttttt
     1321 ttttctatgc atgatatact gtgtgggttt atcaagagtg tagacacagt tgctgttctc
     1381 aaataatagg ccaaataaaa tgcgattctt tttttctttg aa
//
