LOCUS       NM_002989                864 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 21 (CCL21), mRNA.
ACCESSION   NM_002989
VERSION     NM_002989.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Yang,S., Dong,D., Bao,X., Lu,R., Cheng,P., Zhu,S. and Yang,G.
  TITLE     CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis
            in Gastric Cancer
  JOURNAL   Cancer Control 31, 10732748241238616 (2024)
   PUBMED   38553809
  REMARK    GeneRIF: CCL21 and CLDN11 Are Key Driving Factors of Lymph Node
            Metastasis in Gastric Cancer.
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Nayak,N., Pati,A., Pavani,Y., Sahu,S., Ranjan,S. and Panda,A.K.
  TITLE     CCL19 (rs3136658) and CCL21 (rs2812377) Variants Are Associated
            With Susceptibility and Related Mortality of SARS-CoV-2 Infection
  JOURNAL   J Infect Dis 228 (1), 101-102 (2023)
   PUBMED   36723865
  REMARK    GeneRIF: CCL19 (rs3136658) and CCL21 (rs2812377) Variants Are
            Associated With Susceptibility and Related Mortality of SARS-CoV-2
            Infection.
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Geraldo,L.H., Garcia,C., Xu,Y., Leser,F.S., Grimaldi,I., de Camargo
            Magalhaes,E.S., Dejaegher,J., Solie,L., Pereira,C.M., Correia,A.H.,
            De Vleeschouwer,S., Tavitian,B., Canedo,N.H.S., Mathivet,T.,
            Thomas,J.L., Eichmann,A. and Lima,F.R.S.
  TITLE     CCL21-CCR7 signaling promotes microglia/macrophage recruitment and
            chemotherapy resistance in glioblastoma
  JOURNAL   Cell Mol Life Sci 80 (7), 179 (2023)
   PUBMED   37314567
  REMARK    GeneRIF: CCL21-CCR7 signaling promotes microglia/macrophage
            recruitment and chemotherapy resistance in glioblastoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Sah,V.R., Jespersen,H., Karlsson,J., Nilsson,L.M., Bergqvist,M.,
            Johansson,I., Carneiro,A., Helgadottir,H., Levin,M., Ullenhag,G.,
            Stahlberg,A., Olofsson Bagge,R., Nilsson,J.A. and Ny,L.
  TITLE     Chemokine Analysis in Patients with Metastatic Uveal Melanoma
            Suggests a Role for CCL21 Signaling in Combined Epigenetic Therapy
            and Checkpoint Immunotherapy
  JOURNAL   Cancer Res Commun 3 (5), 884-895 (2023)
   PUBMED   37377898
  REMARK    GeneRIF: Chemokine Analysis in Patients with Metastatic Uveal
            Melanoma Suggests a Role for CCL21 Signaling in Combined Epigenetic
            Therapy and Checkpoint Immunotherapy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 864)
  AUTHORS   Artinger,M., Gerken,O.J. and Legler,D.F.
  TITLE     Heparin Specifically Interacts with Basic BBXB Motifs of the
            Chemokine CCL21 to Define CCR7 Signaling
  JOURNAL   Int J Mol Sci 24 (2), 1670 (2023)
   PUBMED   36675182
  REMARK    GeneRIF: Heparin Specifically Interacts with Basic BBXB Motifs of
            the Chemokine CCL21 to Define CCR7 Signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 864)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL21 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 864)
  AUTHORS   Gunn,M.D., Tangemann,K., Tam,C., Cyster,J.G., Rosen,S.D. and
            Williams,L.T.
  TITLE     A chemokine expressed in lymphoid high endothelial venules promotes
            the adhesion and chemotaxis of naive T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 258-263 (1998)
   PUBMED   9419363
REFERENCE   8  (bases 1 to 864)
  AUTHORS   Hromas,R., Kim,C.H., Klemsz,M., Krathwohl,M., Fife,K., Cooper,S.,
            Schnizlein-Bick,C. and Broxmeyer,H.E.
  TITLE     Isolation and characterization of Exodus-2, a novel C-C chemokine
            with a unique 37-amino acid carboxyl-terminal extension
  JOURNAL   J Immunol 159 (6), 2554-2558 (1997)
   PUBMED   9300671
REFERENCE   9  (bases 1 to 864)
  AUTHORS   Hedrick,J.A. and Zlotnik,A.
