LOCUS       NM_032963                875 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens C-C motif chemokine ligand 14 (CCL14), transcript
            variant 3, mRNA.
ACCESSION   NM_032963
VERSION     NM_032963.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 875)
  AUTHORS   Chen,Y.T., Pan,H.C., Hsu,C.K., Sun,C.Y., Chen,C.Y., Chen,Y.H.,
            Hsu,H.J., Wu,I.W., Wu,V.C. and Hoste,E.
  TITLE     Performance of urinary C-C motif chemokine ligand 14 for the
            prediction of persistent acute kidney injury: a systematic review
            and meta-analysis
  JOURNAL   Crit Care 27 (1), 318 (2023)
   PUBMED   37596698
  REMARK    GeneRIF: Performance of urinary C-C motif chemokine ligand 14 for
            the prediction of persistent acute kidney injury: a systematic
            review and meta-analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 875)
  AUTHORS   Zhang,M.M., Zhao,Y.D., Li,Q. and He,Y.J.
  TITLE     Chemokine CCL14 affected the clinical outcome and correlated with
            immune infiltrates in thyroid carcinoma
  JOURNAL   Histol Histopathol 38 (6), 695-707 (2023)
   PUBMED   36409028
  REMARK    GeneRIF: Chemokine CCL14 affected the clinical outcome and
            correlated with immune infiltrates in thyroid carcinoma.
REFERENCE   3  (bases 1 to 875)
  AUTHORS   Bandow,K., Smith,A., Watkins,T., Shenk,S., Gerami-Naini,B. and
            Garlick,J.A.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   4  (bases 1 to 875)
  AUTHORS   Li,Z., Qin,Z., Kong,X., Chen,B., Hu,W., Lin,Z., Feng,Y., Li,H.,
            Wan,Q. and Li,S.
  TITLE     CCL14 exacerbates intraplaque vulnerability by promoting
            neovascularization in the human carotid plaque
  JOURNAL   J Stroke Cerebrovasc Dis 31 (10), 106670 (2022)
   PUBMED   35973397
  REMARK    GeneRIF: CCL14 exacerbates intraplaque vulnerability by promoting
            neovascularization in the human carotid plaque.
REFERENCE   5  (bases 1 to 875)
  AUTHORS   Forssmann,U., Magert,H.J., Adermann,K., Escher,S.E. and
            Forssmann,W.G.
  TITLE     Hemofiltrate CC chemokines with unique biochemical properties:
            HCC-1/CCL14a and HCC-2/CCL15
  JOURNAL   J Leukoc Biol 70 (3), 357-366 (2001)
   PUBMED   11527984
  REMARK    Review article
REFERENCE   6  (bases 1 to 875)
  AUTHORS   Richter,R., Schulz-Knappe,P., John,H. and Forssmann,W.G.
  TITLE     Posttranslationally processed forms of the human chemokine HCC-1
  JOURNAL   Biochemistry 39 (35), 10799-10805 (2000)
   PUBMED   10978165
REFERENCE   7  (bases 1 to 875)
  AUTHORS   Nomiyama,H., Fukuda,S., Iio,M., Tanase,S., Miura,R. and Yoshie,O.
  TITLE     Organization of the chemokine gene cluster on human chromosome
            17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1,
            LEC, and RANTES
  JOURNAL   J Interferon Cytokine Res 19 (3), 227-234 (1999)
   PUBMED   10213461
REFERENCE   8  (bases 1 to 875)
  AUTHORS   Pardigol,A., Forssmann,U., Zucht,H.D., Loetscher,P.,
            Schulz-Knappe,P., Baggiolini,M., Forssmann,W.G. and Magert,H.J.
  TITLE     HCC-2, a human chemokine: gene structure, expression pattern, and
            biological activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6308-6313 (1998)
   PUBMED   9600961
REFERENCE   9  (bases 1 to 875)
  AUTHORS   Naruse,K., Ueno,M., Satoh,T., Nomiyama,H., Tei,H., Takeda,M.,
            Ledbetter,D.H., Coillie,E.V., Opdenakker,G., Gunge,N., Sakaki,Y.,
            Iio,M. and Miura,R.
  TITLE     A YAC contig of the human CC chemokine genes clustered on
            chromosome 17q11.2
  JOURNAL   Genomics 34 (2), 236-240 (1996)
   PUBMED   8661057
REFERENCE   10 (bases 1 to 875)
  AUTHORS   Schulz-Knappe,P., Magert,H.J., Dewald,B., Meyer,M., Cetin,Y.,
            Kubbies,M., Tomeczkowski,J., Kirchhoff,K., Raida,M., Adermann,K.,
            Kist,A., Reinecke,M., Sillard,R., Pardigol,A., Uguccioni,M.,
            Baggiolini,M. and Forssmann,W.G.
