LOCUS       NM_032965                588 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 15 (CCL15), mRNA.
ACCESSION   NM_032965
VERSION     NM_032965.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 588)
  AUTHORS   Liu,Y., Chen,X., Xu,Y., Yang,T., Wang,H., Wang,Z., Hu,Z., Chen,L.,
            Zhang,Z. and Wu,Y.
  TITLE     CTHRC1 promotes colorectal cancer progression by recruiting
            tumor-associated macrophages via up-regulation of CCL15
  JOURNAL   J Mol Med (Berl) 102 (1), 81-94 (2024)
   PUBMED   37987774
  REMARK    GeneRIF: CTHRC1 promotes colorectal cancer progression by
            recruiting tumor-associated macrophages via up-regulation of CCL15.
REFERENCE   2  (bases 1 to 588)
  AUTHORS   Starr,A.E., Dufour,A., Maier,J. and Overall,C.M.
  TITLE     Biochemical analysis of matrix metalloproteinase activation of
            chemokines CCL15 and CCL23 and increased glycosaminoglycan binding
            of CCL16
  JOURNAL   J Biol Chem 287 (8), 5848-5860 (2012)
   PUBMED   22147696
REFERENCE   3  (bases 1 to 588)
  AUTHORS   Richter,R., Bistrian,R., Escher,S., Forssmann,W.G., Vakili,J.,
            Henschler,R., Spodsberg,N., Frimpong-Boateng,A. and Forssmann,U.
  TITLE     Quantum proteolytic activation of chemokine CCL15 by neutrophil
            granulocytes modulates mononuclear cell adhesiveness
  JOURNAL   J Immunol 175 (3), 1599-1608 (2005)
   PUBMED   16034099
  REMARK    GeneRIF: Compared with full-length CCL15, proteolytically processed
            CCL15 isoforms with N-terminal deletions display increased potency
            to induce calcium fluxes and chemotactic activity on monocytes and
            to induce adhesiveness of mononuclear cells to fibronectin.
REFERENCE   4  (bases 1 to 588)
  AUTHORS   Berahovich,R.D., Miao,Z., Wang,Y., Premack,B., Howard,M.C. and
            Schall,T.J.
  TITLE     Proteolytic activation of alternative CCR1 ligands in inflammation
  JOURNAL   J Immunol 174 (11), 7341-7351 (2005)
   PUBMED   15905581
REFERENCE   5  (bases 1 to 588)
  AUTHORS   Nomiyama,H., Fukuda,S., Iio,M., Tanase,S., Miura,R. and Yoshie,O.
  TITLE     Organization of the chemokine gene cluster on human chromosome
            17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1,
            LEC, and RANTES
  JOURNAL   J Interferon Cytokine Res 19 (3), 227-234 (1999)
   PUBMED   10213461
REFERENCE   6  (bases 1 to 588)
  AUTHORS   Pardigol,A., Forssmann,U., Zucht,H.D., Loetscher,P.,
            Schulz-Knappe,P., Baggiolini,M., Forssmann,W.G. and Magert,H.J.
  TITLE     HCC-2, a human chemokine: gene structure, expression pattern, and
            biological activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6308-6313 (1998)
   PUBMED   9600961
REFERENCE   7  (bases 1 to 588)
  AUTHORS   Wang,W., Bacon,K.B., Oldham,E.R. and Schall,T.J.
  TITLE     Molecular cloning and functional characterization of human MIP-1
            delta, a new C-C chemokine related to mouse CCF-18 and C10
  JOURNAL   J Clin Immunol 18 (3), 214-222 (1998)
   PUBMED   9624581
REFERENCE   8  (bases 1 to 588)
  AUTHORS   Youn,B.S., Zhang,S.M., Lee,E.K., Park,D.H., Broxmeyer,H.E.,
            Murphy,P.M., Locati,M., Pease,J.E., Kim,K.K., Antol,K. and
            Kwon,B.S.
  TITLE     Molecular cloning of leukotactin-1: a novel human beta-chemokine, a
            chemoattractant for neutrophils, monocytes, and lymphocytes, and a
            potent agonist at CC chemokine receptors 1 and 3
  JOURNAL   J Immunol 159 (11), 5201-5205 (1997)
   PUBMED   9548457
REFERENCE   9  (bases 1 to 588)
  AUTHORS   Coulin,F., Power,C.A., Alouani,S., Peitsch,M.C., Schroeder,J.M.,
            Moshizuki,M., Clark-Lewis,I. and Wells,T.N.
