LOCUS       NM_004591                834 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 20 (CCL20), transcript
            variant 1, mRNA.
ACCESSION   NM_004591
VERSION     NM_004591.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Wang,S., Sun,Y., Li,C., Chong,Y., Ai,M., Wang,Y., Shi,H. and
            Shang,Y.
  TITLE     TH1L involvement in colorectal cancer pathogenesis by regulation of
            CCL20 through the NF-kappaB signalling pathway
  JOURNAL   J Cell Mol Med 28 (10), e18391 (2024)
   PUBMED   38809918
  REMARK    GeneRIF: TH1L involvement in colorectal cancer pathogenesis by
            regulation of CCL20 through the NF-kappaB signalling pathway.
REFERENCE   2  (bases 1 to 834)
  AUTHORS   Li,H., Ruan,Y., Liu,C., Fan,X., Yao,Y., Dai,Y., Song,Y., Jiang,D.,
            Sun,N., Jiao,G., Chen,Z., Fan,S., Meng,F., Yang,H., Zhang,Y. and
            Li,Z.
  TITLE     VDR promotes pancreatic cancer progression in vivo by activating
            CCL20-mediated M2 polarization of tumor associated macrophage
  JOURNAL   Cell Commun Signal 22 (1), 224 (2024)
   PUBMED   38600588
  REMARK    GeneRIF: VDR promotes pancreatic cancer progression in vivo by
            activating CCL20-mediated M2 polarization of tumor associated
            macrophage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 834)
  AUTHORS   Koksal,B.T., Baris,Z., Sencelikel,T., Ozcay,F. and Ozbek,O.Y.
  TITLE     Food protein-induced allergic proctocolitis in infants is
            associated with low serum levels of macrophage inflammatory
            protein-3a
  JOURNAL   J Pediatr Gastroenterol Nutr 78 (2), 211-216 (2024)
   PUBMED   38374573
  REMARK    GeneRIF: Food protein-induced allergic proctocolitis in infants is
            associated with low serum levels of macrophage inflammatory
            protein-3a.
REFERENCE   4  (bases 1 to 834)
  AUTHORS   Yoo,K.D., Yu,M.Y., Kim,K.H., Lee,S., Park,E., Kang,S., Lim,D.H.,
            Lee,Y., Song,J., Kown,S., Kim,Y.C., Kim,D.K., Lee,J.S., Kim,Y.S.
            and Yang,S.H.
  TITLE     Role of the CCL20/CCR6 axis in tubular epithelial cell injury:
            Kidney-specific translational insights from acute kidney injury to
            chronic kidney disease
  JOURNAL   FASEB J 38 (2), e23407 (2024)
   PUBMED   38197598
  REMARK    GeneRIF: Role of the CCL20/CCR6 axis in tubular epithelial cell
            injury: Kidney-specific translational insights from acute kidney
            injury to chronic kidney disease.
REFERENCE   5  (bases 1 to 834)
  AUTHORS   Li,Y., Li,R., Li,Y., Li,G., Zhao,Y., Mou,H., Chen,Y., Xiao,L. and
            Gong,K.
  TITLE     Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation
            and MMP Secretion in Abdominal Aortic Aneurysm by Regulating
            miR-143-5p /CCL20
  JOURNAL   J Cardiovasc Pharmacol 82 (6), 458-469 (2023)
   PUBMED   37721971
  REMARK    GeneRIF: Transcription Factor TCF3 Promotes Macrophage-Mediated
            Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by
            Regulating miR-143-5p /CCL20.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 834)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL20 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 834)
  AUTHORS   Baba,M., Imai,T., Nishimura,M., Kakizaki,M., Takagi,S.,
            Hieshima,K., Nomiyama,H. and Yoshie,O.
  TITLE     Identification of CCR6, the specific receptor for a novel
            lymphocyte-directed CC chemokine LARC
  JOURNAL   J Biol Chem 272 (23), 14893-14898 (1997)
   PUBMED   9169459
REFERENCE   8  (bases 1 to 834)
  AUTHORS   Hromas,R., Gray,P.W., Chantry,D., Godiska,R., Krathwohl,M.,
            Fife,K., Bell,G.I., Takeda,J., Aronica,S., Gordon,M., Cooper,S.,
            Broxmeyer,H.E. and Klemsz,M.J.
  TITLE     Cloning and characterization of exodus, a novel beta-chemokine
  JOURNAL   Blood 89 (9), 3315-3322 (1997)
   PUBMED   9129037
REFERENCE   9  (bases 1 to 834)
  AUTHORS   Hieshima,K., Imai,T., Opdenakker,G., Van Damme,J., Kusuda,J.,
            Tei,H., Sakaki,Y., Takatsuki,K., Miura,R., Yoshie,O. and
            Nomiyama,H.