  TITLE     Identification and characterization of a novel beta chemokine
            containing six conserved cysteines
  JOURNAL   J Immunol 159 (4), 1589-1593 (1997)
   PUBMED   9257816
REFERENCE   10 (bases 1 to 864)
  AUTHORS   Nagira,M., Imai,T., Hieshima,K., Kusuda,J., Ridanpaa,M., Takagi,S.,
            Nishimura,M., Kakizaki,M., Nomiyama,H. and Yoshie,O.
  TITLE     Molecular cloning of a novel human CC chemokine secondary
            lymphoid-tissue chemokine that is a potent chemoattractant for
            lymphocytes and mapped to chromosome 9p13
  JOURNAL   J Biol Chem 272 (31), 19518-19524 (1997)
   PUBMED   9235955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI833188.1 and BC027918.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002989.3.
            
            Summary: This antimicrobial gene is one of several CC cytokine
            genes clustered on the p-arm of chromosome 9. Cytokines are a
            family of secreted proteins involved in immunoregulatory and
            inflammatory processes. The CC cytokines are proteins characterized
            by two adjacent cysteines. Similar to other chemokines the protein
            encoded by this gene inhibits hemopoiesis and stimulates
            chemotaxis. This protein is chemotactic in vitro for thymocytes and
            activated T cells, but not for B cells, macrophages, or
            neutrophils. The cytokine encoded by this gene may also play a role
            in mediating homing of lymphocytes to secondary lymphoid organs. It
            is a high affinity functional ligand for chemokine receptor 7 that
            is expressed on T and B lymphocytes and a known receptor for
            another member of the cytokine family (small inducible cytokine
            A19). [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.188399.1,
                                           SRR5189667.380449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000259607.7/
                                                  ENSP00000259607.2
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BI833188.1         15-77
            64-864              BC027918.1         1-801
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..864
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /note="C-C motif chemokine ligand 21"
                     /db_xref="GeneID:6366"
                     /db_xref="HGNC:HGNC:10620"
                     /db_xref="MIM:602737"
     exon            1..137
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..475
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 21; beta chemokine exodus-2; secondary lymphoid
                     tissue chemokine; C-C motif chemokine 21; Efficient
                     Chemoattractant for Lymphocytes; chemokine (C-C motif)
                     ligand 21"
                     /codon_start=1
                     /product="C-C motif chemokine 21 precursor"
                     /protein_id="NP_002980.1"
                     /db_xref="CCDS:CCDS6571.1"
                     /db_xref="GeneID:6366"
                     /db_xref="HGNC:HGNC:10620"
                     /db_xref="MIM:602737"
                     /translation="MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKV
                     VRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQG
                     CRKDRGASKTGKKGKGSKGCKRTERSQTPKGP"
     exon            138..258
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            259..441
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            442..864
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /note="hexamer: AATAAA"
     polyA_site      864
                     /gene="CCL21"
                     /gene_synonym="6Ckine; CKb9; ECL; SCYA21; SLC; TCA4"
                     /note="major polyA site"
ORIGIN      
        1 acagaccccc aacttgcagc tgcccacctc accctcagct ctggcctctt actcaccctc
       61 taccacagac atggctcagt cactggctct gagcctcctt atcctggttc tggcctttgg
      121 catccccagg acccaaggca gtgatggagg ggctcaggac tgttgcctca agtacagcca
      181 aaggaagatt cccgccaagg ttgtccgcag ctaccggaag caggaaccaa gcttaggctg
      241 ctccatccca gctatcctgt tcttgccccg caagcgctct caggcagagc tatgtgcaga
      301 cccaaaggag ctctgggtgc agcagctgat gcagcatctg gacaagacac catccccaca
      361 gaaaccagcc cagggctgca ggaaggacag gggggcctcc aagactggca agaaaggaaa
      421 gggctccaaa ggctgcaaga ggactgagcg gtcacagacc cctaaagggc catagcccag
      481 tgagcagcct ggagccctgg agaccccacc agcctcacca gcgcttgaag cctgaaccca
      541 agatgcaaga aggaggctat gctcaggggc cctggagcag ccaccccatg ctggccttgc
      601 cacactcttt ctcctgcttt aaccacccca tctgcattcc cagctctacc ctgcatggct
      661 gagctgccca cagcaggcca ggtccagaga gaccgaggag ggagagtctc ccagggagca
      721 tgagaggagg cagcaggact gtccccttga aggagaatca tcaggaccct ggacctgata
      781 cggctcccca gtacacccca cctcttcctt gtaaatatga tttataccta actgaataaa
      841 aagctgttct gtcttcccac ccaa
//
