LOCUS       NM_006274                683 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 19 (CCL19), mRNA.
ACCESSION   NM_006274
VERSION     NM_006274.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 683)
  AUTHORS   Kersh,A.E., Sati,S., Huang,J., Murphy,C., Ahart,O. and Leung,T.H.
  TITLE     CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to
            skin in lichen planus
  JOURNAL   JCI Insight 9 (20), e179899 (2024)
   PUBMED   39190494
  REMARK    GeneRIF: CXCL9, CXCL10, and CCL19 synergistically recruit T
            lymphocytes to skin in lichen planus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 683)
  AUTHORS   Xu,P., Li,S., Liu,K., Fan,R., Liu,F., Zhang,H., Liu,D. and Shen,D.
  TITLE     Downregulation of dermatopontin in cholangiocarcinoma cells
            suppresses CCL19 secretion of macrophages and immune infiltration
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 66 (2024)
   PUBMED   38300311
  REMARK    GeneRIF: Downregulation of dermatopontin in cholangiocarcinoma
            cells suppresses CCL19 secretion of macrophages and immune
            infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 683)
  AUTHORS   Nayak,N., Pati,A., Pavani,Y., Sahu,S., Ranjan,S. and Panda,A.K.
  TITLE     CCL19 (rs3136658) and CCL21 (rs2812377) Variants Are Associated
            With Susceptibility and Related Mortality of SARS-CoV-2 Infection
  JOURNAL   J Infect Dis 228 (1), 101-102 (2023)
   PUBMED   36723865
  REMARK    GeneRIF: CCL19 (rs3136658) and CCL21 (rs2812377) Variants Are
            Associated With Susceptibility and Related Mortality of SARS-CoV-2
            Infection.
REFERENCE   4  (bases 1 to 683)
  AUTHORS   Xu,D., Liu,X., Ke,S., Guo,Y., Zhu,C. and Cao,H.
  TITLE     CCL19/CCR7 drives regulatory T cell migration and indicates poor
            prognosis in gastric cancer
  JOURNAL   BMC Cancer 23 (1), 464 (2023)
   PUBMED   37208608
  REMARK    GeneRIF: CCL19/CCR7 drives regulatory T cell migration and
            indicates poor prognosis in gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 683)
  AUTHORS   Artinger,M., Gerken,O.J. and Legler,D.F.
  TITLE     Heparin Specifically Interacts with Basic BBXB Motifs of the
            Chemokine CCL21 to Define CCR7 Signaling
  JOURNAL   Int J Mol Sci 24 (2), 1670 (2023)
   PUBMED   36675182
  REMARK    GeneRIF: Heparin Specifically Interacts with Basic BBXB Motifs of
            the Chemokine CCL21 to Define CCR7 Signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 683)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL19 is an antimicrobial protein with bacteriocidal
            activity against E. coli.
REFERENCE   7  (bases 1 to 683)
  AUTHORS   Kim,C.H., Pelus,L.M., White,J.R., Applebaum,E., Johanson,K. and
            Broxmeyer,H.E.
  TITLE     CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand
            chemokine is an efficacious chemoattractant for T and B cells
  JOURNAL   J Immunol 160 (5), 2418-2424 (1998)
   PUBMED   9498785
REFERENCE   8  (bases 1 to 683)
  AUTHORS   Nagira,M., Imai,T., Hieshima,K., Kusuda,J., Ridanpaa,M., Takagi,S.,
            Nishimura,M., Kakizaki,M., Nomiyama,H. and Yoshie,O.
  TITLE     Molecular cloning of a novel human CC chemokine secondary
            lymphoid-tissue chemokine that is a potent chemoattractant for
            lymphocytes and mapped to chromosome 9p13
  JOURNAL   J Biol Chem 272 (31), 19518-19524 (1997)
   PUBMED   9235955
REFERENCE   9  (bases 1 to 683)
  AUTHORS   Yoshida,R., Imai,T., Hieshima,K., Kusuda,J., Baba,M., Kitaura,M.,
            Nishimura,M., Kakizaki,M., Nomiyama,H. and Yoshie,O.