  TITLE     Molecular cloning of a novel human CC chemokine liver and
            activation-regulated chemokine (LARC) expressed in liver.
            Chemotactic activity for lymphocytes and gene localization on
            chromosome 2
  JOURNAL   J Biol Chem 272 (9), 5846-5853 (1997)
   PUBMED   9038201
REFERENCE   10 (bases 1 to 834)
  AUTHORS   Rossi,D.L., Vicari,A.P., Franz-Bacon,K., McClanahan,T.K. and
            Zlotnik,A.
  TITLE     Identification through bioinformatics of two new macrophage
            proinflammatory human chemokines: MIP-3alpha and MIP-3beta
  JOURNAL   J Immunol 158 (3), 1033-1036 (1997)
   PUBMED   9013939
  REMARK    Erratum:[J Immunol 1999 Jul 15;163(2):1091]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D17012.1, D86955.1 and
            U77035.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004591.2.
            
            Summary: This antimicrobial gene belongs to the subfamily of small
            cytokine CC genes. Cytokines are a family of secreted proteins
            involved in immunoregulatory and inflammatory processes. The CC
            cytokines are proteins characterized by two adjacent cysteines. The
            protein encoded by this gene displays chemotactic activity for
            lymphocytes and can repress proliferation of myeloid progenitors.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77035.1, D86955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000358813.5/
                                                  ENSP00000351671.4
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                D17012.1           80-91
            13-720              D86955.1           1-708
            721-834             U77035.1           651-764
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..834
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /note="C-C motif chemokine ligand 20"
                     /db_xref="GeneID:6364"
                     /db_xref="HGNC:HGNC:10619"
                     /db_xref="MIM:601960"
     exon            1..146
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..361
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; macrophage inflammatory protein 3 alpha; small
                     inducible cytokine subfamily A (Cys-Cys), member 20; CC
                     chemokine LARC; beta chemokine exodus-1; small-inducible
                     cytokine A20; chemokine (C-C motif) ligand 20; liver and
                     activation-regulated chemokine"
                     /codon_start=1
                     /product="C-C motif chemokine 20 isoform 1 precursor"
                     /protein_id="NP_004582.1"
                     /db_xref="CCDS:CCDS2469.1"
                     /db_xref="GeneID:6364"
                     /db_xref="HGNC:HGNC:10619"
                     /db_xref="MIM:601960"
                     /translation="MCCTKSLLLAALMSVLLLHLCGESEAASNFDCCLGYTDRILHPK
                     FIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM"
     exon            147..261
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            262..339
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            340..834
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      654..659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /note="hexamer: ATTATA"
     polyA_site      671
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /note="hexamer: AATAAA"
     polyA_site      834
                     /gene="CCL20"
                     /gene_synonym="CKb4; Exodus; LARC; MIP-3-alpha; MIP-3a;
                     MIP3A; SCYA20; ST38"
                     /note="major polyA site"
ORIGIN      
        1 agaatataac agcactccca aagaactggg tactcaacac tgagcagatc tgttctttga
       61 gctaaaaacc atgtgctgta ccaagagttt gctcctggct gctttgatgt cagtgctgct
      121 actccacctc tgcggcgaat cagaagcagc aagcaacttt gactgctgtc ttggatacac
      181 agaccgtatt cttcatccta aatttattgt gggcttcaca cggcagctgg ccaatgaagg
      241 ctgtgacatc aatgctatca tctttcacac aaagaaaaag ttgtctgtgt gcgcaaatcc
      301 aaaacagact tgggtgaaat atattgtgcg tctcctcagt aaaaaagtca agaacatgta
      361 aaaactgtgg cttttctgga atggaattgg acatagccca agaacagaaa gaaccttgct
      421 ggggttggag gtttcacttg cacatcatgg agggtttagt gcttatctaa tttgtgcctc
      481 actggacttg tccaattaat gaagttgatt catattgcat catagtttgc tttgtttaag
      541 catcacatta aagttaaact gtattttatg ttatttatag ctgtaggttt tctgtgttta
      601 gctatttaat actaattttc cataagctat tttggtttag tgcaaagtat aaaattatat
      661 ttggggggga ataagattat atggactttc ttgcaagcaa caagctattt tttaaaaaaa
      721 actatttaac attcttttgt ttatattgtt ttgtctccta aattgttgta attgcattat
      781 aaaataagaa aaatattaat aagacaaata ttgaaaataa agaaacaaaa agtt
//
