LOCUS       NM_002987                616 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 17 (CCL17), mRNA.
ACCESSION   NM_002987
VERSION     NM_002987.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 616)
  AUTHORS   Zou,C., Zhang,W., Li,M., He,D., Han,Y., Liu,M. and Lu,M.
  TITLE     Association between CCL5, CCL11, and CCL17 polymorphisms and atopic
            dermatitis risk: A systematic review and meta-analysis
  JOURNAL   Medicine (Baltimore) 103 (8), e36897 (2024)
   PUBMED   38394497
  REMARK    GeneRIF: Association between CCL5, CCL11, and CCL17 polymorphisms
            and atopic dermatitis risk: A systematic review and meta-analysis.
REFERENCE   2  (bases 1 to 616)
  AUTHORS   Song,N., Paust,H.J., Asada,N., Peters,A., Kaffke,A., Krebs,C.F.,
            Panzer,U. and Riedel,J.H.
  TITLE     Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic
            Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell
            Recruitment
  JOURNAL   Am J Nephrol 55 (2), 214-224 (2024)
   PUBMED   37742620
  REMARK    GeneRIF: Targeting Monocyte Derived CCL17 Attenuates Murine
            Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory
            T-Cell Recruitment.
REFERENCE   3  (bases 1 to 616)
  AUTHORS   Sato,N., Yamaide,F., Nakano,T., Yonekura,S., Okamoto,Y. and
            Shimojo,N.
  TITLE     Association of umbilical cord serum TARC/CCL17 with childhood
            allergies: A birth cohort study
  JOURNAL   Allergol Int 72 (4), 551-556 (2023)
   PUBMED   37105786
  REMARK    GeneRIF: Association of umbilical cord serum TARC/CCL17 with
            childhood allergies: A birth cohort study.
REFERENCE   4  (bases 1 to 616)
  AUTHORS   de Jesus,C.S., Yonekura,S., Nomura,T., Egawa,G. and Kabashima,K.
  TITLE     Serum thymus and activation-regulated chemokine is a surrogate
            marker for bullous pemphigoid disease activity
  JOURNAL   J Eur Acad Dermatol Venereol 37 (9), e1125-e1127 (2023)
   PUBMED   37114340
  REMARK    GeneRIF: Serum thymus and activation-regulated chemokine is a
            surrogate marker for bullous pemphigoid disease activity.
REFERENCE   5  (bases 1 to 616)
  AUTHORS   Hueso,L., Marques,P., Morant,B., Gonzalez-Navarro,H., Ortega,J.,
            Real,J.T., Sanz,M.J. and Piqueras,L.
  TITLE     CCL17 and CCL22 chemokines are upregulated in human obesity and
            play a role in vascular dysfunction
  JOURNAL   Front Endocrinol (Lausanne) 14, 1154158 (2023)
   PUBMED   37124725
  REMARK    GeneRIF: CCL17 and CCL22 chemokines are upregulated in human
            obesity and play a role in vascular dysfunction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 616)
  AUTHORS   Yang,D., Chen,Q., Hoover,D.M., Staley,P., Tucker,K.D., Lubkowski,J.
            and Oppenheim,J.J.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: CCL17 is an antimicrobial protein with bacteriocidal
            activity against E. coli and S. aureus.
REFERENCE   7  (bases 1 to 616)
  AUTHORS   Imai,T., Chantry,D., Raport,C.J., Wood,C.L., Nishimura,M.,
            Godiska,R., Yoshie,O. and Gray,P.W.
  TITLE     Macrophage-derived chemokine is a functional ligand for the CC
            chemokine receptor 4
  JOURNAL   J Biol Chem 273 (3), 1764-1768 (1998)
   PUBMED   9430724
REFERENCE   8  (bases 1 to 616)
  AUTHORS   Imai,T., Baba,M., Nishimura,M., Kakizaki,M., Takagi,S. and
            Yoshie,O.
  TITLE     The T cell-directed CC chemokine TARC is a highly specific
            biological ligand for CC chemokine receptor 4
  JOURNAL   J Biol Chem 272 (23), 15036-15042 (1997)
   PUBMED   9169480
REFERENCE   9  (bases 1 to 616)
  AUTHORS   Nomiyama,H., Imai,T., Kusuda,J., Miura,R., Callen,D.F. and
            Yoshie,O.
