LOCUS       NM_002988               1332 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 18 (CCL18), mRNA.
ACCESSION   NM_002988
VERSION     NM_002988.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Hussain,K., Lim,H.D., Devkota,S.R., Kemp-Harper,B.K., Lane,J.R.,
            Canals,M., Pease,J.E. and Stone,M.J.
  TITLE     The chemokine receptor CCR8 is not a high-affinity receptor for the
            human chemokine CCL18
  JOURNAL   PLoS One 19 (9), e0305312 (2024)
   PUBMED   39259753
  REMARK    GeneRIF: The chemokine receptor CCR8 is not a high-affinity
            receptor for the human chemokine CCL18.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Singh,A., Kraaijeveld,A.O., Curaj,A., Wichapong,K., Hammerich,L.,
            de Jager,S.C.A., Bot,I., Atamas,S.P., van Berkel,T.J.C.,
            Jukema,J.W., Comerford,I., McColl,S.R., Mees,B., Heemskerk,J.W.M.,
            Nicolaes,G.A.F., Hackeng,T., Liehn,E.A., Tacke,F. and
            Biessen,E.A.L.
  TITLE     CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell
            influx and polarization
  JOURNAL   Front Immunol 15, 1327051 (2024)
   PUBMED   38807599
  REMARK    GeneRIF: CCL18 aggravates atherosclerosis by inducing
            CCR6-dependent T-cell influx and polarization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Hohne,K., Wagenknecht,A., Maier,C., Engelhard,P., Goldmann,T.,
            Schliessmann,S.J., Plones,T., Trepel,M., Eibel,H.,
            Muller-Quernheim,J. and Zissel,G.
  TITLE     Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are
            Mediated via CCR6
  JOURNAL   Cells 13 (3), 238 (2024)
   PUBMED   38334630
  REMARK    GeneRIF: Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts
            Are Mediated via CCR6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Yang,B., Fan,Y., Chen,M., Tang,L., Tang,X., Li,H., Gu,A., Liang,R.
            and Wu,Y.
  TITLE     Identification and validation of a CCL18-related signature for
            prediction of overall survival in patients with uveal melanoma
  JOURNAL   Exp Eye Res 230, 109448 (2023)
   PUBMED   36967081
  REMARK    GeneRIF: Identification and validation of a CCL18-related signature
            for prediction of overall survival in patients with uveal melanoma.
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Subramanian,N., Hofwimmer,K., Tavira,B., Massier,L.,
            Andersson,D.P., Arner,P. and Laurencikiene,J.
  TITLE     Adipose tissue specific CCL18 associates with cardiometabolic
            diseases in non-obese individuals implicating CD4+ T cells
  JOURNAL   Cardiovasc Diabetol 22 (1), 84 (2023)
   PUBMED   37046242
  REMARK    GeneRIF: Adipose tissue specific CCL18 associates with
            cardiometabolic diseases in non-obese individuals implicating
            CD4[+] T cells.
            Erratum:[Cardiovasc Diabetol. 2023 Aug 30;22(1):229. doi:
            10.1186/s12933-023-01961-x. PMID: 37649001]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL18 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Kodelja,V., Muller,C., Politz,O., Hakij,N., Orfanos,C.E. and
            Goerdt,S.
  TITLE     Alternative macrophage activation-associated CC-chemokine-1, a
            novel structural homologue of macrophage inflammatory protein-1
            alpha with a Th2-associated expression pattern
  JOURNAL   J Immunol 160 (3), 1411-1418 (1998)
   PUBMED   9570561
REFERENCE   8  (bases 1 to 1332)
  AUTHORS   Hieshima,K., Imai,T., Baba,M., Shoudai,K., Ishizuka,K.,
            Nakagawa,T., Tsuruta,J., Takeya,M., Sakaki,Y., Takatsuki,K.,
            Miura,R., Opdenakker,G., Van Damme,J., Yoshie,O. and Nomiyama,H.
  TITLE     A novel human CC chemokine PARC that is most homologous to
            macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic
            for T lymphocytes, but not for monocytes
  JOURNAL   J Immunol 159 (3), 1140-1149 (1997)
   PUBMED   9233607
REFERENCE   9  (bases 1 to 1332)
  AUTHORS   Adema,G.J., Hartgers,F., Verstraten,R., de Vries,E., Marland,G.,
            Menon,S., Foster,J., Xu,Y., Nooyen,P., McClanahan,T., Bacon,K.B.
            and Figdor,C.G.
  TITLE     A dendritic-cell-derived C-C chemokine that preferentially attracts
            naive T cells
  JOURNAL   Nature 387 (6634), 713-717 (1997)
   PUBMED   9192897
REFERENCE   10 (bases 1 to 1332)
  AUTHORS   Wells,T.N. and Peitsch,M.C.
  TITLE     The chemokine information source: identification and
            characterization of novel chemokines using the WorldWideWeb and
            expressed sequence tag databases
  JOURNAL   J Leukoc Biol 61 (5), 545-550 (1997)
   PUBMED   9129202
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243829.3, BC096124.3 and
            BU617136.1.
