LOCUS       NM_005064                628 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 23 (CCL23), transcript
            variant 1, mRNA.
ACCESSION   NM_005064
VERSION     NM_005064.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 628)
  AUTHORS   deKay,J.T., Chepurko,E., Chepurko,V., Knudsen,L., Lord,C.,
            Searight,M., Tsibulnikov,S., Robich,M.P., Sawyer,D.B., Gagnon,D.J.,
            May,T., Riker,R., Seder,D.B. and Ryzhov,S.
  TITLE     Delayed CCL23 response is associated with poor outcomes after
            cardiac arrest
  JOURNAL   Cytokine 176, 156536 (2024)
   PUBMED   38325139
  REMARK    GeneRIF: Delayed CCL23 response is associated with poor outcomes
            after cardiac arrest.
REFERENCE   2  (bases 1 to 628)
  AUTHORS   Kamat,K., Krishnan,V. and Dorigo,O.
  TITLE     Macrophage-derived CCL23 upregulates expression of T-cell
            exhaustion markers in ovarian cancer
  JOURNAL   Br J Cancer 127 (6), 1026-1033 (2022)
   PUBMED   35750747
  REMARK    GeneRIF: Macrophage-derived CCL23 upregulates expression of T-cell
            exhaustion markers in ovarian cancer.
REFERENCE   3  (bases 1 to 628)
  AUTHORS   Starr,A.E., Dufour,A., Maier,J. and Overall,C.M.
  TITLE     Biochemical analysis of matrix metalloproteinase activation of
            chemokines CCL15 and CCL23 and increased glycosaminoglycan binding
            of CCL16
  JOURNAL   J Biol Chem 287 (8), 5848-5860 (2012)
   PUBMED   22147696
REFERENCE   4  (bases 1 to 628)
  AUTHORS   Berahovich,R.D., Miao,Z., Wang,Y., Premack,B., Howard,M.C. and
            Schall,T.J.
  TITLE     Proteolytic activation of alternative CCR1 ligands in inflammation
  JOURNAL   J Immunol 174 (11), 7341-7351 (2005)
   PUBMED   15905581
REFERENCE   5  (bases 1 to 628)
  AUTHORS   Macphee,C.H., Appelbaum,E.R., Johanson,K., Moores,K.E.,
            Imburgia,C.S., Fornwald,J., Berkhout,T., Brawner,M., Groot,P.H.,
            O'Donnell,K., O'Shannessy,D., Scott,G. and White,J.R.
  TITLE     Identification of a truncated form of the CC chemokine CK beta-8
            demonstrating greatly enhanced biological activity
  JOURNAL   J Immunol 161 (11), 6273-6279 (1998)
   PUBMED   9834116
REFERENCE   6  (bases 1 to 628)
  AUTHORS   Youn,B.S., Zhang,S.M., Broxmeyer,H.E., Cooper,S., Antol,K.,
            Fraser,M. Jr. and Kwon,B.S.
  TITLE     Characterization of CKbeta8 and CKbeta8-1: two alternatively
            spliced forms of human beta-chemokine, chemoattractants for
            neutrophils, monocytes, and lymphocytes, and potent agonists at CC
            chemokine receptor 1
  JOURNAL   Blood 91 (9), 3118-3126 (1998)
   PUBMED   9558365
REFERENCE   7  (bases 1 to 628)
  AUTHORS   Forssmann,U., Delgado,M.B., Uguccioni,M., Loetscher,P., Garotta,G.
            and Baggiolini,M.
  TITLE     CKbeta8, a novel CC chemokine that predominantly acts on monocytes
  JOURNAL   FEBS Lett 408 (2), 211-216 (1997)
   PUBMED   9187369
REFERENCE   8  (bases 1 to 628)
  AUTHORS   Wells,T.N. and Peitsch,M.C.
  TITLE     The chemokine information source: identification and
            characterization of novel chemokines using the WorldWideWeb and
            expressed sequence tag databases
  JOURNAL   J Leukoc Biol 61 (5), 545-550 (1997)
   PUBMED   9129202
  REMARK    Review article
REFERENCE   9  (bases 1 to 628)
  AUTHORS   Patel,V.P., Kreider,B.L., Li,Y., Li,H., Leung,K., Salcedo,T.,
            Nardelli,B., Pippalla,V., Gentz,S., Thotakura,R., Parmelee,D.,
            Gentz,R. and Garotta,G.
