LOCUS       NM_002990               2917 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 22 (CCL22), mRNA.
ACCESSION   NM_002990
VERSION     NM_002990.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Yuan,Y., Hu,R., Park,J., Xiong,S., Wang,Z., Qian,Y., Shi,Z., Wu,R.,
            Han,Z., Ong,S.G., Lin,S., Varady,K.A., Xu,P., Berry,D.C., Shu,G.
            and Jiang,Y.
  TITLE     Macrophage-derived chemokine CCL22 establishes local LN-mediated
            adaptive thermogenesis and energy expenditure
  JOURNAL   Sci Adv 10 (26), eadn5229 (2024)
   PUBMED   38924414
  REMARK    GeneRIF: Macrophage-derived chemokine CCL22 establishes local
            LN-mediated adaptive thermogenesis and energy expenditure.
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Yang,S., Liu,Y., Li,Y., Ji,X., Yun,Y., Yang,G., Liu,H., Liang,X.
            and Dang,H.
  TITLE     LINC00472 suppresses non-small cell lung cancer progression via
            regulating miR-23a-3p/CCL22 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (6), 54-60 (2024)
   PUBMED   38836681
  REMARK    GeneRIF: LINC00472 suppresses non-small cell lung cancer
            progression via regulating miR-23a-3p/CCL22 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Chen,J., Zhao,D., Zhang,L., Zhang,J., Xiao,Y., Wu,Q., Wang,Y. and
            Zhan,Q.
  TITLE     Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin
            resistance of esophageal squamous cell carcinoma (ESCC) cells via
            regulating the activity of diacylglycerol kinase alpha
            (DGKalpha)/NOX4 axis
  JOURNAL   Drug Resist Updat 73, 101055 (2024)
   PUBMED   38387281
  REMARK    GeneRIF: Tumor-associated macrophage (TAM)-secreted CCL22 confers
            cisplatin resistance of esophageal squamous cell carcinoma (ESCC)
            cells via regulating the activity of diacylglycerol kinase alpha
            (DGKalpha)/NOX4 axis.
REFERENCE   4  (bases 1 to 2917)
  AUTHORS   Korobova,Z.R., Arsentieva,N.A. and Totolian,A.A.
  TITLE     Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous Finding in
            COVID-19
  JOURNAL   Int J Mol Sci 24 (17), 13083 (2023)
   PUBMED   37685890
  REMARK    GeneRIF: Macrophage-Derived Chemokine MDC/CCL22: An Ambiguous
            Finding in COVID-19.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2917)
  AUTHORS   Hueso,L., Marques,P., Morant,B., Gonzalez-Navarro,H., Ortega,J.,
            Real,J.T., Sanz,M.J. and Piqueras,L.
  TITLE     CCL17 and CCL22 chemokines are upregulated in human obesity and
            play a role in vascular dysfunction
  JOURNAL   Front Endocrinol (Lausanne) 14, 1154158 (2023)
   PUBMED   37124725
  REMARK    GeneRIF: CCL17 and CCL22 chemokines are upregulated in human
            obesity and play a role in vascular dysfunction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2917)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL22 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 2917)
  AUTHORS   Imai,T., Chantry,D., Raport,C.J., Wood,C.L., Nishimura,M.,
            Godiska,R., Yoshie,O. and Gray,P.W.
  TITLE     Macrophage-derived chemokine is a functional ligand for the CC
            chemokine receptor 4
  JOURNAL   J Biol Chem 273 (3), 1764-1768 (1998)
   PUBMED   9430724
REFERENCE   8  (bases 1 to 2917)
  AUTHORS   Pal,R., Garzino-Demo,A., Markham,P.D., Burns,J., Brown,M.,
            Gallo,R.C. and DeVico,A.L.
  TITLE     Inhibition of HIV-1 infection by the beta-chemokine MDC
  JOURNAL   Science 278 (5338), 695-698 (1997)
   PUBMED   9381181
REFERENCE   9  (bases 1 to 2917)
  AUTHORS   Chang,Ms., McNinch,J., Elias,C. 3rd, Manthey,C.L., Grosshans,D.,
            Meng,T., Boone,T. and Andrew,D.P.