  TITLE     Molecular cloning of a novel human CC chemokine EBI1-ligand
            chemokine that is a specific functional ligand for EBI1, CCR7
  JOURNAL   J Biol Chem 272 (21), 13803-13809 (1997)
   PUBMED   9153236
REFERENCE   10 (bases 1 to 683)
  AUTHORS   Rossi,D.L., Vicari,A.P., Franz-Bacon,K., McClanahan,T.K. and
            Zlotnik,A.
  TITLE     Identification through bioinformatics of two new macrophage
            proinflammatory human chemokines: MIP-3alpha and MIP-3beta
  JOURNAL   J Immunol 158 (3), 1033-1036 (1997)
   PUBMED   9013939
  REMARK    Erratum:[J Immunol 1999 Jul 15;163(2):1091]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162231.20.
            
            On Nov 26, 2018 this sequence version replaced NM_006274.2.
            
            Summary: This antimicrobial gene is one of several CC cytokine
            genes clustered on the p-arm of chromosome 9. Cytokines are a
            family of secreted proteins involved in immunoregulatory and
            inflammatory processes. The CC cytokines are proteins characterized
            by two adjacent cysteines. The cytokine encoded by this gene may
            play a role in normal lymphocyte recirculation and homing. It also
            plays an important role in trafficking of T cells in thymus, and in
            T cell and B cell migration to secondary lymphoid organs. It
            specifically binds to chemokine receptor CCR7. [provided by RefSeq,
            Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.181375.1, AB000887.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000311925.7/
                                                  ENSP00000308815.2
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AL162231.20        46621-46806         c
            187-319             AL162231.20        45740-45872         c
            320-413             AL162231.20        45460-45553         c
            414-683             AL162231.20        45100-45369         c
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..683
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /note="C-C motif chemokine ligand 19"
                     /db_xref="GeneID:6363"
                     /db_xref="HGNC:HGNC:10617"
                     /db_xref="MIM:602227"
     exon            1..186
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..434
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 19; CC chemokine ligand 19; macrophage inflammatory
                     protein 3-beta; beta chemokine exodus-3; CK beta-11; C-C
                     motif chemokine 19; EBI1-ligand chemokine; chemokine (C-C
                     motif) ligand 19; MIP-3-beta; small-inducible cytokine
                     A19; epstein-Barr virus-induced molecule 1 ligand
                     chemokine"
                     /codon_start=1
                     /product="C-C motif chemokine 19 precursor"
                     /protein_id="NP_006265.1"
                     /db_xref="CCDS:CCDS6570.1"
                     /db_xref="GeneID:6363"
                     /db_xref="HGNC:HGNC:10617"
                     /db_xref="MIM:602227"
                     /translation="MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVR
                     NFHYLLIKDGCRVPAVVFTTLRGRQLCAPPDQPWVERIIQRLQRTSAKMKRRSS"
     exon            187..319
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /inference="alignment:Splign:2.1.0"
     exon            320..413
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /inference="alignment:Splign:2.1.0"
     exon            414..683
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /note="hexamer: AATAAA"
     polyA_site      683
                     /gene="CCL19"
                     /gene_synonym="CKb11; ELC; MIP-3b; MIP3B; SCYA19"
                     /note="major polyA site"
ORIGIN      
        1 attcccagcc tcacatcact cacaccttgc atttcacccc tgcatcccag tcgccctgca
       61 gcctcacaca gatcctgcac acacccagac agctggcgct cacacattca ccgttggcct
      121 gcctctgttc accctccatg gccctgctac tggccctcag cctgctggtt ctctggactt
      181 ccccagcccc aactctgagt ggcaccaatg atgctgaaga ctgctgcctg tctgtgaccc
      241 agaaacccat ccctgggtac atcgtgagga acttccacta ccttctcatc aaggatggct
      301 gcagggtgcc tgctgtagtg ttcaccacac tgaggggccg ccagctctgt gcacccccag
      361 accagccctg ggtagaacgc atcatccaga gactgcagag gacctcagcc aagatgaagc
      421 gccgcagcag ttaacctatg accgtgcaga gggagcccgg agtccgagtc aagcattgtg
      481 aattattacc taacctgggg aaccgaggac cagaaggaag gaccaggctt ccagctcctc
      541 tgcaccagac ctgaccagcc aggacagggc ctggggtgtg tgtgagtgtg agtgtgagcg
      601 agagggtgag tgtggtcaga gtaaagctgc tccaccccca gattgcaatg ctaccaataa
      661 agccgcctgg tgtttacaac taa
//