  TITLE     Molecular and functional characterization of two novel human C-C
            chemokines as inhibitors of two distinct classes of myeloid
            progenitors
  JOURNAL   J Exp Med 185 (7), 1163-1172 (1997)
   PUBMED   9104803
REFERENCE   10 (bases 1 to 628)
  AUTHORS   Naruse,K., Ueno,M., Satoh,T., Nomiyama,H., Tei,H., Takeda,M.,
            Ledbetter,D.H., Coillie,E.V., Opdenakker,G., Gunge,N., Sakaki,Y.,
            Iio,M. and Miura,R.
  TITLE     A YAC contig of the human CC chemokine genes clustered on
            chromosome 17q11.2
  JOURNAL   Genomics 34 (2), 236-240 (1996)
   PUBMED   8661057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244100.3, U58913.1,
            BC143310.1 and U85767.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005064.5.
            
            Summary: This gene is one of several chemokine genes clustered on
            the q-arm of chromosome 17. Chemokines form a superfamily of
            secreted proteins involved in immunoregulatory and inflammatory
            processes. The superfamily is divided into four subfamilies based
            on the arrangement of the N-terminal cysteine residues of the
            mature peptide. This chemokine, a member of the CC subfamily,
            displays chemotactic activity on resting T lymphocytes and
            monocytes, lower activity on neutrophils and no activity on
            activated T lymphocytes. The protein is also a strong suppressor of
            colony formation by a multipotential hematopoietic progenitor cell
            line. In addition, the product of this gene is a potent agonist of
            the chemokine (C-C motif) receptor 1. Alternative splicing results
            in multiple transcript variants that encode different isoforms.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (CKbeta8-1) represents the longer
            transcript and encodes the longer isoform (CKbeta8-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58913.1, BC143310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615050.2/ ENSP00000481357.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC244100.3         182653-182656       c
            5-10                U58913.1           1-6
            11-522              BC143310.1         1-512
            523-628             U85767.1           427-532
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..628
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /note="C-C motif chemokine ligand 23"
                     /db_xref="GeneID:6368"
                     /db_xref="HGNC:HGNC:10622"
                     /db_xref="MIM:602494"
     exon            1..151
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..489
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /note="isoform CKbeta8-1 precursor is encoded by
                     transcript variant 1; small inducible cytokine subfamily A
                     (Cys-Cys), member 23; macrophage inflammatory protein 3;
                     C6 beta-chemokine; myeloid progenitor inhibitory factor 1;
                     chemokine (C-C motif) ligand 23"
                     /codon_start=1
                     /product="C-C motif chemokine 23 isoform CKbeta8-1
                     precursor"
                     /protein_id="NP_005055.3"
                     /db_xref="CCDS:CCDS11305.1"
                     /db_xref="GeneID:6368"
                     /db_xref="HGNC:HGNC:10622"
                     /db_xref="MIM:602494"
                     /translation="MKVSVAALSCLMLVTALGSQARVTKDAETEFMMSKLPLENPVLL
                     DMLWRRKIGPQMTLSHAAGFHATSADCCISYTPRSIPCSLLESYFETNSECSKPGVIF
                     LTKKGRRFCANPSDKQVQVCMRMLKLDTRIKTRKN"
     exon            152..211
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /inference="alignment:Splign:2.1.0"
     exon            212..377
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /inference="alignment:Splign:2.1.0"
     exon            378..628
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      610..615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /note="hexamer: AATAAA"
     polyA_site      628
                     /gene="CCL23"
                     /gene_synonym="CK-BETA-8; Ckb-8; Ckb-8-1; CKb8; hmrp-2a;
                     MIP-3; MIP3; MPIF-1; SCYA23"
                     /note="major polyA site"
ORIGIN      
        1 agaactggca tcccgagaag ccaggaagca gtgagcccag gagtcctcgg ccagccctgc
       61 ctgcccacca ggaggatgaa ggtctccgtg gctgccctct cctgcctcat gcttgttact
      121 gcccttggat cccaggcccg ggtcacaaaa gatgcagaga cagagttcat gatgtcaaag
      181 cttccattgg aaaatccagt acttctggac atgctctgga ggagaaagat tggtcctcag
      241 atgacccttt ctcatgctgc aggattccat gctactagtg ctgactgctg catctcctac
      301 accccacgaa gcatcccgtg ttcactcctg gagagttact ttgaaacgaa cagcgagtgc
      361 tccaagccgg gtgtcatctt cctcaccaag aaggggcgac gtttctgtgc caaccccagt
      421 gataagcaag ttcaggtttg catgagaatg ctgaagctgg acacacggat caagaccagg
      481 aagaattgaa cttgtcaagg tgaagggaca caagttgcca gccaccaact ttcttgcctc
      541 aactaccttc ctgaattatt tttttaagaa gcatttattc ttgtgttctg gatttagagc
      601 aattcatcta ataaacagtt tctcactt
//