  TITLE     Molecular cloning and functional characterization of a novel CC
            chemokine, stimulated T cell chemotactic protein (STCP-1) that
            specifically acts on activated T lymphocytes
  JOURNAL   J Biol Chem 272 (40), 25229-25237 (1997)
   PUBMED   9312138
REFERENCE   10 (bases 1 to 2917)
  AUTHORS   Godiska,R., Chantry,D., Raport,C.J., Sozzani,S., Allavena,P.,
            Leviten,D., Mantovani,A. and Gray,P.W.
  TITLE     Human macrophage-derived chemokine (MDC), a novel chemoattractant
            for monocytes, monocyte-derived dendritic cells, and natural killer
            cells
  JOURNAL   J Exp Med 185 (9), 1595-1604 (1997)
   PUBMED   9151897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA815965.1, DB154173.1,
            AC009052.8 and U83171.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002990.4.
            
            Summary: This antimicrobial gene is one of several Cys-Cys (CC)
            cytokine genes clustered on the q arm of chromosome 16. Cytokines
            are a family of secreted proteins involved in immunoregulatory and
            inflammatory processes. The CC cytokines are proteins characterized
            by two adjacent cysteines. The cytokine encoded by this gene
            displays chemotactic activity for monocytes, dendritic cells,
            natural killer cells and for chronically activated T lymphocytes.
            It also displays a mild activity for primary activated T
            lymphocytes and has no chemoattractant activity for neutrophils,
            eosinophils and resting T lymphocytes. The product of this gene
            binds to chemokine receptor CCR4. This chemokine may play a role in
            the trafficking of activated T lymphocytes to inflammatory sites
            and other aspects of activated T lymphocyte physiology. [provided
            by RefSeq, Sep 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.47952.1, U83171.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000219235.5/
                                                  ENSP00000219235.4
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DA815965.1         1-38
            39-231              DB154173.1         37-229
            232-2886            AC009052.8         61221-63875
            2887-2917           U83171.1           2877-2907
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2917
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /note="C-C motif chemokine ligand 22"
                     /db_xref="GeneID:6367"
                     /db_xref="HGNC:HGNC:10621"
                     /db_xref="MIM:602957"
     exon            1..107
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..316
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 22; macrophage-derived chemokine; chemokine (C-C
                     motif) ligand 22; stimulated T cell chemotactic protein 1;
                     CC chemokine STCP-1; small inducible cytokine A22; C-C
                     motif chemokine 22; MDC(1-69)"
                     /codon_start=1
                     /product="C-C motif chemokine 22 precursor"
                     /protein_id="NP_002981.2"
                     /db_xref="CCDS:CCDS10778.1"
                     /db_xref="GeneID:6367"
                     /db_xref="HGNC:HGNC:10621"
                     /db_xref="MIM:602957"
                     /translation="MDRLQTALLVVLVLLAVALQATEAGPYGANMEDSVCCRDYVRYR
                     LPLRVVKHFYWTSDSCPRPGVVLLTFRDKEICADPRVPWVKMILNKLSQ"
     exon            108..231
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..2917
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2917
                     /gene="CCL22"
                     /gene_synonym="A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22;