  TITLE     Assignment of the human CC chemokine gene TARC (SCYA17) to
            chromosome 16q13
  JOURNAL   Genomics 40 (1), 211-213 (1997)
   PUBMED   9070951
REFERENCE   10 (bases 1 to 616)
  AUTHORS   Imai,T., Yoshida,T., Baba,M., Nishimura,M., Kakizaki,M. and
            Yoshie,O.
  TITLE     Molecular cloning of a novel T cell-directed CC chemokine expressed
            in thymus by signal sequence trap using Epstein-Barr virus vector
  JOURNAL   J Biol Chem 271 (35), 21514-21521 (1996)
   PUBMED   8702936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069107.1 and AC009052.8.
            
            On May 17, 2019 this sequence version replaced NM_002987.2.
            
            Summary: This antimicrobial gene is one of several Cys-Cys (CC)
            cytokine genes clustered on the q arm of chromosome 16. Cytokines
            are a family of secreted proteins involved in immunoregulatory and
            inflammatory processes. The CC cytokines are proteins characterized
            by two adjacent cysteines. The cytokine encoded by this gene
            displays chemotactic activity for T lymphocytes, but not monocytes
            or granulocytes. The product of this gene binds to chemokine
            receptors CCR4 and CCR8. This chemokine plays important roles in T
            cell development in thymus as well as in trafficking and activation
            of mature T cells. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2156670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            MANE Ensembl match                 :: ENST00000219244.9/
                                                  ENSP00000219244.4
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               BC069107.1         1-615
            616-616             AC009052.8         113780-113780
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..616
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /note="C-C motif chemokine ligand 17"
                     /db_xref="GeneID:6361"
                     /db_xref="HGNC:HGNC:10615"
                     /db_xref="MIM:601520"
     exon            1..70
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /inference="alignment:Splign:2.1.0"
     exon            71..199
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..414
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 17; thymus and activation-regulated chemokine; T
                     cell-directed CC chemokine; C-C motif chemokine 17; CC
                     chemokine TARC; small-inducible cytokine A17; chemokine
                     (C-C motif) ligand 17"
                     /codon_start=1
                     /product="C-C motif chemokine 17 precursor"
                     /protein_id="NP_002978.1"
                     /db_xref="CCDS:CCDS10780.1"
                     /db_xref="GeneID:6361"
                     /db_xref="HGNC:HGNC:10615"
                     /db_xref="MIM:601520"
                     /translation="MAPLKMLALVTLLLGASLQHIHAARGTNVGRECCLEYFKGAIPL
                     RKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKNAVKYLQSLERS"
     exon            200..317
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /inference="alignment:Splign:2.1.0"
     exon            318..616
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      598..603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /note="hexamer: ATTAAA"
     polyA_site      616
                     /gene="CCL17"
                     /gene_synonym="A-152E5.3; ABCD-2; SCYA17; TARC"
                     /note="major polyA site"
ORIGIN      
        1 gctcagagag aagtgacttt gagctcacag tgtcaccgcc tgctgatggg agagctgaat
       61 tcaaaaccag ggtgtctccc tgagcagagg gacctgcaca cagagactcc ctcctgggct
      121 cctggcacca tggccccact gaagatgctg gccctggtca ccctcctcct gggggcttct
      181 ctgcagcaca tccacgcagc tcgagggacc aatgtgggcc gggagtgctg cctggagtac
      241 ttcaagggag ccattcccct tagaaagctg aagacgtggt accagacatc tgaggactgc
      301 tccagggatg ccatcgtttt tgtaactgtg cagggcaggg ccatctgttc ggaccccaac
      361 aacaagagag tgaagaatgc agttaaatac ctgcaaagcc ttgagaggtc ttgaagcctc
      421 ctcaccccag actcctgact gtctcccggg actacctggg acctccaccg ttggtgttca
      481 ccgcccccac cctgagcgcc tgggtccagg ggaggccttc cagggacgaa gaagagccac
      541 agtgagggag atcccatccc cttgtctgaa ctggagccat gggcacaaag ggcccagatt
      601 aaagtcttta tcctca
//