  TITLE     Characterisation of macrophage inflammatory protein-5/human CC
            cytokine-2, a member of the macrophage-inflammatory-protein family
            of chemokines
  JOURNAL   Eur J Biochem 248 (2), 507-515 (1997)
   PUBMED   9346309
REFERENCE   10 (bases 1 to 588)
  AUTHORS   Naruse,K., Ueno,M., Satoh,T., Nomiyama,H., Tei,H., Takeda,M.,
            Ledbetter,D.H., Coillie,E.V., Opdenakker,G., Gunge,N., Sakaki,Y.,
            Iio,M. and Miura,R.
  TITLE     A YAC contig of the human CC chemokine genes clustered on
            chromosome 17q11.2
  JOURNAL   Genomics 34 (2), 236-240 (1996)
   PUBMED   8661057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX098368.1 and AI244164.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032965.5.
            
            Summary: This gene is located in a cluster of similar genes in the
            same region of chromosome 17. These genes encode CC cytokines,
            which are secreted proteins characterized by two adjacent
            cysteines. The product of this gene is chemotactic for T cells and
            monocytes, and acts through C-C chemokine receptor type 1 (CCR1).
            The proprotein is further processed into numerous smaller
            functional peptides. Naturally-occurring readthrough transcripts
            occur from this gene into the downstream gene, CCL14 (chemokine
            (C-C motif) ligand 14). [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58914.1, ERR279836.87.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617897.2/ ENSP00000484078.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               BX098368.1         486-717
            233-588             AI244164.1         2-357               c
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..588
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /note="C-C motif chemokine ligand 15"
                     /db_xref="GeneID:6359"
                     /db_xref="HGNC:HGNC:10613"
                     /db_xref="MIM:601393"
     exon            1..137
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..403
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /note="small inducible cytokine subfamily A (Cys-Cys),
                     member 15; C-C motif chemokine 15; leukotactin 1;
                     macrophage inflammatory protein 5; chemokine CC-2; new CC
                     chemokine 3; chemokine (C-C motif) ligand 15;
                     small-inducible cytokine A15"
                     /codon_start=1
                     /product="C-C motif chemokine 15 preproprotein"
                     /protein_id="NP_116741.2"
                     /db_xref="CCDS:CCDS11304.1"
                     /db_xref="GeneID:6359"
                     /db_xref="HGNC:HGNC:10613"
                     /db_xref="MIM:601393"
                     /translation="MKVSVAALSCLMLVAVLGSQAQFTNDAETELMMSKLPLENPVVL
                     NSFHFAADCCTSYISQSIPCSLMKSYFETSSECSKPGVIFLTKKGRQVCAKPSGPGVQ
                     DCMKKLKPYSI"
     exon            138..197
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /inference="alignment:Splign:2.1.0"
     exon            198..309
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /inference="alignment:Splign:2.1.0"
     exon            310..588
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      521..526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /note="hexamer: AATAAA"
     polyA_site      544
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /note="major polyA site"
     regulatory      567..572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /note="hexamer: AATAAA"
     polyA_site      588
                     /gene="CCL15"
                     /gene_synonym="HCC-2; HMRP-2B; LKN-1; LKN1; MIP-1 delta;
                     MIP-1D; MIP-5; MRP-2B; NCC-3; NCC3; SCYA15; SCYL3; SY15"
                     /note="major polyA site"
ORIGIN      
        1 ggggagccag gaagcagtga gcccaggagt cctcggccag ccctgcctgc ccaccaggag
       61 gatgaaggtc tccgtggctg ccctctcctg cctcatgctt gttgctgtcc ttggatccca
      121 ggcccagttc acaaatgatg cagagacaga gttaatgatg tcaaagcttc cactggaaaa
      181 tccagtagtt ctgaacagct ttcactttgc tgctgactgc tgcacctcct acatctcaca
      241 aagcatcccg tgttcactca tgaaaagtta ttttgaaacg agcagcgagt gctccaagcc
      301 aggtgtcata ttcctcacca agaaggggcg gcaagtctgt gccaaaccca gtggtccggg
      361 agttcaggat tgcatgaaaa agctgaagcc ctactcaata taataataaa gagacaaaag
      421 aggccagcca cccacctcca acacctcctg tgagtttctt ggtctgaaat acttaaaaaa
      481 tatatatatt gttgtgtctg gtaatgaaag taatgcatct aataaagagt attcaatttt
      541 ttaactttgc ttgagtttta agaggaaata aactaatata aaactgaa
//