            
            On May 17, 2019 this sequence version replaced NM_002988.3.
            
            Summary: This antimicrobial gene is one of several Cys-Cys (CC)
            cytokine genes clustered on the q arm of chromosome 17. Cytokines
            are a family of secreted proteins involved in immunoregulatory and
            inflammatory processes. The CC cytokines are proteins characterized
            by two adjacent cysteines. The cytokine encoded by this gene
            displays chemotactic activity for naive T cells, CD4+ and CD8+ T
            cells and nonactivated lymphocytes, but not for monocytes or
            granulocytes. This chemokine attracts naive T lymphocytes toward
            dendritic cells and activated macrophages in lymph nodes. It may
            play a role in both humoral and cell-mediated immunity responses.
            [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.711337.1,
                                           DRR138517.1089033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000616054.2/
                                                  ENSP00000479955.1
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC243829.3         31507-31518
            13-468              BC096124.3         3-458
            469-781             BU617136.1         18-330              c
            782-1332            AC243829.3         38717-39267
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1332
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /note="C-C motif chemokine ligand 18"
                     /db_xref="GeneID:6362"
                     /db_xref="HGNC:HGNC:10616"
                     /db_xref="MIM:603757"
     exon            1..138
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..341
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 18, pulmonary and activation-regulated; macrophage
                     inflammatory protein 4; pulmonary and activation-regulated
                     chemokine; alternative macrophage activation-associated CC
                     chemokine 1; dendritic cell chemokine 1; CC chemokine
                     ligand 18; C-C motif chemokine 18; chemokine (C-C),
                     dendritic; small inducible cytokine A18; CC chemokine
                     PARC; chemokine (C-C motif) ligand 18 (pulmonary and
                     activation-regulated)"
                     /codon_start=1
                     /product="C-C motif chemokine 18 precursor"
                     /protein_id="NP_002979.1"
                     /db_xref="CCDS:CCDS11306.1"
                     /db_xref="GeneID:6362"
                     /db_xref="HGNC:HGNC:10616"
                     /db_xref="MIM:603757"
                     /translation="MKGLAAALLVLVCTMALCSCAQVGTNKELCCLVYTSWQIPQKFI
                     VDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLKLNA"
     exon            139..250
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /inference="alignment:Splign:2.1.0"
     exon            251..1332
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      751..756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /note="hexamer: TATAAA"
     polyA_site      769
                     /gene="CCL18"
                     /gene_synonym="AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4;
                     PARC; SCYA18"
                     /note="major polyA site"
ORIGIN      
        1 agaaggaggc caggagttgt gagtttccaa gccccagctc actctgacca cttctctgcc
       61 tgcccagcat catgaagggc cttgcagctg ccctccttgt cctcgtctgc accatggccc
      121 tctgctcctg tgcacaagtt ggtaccaaca aagagctctg ctgcctcgtc tatacctcct
      181 ggcagattcc acaaaagttc atagttgact attctgaaac cagcccccag tgccccaagc
      241 caggtgtcat cctcctaacc aagagaggcc ggcagatctg tgctgacccc aataagaagt
      301 gggtccagaa atacatcagc gacctgaagc tgaatgcctg aggggcctgg aagctgcgag
      361 ggcccagtga acttggtggg cccaggaggg aacaggagcc tgagccaggg caatggccct
      421 gccaccctgg aggctacctc ttctaagagt cccatctgct atgcccagcc acattaacta
      481 actttaatct tagtttatgc atcatatttc attttgaaat tgatttctat tgttgagctg
      541 cattatgaaa ttagtatttt ctctgacatc tcatgacatt gtctttatca tcctttcccc
      601 tttcccttca actcttcgta cattcaatgc atggatcaat cagtgtgatt agctttctca
      661 gcagacattg tgccatatgt atcaaatgac aaatctttat tgaatggttt tgctcagcac
      721 caccttttaa tatattggca gtacttatta tataaaaggt aaaccagcat tctcactgtg
      781 acgactctgt tgattttgtt tcactaatcg gaatcacaga ctgagaggaa ttctggggga
      841 ggagtaggga aatatgaaaa ggggcagaaa cagcaagata gggaccaagt acttctacag
      901 tcataccaga catttccctg gagatacttt cctgaaaagt tgaaacagac accattagtt
      961 tataaaccat attgtaactg aaatgtgata gaaaaatttt ctacttaaat gaatatcaag
     1021 atgacgctgc aatgcatatt tacgcacaca agctcatttt cataaatgaa gctttcctca
     1081 gaatgatggc taacatctgt tgaggtctta ccaagtgctg ggttttgggc taagtactta
     1141 tattagtaaa agtctagcaa atactgccca tagtctagca aggactcctt acctggaagt
     1201 tgctgaaagc cttggtaatg ttatctttgt tctccactct gcttttgggg aggatgtttt
     1261 ccatgactat acgagatgag gcttggggct gggtggccag agttagcaaa taaaaataca
     1321 gaatggatac ta
//