                     STCP-1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacacct gggctgagac atacaggaca gagcatggat cgcctacaga ctgcactcct
       61 ggttgtcctc gtcctccttg ctgtggcgct tcaagcaact gaggcaggcc cctacggcgc
      121 caacatggaa gacagcgtct gctgccgtga ttacgtccgt taccgtctgc ccctgcgcgt
      181 ggtgaaacac ttctactgga cctcagactc ctgcccgagg cctggcgtgg tgttgctaac
      241 cttcagggat aaggagatct gtgccgatcc cagagtgccc tgggtgaaga tgattctcaa
      301 taagctgagc caatgaagag cctactctga tgaccgtggc cttggctcct ccaggaaggc
      361 tcaggagccc tacctccctg ccattatagc tgctccccgc cagaagcctg tgccaactct
      421 ctgcattccc tgatctccat ccctgtggct gtcacccttg gtcacctccg tgctgtcact
      481 gccatctccc ccctgacccc tctaacccat cctctgcctc cctccctgca gtcagagggt
      541 cctgttccca tcagcgattc ccctgcttaa acccttccat gactccccac tgccctaagc
      601 tgaggtcagt ctcccaagcc tggcatgtgg ccctctggat ctgggttcca tctctgtctc
      661 cagcctgccc acttcccttc atgaatgttg ggttctagct ccctgttctc caaacccata
      721 ctacacatcc cacttctggg tctttgcctg ggatgttgct gacacccaga aagtcccacc
      781 acctgcacat gtgtagcccc accagccctc caaggcattg ctcgcccaag cagctggtaa
      841 ttccatttca tgtattagat gtcccctggc cctctgtccc ctcttaataa ccctagtcac
      901 agtctccgca gattcttggg atttgggggt tttctccccc acctctccac tagttggacc
      961 aaggtttcta gctaagttac tctagtctcc aagcctctag catagagcac tgcagacagg
     1021 ccctggctca gaatcagagc ccagaaagtg gctgcagaca aaatcaataa aactaatgtc
     1081 cctcccctct ccctgccaaa aggcagttac atatcaatac agagactcaa ggtcactaga
     1141 aatgggccag ctgggtcaat gtgaagcccc aaatttgccc agattcacct ttcttccccc
     1201 actccctttt tttttttttt tttgagatgg agtttcgctc ttgtcaccca cgctggagtg
     1261 caatggtgtg gtcttggctt attgaagcct ctgcctcctg ggttcaagtg attctcttgc
     1321 ctcagcctcc tgagtagctg ggattacagg ttcctgctac cacgcccagc taatttttgt
     1381 atttttagta gagacgaggc ttcaccatgt tggccaggct ggtctcgaac tcctgtcctc
     1441 aggtaatccg cccacctcag cctcccaaag tgctgggatt acaggcgtga gccacagtgc
     1501 ctggcctctt ccctctcccc accccccccc caactttttt ttttttttat ggcagggtct
     1561 cactctgtcg cccaggctgg agtgcagtgg cgtgatctcg gctcactaca acctcgacct
     1621 cctgggttca agcgattctc ccaccccagc ctcccaagta gctgggatta caggtgtgtg
     1681 ccactacggc tggctaattt ttgtattttt agtagagaca ggtttcacca tattggccag
     1741 gctggtcttg aactcctgac ctcaagtgat ccaccttcct tgtgctccca aagtgctgag
     1801 attacaggcg tgagctatca cacccagcct cccccttttt ttcctaatag gagactcctg
     1861 tacctttctt cgttttacct atgtgtcgtg tctgcttaca tttccttctc ccctcaggct
     1921 ttttttgggt ggtcctccaa cctccaatac ccaggcctgg cctcttcaga gtacccccca
     1981 ttccactttc cctgcctcct tccttaaata gctgacaatc aaattcatgc tatggtgtga
     2041 aagactacct ttgacttggt attataagct ggagttatat atgtatttga aaacagagta
     2101 aatacttaag aggccaaata gatgaatgga agaattttag gaactgtgag agggggacaa
     2161 ggtggagctt tcctggccct gggaggaagc tggctgtggt agcgtagcgc tctctctctc
     2221 tgtctgtggc aggaggcaaa gagtagggtg taattgagtg aaggaatcct gggtagagac
     2281 cattctcagg tggttgggcc aggctaaaga ctgggatttg ggtctatcta tgcctttctg
     2341 gctgattttt gtagagacgg ggttttgcca tgttacccag gctggtctca aactcctggg
     2401 ctcaagcgat cctcctggct cagcctccca aagtgctggg attacaggcg tgagtcactg
     2461 cgcctggctt cctcttcctc ttgagaaata ttcttttcat acagcaagta tgggacagca
     2521 gtgtcccagg taaaggacat aaatgttaca agtgtctggt cctttctgag ggaggctggt
     2581 gccgctctgc agggtatttg aacctgtgga attggaggag gccatttcac tccctgaacc
     2641 cagcctgaca aatcacagtg agaatgttca ccttataggc ttgctgtggg gctcaggttg
     2701 aaagtgtggg gagtgacact gcctaggcat ccagctcagt gtcatccagg gcctgtgtcc
     2761 ctcccgaacc cagggtcaac ctgcctacca caggcactag aaggacgaat ctgcctactg
     2821 cccatgaacg gggccctcaa gcgtcctggg atctccttct ccctcctgtc ctgtccttgc
     2881 ccctcaggac tgctggaaaa taaatccttt aaaatag
//