  TITLE     HCC-1, a novel chemokine from human plasma
  JOURNAL   J Exp Med 183 (1), 295-299 (1996)
   PUBMED   8551235
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244100.3 and DA821276.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032963.3.
            
            Summary: This gene, chemokine (C-C motif) ligand 14, is one of
            several CC cytokine genes clustered on 17q11.2. The CC cytokines
            are secreted proteins characterized by two adjacent cysteines. The
            cytokine encoded by this gene induces changes in intracellular
            calcium concentration and enzyme release in monocytes. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. Read-through transcripts are also expressed that include
            exons from the upstream cytokine gene, chemokine (C-C motif) ligand
            15, and are represented as GeneID: 348249. [provided by RefSeq, Dec
            2009].
            
            Transcript Variant: This variant (3, CCL14a) lacks an alternate
            in-frame exon in the 5' coding region, compared to variant 2. The
            resulting isoform (1) lacks an alternate segment near the
            N-terminus, compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA821276.1, HY071902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618404.5/ ENSP00000481023.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC244100.3         151413-151413       c
            2-507               DA821276.1         3-508
            508-875             AC244100.3         147972-148339       c
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..875
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /note="C-C motif chemokine ligand 14"
                     /db_xref="GeneID:6358"
                     /db_xref="HGNC:HGNC:10612"
                     /db_xref="MIM:601392"
     exon            1..159
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..362
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; small inducible cytokine subfamily A (Cys-Cys),
                     member 14; chemokine CC-3; C-C motif chemokine 14; new CC
                     chemokine 2; hemofiltrate CC chemokine 1; chemokine
                     CC-1/CC-3; small-inducible cytokine A14; chemokine (C-C
                     motif) ligand 14"
                     /codon_start=1
                     /product="C-C motif chemokine 14 isoform 1 precursor"
                     /protein_id="NP_116739.1"
                     /db_xref="CCDS:CCDS32624.1"
                     /db_xref="GeneID:6358"
                     /db_xref="HGNC:HGNC:10612"
                     /db_xref="MIM:601392"
                     /translation="MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKI
                     PRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN"
     exon            160..274
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /inference="alignment:Splign:2.1.0"
     exon            275..875
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      485..490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /note="hexamer: ATTAAA"
     polyA_site      504
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /note="major polyA site"
     regulatory      849..854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
                     /note="hexamer: CATAAA"
     polyA_site      875
                     /gene="CCL14"
                     /gene_synonym="CC-1; CC-3; CKB1; HCC-1; HCC-1(1-74);
                     HCC-1/HCC-3; HCC-3; MCIF; NCC-2; NCC2; SCYA14; SCYL2;
                     SY14"
ORIGIN      
        1 atttctcaac aattcctcac cgcaggagcc tctgaagctc ccaccaggcc agctctcctc
       61 ccacaacagc ttcccacagc atgaagatct ccgtggctgc cattcccttc ttcctcctca
      121 tcaccatcgc cctagggacc aagactgaat cctcctcacg gggaccttac cacccctcag
      181 agtgctgctt cacctacact acctacaaga tcccgcgtca gcggattatg gattactatg
      241 agaccaacag ccagtgctcc aagcccggaa ttgtcttcat caccaaaagg ggccattccg
      301 tctgtaccaa ccccagtgac aagtgggtcc aggactatat caaggacatg aaggagaact
      361 gagtgaccca gaaggggtgg cgaaggcaca gctcagagac ataaagagaa gatgccaagg
      421 ccccctcctc cacccaccgc taactctcag ccccagtcac cctcttggag cttccctgct
      481 ttgaattaaa gaccactcat gctcttccct ggcctcattc ctttctacgg gatttactca
      541 ttggccatgc actgaggaca ccagggtgtg gcaccctcgg catcaagcct cgctctgcag
      601 aagttttgct ggagcctggt acaaaaaata ggtcaggcct gcaatgcagg tagtgagaag
      661 cagaaagtga gaaagaaaag cagtgtaaag accgtctcct cctcagcaac aacagtagca
      721 gaccccgttt tcttaatgct ttctatactc caagcactct gctaggcagt ctgtatgcat
      781 tatcttattt aagcttcatg acaagtgtaa aagctacaaa tcatcatttg attttttagg
      841 taacacttca taaagggctc tctatagcag tcaaa
//
